Clinical Research
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Year 2021, , 645 - 650, 01.07.2021

Veysi Hakan Yardımcı , Cihan Uras

https://doi.org/10.31067/acusaglik.888217

Abstract

References

  • Limaiem F, Arfa N, Marsaoui L, Bouraoui S, Lahmar A, Mzabi S. Unexpected Histopathological Findings in Appendectomy Specimens: a Retrospective Study of 1627 Cases. Indian J Surg. 2015;77: 1285-90. DOI:10.1007/s12262-015-1278-8.
  • Akbulut S, Tas M, Sogutcu N, et al. Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review. World J Gastroenterol. 2011;17: 1961-70. DOI: 10.3748/wjg.v17.i15.1961.
  • Elfaedy O, Benkhadoura M, Elshaikhy A, Elgazwi K. Impact of routine histopathological examination of appendectomy specimens on patient management: a study of 4012 appendectomy specimens. Turk J Surg. 2019;35: 196-201. DOI: 10.5578/turkjsurg.4253.
  • Dincel O, Göksu M, Türk BA, Pehlivanoğlu B, İsler S. Incidental Findings in Routine Histopathological Examination of Appendectomy Specimens; Retrospective Analysis of 1970 Patients. Indian J Surg. 2018;80 :48-53. DOI: 10.1007/s12262-016-1557-z.
  • Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol. 1990;132: 910-25.DOI: 10.1093/oxfordjournals.aje.a115734.
  • Unver N, Coban G, Arıcı DS, et al. Unusual Histopathological Findings in Appendectomy Specimens: A Retrospective Analysis of 2047 Cases. Int J Surg Pathol. 2019;27: 142-6. DOI: 10.1177/1066896918784650.
  • Tumay V, Ozturk E, Ozturk H, Yilmazlar T. Appendiceal endometriosis mimicking acute appendicitis. Acta Chir Belg. 2006;106: 712-3. DOI: 10.1080/00015458.2006.11679989.
  • Faucheron JL, Pasquier D, Voirin D. Endometriosis of the vermiform appendix as an exceptional cause of acute perforated appendicitis during pregnancy. Colorectal Dis. 2008;10: 518-9. DOI: 10.1111/j.1463-1318.2007.01428.x.
  • Yardimci AH, Bektas CT, Pasaoglu E, et al. Retrospective study of 24 cases of acute appendiceal diverticulitis: CT findings and pathological correlations. Jpn J Radiol. 2017;35: 225-32. DOI: 10.1007/s11604-017-0625-z.
  • Klingler PJ, Seelig MH, DeVault KR, et al. foreign bodies within the appendix: A 100-year review of the literature. Dig Dis. 1998;16: 308-14. DOI: doi: 10.1159/000016880.
  • Yildirim S, Nursal TZ, Tarim A, Kayaselcuk F, Noyan T. A rare cause of acute appendicitis: parasitic infection. Scand J Infect Dis. 2005;37: 757-9. DOI: 10.1080/00365540510012161.
  • Chamisa I. A clinicopathological review of 324 appendices removed for acute appendicitis in Durban, South Africa: a retrospective analysis. Ann R Coll Surg Engl. 2009;91: 688-92. DOI:10.1308/003588409X12486167521677.
  • Nissotakis C, Sakorafas GH, Koureta T, Revelos K, Kassaras G, Peros G. Actinomycosis of the appendix: diagnostic and therapeutic considerations. Int J Infect Dis. 2008;12: 562-4. DOI: 10.1016/j.ijid.2007.12.015.
  • Shapiro R, Eldar S, Sadot E, Venturero M, Papa MZ, Zippel DB. The significance of occult carcinoids in the era of laparoscopic appendectomies. Surg Endosc. 2010;24: 2197-9. DOI: 10.1007/s00464-010-0926-0.
  • Jones AE, Phillips AW, Jarvis JR, Sargen K. The value of routine histopathological examination of appendicectomy specimens. BMC Surg. 2007;7: 17. DOI: 10.1186/1471-2482-7-17.
  • Rabah R. Pathology of the appendix in children: an institutional experience and review of the literature. Pediatr Radiol. 2007;37: 15-20. DOI: 10.1007/s00247-006-0288-x.
  • Ma KW, Chia NH, Yeung HW, Cheung MT. If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies. Hong Kong Med J. 2010;16: 12-7.
  • Charfi S, Sellami A, Affes A, Yaïch K, Mzali R, Boudawara TS. Histopathological findings in appendectomy specimens: a study of 24,697 cases. Int J Colorectal Dis. 2014;29: 1009-12. DOİ: 10.1007/s00384-014-1934-7.
  • Khairy G. Acute appendicitis: is removal of a normal appendix still existing and can we reduce its rate? Saudi J Gastroenterol. 2009;15: 167-70. DOI: 10.4103/1319-3767.51367.
  • Chiang DT, Tan EI, Birks D. 'To have...or not to have'. Should computed tomography and ultrasonography be implemented as a routine work-up for patients with suspected acute appendicitis in a regional hospital? Ann R Coll Surg Engl. 2008;90: 17-21. DOI: 10.1308/003588408X242259.
  • Bastiaenen VP, Allema WM, Klaver CEL, et al. Routine histopathologic examination of the appendix after appendectomy for presumed appendicitis: Is it really necessary? A systematic review and meta-analysis. Surgery. 2020;168: 305-12. DOI: 10.1016/j.surg.2020.03.032.
  • Patel AV, Friedman M, MacDermott RP. Crohn's disease patient with right lower quadrant abdominal pain for 20 years due to an appendiceal neuroma (Fibrous obliteration of the appendix). Inflamm Bowel Dis. 2010;16: 1093-4. DOI: 10.1002/ibd.21143.
  • Khan RA, Ghani I, Chana RS. Routine histopathological examination of appendectomy specimens in children: is there any rationale? Pediatr Surg Int. 2011;27: 1313-5. DOI: 10.1007/s00383-011-2926-0.
  • Matthyssens LE, Ziol M, Barrat C, Champault GG. Routine surgical pathology in general surgery. Br J Surg. 2006;93: 362-8. DOI: 10.1002/bjs.5268.

