BibTex RIS Kaynak Göster

Şizofreni Hastalarının Ebeveynlerinde Mentalizasyon Problemleri: Çapraz Kesitsel Bir Çalışma

Yıl 2016, Cilt: 16 Sayı: 2, 0 - 0, 20.05.2016
https://doi.org/10.17098/amj.66316

Öz

Amaç:    Bilişsel  bozukluklar  ve  nöropsikoloji    alanında,  şizofreni  hastalarının  akrabaları  ile  yapılan  çalışmaların  sayısı  gün  geçtikçe  artmakla  beraber,  bu  örneklem  üzerinde  mentalizasyon  üzerine çalışmalar nispeten az  sayıdadır.  Bu  çalışmanın  amacı  şizofreni  hastalarının  ebeveynlerinde  olası  mentalizasyon  sorunlarının  varlığını  bir  endofenotip  göstergesi  olarak  araştırmaktır. 

Materyal ve Metot:  DSM-IV-TR’  ye  göre  şizofreni  tanısı  almış  50  hastanın  herhangi  bir  ebeveyni    risk  grubunu  oluştururken,    kronik  fiziksel  hastalıkları  olan  50  hastanın    herhangi  bir  ebeveyni  ise  sağlıklı  karşılaştırma  grubu  olarak  seçildi.    Çalışmada  tüm  katılımcılara  Dokuz  Eylül  Zihin  Teorisi  Ölçeği  uygulandı. 

Bulgular:  Sağlıklı  karşılaştırma  grubuna  göre  şizofreni  hastalarının  ebeveynlerinde  birinci  derece  yanlış  inanış,  metafor,  ironi  kavrama,  faux  pas  kavrama  ve  empatik  anlayış  testlerini  içeren  tüm  mentalizasyon  alt    puanlarda    daha  düşük  performans  gözlendi. 

Tartışma:  Bulgularımız,  şizofreni  hastalarında  gözlemlediğimiz  mentalizayon  sorunlarının  şizofreni  için  bir  endofenotip  olarak  dikkate  alınabileceğine  işaret  etmektedir.  Bununla  beraber  bu  değerlendirmeye  varmadan  önce  daha  fazla  sayıda benzer  çalışmalara  ihtiyaç  vardır.    

