Abstract
Amaç:Direkt inguinal herni, visseral içeriğin karın duvarının zayıflayan kısmından protrüde olmasıdır. Serum D vitamini düzeyi kas kitlesi ve kas fonksiyonları ile pozitif bir ilişki gösterir. Bu nedenle, düşük serum D vitamini düzeyleri direkt inguinal herni gelişmesini kolaylaştırabilir. Biz de bu çalışmada, inguinal hernili hastaların ve sağlıklı bireylerin serum D vitamini düzeylerini karşılaştırmayı amaçladık.
Hastalar ve Yöntem:Çalışmaya Nisan 2018 ve Ekim 2018 tarihleri arasında değerlendirilen direkt inguinal hernili 30 hasta (28 erkek, 2 kadın) ve kontrol grubu içerisindeki 30 sağlıklı birey (28 erkek, 2 kadın) dahil edilmiştir. Tüm katılımcıların serum D vitamini düzeyleri ve hastaların ultrason bulguları retrospektif olarak değerlendirilmiştir.
Bulgular:Hastaların ve sağlıklı bireylerin ortalama serum 25(OH)D düzeyleri sırasıyla 23.11±8.42 ng/mL ve 24,77±10,67 ng/mL olarak bulunmuştur (p=0.77). Serum 25(OH)D düzeyleri 27 (90%) hastada düşük, 3 (10%) hastada ise normal sınırlar içerisindeydi. Serum 25(OH)D düzeyleri kontrol grubundaki 21 (70%) sağlıklı bireyde düşük, 9 (30%) sağlıklı bireyde ise normal sınırlar içerisindeydi (p=0.11).
Sonuç:Bu çalışmadan elde edilen sonuçlar, direkt inguinal hernili hastaların sağlıklı bireylere göre daha düşük serum D vitamini düzeylerine sahip olduğunu göstermiştir. Bununla birlikte, inguinal hernili hastalar ile kontrol grubu arasında serum D vitamini düzeyleri açısından istatiksel olarak anlamlı bir fark yoktu. Dolayısıyla düşük serum 25(OH)D düzeylerinin direkt inguinal herni oluşmasına neden olacağı hipotezimiz kanıtlanamamıştır. İleri araştırma için daha geniş bir örneklem grubuna ihtiyaç vardır.
Keywords
References
- 1. Köckerling F, Simons MP., Current concepts of inguinal hernia repair, Visc Med 2018;34:145-50.
- 2. Öberg S, Andresen K, Rosenberg J., Etiology of inguinal hernias: A comprehensive review, Front Surg 2017;4:52.
- 3. Jenkins JT, O'Dwyer PJ., Inguinal hernias, BMJ 2008;336:269-72.
- 4. Amato G, Agrusa A, Romano G, Salamone G, Gulotta G, Silvestri F, et al., Muscle degeneration in inguinal hernia specimens, Hernia 2012;16:327-31.
- 5. Muscogiuri G., Vitamin D: Past, present and future perspectives in the prevention of chronic diseases, Eur J Clin Nutr 2018;72:1221-5.
- 6. Beaudart C, Buckinx F, Rabenda V, Gillain S, Cavalier E, Slomian J, et al., The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: A systematic review and meta-analysis of randomized controlled trials, J Clin Endocrinol Metab 2014;99:4336-45.
- 7. Meehan M, Penckofer S., The role of vitamin D in the aging adult, J Aging Gerontol 2014;2:60-71.
- 8. Miller HJ., Inguinal hernia: Mastering the anatomy, Surg Clin North Am 2018;98:607-21.
- 9. Zhao H, Zhou L, Li L, Coon V J, Chatterton RT, Brooks DC, et al., Shift from androgen to estrogen action causes abdominal muscle fibrosis, atrophy, and inguinal hernia in a transgenic male mouse model, Proc Natl Acad Sci U S A 2018;115:10427-36.
- 10. O'Rourke MG, O'Rourke TR., Inguinal hernia: Etiology, diagnosis, post-repair pain and compensation, ANZ J Surg 2012;82:201-6.
- 11. Burcharth J, Pommergaard HC, Bisgaard T, Rosenberg J., Patient-related risk factors for recurrence after inguinal hernia repair: A systematic review and meta-analysis of observational studies, Surg Innov 2015;22:303-17.
- 12. Mieszkowski J, Niespodziński B, Kochanowicz A, Gmiat A, Prusik K, Prusik K, et al., The effect of nordic walking training combined with vitamin D supplementation on postural control and muscle strength in elderly people-a randomized controlled trial, Int J Environ Res Public Health 2018;15:1951.
- 13. Agostini D, Zeppa Donati S, Lucertini F, Annibalini G, Gervasi M, Ferri Marini C, et al., Muscle and bone health in postmenopausal women: role of protein and vitamin D supplementation combined with exercise training, Nutrients 2018;10:1103.
- 14. Carson EL, Pourshahidi LK, Madigan SM, Baldrick FR, Kelly MG, Lairde E, et al., Vitamin D status is associated with muscle strength and quality of life in patients with COPD: A seasonal prospective observation study, Int J Chron Obstruct Pulmon Dis 2018;13:2613–22.
