Araştırma Makalesi
Yıl 2022,
Cilt: 13 Sayı: 2, 234 - 240, 15.03.2022
Öz
Amaç: Hashimoto tiroiditi (HT) olan hastalarda makula, retina sinir lifi tabakası (RSLT) ve santral kornea kalınlığındaki (SKK) değişiklikleri yaşa uygun sağlıklı kontrol grubu ile karşılaştırmak.
Hastalar ve Yöntemler: Çalışmaya katılan bireyler 2 gruba ayrıldı: HT tanısı olan hastalar (grup 1, n: 54 göz) ve yaşları eşleştirilmiş sağlıklı katılımcılar (grup 2, n: 70 göz). Optik koherens tomografi(OKT) ile kornea, retina ve maküler kalınlıklar ölçüldü. Ortalama sonuç ölçümleri SKK, göz içi basıncı (GİB), merkezi 1 mm foveal kalınlık (MFK), subfoveal koroid kalınlığı (SFKK), toplam maküler hacim (TMH), santral 1 mm foveal hacim (SFH) ve üst, nazal, alt ve temporal kadranlardı.
Bulgular: Ortalama GİB grup 1'de 17.07 ± 2.34μm, grup 2'de 14.20 ± 2.76μm idi (p <0.001). Ortalama SKK'lar 539.44 ± 35.27μm ve 555.06 ± 40.53μm (p = 0.001), SFK'lar 227.35 ± 17.52µm ve 230.38 ± 23.52µm (p = 0.57), SFKK 210,79 ± 20,13µm ve 268,47 ± 24,56µm idi Grup 1 ve grup 2'de sırasıyla, (p <0.001), TMH'lar 7.16 ± 0.35mm3 ve 7.02 ± 0.26mm3 (p = 0.07), CFV'ler 0.17 ± 0.01mm3 ve 0.19 ± 0.07mm3 (p = 0.16) idi. Grup 1'de RSLT kalınlık değerleri, nazal kadran hariç tüm kadranlarda anlamlı olarak daha ince bulundu (p <0.05) (p = 0.086).
Sonuç: HT'ye bağlı hipotiroidizm, kornea ve retinanın gelişimini etkileyen belirleyici bir faktör olabilir. HT'li çocuklarda yüksek GİB ve RSLT kalınlığının azalması, glokom gelişme riskini artırdığı gibi, azalmış SFKK de gelecekte korioretinal bozuklukların gelişimine yatkınlık yaratabilir.
Anahtar Kelimeler
Corneal thickness Hashimoto retinal nerve fiber layer thickness macula.
Kaynakça
- 1.Hashimoto H. Zur Kenntniss der lymphomatösen Veränderung der Schilddrüse (Struma lymphomatosa). Arch Klin Chir 1912; 97:219-50.
- 2. Vanderpump MPJ. The epidemiology of thyroid disease. In Braverman L.E., and Utiger R.D. (eds): Werner & Ingbar’s the thyroid: a fundamental and clinical text, 9th ed. Philadelphia: Lippincott Williams & Wilkins; 2005:398-406.
- 3. Rose NR, Witebsky E. Studies in organ specificity. V. Changes in the thyroid glands of rabbits following active immunisation with rabbit thyroid extracts. J Immunol 1956; 76(6):417-27.
- 4. Thompson CC, Potter GB. Thyroid hormone action in neural development. Cereb Cortex 2000; 10(10):939–45.
- 5. Karabulut GO, Fazil K, Ozturker C, et al. Do ocular pulse amplitude and choroidal thickness change in patients with thyroid eye disease? Orbit 2019 Oct;38(5):347-352.
- 6. Gul A, Basural E, Ozturk HE. Comparison of choroidal thickness in patients with active and stable thyroid eye disease. Arq Bras Oftalmol. 2019 Mar-Apr;82(2):124-128.
- 7. Kırgız A, Çabuk KS, Yetmis M, et al. Corneal biomechanical properties in patients with Hashimoto's thyroiditis. Adv Clin Exp Med. 2019 Jan;28(1):109-112.
- 8. Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol. 2008 Oct;146(4):496-500.
- 9. Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012;18(6):988-1028.
- 10. Nossal GJ, Pike BL. Evidence for the clonal abortion theory of B-lymphocyte tolerance. J Immunol 1975;179(9): 5619-32.
- 11. Lin WY, Wan L, Tsai CH, et al. Vitamin D receptor gene polymorphisms are associated with risk of Hashimoto’s thyroiditis Chinese patients in Taiwan. J Clin Lab Anal 2006; 20: 109-12.
- 12. Chen RH, Chang CT, Chen WC, et al. Proinflammatory cytokine gene polymorphisms among Hashimoto’s thyroiditis patients. J Clin Lab Anal 2006; 20(6):260-5.
- 13. Ito C, Watanabe M, Okuda N, et al. Association between the severity of Hashimoto’s disease and the functional +874A/T polymorphism in the interferon-gamma gene. Endocr J 2006; 53(4):473-8.
