Öz
Introduction: Fungal prosthetic joint infections, constitute a small portion of all prosthetic infection cases and candida species are the causative agent in the majority of these cases. Most fungal prosthetic joint infections occur after revision arthroplasty.
Case: A 72-year-old male patient, underwent total knee prosthesis operation for the right knee due to gonarthrosis. About 5 months later, he was hospitalized and treated due to bacterial prosthesis infection. 8 days after discharge, he applied again with the complaints of swelling, pain, temperature increase and redness in the right knee. He was hospitalized again due to prosthesis infection. Antifungal treatment was started for the patient due to the growth of Candida albicans in the knee joint. A total of 2.5 months of antifungal therapy was given. The patient, who recovered without any problems, continues to follow up in the outpatient clinic.
Discussion: In this case report, we wanted to emphasize that in the presence of risk factors in prosthesis infection, we should not forget that the cause may also be fungus, that culture should be taken during the operation and that effective and long-term antifungal treatment should be given in fungal-related prosthesis infections.
Anahtar Kelimeler
Kaynakça
- 1. Gamaletsou MN, Kontoyiannis DP, Sipsas NV, et al. Candidaosteo-myelitis: analysis of 207 pediatri cand adult cases (1970–2011). Clin Infect Dis. 2012;15:1338-1351.
- 2. Slenker AK, Keith SW, Horn DL. Two hundred and elevencases of Candida osteomyelitis: 17 case reports and a review of the literature. Diagn Microbiol Infect Dis. 2012;73:89-93.
- 3. Morrow JD, Manian FA. Vertebral osteomyelitis due to Candida gla-brata: a case report. J Tenn Med Assoc. 1986;79:409-410.
- 4.J.W. Kuiper, M.P. van den Bekerom, J. van der Stappen, P.A. Nolte, S. Colen2-stage revision recommended for treatment of fungal hip and knee prosthetic joint infections ActaOrthop, 84 (2013), pp. 517-523
- 5.R.O. Darouiche, R.J. Hamill, D.M. Musher, E.J. Young, R.L. Harris Peri prosthetic candidal infections following arthroplasty RevInfectDis, 11 (1989), pp. 89-96
- 6.C. Tsui, E.F. Kong, M.A. Jabra-RizkPathogenesis of Candida albicans biofilm PathogDis, 74 (2016), Article ftw018
- 7.Ulrich SD, Seyler TM, Bennett D, et al. Total hiparthroplasties: what are the reasons for revision? IntOrthop. 2008;32:597-604.
- 8. Pfaller MA, Diekema DJ. Epidemiology of invasive candidia-sis: a persistent public health problem. ClinMicrobiolRev. 2007;20:133-163.
- 9.K. Azzam, J. Parvizi, D. Jungkind, A. Hanssen, T. Fehring, B. Springer, et al.Microbiological, clinical, and surgical features of fungal prosthetic joint infections: a multi-institutiona lexperience J Bone JointSurgAm, 91 (Suppl. 6) (2009), pp. 142-149
- 10.J.T. Bariteau, G.R. Waryasz, M. McDonnell, S.A. Fischer, R.A. Hayda, C.T. Born Fungal osteomyelitis and septicarthritis J AmAcadOrthopSurg, 22 (2014), pp. 390-401
- 11. Cobo F, Rodríguez-Granger J, Sampedro A, Aliaga-Martínez L, Navarro-Marí JM. Candida prosthetic joint infection. A review of treatment methods. J Bone JtInfect. 2017;2:114-121.
- 12.K. Anagnostakos, J. Kelm, E. Schmitt, J. Jung Fungal periprosthetic hip and knee joint infections clinical experience with a 2-stage treatment protocol J Arthroplasty, 27 (2012), pp. 293-298
- 13. J. Merrer, B. Dupont, A. Nieszkowska, B. De Jonghe, H. Outin Candida albicans prosthetic arthritis treated with fluconazolealone J Infect, 42 (2001), pp. 208-209
- 14. Koutserimpas C, Samonis G, Velivassakis E ve ark. Candida glabrata prosthetic joint infection, successfully treated with anidulafungin: A case report and review of the literatüre. Mycoses. 2018 Apr;61(4):266-269.
- 15.Hall RL, Frost RM, Vasukutty NL, Minhas H. Candidaglabrata: an unusual fungal infection following a total hip replacement. BMJ Case Rep 2012; 2012.
Öz
Giriş: Mantar protez eklem enfeksiyonları, tüm protez enfeksiyonu vakalarının az bir kısmını oluşturur ve candida türleri de bu vakaların çoğunluğunda etkendir. Mantar protez eklem enfeksiyonlarının çoğu revizyon artroplastisinden sonra ortaya çıkar.
