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Clinical value of neutrophil to lymphocyte ratio in the region of lower extremity deep venous thrombosis

Yıl 2017, Cilt: 3 Sayı: 1, 43 - 48, 04.03.2017

Engin Akgul Nurhayat Bircan Gunduz Yumun Ahmet Hakan Vural

https://doi.org/10.18621/eurj.2017.5000199818
Cited By: 2

Öz

Objectives. Many
studies have demonstrated a significant association between cardiovascular
disease and neutrophil to lymphocyte ratio (NLR). To our knowledge, no study
has been reported in patients with deep venous thrombosis (DVT) which affecting
proximal or distal leg. In this study we analyzed proximal and distal DVT
according to the NLR. Methods. This retrospective study
was obtained from patients’ records of a tertiary university hospital between
May 2011 to January 2014. A total of 57 patients with the diagnosis of acute
primary DVT and 30 patients as control group included in the study. All of them
were confirmed with lower extremity venous duplex examinations. Of these, 37
examinations with the diagnosis of proximal DVT were compared to 20
examinations with distal DVT. The groups compared regarding to complete blood
counter values. Results. Mean eosinophil
level was higher in the distal DVT group (0.28±0.24 vs. 0.12±0.01, p=0.001), whereas median NLR were higher
in the proximal DVT group than the distal DVT group (3.5 [0.5-4.3] vs. 2.3 [1.2-9.7],
respectively; p=0.002). In addition, median
NLR, leukocyte and neutrophil counts were statistically lower in the control
group than the others (p=0.014, p=0.027 and p=0.004, respectively). Conclusion. NLR, an inexpensive and
easily measurable laboratory variable, was independently and significantly
associated with the presence and severity of DVT, especially acute proximal
DVT. 

Anahtar Kelimeler

Deep venous thrombosis neutrophil to lymphocyte ratio (NLR)

Kaynakça

  • [1] Anderson FA Jr, Spencer FA. Risk factors for venous thromboembolism. Circulation 2003;107 (23 Suppl 1):I9-16.
  • [2] Johnson SA, Stevens SM, Woller SC, Lake E, Donadini M, Cheng J, et al. Risk of deep vein thrombosis following a single negative whole-leg compression ultrasound: a systematic review and meta-analysis. JAMA 2010;303:438-45.
  • [3] Hull RD, Hirsh J, Carter CJ, Jay RM, Ockelford PA, Buller HR. Pulmonary angiography, ventilation lung scanning, and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scanning. Ann Intern Med 1983;98:891-9.
  • [4] Salcuni M, Fiorentino P, Pedicelli A, Di Stasi C. Diagnostic imaging in deep vein thrombosis of the limbs. Rays 1996;21:328-39.
  • [5] Afari ME, Bhat T. Neutrophil to lymphocyte ratio (NLR) and cardiovascular diseases: an update. Expert Rev Cardiovasc Ther 2016;14:573-7.
  • [6] Gijsberts CM, Ellenbroek GH, Ten Berg MJ, Huisman A, van Solinge WW, Asselbergs FW, et al. Routinely analyzed leukocyte characteristics improve prediction of mortality after coronary angiography. Eur J Prev Cardiol 2016;23:1211-20.
  • [7] Zhou D, Wan Z, Fan Y, Zhou J, Yuan Z. A combination of the neutrophil to lymphocite ratio and the GRACE risk score better predicts PCI outcomes in Chinese Han patients with acute coronary syndrome. Anatol J Cardiol 2015;15:995-1001.
  • [8] Uthamalingam S, Patvardhan EA, Subramanian S, Ahmed W, Martin W, Daley M, et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol 2011;107:433-8.
  • [9] Papa A, Emdin M, Passino C, Michelassi C, Battaglia D, Cocci F. Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. Clin Chim Acta 2008;395:27-31.
  • [10] Duffy BK, Gurm HS, Rajagopal V, Gupta R, Ellis SG, Bhatt DL. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. Am J Cardiol 2006;97:993-6.
  • [11] Eagleton MJ, Henke PK, Luke CE, Hawley AE, Bedi A, Knipp BS, et al. Southern Association for Vascular Surgery William J. von Leibig Award. Inflammation and intimal hyperplasia associated with experimental pulmonary embolism. J Vasc Surg 2002;36:581-8.
  • [12] Kayrak M, Erdogan HI, Solak Y, Akilli H, Gul EE, Yildirim O, el al. Prognostic value of neutrophil to lymphocyte ratio in patients with acute pulmonary embolism: a retrospective study. Heart Lung Circ 2014;23:56-62.
  • [13] Fraser RS, Muller NL, Colman N. Thrombosis and thromboembolism. In: Fraser RS, Muller NL, Colman N, Pare PD, eds. Diagnosis of diseases of the chest. 4th ed. Philadelphia: WB Saunders; 1999, pp. 1773-843.
  • [14] Yavuz S, Toktas F, Goncu T, Eris C, Gucu A, Ay D, et al. Surgical embolectomy for acute massive pulmonary embolism. Int J Clin Exp Med 2014;7:5362-75.
  • [15] Di Minno MN, Ambrosino P, Ambrosini F, Tremoli E, Minno GD, Dentali F. Prevalence of deep vein thrombosis and pulmonary embolism in patients with superficial veint hrombosis: a systematic review and meta-analysis. J Thromb Haemost 2016;14:964-72.