- 14. Ito M, Tanimoto M, Kamura H, et al. Association of HLA antigen and restriction fragment length polymorphism of T cell receptor beta-chain gene with Graves’ disease and Hashimoto’s thyroiditis. J Clin Endocrinol Metab 1989; 69(1):100-4.
- 15. Dussault JH, Ruel J. Thyroid hormones and brain development. Annual Revue of Physiology 1987; 49(1): 321–34. 16. Mader MM, Cameron DA. Photoreceptor differentiation during retinal development, growth, and regeneration in a metamorphic vertebrate. Journal of Neuroscience 2004; 24(50): 11463–72.
- 17. Yin X, Latif R, Tomer Y, et al. Thyroid epigenetics: X chromosome inactivation in patients with autoimmune thyroid disease. Ann N Y Acad Sci 2007; 1110(1):193-200.
- 18. Mader MM, Cameron DA. Effects of induced systemic hypothyroidism upon the retina: regulation of thyroid hormone receptor alpha and photoreceptor production. Molecular Vision 2006; 12(1): 915–30.
- 19. Bernal J. Thyroid hormones and brain development. Vitam. Horm. 2005; 71:95–122.
- 20. Morreale de Escobar, Calvo GR, Obregon MJ, et al. Contribution of maternal thyroxine to fetal thyronine pools in normal rats near term. Endocrinology 1990; 126(5): 2765–7.
- 21. Santisteban P, Bernal J. Thyroid development and effect on the nervous system. Rev. Endocr. Metab. Disord. 2005; 6(3):217–28.
- 22. Pinazo-Durán MD, Pons-Vázquez S, Gallego-Pinazo R, et al. Thyroid hormone deficiency disrupts rat eye neurodevelopment. Brain Res. 2011(1); 1392:16-26.
- 23. Durieux P, Rigaudière F, Le Gargasson JF, et al. ERG findings in three hypothyroid adult dogs with and without levothyroxine treatment. Vet Ophthalmol. 2008;11(6):406-11.
- 24. Ittermann T, Dörr M, Völzke H, et al. High serum thyrotropin levels are associated with retinal arteriolar narrowing in the general population. Thyroid. 2014; 24(10):1473-8.
- 25. Conrad AH, Zhang Y, Walker AR, et al. Thyroxine affects expression of KSPG- related genes, the carbonic anhydrase II gene, and KS sulfation in the embryonic chicken cornea. Invest Ophthalmol Vis Sci. 2006; 47(1):120-32.
- 26. Bahceci UA, Ozdek S, Pehlivanli Z, et al. Changes in intraocular pressure and corneal and retinal nerve fiber layer thicknesses in hypothyroidism. Eur J Ophthalmol 2005; 15(5): 556-61.
- 27. Lee AJ, Rochtchina E, Wang JJ, et al. Open-angle glaucoma and systemic thyroid disease in an older population: the Blue Mountains Eye Study. Eye (Lond) 2004; 18(6):600–8.
- 28. Motsko SP, Jones JK. Is there an association between hypothyroidism and open- angle glaucoma in an elderly population? An epidemiologic study. Ophthalmology 2008; 115(9):1581– 4.
- 29. Cross JM, Girkin CA, Owsley C, et al. The association between thyroid problems and glaucoma. Br J Ophthalmol 2008; 92(11):1503–5.
- 30. Lin HC, Kang JH, Jiang YD, et al. Hypothyroidism and the risk of developing open-angle glaucoma: a five-year population-based follow-up study. Ophtalmology 2010 Oct;117(10):1960-6.
- 31. Ozturk BT, Kerimoglu H, Dikbas O, et al. Ocular changes in primary hypothyroidism. BMC Res Notes. 2009; 2:266.
Yıl 2022,
Cilt: 13 Sayı: 2, 234 - 240, 15.03.2022
Öz
Kaynakça
- 1.Hashimoto H. Zur Kenntniss der lymphomatösen Veränderung der Schilddrüse (Struma lymphomatosa). Arch Klin Chir 1912; 97:219-50.
- 2. Vanderpump MPJ. The epidemiology of thyroid disease. In Braverman L.E., and Utiger R.D. (eds): Werner & Ingbar’s the thyroid: a fundamental and clinical text, 9th ed. Philadelphia: Lippincott Williams & Wilkins; 2005:398-406.
- 3. Rose NR, Witebsky E. Studies in organ specificity. V. Changes in the thyroid glands of rabbits following active immunisation with rabbit thyroid extracts. J Immunol 1956; 76(6):417-27.
- 4. Thompson CC, Potter GB. Thyroid hormone action in neural development. Cereb Cortex 2000; 10(10):939–45.
- 5. Karabulut GO, Fazil K, Ozturker C, et al. Do ocular pulse amplitude and choroidal thickness change in patients with thyroid eye disease? Orbit 2019 Oct;38(5):347-352.
- 6. Gul A, Basural E, Ozturk HE. Comparison of choroidal thickness in patients with active and stable thyroid eye disease. Arq Bras Oftalmol. 2019 Mar-Apr;82(2):124-128.
