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Yıl 2021, Cilt: 3 Sayı: 1, 36 - 38, 15.04.2021

Mehmet Özgür Arslanoğlu Ebru Kaçmaz Gürkan Bozan Ener Cagri Dınleyıcı Burak Özkan Sabiha Sahin

Öz

Kaynakça

  • 1.Sztajnkrycer MD. Valproic acid toxicity: overview and management. J Toxicol Clin Toxicol. 2002; 40(6): 789-801.
  • 2.Andersen GO, Ritland S. Life threatening intoxication with sodium valproate. J Toxicol Clin Toxicol. 1995; 33(3): 279-284.
  • 3.Nau H, Loscher W. Valproic acid and metabolites: pharmacological and toxicological studies. Epilepsia. 1984; 25 Suppl 1:S14-22.
  • 4.Lheureux PE, Penaloza A, Zahir S, Gris M. Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence? Crit Care. 2005; 9(5): 431-40.
  • 5.Lheureux PE, Hantson P. Carnitine in the treatment of valproic acid-induced toxicity. Clin Toxicol (Phila). 2009; 47(2): 101-11.
  • 6.Katiyar A, Aaron C. Case files of the Children's Hospital of Michigan Regional Poison Control Center: the use of carnitine for the management of acute valproic acid toxicity. J Med Toxicol. 2007; 3(3): 129-38.
  • 7.Ingels M, Beauchamp J, Clark RF, Williams SR. Delayed valproic acid toxicity: a retrospective case series. Ann Emerg Med. 2002;39(6): 616-21
  • 8.Ghannoum M, Laliberté M, Nolin TD, MacTier R, Lavergne V, Hoffman RS, Gosselin S; EXTRIP Workgroup. Extracorporeal treatment for valproic acid poisoning: systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila). 2015; 53(5): 454-65.
  • 9.Ishikura H, Matsuo N, Matsubara M, Ishihara T, Takeyama N, Tanaka T. Valproic acid overdose and L-carnitine therapy. J Anal Toxicol. 1996; 20(1): 55-8.

L-Carnitine treatment in a child with valproic acid intoxication

Yıl 2021, Cilt: 3 Sayı: 1, 36 - 38, 15.04.2021

Mehmet Özgür Arslanoğlu Ebru Kaçmaz Gürkan Bozan Ener Cagri Dınleyıcı Burak Özkan Sabiha Sahin

Öz

With its growing application in neurological and psychiatric diseases, valproic acid overdose due to acute and chronic use has been causing emergency admission. Asymptomatic cases of hyperammonemia may be found in valproic acid poisoning ranging from central nervous system depression to coma. While supportive therapy is adequate, in most cases active charcoal, levocarnitine supplementation, and treatment with naloxane and hemodialysis, when needed, can also be used. In the case study reported in this paper, we aimed to focus at bringing awareness to the use of levocarnitine in asymptomatic patients with valproic acid poisoning accompanied by hyperammonemia.

Anahtar Kelimeler

hyperammonemia intoxication L-carinitine valproik acid

Kaynakça

  • 1.Sztajnkrycer MD. Valproic acid toxicity: overview and management. J Toxicol Clin Toxicol. 2002; 40(6): 789-801.
  • 2.Andersen GO, Ritland S. Life threatening intoxication with sodium valproate. J Toxicol Clin Toxicol. 1995; 33(3): 279-284.
  • 3.Nau H, Loscher W. Valproic acid and metabolites: pharmacological and toxicological studies. Epilepsia. 1984; 25 Suppl 1:S14-22.
  • 4.Lheureux PE, Penaloza A, Zahir S, Gris M. Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence? Crit Care. 2005; 9(5): 431-40.
  • 5.Lheureux PE, Hantson P. Carnitine in the treatment of valproic acid-induced toxicity. Clin Toxicol (Phila). 2009; 47(2): 101-11.
  • 6.Katiyar A, Aaron C. Case files of the Children's Hospital of Michigan Regional Poison Control Center: the use of carnitine for the management of acute valproic acid toxicity. J Med Toxicol. 2007; 3(3): 129-38.
  • 7.Ingels M, Beauchamp J, Clark RF, Williams SR. Delayed valproic acid toxicity: a retrospective case series. Ann Emerg Med. 2002;39(6): 616-21
  • 8.Ghannoum M, Laliberté M, Nolin TD, MacTier R, Lavergne V, Hoffman RS, Gosselin S; EXTRIP Workgroup. Extracorporeal treatment for valproic acid poisoning: systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila). 2015; 53(5): 454-65.
  • 9.Ishikura H, Matsuo N, Matsubara M, Ishihara T, Takeyama N, Tanaka T. Valproic acid overdose and L-carnitine therapy. J Anal Toxicol. 1996; 20(1): 55-8.
Toplam 9 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yoğun Bakım
Bölüm Case Reports
Yazarlar