Kaynakça

  • Stone VE, Baron-Cohen S Knight RT. Frontal lobe contributions to theory of mind. J Cogn Neurosci 1998;10:640-56.
  • Brune M, Brune-Cohrs U. Theory of mind--evolution, ontogeny, brain mechanisms and psychopathology. Neurosci Biobehav Rev 2006;30:437-55.
  • Premack D, Woodruff G. Does the chimpanzee have a theory of mind? Behavioral and Brain Sciences 1978;1:515-26.
  • Sayin A, Candansayar S. Theory of Mind in Schizophrenia. New/Yeni Symposium Journal 2008;46:74-80.
  • Bora E. Theory of mind in schizophrenia spectrum disorders. Turk Psikiyatri Derg 2009;20:269-81.
  • Abu-Akel A, Abushua'leh K. 'Theory of mind' in violent and nonviolent patients with paranoid schizophrenia. Schizophr Res 2004;69:45-53.
  • Brüne M. “Theory of Mind” in Schizophrenia: A Review of the Literature. Schizophrenia Bulletin 2005;31:21-42.
  • Schizophrenia Working Group of the Psychiatric Genomics C. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014;511:421-7.
  • Sadock BJ, Sadock VA. Kaplan and Sadock's synopsis of psychiatry: Behavioral sciences/clinical psychiatry. 10th ed., Philedelphia: Lippincott Williams & Wilkins; 2011.
  • Cannon TD, Gasperoni TL, van Erp TG Rosso IM. Quantitative neural indicators of liability to schizophrenia: implications for molecular genetic studies. Am J Med Genet 2001;105:16-9.
  • Leboyer M, Bellivier F, Nosten-Bertrand M, Jouvent R, Pauls D Mallet J. Psychiatric genetics: search for phenotypes. Trends Neurosci 1998;21:102-5.
  • Ozer S, Ayhan Y Uluşahin A. The utility of an endophenotype approach in overcoming the difficulties in bipolar and schizophrenia genetics. Turkish Journal of Psychiatry 2003;15:125-37.
  • Ulaş H, Taşlıca S, Alptekin K. Şizofrenide nörofizyolojik ve nörokognitif genetik belirleyicilerin (endofenotip) yeri. Klinik Psikiyatri Dergisi 2008;11:12-9.
  • Sitskoorn MM, Aleman A, Ebisch SJ, Appels MC Kahn RS. Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophr Res 2004;71:285-95.
  • Seidman LJ, Giuliano AJ, Smith CW, et al. Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk Studies. Schizophr Bull 2006;32:507-24.
  • First M, Spitzer R, Gibbon M Williams J. Structured clinical interview for DSM-IV Axis I (SCID-I), clinician version. Washington, DC: American Psychiatric Association; 1997.
  • Özkürkçügil A, Aydemir Ö, Yıldız M, Esen Danacı A Köroğlu IV E. DSM-IV eksen I bozuklukları için yapılandırılmış klinik görüşmenin Türkçe’ye uyarlanması ve güvenilirlik çalışması. İlaç ve Tedavi Dergisi 1999;12:233-6.
  • Değirmencioğlu B. İlk kez geliştirilecek olan Dokuz Eylül Zihin Teorisi Ölçeği'nin (DEZTÖ) Geçerlik ve Güvenirlik çalışması. Sinirbilimler Anabilim Dalı. DEÜ Sağlık Bilimleri Enstitüsü, İzmir, 2008. (Yüksek Lisans Tezi) https://dspace.deu.edu.tr/xmlui/handle/12345/10171 Erişim tarihi: 14 Mart 2016.
  • Janssen I, Krabbendam L, Jolles J van Os J. Alterations in theory of mind in patients with schizophrenia and non-psychotic relatives. Acta Psychiatr Scand 2003;108:110-7.
  • Irani F, Platek SM, Panyavin IS, et al. Self-face recognition and theory of mind in patients with schizophrenia and first-degree relatives. Schizophr Res 2006;88:151-60.
  • Anselmetti S, Bechi M, Bosia M, et al. 'Theory' of mind impairment in patients affected by schizophrenia and in their parents. Schizophr Res 2009;115:278-85.
  • de Achaval D, Costanzo EY, Villarreal M, Jauregui IO, Chiodi A, Castro MN, et al. Emotion processing and theory of mind in schizophrenia patients and their unaffected first-degree relatives. Neuropsychologia 2010;48:1209-15.
  • Kelemen O, Keri S, Must A, Benedek G Janka Z. No evidence for impaired 'theory of mind' in unaffected first-degree relatives of schizophrenia patients. Acta Psychiatr Scand 2004;110:146-9.
  • Pentaraki A, Stefanis N, Stahl D, Kaliora S, Roukas D, Theleritis C, et al. 170–Theory of mind as a potential endophenotype of schizophrenia: Understanding false beliefs in families with schizophrenia. Schizophrenia Research 2008;98:103.
  • Pentaraki AD, Stefanis NC, Stahl D, Theleritis C, Toulopoulou T, Roukas D, et al. Theory of Mind as a potential trait marker of schizophrenia: a family study. Cogn Neuropsychiatry 2012;17:64-89.
  • Jimenez-Trevino L, Blasco-Fontecilla H, Braquehais MD, Ceverino-Dominguez A Baca-Garcia E. Endophenotypes and suicide behaviour. Actas Esp Psiquiatr 2011;39:61-9.
  • Hasler G. Evaluating endophenotypes for psychiatric disorders. Rev Bras Psiquiatr 2006;28:91-2.
  • Frith U Frith CD. Development and neurophysiology of mentalizing. Philos Trans R Soc Lond B Biol Sci 2003;358:459-73.
  • Wellman HM Liu D. Scaling of theory-of-mind tasks. Child Dev 2004;75:523-41.
  • Charman T, Baron-Cohen S, Swettenham J, Baird G, Cox A Drew A. Testing joint attention, imitation, and play as infancy precursors to language and theory of mind. Cognitive Development 2000;15:481-98.
  • Dolan M Fullam R. Theory of mind and mentalizing ability in antisocial personality disorders with and without psychopathy. Psychol Med 2004;34:1093-102.
  • Hiller RM, Weber N Young RL. The validity and scalability of the Theory of Mind Scale with toddlers and preschoolers. Psychol Assess 2014;26:1388-93.
  • Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 1998;12:426.

Mentalizing Deficits in Parents of Patients with Schizophrenia: A Cross Sectional Study.

Yıl 2016, Cilt: 16 Sayı: 2, 0 - 0, 20.05.2016
https://doi.org/10.17098/amj.66316

Öz

Objectives: Although, there is an increasing number of studies about cognitive and neuropsychological deficits in the parents of patients with schizophrenia, there are few studies on mentalizing in this population. The aims of this study are to determine the presence of mentalizing deficits as an endophenotype in parents of patients with schizophrenia, as well as in patients with schizophrenia.

Materials and Methods: Fifty parents of patients with schizophrenia were selected according to the DSM IV-TR criteria. For the comparison group, 50 parents of patients suffering from chronic physical diseases were also included in the study for a total of 100 participants. We used the Dokuz Eylül Theory of Mind Scale to assess the parents of patients with schizophrenia and the healthy comparisons. 