Olgu: Yetmiş iki yaşında erkek hasta, gonartroz nedeniyle sağ dizine yönelik total diz protez operasyonu uygulanmış. Yaklaşık 5 ay sonra bakteriyel protez enfeksiyonu nedeni ile yatırılarak tedavi edildi. Taburculuktan 8 gün sonra sağ dizde şişlik, ağrı, ısı artışı ve kızarıklık şikayetleri ile tekrar başvurdu. Protez enfeksiyonu nedeni ile tekrar yatırıldı. Hastanın diz ekleminde Candida albicans üremesi olması nedeni ile hastaya antifungal tedavi başlandı. Toplamda 2.5 ay antifungal tedavi verildi. Sorunsuz şekilde iyileşen hasta poliklinik takiplerine devam etmektedir.
Tartışma: Biz bu olgu sunumunda protez enfeksiyonunda risk faktörleri varlığında etkenin mantar da olabileceğini unutmamamız gerektiğini, operasyon esnasında mutlaka kültür alınması gerektiğini ve sonuçta mantar ilişkili protez enfeksiyonlarında etkili ve uzun bir süre antifungal tedavi verilmesi gerektiğini vurgulamak istedik.
Anahtar Kelimeler
Kaynakça
- 1. Gamaletsou MN, Kontoyiannis DP, Sipsas NV, et al. Candidaosteo-myelitis: analysis of 207 pediatri cand adult cases (1970–2011). Clin Infect Dis. 2012;15:1338-1351.
- 2. Slenker AK, Keith SW, Horn DL. Two hundred and elevencases of Candida osteomyelitis: 17 case reports and a review of the literature. Diagn Microbiol Infect Dis. 2012;73:89-93.
- 3. Morrow JD, Manian FA. Vertebral osteomyelitis due to Candida gla-brata: a case report. J Tenn Med Assoc. 1986;79:409-410.
- 4.J.W. Kuiper, M.P. van den Bekerom, J. van der Stappen, P.A. Nolte, S. Colen2-stage revision recommended for treatment of fungal hip and knee prosthetic joint infections ActaOrthop, 84 (2013), pp. 517-523
- 5.R.O. Darouiche, R.J. Hamill, D.M. Musher, E.J. Young, R.L. Harris Peri prosthetic candidal infections following arthroplasty RevInfectDis, 11 (1989), pp. 89-96
- 6.C. Tsui, E.F. Kong, M.A. Jabra-RizkPathogenesis of Candida albicans biofilm PathogDis, 74 (2016), Article ftw018
- 7.Ulrich SD, Seyler TM, Bennett D, et al. Total hiparthroplasties: what are the reasons for revision? IntOrthop. 2008;32:597-604.
- 8. Pfaller MA, Diekema DJ. Epidemiology of invasive candidia-sis: a persistent public health problem. ClinMicrobiolRev. 2007;20:133-163.
- 9.K. Azzam, J. Parvizi, D. Jungkind, A. Hanssen, T. Fehring, B. Springer, et al.Microbiological, clinical, and surgical features of fungal prosthetic joint infections: a multi-institutiona lexperience J Bone JointSurgAm, 91 (Suppl. 6) (2009), pp. 142-149
- 10.J.T. Bariteau, G.R. Waryasz, M. McDonnell, S.A. Fischer, R.A. Hayda, C.T. Born Fungal osteomyelitis and septicarthritis J AmAcadOrthopSurg, 22 (2014), pp. 390-401
- 11. Cobo F, Rodríguez-Granger J, Sampedro A, Aliaga-Martínez L, Navarro-Marí JM. Candida prosthetic joint infection. A review of treatment methods. J Bone JtInfect. 2017;2:114-121.
- 12.K. Anagnostakos, J. Kelm, E. Schmitt, J. Jung Fungal periprosthetic hip and knee joint infections clinical experience with a 2-stage treatment protocol J Arthroplasty, 27 (2012), pp. 293-298
- 13. J. Merrer, B. Dupont, A. Nieszkowska, B. De Jonghe, H. Outin Candida albicans prosthetic arthritis treated with fluconazolealone J Infect, 42 (2001), pp. 208-209
- 14. Koutserimpas C, Samonis G, Velivassakis E ve ark. Candida glabrata prosthetic joint infection, successfully treated with anidulafungin: A case report and review of the literatüre. Mycoses. 2018 Apr;61(4):266-269.
- 15.Hall RL, Frost RM, Vasukutty NL, Minhas H. Candidaglabrata: an unusual fungal infection following a total hip replacement. BMJ Case Rep 2012; 2012.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Case Report |
| Yazarlar | |
| Erken Görünüm Tarihi | 30 Nisan 2023 |
| Yayımlanma Tarihi | 30 Nisan 2023 |
| Gönderilme Tarihi | 3 Ağustos 2022 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 33 Sayı: 2 |
Genel Tıp Dergisi Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı (CC BY NC) ile lisanslanmıştır.