Usual and Unusual Pathologies of Appendicitis: A Retrospective Analysis of 385 Patients

Year 2021, , 645 - 650, 01.07.2021

Veysi Hakan Yardımcı , Cihan Uras

https://doi.org/10.31067/acusaglik.888217

Abstract

Purpose: Appendectomy is the most common abdominal surgery performed worldwide. In this report, we evaluated the results of pathological examinations of acute appendicitis specimens. Methods: We performed a retrospective analysis of patients operated on for acute appendicitis at our surgical department from 2009 to 2017. Data on age, gender, and pathological diagnostic parameters were analyzed. Results: A total of 385 patients (168 women [43.6%] and 217 men [56.4%]), were classified into acute appendicitis (Group 1), normal appendix (Group 2), and unusual pathological findings (Group 3) groups. The patients undergoing appendectomy were mostly in the 21–30 (n = 136, 35.3%) and 31–40 years (n = 118, 30.6%) age groups. The negative appendectomy rate was 4.4% in Group 2, and the proportion of women (70.6%) was significantly higher in that group than the other groups (p <0.05). In total, 24 (6.2%) patients had unexpected findings. Among the appendix tumors (n = 12 [3.1%]) in our series, low-grade mucinous neoplasm (n = 6, 1.6%) was the most common, followed by a well-differentiated neuroendocrine tumor (n = 3, 0.8%).Conclusion: Although unusual pathological findings are rare during appendectomy, all appendectomy specimens should be sent for routine histopathological examination. The abnormal incidental findings of 24 cases in this series had a significant impact on management. Patients with rare abnormalities should be treated according to the results of their pathological reports.