Results: When compared with healthy comparisons, the parents of patients with schizophrenia showed lower performance in first degree wrong belief, metaphor, irony coupler, faux pas coupler, and empathic understanding tests with all components of mentalizing.

Conclusion: Our finding determining that mentalizing deficits in parents of patients with schizophrenia suggest that mentalizing deficits indicates a possible endophenotype of schizophrenia. However, many studies supporting these conclusion are needed.

Kaynakça

  • Stone VE, Baron-Cohen S Knight RT. Frontal lobe contributions to theory of mind. J Cogn Neurosci 1998;10:640-56.
  • Brune M, Brune-Cohrs U. Theory of mind--evolution, ontogeny, brain mechanisms and psychopathology. Neurosci Biobehav Rev 2006;30:437-55.
  • Premack D, Woodruff G. Does the chimpanzee have a theory of mind? Behavioral and Brain Sciences 1978;1:515-26.
  • Sayin A, Candansayar S. Theory of Mind in Schizophrenia. New/Yeni Symposium Journal 2008;46:74-80.
  • Bora E. Theory of mind in schizophrenia spectrum disorders. Turk Psikiyatri Derg 2009;20:269-81.
  • Abu-Akel A, Abushua'leh K. 'Theory of mind' in violent and nonviolent patients with paranoid schizophrenia. Schizophr Res 2004;69:45-53.
  • Brüne M. “Theory of Mind” in Schizophrenia: A Review of the Literature. Schizophrenia Bulletin 2005;31:21-42.
  • Schizophrenia Working Group of the Psychiatric Genomics C. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014;511:421-7.
  • Sadock BJ, Sadock VA. Kaplan and Sadock's synopsis of psychiatry: Behavioral sciences/clinical psychiatry. 10th ed., Philedelphia: Lippincott Williams & Wilkins; 2011.
  • Cannon TD, Gasperoni TL, van Erp TG Rosso IM. Quantitative neural indicators of liability to schizophrenia: implications for molecular genetic studies. Am J Med Genet 2001;105:16-9.
  • Leboyer M, Bellivier F, Nosten-Bertrand M, Jouvent R, Pauls D Mallet J. Psychiatric genetics: search for phenotypes. Trends Neurosci 1998;21:102-5.
  • Ozer S, Ayhan Y Uluşahin A. The utility of an endophenotype approach in overcoming the difficulties in bipolar and schizophrenia genetics. Turkish Journal of Psychiatry 2003;15:125-37.
  • Ulaş H, Taşlıca S, Alptekin K. Şizofrenide nörofizyolojik ve nörokognitif genetik belirleyicilerin (endofenotip) yeri. Klinik Psikiyatri Dergisi 2008;11:12-9.
  • Sitskoorn MM, Aleman A, Ebisch SJ, Appels MC Kahn RS. Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophr Res 2004;71:285-95.
  • Seidman LJ, Giuliano AJ, Smith CW, et al. Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk Studies. Schizophr Bull 2006;32:507-24.
  • First M, Spitzer R, Gibbon M Williams J. Structured clinical interview for DSM-IV Axis I (SCID-I), clinician version. Washington, DC: American Psychiatric Association; 1997.
  • Özkürkçügil A, Aydemir Ö, Yıldız M, Esen Danacı A Köroğlu IV E. DSM-IV eksen I bozuklukları için yapılandırılmış klinik görüşmenin Türkçe’ye uyarlanması ve güvenilirlik çalışması. İlaç ve Tedavi Dergisi 1999;12:233-6.
  • Değirmencioğlu B. İlk kez geliştirilecek olan Dokuz Eylül Zihin Teorisi Ölçeği'nin (DEZTÖ) Geçerlik ve Güvenirlik çalışması. Sinirbilimler Anabilim Dalı. DEÜ Sağlık Bilimleri Enstitüsü, İzmir, 2008. (Yüksek Lisans Tezi) https://dspace.deu.edu.tr/xmlui/handle/12345/10171 Erişim tarihi: 14 Mart 2016.
  • Janssen I, Krabbendam L, Jolles J van Os J. Alterations in theory of mind in patients with schizophrenia and non-psychotic relatives. Acta Psychiatr Scand 2003;108:110-7.
  • Irani F, Platek SM, Panyavin IS, et al. Self-face recognition and theory of mind in patients with schizophrenia and first-degree relatives. Schizophr Res 2006;88:151-60.
  • Anselmetti S, Bechi M, Bosia M, et al. 'Theory' of mind impairment in patients affected by schizophrenia and in their parents. Schizophr Res 2009;115:278-85.
  • de Achaval D, Costanzo EY, Villarreal M, Jauregui IO, Chiodi A, Castro MN, et al. Emotion processing and theory of mind in schizophrenia patients and their unaffected first-degree relatives. Neuropsychologia 2010;48:1209-15.
  • Kelemen O, Keri S, Must A, Benedek G Janka Z. No evidence for impaired 'theory of mind' in unaffected first-degree relatives of schizophrenia patients. Acta Psychiatr Scand 2004;110:146-9.
  • Pentaraki A, Stefanis N, Stahl D, Kaliora S, Roukas D, Theleritis C, et al. 170–Theory of mind as a potential endophenotype of schizophrenia: Understanding false beliefs in families with schizophrenia. Schizophrenia Research 2008;98:103.
  • Pentaraki AD, Stefanis NC, Stahl D, Theleritis C, Toulopoulou T, Roukas D, et al. Theory of Mind as a potential trait marker of schizophrenia: a family study. Cogn Neuropsychiatry 2012;17:64-89.
  • Jimenez-Trevino L, Blasco-Fontecilla H, Braquehais MD, Ceverino-Dominguez A Baca-Garcia E. Endophenotypes and suicide behaviour. Actas Esp Psiquiatr 2011;39:61-9.
  • Hasler G. Evaluating endophenotypes for psychiatric disorders. Rev Bras Psiquiatr 2006;28:91-2.
  • Frith U Frith CD. Development and neurophysiology of mentalizing. Philos Trans R Soc Lond B Biol Sci 2003;358:459-73.
  • Wellman HM Liu D. Scaling of theory-of-mind tasks. Child Dev 2004;75:523-41.
  • Charman T, Baron-Cohen S, Swettenham J, Baird G, Cox A Drew A. Testing joint attention, imitation, and play as infancy precursors to language and theory of mind. Cognitive Development 2000;15:481-98.
  • Dolan M Fullam R. Theory of mind and mentalizing ability in antisocial personality disorders with and without psychopathy. Psychol Med 2004;34:1093-102.
  • Hiller RM, Weber N Young RL. The validity and scalability of the Theory of Mind Scale with toddlers and preschoolers. Psychol Assess 2014;26:1388-93.
  • Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 1998;12:426.
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Bölüm Araştırmalar
Yazarlar