Mehmet Özgür Arslanoğlu 0000-0003-3798-0260

Ebru Kaçmaz Bu kişi benim 0000-0002-7136-9441

Gürkan Bozan 0000-0001-5041-8892

Ener Cagri Dınleyıcı 0000-0002-0339-0134

Burak Özkan Bu kişi benim 0000-0002-7738-9347

Sabiha Sahin 0000-0003-0759-4158

Yayımlanma Tarihi 15 Nisan 2021
Gönderilme Tarihi 25 Aralık 2020
Kabul Tarihi 4 Ocak 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 3 Sayı: 1

Kaynak Göster

APA Arslanoğlu, M. Ö., Kaçmaz, E., Bozan, G., Dınleyıcı, E. C., vd. (2021). L-Carnitine treatment in a child with valproic acid intoxication. Eurasian Journal of Critical Care, 3(1), 36-38.
AMA Arslanoğlu MÖ, Kaçmaz E, Bozan G, Dınleyıcı EC, Özkan B, Sahin S. L-Carnitine treatment in a child with valproic acid intoxication. Eurasian j Crit Care. Nisan 2021;3(1):36-38.
Chicago Arslanoğlu, Mehmet Özgür, Ebru Kaçmaz, Gürkan Bozan, Ener Cagri Dınleyıcı, Burak Özkan, ve Sabiha Sahin. “L-Carnitine Treatment in a Child With Valproic Acid Intoxication”. Eurasian Journal of Critical Care 3, sy. 1 (Nisan 2021): 36-38.
EndNote Arslanoğlu MÖ, Kaçmaz E, Bozan G, Dınleyıcı EC, Özkan B, Sahin S (01 Nisan 2021) L-Carnitine treatment in a child with valproic acid intoxication. Eurasian Journal of Critical Care 3 1 36–38.
IEEE M. Ö. Arslanoğlu, E. Kaçmaz, G. Bozan, E. C. Dınleyıcı, B. Özkan, ve S. Sahin, “L-Carnitine treatment in a child with valproic acid intoxication”, Eurasian j Crit Care, c. 3, sy. 1, ss. 36–38, 2021.
ISNAD Arslanoğlu, Mehmet Özgür vd. “L-Carnitine Treatment in a Child With Valproic Acid Intoxication”. Eurasian Journal of Critical Care 3/1 (Nisan 2021), 36-38.
JAMA Arslanoğlu MÖ, Kaçmaz E, Bozan G, Dınleyıcı EC, Özkan B, Sahin S. L-Carnitine treatment in a child with valproic acid intoxication. Eurasian j Crit Care. 2021;3:36–38.
MLA Arslanoğlu, Mehmet Özgür vd. “L-Carnitine Treatment in a Child With Valproic Acid Intoxication”. Eurasian Journal of Critical Care, c. 3, sy. 1, 2021, ss. 36-38.
Vancouver Arslanoğlu MÖ, Kaçmaz E, Bozan G, Dınleyıcı EC, Özkan B, Sahin S. L-Carnitine treatment in a child with valproic acid intoxication. Eurasian j Crit Care. 2021;3(1):36-8.
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