Yıl 2017, Cilt: 3 Sayı: 1, 43 - 48, 04.03.2017

Engin Akgul Nurhayat Bircan Gunduz Yumun Ahmet Hakan Vural

https://doi.org/10.18621/eurj.2017.5000199818
Cited By: 2

Öz

Kaynakça

  • [1] Anderson FA Jr, Spencer FA. Risk factors for venous thromboembolism. Circulation 2003;107 (23 Suppl 1):I9-16.
  • [2] Johnson SA, Stevens SM, Woller SC, Lake E, Donadini M, Cheng J, et al. Risk of deep vein thrombosis following a single negative whole-leg compression ultrasound: a systematic review and meta-analysis. JAMA 2010;303:438-45.
  • [3] Hull RD, Hirsh J, Carter CJ, Jay RM, Ockelford PA, Buller HR. Pulmonary angiography, ventilation lung scanning, and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scanning. Ann Intern Med 1983;98:891-9.
  • [4] Salcuni M, Fiorentino P, Pedicelli A, Di Stasi C. Diagnostic imaging in deep vein thrombosis of the limbs. Rays 1996;21:328-39.
  • [5] Afari ME, Bhat T. Neutrophil to lymphocyte ratio (NLR) and cardiovascular diseases: an update. Expert Rev Cardiovasc Ther 2016;14:573-7.
  • [6] Gijsberts CM, Ellenbroek GH, Ten Berg MJ, Huisman A, van Solinge WW, Asselbergs FW, et al. Routinely analyzed leukocyte characteristics improve prediction of mortality after coronary angiography. Eur J Prev Cardiol 2016;23:1211-20.
  • [7] Zhou D, Wan Z, Fan Y, Zhou J, Yuan Z. A combination of the neutrophil to lymphocite ratio and the GRACE risk score better predicts PCI outcomes in Chinese Han patients with acute coronary syndrome. Anatol J Cardiol 2015;15:995-1001.
  • [8] Uthamalingam S, Patvardhan EA, Subramanian S, Ahmed W, Martin W, Daley M, et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol 2011;107:433-8.
  • [9] Papa A, Emdin M, Passino C, Michelassi C, Battaglia D, Cocci F. Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. Clin Chim Acta 2008;395:27-31.
  • [10] Duffy BK, Gurm HS, Rajagopal V, Gupta R, Ellis SG, Bhatt DL. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. Am J Cardiol 2006;97:993-6.
  • [11] Eagleton MJ, Henke PK, Luke CE, Hawley AE, Bedi A, Knipp BS, et al. Southern Association for Vascular Surgery William J. von Leibig Award. Inflammation and intimal hyperplasia associated with experimental pulmonary embolism. J Vasc Surg 2002;36:581-8.
  • [12] Kayrak M, Erdogan HI, Solak Y, Akilli H, Gul EE, Yildirim O, el al. Prognostic value of neutrophil to lymphocyte ratio in patients with acute pulmonary embolism: a retrospective study. Heart Lung Circ 2014;23:56-62.
  • [13] Fraser RS, Muller NL, Colman N. Thrombosis and thromboembolism. In: Fraser RS, Muller NL, Colman N, Pare PD, eds. Diagnosis of diseases of the chest. 4th ed. Philadelphia: WB Saunders; 1999, pp. 1773-843.
  • [14] Yavuz S, Toktas F, Goncu T, Eris C, Gucu A, Ay D, et al. Surgical embolectomy for acute massive pulmonary embolism. Int J Clin Exp Med 2014;7:5362-75.
  • [15] Di Minno MN, Ambrosino P, Ambrosini F, Tremoli E, Minno GD, Dentali F. Prevalence of deep vein thrombosis and pulmonary embolism in patients with superficial veint hrombosis: a systematic review and meta-analysis. J Thromb Haemost 2016;14:964-72.
Toplam 15 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Original Article
Yazarlar

Engin Akgul

Nurhayat Bircan Bu kişi benim

Gunduz Yumun

Ahmet Hakan Vural Bu kişi benim

Yayımlanma Tarihi 4 Mart 2017
Gönderilme Tarihi 22 Kasım 2016
Kabul Tarihi 1 Ekim 2016
Yayımlandığı Sayı Yıl 2017 Cilt: 3 Sayı: 1

Kaynak Göster

AMA Akgul E, Bircan N, Yumun G, Vural AH. Clinical value of neutrophil to lymphocyte ratio in the region of lower extremity deep venous thrombosis. Eur Res J. Mart 2017;3(1):43-48. doi:10.18621/eurj.2017.5000199818

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https://doi.org/10.1097/MD.0000000000033008

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