Mustafa Uğurlu Bu kişi benim

Derya Büyüköz Bu kişi benim

Görkem Karakaş Uğurlu

Ali Çayköylü

Yayımlanma Tarihi 20 Mayıs 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 16 Sayı: 2

Kaynak Göster

APA Uğurlu, M., Büyüköz, D., Karakaş Uğurlu, G., Çayköylü, A. (2016). Mentalizing Deficits in Parents of Patients with Schizophrenia: A Cross Sectional Study. Ankara Medical Journal, 16(2). https://doi.org/10.17098/amj.66316
AMA Uğurlu M, Büyüköz D, Karakaş Uğurlu G, Çayköylü A. Mentalizing Deficits in Parents of Patients with Schizophrenia: A Cross Sectional Study. Ankara Med J. Mayıs 2016;16(2). doi:10.17098/amj.66316
Chicago Uğurlu, Mustafa, Derya Büyüköz, Görkem Karakaş Uğurlu, ve Ali Çayköylü. “Mentalizing Deficits in Parents of Patients With Schizophrenia: A Cross Sectional Study”. Ankara Medical Journal 16, sy. 2 (Mayıs 2016). https://doi.org/10.17098/amj.66316.
EndNote Uğurlu M, Büyüköz D, Karakaş Uğurlu G, Çayköylü A (01 Mayıs 2016) Mentalizing Deficits in Parents of Patients with Schizophrenia: A Cross Sectional Study. Ankara Medical Journal 16 2
IEEE M. Uğurlu, D. Büyüköz, G. Karakaş Uğurlu, ve A. Çayköylü, “Mentalizing Deficits in Parents of Patients with Schizophrenia: A Cross Sectional Study”., Ankara Med J, c. 16, sy. 2, 2016, doi: 10.17098/amj.66316.
ISNAD Uğurlu, Mustafa vd. “Mentalizing Deficits in Parents of Patients With Schizophrenia: A Cross Sectional Study”. Ankara Medical Journal 16/2 (Mayıs 2016). https://doi.org/10.17098/amj.66316.
JAMA Uğurlu M, Büyüköz D, Karakaş Uğurlu G, Çayköylü A. Mentalizing Deficits in Parents of Patients with Schizophrenia: A Cross Sectional Study. Ankara Med J. 2016;16. doi:10.17098/amj.66316.
MLA Uğurlu, Mustafa vd. “Mentalizing Deficits in Parents of Patients With Schizophrenia: A Cross Sectional Study”. Ankara Medical Journal, c. 16, sy. 2, 2016, doi:10.17098/amj.66316.
Vancouver Uğurlu M, Büyüköz D, Karakaş Uğurlu G, Çayköylü A. Mentalizing Deficits in Parents of Patients with Schizophrenia: A Cross Sectional Study. Ankara Med J. 2016;16(2).