Keywords

Appendicitis appendectomy unexpected findings histopathology

References

  • Limaiem F, Arfa N, Marsaoui L, Bouraoui S, Lahmar A, Mzabi S. Unexpected Histopathological Findings in Appendectomy Specimens: a Retrospective Study of 1627 Cases. Indian J Surg. 2015;77: 1285-90. DOI:10.1007/s12262-015-1278-8.
  • Akbulut S, Tas M, Sogutcu N, et al. Unusual histopathological findings in appendectomy specimens: a retrospective analysis and literature review. World J Gastroenterol. 2011;17: 1961-70. DOI: 10.3748/wjg.v17.i15.1961.
  • Elfaedy O, Benkhadoura M, Elshaikhy A, Elgazwi K. Impact of routine histopathological examination of appendectomy specimens on patient management: a study of 4012 appendectomy specimens. Turk J Surg. 2019;35: 196-201. DOI: 10.5578/turkjsurg.4253.
  • Dincel O, Göksu M, Türk BA, Pehlivanoğlu B, İsler S. Incidental Findings in Routine Histopathological Examination of Appendectomy Specimens; Retrospective Analysis of 1970 Patients. Indian J Surg. 2018;80 :48-53. DOI: 10.1007/s12262-016-1557-z.
  • Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol. 1990;132: 910-25.DOI: 10.1093/oxfordjournals.aje.a115734.
  • Unver N, Coban G, Arıcı DS, et al. Unusual Histopathological Findings in Appendectomy Specimens: A Retrospective Analysis of 2047 Cases. Int J Surg Pathol. 2019;27: 142-6. DOI: 10.1177/1066896918784650.
  • Tumay V, Ozturk E, Ozturk H, Yilmazlar T. Appendiceal endometriosis mimicking acute appendicitis. Acta Chir Belg. 2006;106: 712-3. DOI: 10.1080/00015458.2006.11679989.
  • Faucheron JL, Pasquier D, Voirin D. Endometriosis of the vermiform appendix as an exceptional cause of acute perforated appendicitis during pregnancy. Colorectal Dis. 2008;10: 518-9. DOI: 10.1111/j.1463-1318.2007.01428.x.
  • Yardimci AH, Bektas CT, Pasaoglu E, et al. Retrospective study of 24 cases of acute appendiceal diverticulitis: CT findings and pathological correlations. Jpn J Radiol. 2017;35: 225-32. DOI: 10.1007/s11604-017-0625-z.
  • Klingler PJ, Seelig MH, DeVault KR, et al. foreign bodies within the appendix: A 100-year review of the literature. Dig Dis. 1998;16: 308-14. DOI: doi: 10.1159/000016880.
  • Yildirim S, Nursal TZ, Tarim A, Kayaselcuk F, Noyan T. A rare cause of acute appendicitis: parasitic infection. Scand J Infect Dis. 2005;37: 757-9. DOI: 10.1080/00365540510012161.
  • Chamisa I. A clinicopathological review of 324 appendices removed for acute appendicitis in Durban, South Africa: a retrospective analysis. Ann R Coll Surg Engl. 2009;91: 688-92. DOI:10.1308/003588409X12486167521677.
  • Nissotakis C, Sakorafas GH, Koureta T, Revelos K, Kassaras G, Peros G. Actinomycosis of the appendix: diagnostic and therapeutic considerations. Int J Infect Dis. 2008;12: 562-4. DOI: 10.1016/j.ijid.2007.12.015.
  • Shapiro R, Eldar S, Sadot E, Venturero M, Papa MZ, Zippel DB. The significance of occult carcinoids in the era of laparoscopic appendectomies. Surg Endosc. 2010;24: 2197-9. DOI: 10.1007/s00464-010-0926-0.
  • Jones AE, Phillips AW, Jarvis JR, Sargen K. The value of routine histopathological examination of appendicectomy specimens. BMC Surg. 2007;7: 17. DOI: 10.1186/1471-2482-7-17.
  • Rabah R. Pathology of the appendix in children: an institutional experience and review of the literature. Pediatr Radiol. 2007;37: 15-20. DOI: 10.1007/s00247-006-0288-x.
  • Ma KW, Chia NH, Yeung HW, Cheung MT. If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies. Hong Kong Med J. 2010;16: 12-7.
  • Charfi S, Sellami A, Affes A, Yaïch K, Mzali R, Boudawara TS. Histopathological findings in appendectomy specimens: a study of 24,697 cases. Int J Colorectal Dis. 2014;29: 1009-12. DOİ: 10.1007/s00384-014-1934-7.
  • Khairy G. Acute appendicitis: is removal of a normal appendix still existing and can we reduce its rate? Saudi J Gastroenterol. 2009;15: 167-70. DOI: 10.4103/1319-3767.51367.
  • Chiang DT, Tan EI, Birks D. 'To have...or not to have'. Should computed tomography and ultrasonography be implemented as a routine work-up for patients with suspected acute appendicitis in a regional hospital? Ann R Coll Surg Engl. 2008;90: 17-21. DOI: 10.1308/003588408X242259.
  • Bastiaenen VP, Allema WM, Klaver CEL, et al. Routine histopathologic examination of the appendix after appendectomy for presumed appendicitis: Is it really necessary? A systematic review and meta-analysis. Surgery. 2020;168: 305-12. DOI: 10.1016/j.surg.2020.03.032.
  • Patel AV, Friedman M, MacDermott RP. Crohn's disease patient with right lower quadrant abdominal pain for 20 years due to an appendiceal neuroma (Fibrous obliteration of the appendix). Inflamm Bowel Dis. 2010;16: 1093-4. DOI: 10.1002/ibd.21143.
  • Khan RA, Ghani I, Chana RS. Routine histopathological examination of appendectomy specimens in children: is there any rationale? Pediatr Surg Int. 2011;27: 1313-5. DOI: 10.1007/s00383-011-2926-0.
  • Matthyssens LE, Ziol M, Barrat C, Champault GG. Routine surgical pathology in general surgery. Br J Surg. 2006;93: 362-8. DOI: 10.1002/bjs.5268.
There are 24 citations in total.

Details

Primary Language English
Subjects Surgery
Journal Section Research Articles
Authors

Veysi Hakan Yardımcı 0000-0003-1395-3882

Cihan Uras 0000-0002-6838-2311

Publication Date July 1, 2021
Submission Date March 4, 2021
Published in Issue Year 2021

Cite

EndNote Yardımcı VH, Uras C (July 1, 2021) Usual and Unusual Pathologies of Appendicitis: A Retrospective Analysis of 385 Patients. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 12 3 645–650.