Araştırma Makalesi
BibTex RIS Kaynak Göster

Investigation of the Relationship Between Endovascularly Treated Subarachnoid Hemorrhage Disease and Vitamin D Levels

Yıl 2022, Cilt: 19 Sayı: 2, 378 - 381, 28.08.2022
https://doi.org/10.35440/hutfd.1079834

Öz

Object: Subarachnoid hemorrhage, which is a rare group of cerebrovascular diseases, is a disease with high mortality and morbidity. The treatment and follow-up process is quite difficult. Its treatment requires a multidisciplinary approach. The parameters affecting the clinical course have always been a matter of curiosity in this disease. Our aim in this article was to investigate the effect of vitamin-D levels on the clinical course of patients with subarachnoid hemorrhage followed in the neurological intensive care unit.
Methods: Patients who applied to the emergency department of our hospital with subarachnoid hemorrhage between October 2019 and October 2021 were screened retrospectively. Clinical, laboratory and detailed angio reports of these patients were obtained from patient files.
Results: The cases were divided into two groups as those with vitamin D less than 20ng/ml and those with higher than this value. Gender, Vasospasm, Hydrocephalus, Epiletic seizure, length of stay in intensive care unit, duration of mechanical ventilation, Glasgow coma scale (GCS) and exitus rates were compared between these two groups, no statistical significance was found.
Conclusion: Our patients with a diagnosis of subarachnoid hemorrhage had a high rate of Vit-D deficiency and/or insufficiency. Although further studies are needed, no correlation was found between the Vit-D level and the prognosis of patients with subarachnoid hemorrhage.

Kaynakça

  • Referans 1. Chibuzor MT, Graham-Kalio D, Osaji JO, et al. Vitamin D, calcium or a combination of vitamin D and calcium for the treatment of nutritional rickets in children. Cochrane Database Syst Rev 2020; 4: CD012581.
  • Referans 2. Judd SE, Tangpricha V. Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci 2009; 338: 40-44.
  • Referans3. Marniemi J, AlanenE, ImpivaaraO, et al. Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects.NutrMetabCardiovasc Dis 2005;15:188-197.
  • Referans4. Sun Q, Pan A, Hu FB, et al. 25-Hydroxyvitamin D Levels and the Risk of Stroke: A Prospective Study and Meta-analysis. Stroke 2012; 43(6):1470-1477.
  • Referans5. Balden R, Selvamani A, Sohrabji F. Vitamin D deficiency exacerbates experimental stroke injury and dysregulates ischemia-induced inflammation in adult rats. Endocrinology 2012;153:2420-2435.
  • Referans 6. Sander-Connolly E, Rabinstein AA, Carhuapoma JR, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2012;43:1711-1737.
  • Referans 7. Al Mheid I, Quyyumi AA. Vitamin D and Cardiovascular Disease: Controversy Unresolved. J Am CollCardiol2017;4;70(1):89-100.
  • Referans 8. Al Mheid I, Patel RS, Tangpricha V, et al. Vitamin D and cardiovascular disease: is the evidence solid? Eur Heart J 2013; 34(48):3691-3698.
  • Referans 9. Dalan R, Liewa H, Alvin Tan WK, et al. Vitamin D and the endothelium: basic, translational and clinical research updates. IJC MetabEndocr2014;4:4-17.
  • Referans 10. Ostrowski RP, Colohan AR, Zhang JH. Molecular mechanisms of early brain injury after subarachnoid hemorrhage. Neurol Res 2006;28(4):399-414.
  • Referans 11. Pluta RM, Hansen-Schwartz J, Dreier J, et al. Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought. Neurol Res 2009;31(2):151-158.
  • Referans 12. Vikman P, Beg S, Khurana TS, et al. Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in the rat. J Neurosurg 2006;105(3):438-444.
  • Referans 13. Quraishi SA, McCarthy C, Blum L, et al. Plasma 25-Hydroxyvitamin D Levels at Initiation of Care and Duration of Mechanical Ventilation in Critically Ill Surgical Patients. J Parenter Enteral Nutr 2016;40(2):273-278.

