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The efficacy of adalimumab in the treatment of hidradenitis suppurativa

Yıl 2018, Cilt: 45 Sayı: 1, 19 - 27, 17.03.2018

Ali Balevi Pelin Ustuner Mustafa Özdemir

https://doi.org/10.5798/dicletip.407240

Öz

Objectives:  Hidradenitis  suppurativa  is  seen  as  a  result  of  the  occlusion,  constriction  and  bacterial  infection  of  the apocrine  glands  in  bilateral  axillas,  submammarian  areas,  neck,  inguinal  regions,  flexural  surfaces  of  the  thighs  and anogenital areas. Among the biological agents adalimumab is a recombinant human IgG1 monoclonal antibody; TNF-α antagonist approved to be used in the treatment of hidradenitissuppurativa. 

Methods: In this study, 12 patients resistant to conventional treatments with moderate severity, Hurley stage 2 or 3 were started subcutaneous adalimumab treatment. The disease activities upon the hidradenitis suppurativa, clinical severity index and life quality index of the patients were examined both before and 1 year after the treatment. 

Results: Twelve  patients were recruited. In the examination of  the  hidradenitis  suppurativa  clinical  severity  scores, significant  clinical  responses  were  noted  in  9  (75%)  patients.  While  the  mean  value  of  the  life  quality  index  was 14.4±6.9 before the treatment, it was determined to be significantly decreased to 4.3±3.8 after the treatment.

Conclusion:  We  concluded  that  adalimumab;  the  unique  biological  agent  approved  to  be  used  in  the  treatment  of treatment-resistant, moderate-severe hidradenitis suppurativa is efficient and safe in similar ratios with the previous clinical studies in the literature.






Anahtar Kelimeler

Adalimumab eccrine glands

Kaynakça

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Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Yazıları
Yazarlar

Ali Balevi Bu kişi benim 0000-0001-5057-0405

Pelin Ustuner 0000-0002-7885-0537

Mustafa Özdemir Bu kişi benim 0000-0002-7022-913X

Yayımlanma Tarihi 17 Mart 2018
Gönderilme Tarihi 17 Mart 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 45 Sayı: 1

Kaynak Göster

APA Balevi, A., Ustuner, P., & Özdemir, M. (2018). The efficacy of adalimumab in the treatment of hidradenitis suppurativa. Dicle Tıp Dergisi, 45(1), 19-27. https://doi.org/10.5798/dicletip.407240
AMA Balevi A, Ustuner P, Özdemir M. The efficacy of adalimumab in the treatment of hidradenitis suppurativa. diclemedj. Mart 2018;45(1):19-27. doi:10.5798/dicletip.407240
Chicago Balevi, Ali, Pelin Ustuner, ve Mustafa Özdemir. “The Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa”. Dicle Tıp Dergisi 45, sy. 1 (Mart 2018): 19-27. https://doi.org/10.5798/dicletip.407240.
EndNote Balevi A, Ustuner P, Özdemir M (01 Mart 2018) The efficacy of adalimumab in the treatment of hidradenitis suppurativa. Dicle Tıp Dergisi 45 1 19–27.
IEEE A. Balevi, P. Ustuner, ve M. Özdemir, “The efficacy of adalimumab in the treatment of hidradenitis suppurativa”, diclemedj, c. 45, sy. 1, ss. 19–27, 2018, doi: 10.5798/dicletip.407240.
ISNAD Balevi, Ali vd. “The Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa”. Dicle Tıp Dergisi 45/1 (Mart 2018), 19-27. https://doi.org/10.5798/dicletip.407240.
JAMA Balevi A, Ustuner P, Özdemir M. The efficacy of adalimumab in the treatment of hidradenitis suppurativa. diclemedj. 2018;45:19–27.
MLA Balevi, Ali vd. “The Efficacy of Adalimumab in the Treatment of Hidradenitis Suppurativa”. Dicle Tıp Dergisi, c. 45, sy. 1, 2018, ss. 19-27, doi:10.5798/dicletip.407240.
Vancouver Balevi A, Ustuner P, Özdemir M. The efficacy of adalimumab in the treatment of hidradenitis suppurativa. diclemedj. 2018;45(1):19-27.