Research Article
Year 2022,
, 90 - 95, 01.01.2022
Abstract
References
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- 16. Chen N, Zhou M, Dong X et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020;395:507–13. DOI: 10.1016/S0140-6736(20)30211-7
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Year 2022,
, 90 - 95, 01.01.2022
Abstract
Purpose: The coronavirus disease 2019 (COVID-19) is an active epidemic that is rapidly spreading globally with various complications. Although there are publications on the frequency of thromboembolic complications with COVID-19, the number of publications showing a strong relationship with acute ischemic stroke is few. We aimed to evaluate the link between COVID-19 and acute ischemic stroke.
Methods: One hundred and six patient were screened retrospectively who were underwent brain diffusion MRI with the suspicion of acute stroke in our institution between April and August 2020 when the COVID-19 pandemic intense. The data on diagnosis of COVID-19 infection were analyzed according to patient demographics and risk factors; patients are separated into two groups as with and without acute ischemic stroke findings. A univariate analysis was performed to show the relationship of risk factors and the presence of COVID-19 with acute ischemic stroke.
Results: Acute stroke imaging findings were detected in 39 of 106 patients; and 67 patients without signs of acute ischemic stroke were considered as the control group. The mean age for subjects and controls was 61.8±4.8 and 61.2±4.9 years, respectively. Seventeen (43.6%) of the patients with acute ischemic stroke findings had COVID-19 infection. In the control group, 12 (17.9%) were positive for COVID-19 (p<0.05). No significant relationship was found for age, gender and other risk factors. However, COVID-19 infection had a significant independent association with acute ischemic stroke compared to control subjects (OR 3.5; 95% CI 1.4–8.6; P < 0.005).
Conclusion: COVID-19 infection poses an increased risk for acute ischemic stroke, and therefore, it is necessary to be careful in terms of acute ischemic stroke in patients followed up for COVID-19, and imaging with diffusion MRI in suspected cases.
References
- 1. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497–506. DOI: 10.1016/S0140-6736(20)30183-5
- 2. World Health Organization. Coronavirus disease 2019 (COVID-19) Situation report. https://covid19.who.int/. Accessed 23 March 2021.
- 3. Mahajan A, Hirsch JA. Novel coronavirus: what neuroradiologists as citizens of the world need to know. AJNR Am J Neuroradiol. 2020;41:552–54. DOI: 10.3174/ajnr.A6526
- 4. Jiang F, Deng L, Zhang L, et al. Review of the clinical characteristics of coronavirus disease. J Gen Intern Med. 2020;35:1545–49. DOI: 10.1007/s11606-020-05762-w
- 5. Zurrú MC, Alonzo C, Brescacín L, et al. Recent respiratory infection predicts atherothrombotic stroke: case-control study in a Buenos Aires healthcare system. Stroke 2009;40:1986–90. DOI: 10.1161/STROKEAHA.108.535559
- 6. Grau AJ, Buggle F, Heindl S, et al.Recent infection as a risk factor for cerebrovascular ischemia. Stroke 1995;26:373–79.
- 7. Grau AJ, Buggle F, Becher H, et al. Recent bacterial and viral infection is a risk factor for cerebrovascular ischemia: clinical and biochemical studies. Neurology 1998;50:196–203.
- 8. Bova IY, Bornstein NM, Korczyn AD.Acute infection as a risk factor for ischemic stroke. Stroke 1996;27:2204–06.
- 9. Clayton TC, ThompsonM, Meade TW. Recent respiratory infection and risk of cardiovascular disease: case-control study through a general practice database. Eur Heart J. 2008;29:96–103. DOI: 10.1093/eurheartj/ehm516
- 10. Mao L, Jin H, Wang M, et al. Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6), 683-690. DOI: 10.1001/jamaneurol.2020.1127
- 11. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395:1054–62. DOI: 10.1016/S0140-6736(20)30566-3
- 12. Hamming I, Timens W, Bulthuis M et al. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus: a first step in understanding SARS pathogenesis. J Pathol. 2004;203:631–637. DOI: 10.1002/path.1570
- 13. Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 2020;395:1033–4. DOI: 10.1016/S0140-6736(20)30628-0
- 14. Connors JM, Levy JH.COVID-19 and its implications for thrombosis and anticoagulation. Blood 2020;135(23):2033-40. DOI: 10.1182/blood.2020006000
- 15. Algahtani H, Subahi A, Shirah B. Neurological complications of Middle East respiratory syndrome coronavirus: a report of two cases and review of the literature. Case Rep Neurol Med. 2016;1:6. DOI:10.1155/2016/3502683
- 16. Chen N, Zhou M, Dong X et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020;395:507–13. DOI: 10.1016/S0140-6736(20)30211-7
- 17. Han H, Yang L, Liu R, et al. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clin Chem Lab Med. 2020;58(7):1116-20. DOI: 10.1515/cclm-2020-0188
- 18. Belani P, Schefflein J, Kihira S, et al. COVID-19 Is an Independent Risk Factor for Acute Ischemic Stroke. AJNR Am J Neuroradiol. 2020;41(8):1361-4. DOI: 10.3174/ajnr.A6650
- 19. Li B, Yang J, Zhao F, et al. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clin Res Cardiol. 2020;109:531–38. DOI: 10.1007/s00392-020-01626-9
- 20. Kaur P, Qaqa F, Ramahi A , et al. Acute upper limb ischemia in a patient with COVID-19. Hematol Oncol Stem Cell Ther 2020. [Epub ahead of print] DOI: 10.1016/j.hemonc.2020.05.001
- 21. Ameriso SF, Wong VL, Quismorio FP, et al. Immunohematologic characteristics of infection-associated cerebral infarction. Stroke 1991;22:1004–09.
- 22. Mittleman MA, Mostofsky E. Physical, psychological and chemical triggers of acute cardiovascular events: preventive strategies. Circulation 2011;124:346–54. doi: 10.1161/CIRCULATIONAHA.110.968776
- 23. Wu Y, Xu X, Chen Z, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020;87:18-22. DOI: 10.1016/j.bbi.2020.03.031
There are 23 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Radiology and Organ Imaging |
| Journal Section | Research Article |
| Authors | |
| Publication Date | January 1, 2022 |
| Submission Date | September 17, 2021 |
| Published in Issue | Year 2022 |