BibTex RIS Kaynak Göster

Continuous Venovenous Hemodiafiltration in Three Newborn Patients with Hyperammonemia

Yıl 2015, Cilt: 40 Sayı: Ek 1, 161 - 166, 09.10.2015
https://doi.org/10.17826/cutf.14426

Öz

In newborns, hyperammonemia leads to encephalopathy which is usually characterized by vomiting, hypotonia, lethargy, seizures and coma. Continuous venovenous hemodiafiltration (CVVHDF) is a modality choice to treat acute decompensation in hyperammonemia. Here we report three newborn patients with hypotonia, convulsion and hyperammonaemia. In the first three days of life, their serum ammonia levels were 4609, 1023 and 1949 µg/ml. They were successfully treated with CVVHDF and serum ammonia levels subsequently decreased to 268, 164 and 65 µg/ml in the first 24 hours of treatment. The complications were mild hypothermia and anemia.

Kaynakça

  • Haller M, Henzler- Le Boulanger A, Saas JO, Brandis M, Zimmerhackl LB. Successful extracorporeal treatment of a male with hyperammonaemic coma. Nephrol Dial Transplant. 2005;20:453-5. Ammonia clearance by peritoneal dialysis and continuous arteriovenous hemodiafiltration. Pediatr Nephrol. 1998;12:589-91.
  • Falk MC, Knight JF, Roy LR, et al. Continuous venovenous haemofiltration in the acute treatment of inborn errors of metabolism. Pediatr Nephrol. 1994; 8:330–3.
  • Wong KY,Wong SN, Lam SY,Tam S,Tsoi NS. Ammonia clearance by peritoneal dialysis and continuous arteriovenous hemodiafiltration. Pediatr Nephrol. 1998;12:589–91.
  • Bishof NA, Welch TR, Strief CF, Ryckman FC. Continuous hemodiafiltration in children. Pediatrics 1990;85:819–23.
  • Jouvet P, Poggi F, Rabier D, et al. Continuous venovenous haemodiafiltration in the acute phase of neonatal maple syrup urine disease. J Inherit Dis. 1997;20:463–72.
  • Gouyon JB, Petion AM, Huet F, Lallemant C. Urea removal by hemofiltration and hemodiafiltration. Biol Neonate. 1994;65:36–40.
  • Jouvet P, Colomer S, Jugie M, Meftali Y, Vassault A, Man NK. Continuous venovenous hemodialysis in a neonate model: a two-pump system. Crit Care Med. 1998;26:115-9..
  • Heney D, Brocklebank T, Wilson N. Continuous arteriovenous haemofiltration in the newlyborn with acute renal failure and congenital heart disease. Nephrol Dial Transplant. 1989;16:870–976.
  • Coulthard MG, Sharp J. Haemodialysis and ultrafiltration in babies weighing under 1000g. Arch Dis Child. 1995;73:F162–F165.
  • Bellomo R, Ronco C. Continuous renal replacement therapy in the intensive care unit. Intensive Care Med. 1999;25:781-9.
  • Msall M, Batshaw ML, Suss R, Brusilow SW, Mellits ED. Neurologic outcome in children with inborn errors of urea synthesis. Outcome of urea-cycle enzymopathies. N Engl J Med. 1984;310:1500- 5.

Hiperamonemili Üç Yenidoğan Bebekte Devamlı Venovenöz Hemodiafiltrasyon

Yıl 2015, Cilt: 40 Sayı: Ek 1, 161 - 166, 09.10.2015
https://doi.org/10.17826/cutf.14426

Öz

Yenidoğan bebeklerde hiperamonemi, hipotoni, letarji, nöbetler ve koma ile karakterize ensefalopati tablosuna yol açabilir. Akut dekompanse olmuş hiperamonemi tedavisinde devamlı venovenöz hemodiafiltrasyon tedavi seçeneği olabilir. Burada hipotoni, konvülziyon ve hiperamonemi olan üç yenidoğan olgusu sunulmuştur.yaşamlarının ilk üç gününde amonyak değerleri 4609, 1023, 1949 microgram/ml idi. Devamlı venovenöz hemodiafiltrasyon ile başarılı bir şekilde tedavi edilerek tedavinin ilk 24 saatinde amonyak değerleri 268, 164 65 microgram/ml'ye azaltıldı.hafif hipotermi ve anemi komplikasyon olarak saptandı.

Kaynakça

  • Haller M, Henzler- Le Boulanger A, Saas JO, Brandis M, Zimmerhackl LB. Successful extracorporeal treatment of a male with hyperammonaemic coma. Nephrol Dial Transplant. 2005;20:453-5. Ammonia clearance by peritoneal dialysis and continuous arteriovenous hemodiafiltration. Pediatr Nephrol. 1998;12:589-91.
  • Falk MC, Knight JF, Roy LR, et al. Continuous venovenous haemofiltration in the acute treatment of inborn errors of metabolism. Pediatr Nephrol. 1994; 8:330–3.
  • Wong KY,Wong SN, Lam SY,Tam S,Tsoi NS. Ammonia clearance by peritoneal dialysis and continuous arteriovenous hemodiafiltration. Pediatr Nephrol. 1998;12:589–91.
  • Bishof NA, Welch TR, Strief CF, Ryckman FC. Continuous hemodiafiltration in children. Pediatrics 1990;85:819–23.
  • Jouvet P, Poggi F, Rabier D, et al. Continuous venovenous haemodiafiltration in the acute phase of neonatal maple syrup urine disease. J Inherit Dis. 1997;20:463–72.
  • Gouyon JB, Petion AM, Huet F, Lallemant C. Urea removal by hemofiltration and hemodiafiltration. Biol Neonate. 1994;65:36–40.
  • Jouvet P, Colomer S, Jugie M, Meftali Y, Vassault A, Man NK. Continuous venovenous hemodialysis in a neonate model: a two-pump system. Crit Care Med. 1998;26:115-9..
  • Heney D, Brocklebank T, Wilson N. Continuous arteriovenous haemofiltration in the newlyborn with acute renal failure and congenital heart disease. Nephrol Dial Transplant. 1989;16:870–976.
  • Coulthard MG, Sharp J. Haemodialysis and ultrafiltration in babies weighing under 1000g. Arch Dis Child. 1995;73:F162–F165.
  • Bellomo R, Ronco C. Continuous renal replacement therapy in the intensive care unit. Intensive Care Med. 1999;25:781-9.
  • Msall M, Batshaw ML, Suss R, Brusilow SW, Mellits ED. Neurologic outcome in children with inborn errors of urea synthesis. Outcome of urea-cycle enzymopathies. N Engl J Med. 1984;310:1500- 5.
Toplam 11 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Olgu Sunumu
Yazarlar

Hacer Yıldızdaş Bu kişi benim

Dinçer Yıldızdaş Bu kişi benim

Ferda Özlü

Kurthan Mert Bu kişi benim

Neslihan Mungan Bu kişi benim

Yayımlanma Tarihi 9 Ekim 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 40 Sayı: Ek 1

Kaynak Göster

MLA Yıldızdaş, Hacer vd. “Continuous Venovenous Hemodiafiltration in Three Newborn Patients With Hyperammonemia”. Cukurova Medical Journal, c. 40, 2015, ss. 161-6, doi:10.17826/cutf.14426.