- 7. Kırgız A, Çabuk KS, Yetmis M, et al. Corneal biomechanical properties in patients with Hashimoto's thyroiditis. Adv Clin Exp Med. 2019 Jan;28(1):109-112.
- 8. Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol. 2008 Oct;146(4):496-500.
- 9. Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012;18(6):988-1028.
- 10. Nossal GJ, Pike BL. Evidence for the clonal abortion theory of B-lymphocyte tolerance. J Immunol 1975;179(9): 5619-32.
- 11. Lin WY, Wan L, Tsai CH, et al. Vitamin D receptor gene polymorphisms are associated with risk of Hashimoto’s thyroiditis Chinese patients in Taiwan. J Clin Lab Anal 2006; 20: 109-12.
- 12. Chen RH, Chang CT, Chen WC, et al. Proinflammatory cytokine gene polymorphisms among Hashimoto’s thyroiditis patients. J Clin Lab Anal 2006; 20(6):260-5.
- 13. Ito C, Watanabe M, Okuda N, et al. Association between the severity of Hashimoto’s disease and the functional +874A/T polymorphism in the interferon-gamma gene. Endocr J 2006; 53(4):473-8.
- 14. Ito M, Tanimoto M, Kamura H, et al. Association of HLA antigen and restriction fragment length polymorphism of T cell receptor beta-chain gene with Graves’ disease and Hashimoto’s thyroiditis. J Clin Endocrinol Metab 1989; 69(1):100-4.
- 15. Dussault JH, Ruel J. Thyroid hormones and brain development. Annual Revue of Physiology 1987; 49(1): 321–34. 16. Mader MM, Cameron DA. Photoreceptor differentiation during retinal development, growth, and regeneration in a metamorphic vertebrate. Journal of Neuroscience 2004; 24(50): 11463–72.
- 17. Yin X, Latif R, Tomer Y, et al. Thyroid epigenetics: X chromosome inactivation in patients with autoimmune thyroid disease. Ann N Y Acad Sci 2007; 1110(1):193-200.
- 18. Mader MM, Cameron DA. Effects of induced systemic hypothyroidism upon the retina: regulation of thyroid hormone receptor alpha and photoreceptor production. Molecular Vision 2006; 12(1): 915–30.
- 19. Bernal J. Thyroid hormones and brain development. Vitam. Horm. 2005; 71:95–122.
- 20. Morreale de Escobar, Calvo GR, Obregon MJ, et al. Contribution of maternal thyroxine to fetal thyronine pools in normal rats near term. Endocrinology 1990; 126(5): 2765–7.
- 21. Santisteban P, Bernal J. Thyroid development and effect on the nervous system. Rev. Endocr. Metab. Disord. 2005; 6(3):217–28.
- 22. Pinazo-Durán MD, Pons-Vázquez S, Gallego-Pinazo R, et al. Thyroid hormone deficiency disrupts rat eye neurodevelopment. Brain Res. 2011(1); 1392:16-26.
- 23. Durieux P, Rigaudière F, Le Gargasson JF, et al. ERG findings in three hypothyroid adult dogs with and without levothyroxine treatment. Vet Ophthalmol. 2008;11(6):406-11.
- 24. Ittermann T, Dörr M, Völzke H, et al. High serum thyrotropin levels are associated with retinal arteriolar narrowing in the general population. Thyroid. 2014; 24(10):1473-8.
- 25. Conrad AH, Zhang Y, Walker AR, et al. Thyroxine affects expression of KSPG- related genes, the carbonic anhydrase II gene, and KS sulfation in the embryonic chicken cornea. Invest Ophthalmol Vis Sci. 2006; 47(1):120-32.
- 26. Bahceci UA, Ozdek S, Pehlivanli Z, et al. Changes in intraocular pressure and corneal and retinal nerve fiber layer thicknesses in hypothyroidism. Eur J Ophthalmol 2005; 15(5): 556-61.
- 27. Lee AJ, Rochtchina E, Wang JJ, et al. Open-angle glaucoma and systemic thyroid disease in an older population: the Blue Mountains Eye Study. Eye (Lond) 2004; 18(6):600–8.
- 28. Motsko SP, Jones JK. Is there an association between hypothyroidism and open- angle glaucoma in an elderly population? An epidemiologic study. Ophthalmology 2008; 115(9):1581– 4.
- 29. Cross JM, Girkin CA, Owsley C, et al. The association between thyroid problems and glaucoma. Br J Ophthalmol 2008; 92(11):1503–5.
- 30. Lin HC, Kang JH, Jiang YD, et al. Hypothyroidism and the risk of developing open-angle glaucoma: a five-year population-based follow-up study. Ophtalmology 2010 Oct;117(10):1960-6.
- 31. Ozturk BT, Kerimoglu H, Dikbas O, et al. Ocular changes in primary hypothyroidism. BMC Res Notes. 2009; 2:266.
Toplam 30 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Göz Hastalıkları |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 15 Mart 2022 |
| Gönderilme Tarihi | 24 Ekim 2021 |
| Yayımlandığı Sayı | Yıl 2022Cilt: 13 Sayı: 2 |