- 15. Nejatinamini S, Debenham BJ, Clugston RD, Mawani A, Parliament M, Wismer WV, et al., Poor vitamin status is associated with skeletal muscle loss and mucositis in head and neck cancer patients, Nutrients 2018;10:1236.
Abstract
Purpose:Direct inguinal hernia is the protrusion of the visceral contents through the weakened part of the abdominal wall. Serum level of vitamin D has a positive correlation with muscle mass and functions. Therefore, decreased serum levels of vitamin D may facilitate the direct inguinal hernia development. We aimed to compare the serum levels of vitamin D in patients with direct inguinal hernia and in healthy individuals.
Patients and Methods:Between April 2018 and October 2018, 30 patients with direct inguinal hernia (28 male, 2 female) and 30 healthy individuals within the control group (28 male, 2 female) were included in the study. Serum vitamin D levels of the participants and ultrasound findings of the patients were reviewed retrospectively.
Results:The mean serum 25(OH)D level was 23.11±8.42 ng/mL in patients and 24,77±10,67 ng/mL in healthy individuals, respectively (p=0.77). Serum 25(OH)D level was decreased in 27 (90%) patients, and it was within normal limits in 3 (10%) patients. Serum 25(OH)D level was decreased in 21 (70%) healthy individuals, and it was normal in 9 (30%) healthy individuals within the control group (p=0.11).
Conclusion:The results obtained from this study revealed that the patients with direct inguinal hernia had lower serum vitamin D levels than healthy individuals. However, there was no statistically significant difference in serum vitamin D levels, between patients with inguinal hernia and control group. Therefore, our hypothesis if low serum 25(OH)D levels caused direct inguinal hernia could not be proved. A larger sample group is needed for further investigation.
References
- 1. Köckerling F, Simons MP., Current concepts of inguinal hernia repair, Visc Med 2018;34:145-50.
- 2. Öberg S, Andresen K, Rosenberg J., Etiology of inguinal hernias: A comprehensive review, Front Surg 2017;4:52.
- 3. Jenkins JT, O'Dwyer PJ., Inguinal hernias, BMJ 2008;336:269-72.
- 4. Amato G, Agrusa A, Romano G, Salamone G, Gulotta G, Silvestri F, et al., Muscle degeneration in inguinal hernia specimens, Hernia 2012;16:327-31.
- 5. Muscogiuri G., Vitamin D: Past, present and future perspectives in the prevention of chronic diseases, Eur J Clin Nutr 2018;72:1221-5.
- 6. Beaudart C, Buckinx F, Rabenda V, Gillain S, Cavalier E, Slomian J, et al., The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: A systematic review and meta-analysis of randomized controlled trials, J Clin Endocrinol Metab 2014;99:4336-45.
- 7. Meehan M, Penckofer S., The role of vitamin D in the aging adult, J Aging Gerontol 2014;2:60-71.
- 8. Miller HJ., Inguinal hernia: Mastering the anatomy, Surg Clin North Am 2018;98:607-21.
- 9. Zhao H, Zhou L, Li L, Coon V J, Chatterton RT, Brooks DC, et al., Shift from androgen to estrogen action causes abdominal muscle fibrosis, atrophy, and inguinal hernia in a transgenic male mouse model, Proc Natl Acad Sci U S A 2018;115:10427-36.
- 10. O'Rourke MG, O'Rourke TR., Inguinal hernia: Etiology, diagnosis, post-repair pain and compensation, ANZ J Surg 2012;82:201-6.
- 11. Burcharth J, Pommergaard HC, Bisgaard T, Rosenberg J., Patient-related risk factors for recurrence after inguinal hernia repair: A systematic review and meta-analysis of observational studies, Surg Innov 2015;22:303-17.
- 12. Mieszkowski J, Niespodziński B, Kochanowicz A, Gmiat A, Prusik K, Prusik K, et al., The effect of nordic walking training combined with vitamin D supplementation on postural control and muscle strength in elderly people-a randomized controlled trial, Int J Environ Res Public Health 2018;15:1951.
- 13. Agostini D, Zeppa Donati S, Lucertini F, Annibalini G, Gervasi M, Ferri Marini C, et al., Muscle and bone health in postmenopausal women: role of protein and vitamin D supplementation combined with exercise training, Nutrients 2018;10:1103.
- 14. Carson EL, Pourshahidi LK, Madigan SM, Baldrick FR, Kelly MG, Lairde E, et al., Vitamin D status is associated with muscle strength and quality of life in patients with COPD: A seasonal prospective observation study, Int J Chron Obstruct Pulmon Dis 2018;13:2613–22.
- 15. Nejatinamini S, Debenham BJ, Clugston RD, Mawani A, Parliament M, Wismer WV, et al., Poor vitamin status is associated with skeletal muscle loss and mucositis in head and neck cancer patients, Nutrients 2018;10:1236.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | December 16, 2020 |
| Submission Date | May 6, 2019 |
| Published in Issue | Year 2021 |