Endovasküler Tedavi Uygulanmış Subaraknoid Kanama Hastalığı ile Vitamin D Düzeyleri Arasındaki İlişkinin Araştırılması

Yıl 2022, Cilt: 19 Sayı: 2, 378 - 381, 28.08.2022
https://doi.org/10.35440/hutfd.1079834

Öz

Amaç: Beyin damar hastalıklarının nadir görülen grubunu oluşturan subaraknoid kanama, mortalite ve morbiditesi yüksek bir hastalıktır. Tedavi ve takip süreci oldukça zordur. Tedavisi multidisipliner yaklaşım gerektirir. Klinik gidişata etki eden parametreler bu hastalıkta hep bir merak konusu olmuştur. Bu yazıda bizim amacımız; Vitamin-D seviyelerinin nörolojik yoğun bakım ünitesinde takip edilen subaraknoid kana-malı hastaların klinik gidişatları üzerine etkisini araştırmak oldu.
Materyal ve metod: Ekim 2019-Ekim 2021 tarihleri arasında subaraknoid kanama ile hastanemiz acil servisine başvuran 45 hasta retrospektif olarak taranmıştır.Bu hastaların klinik, labaratuvar ve detaylı anjio raporları hasta dosyalarından elde edilmiştir.
Bulgular: Olgular D vitamini 20ng/ml den düşük olanlar ve bu değerden daha yüksek olanlar şeklinde iki gruba ayrıldı. Tüm olguların 23’inde (% 51) Vit-D düzeyleri 20 ng/ml’den düşük saptanmış olup, 22’sinde ise (%49) Vit-D 20ng/ml’den daha yüksek olarak saptandı .Cinsiyet, Vasospazm, Hidrosefali, Epiletik nöbet, yoğun bakım yatış süresi, mekanik ventilasyon süresi, Glaskow koma skalası (GKS) ve exitus oranları bu iki grup arasında karşılaştırıldı birçoğunda istatistiksel olarak anlamlılık saptanmadı.
Sonuç: Subaraknoid kanama tanılı hastalarımızda Vit-D eksikliği ve/veya yetersizliği yüksek oranda mev-cuttu. Daha ileri çalışmalara gerek duymakla birlikte Vit-D seviyesi ile subaraknoid kanamalı hastaların prognozu arasında ilişki bulunamamıştır.

Anahtar Kelimeler: Subaraknoid kanama, Nörolojik yoğun bakım, Vit-D

Kaynakça

  • Referans 1. Chibuzor MT, Graham-Kalio D, Osaji JO, et al. Vitamin D, calcium or a combination of vitamin D and calcium for the treatment of nutritional rickets in children. Cochrane Database Syst Rev 2020; 4: CD012581.
  • Referans 2. Judd SE, Tangpricha V. Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci 2009; 338: 40-44.
  • Referans3. Marniemi J, AlanenE, ImpivaaraO, et al. Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects.NutrMetabCardiovasc Dis 2005;15:188-197.
  • Referans4. Sun Q, Pan A, Hu FB, et al. 25-Hydroxyvitamin D Levels and the Risk of Stroke: A Prospective Study and Meta-analysis. Stroke 2012; 43(6):1470-1477.
  • Referans5. Balden R, Selvamani A, Sohrabji F. Vitamin D deficiency exacerbates experimental stroke injury and dysregulates ischemia-induced inflammation in adult rats. Endocrinology 2012;153:2420-2435.
  • Referans 6. Sander-Connolly E, Rabinstein AA, Carhuapoma JR, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2012;43:1711-1737.
  • Referans 7. Al Mheid I, Quyyumi AA. Vitamin D and Cardiovascular Disease: Controversy Unresolved. J Am CollCardiol2017;4;70(1):89-100.
  • Referans 8. Al Mheid I, Patel RS, Tangpricha V, et al. Vitamin D and cardiovascular disease: is the evidence solid? Eur Heart J 2013; 34(48):3691-3698.
  • Referans 9. Dalan R, Liewa H, Alvin Tan WK, et al. Vitamin D and the endothelium: basic, translational and clinical research updates. IJC MetabEndocr2014;4:4-17.
  • Referans 10. Ostrowski RP, Colohan AR, Zhang JH. Molecular mechanisms of early brain injury after subarachnoid hemorrhage. Neurol Res 2006;28(4):399-414.
  • Referans 11. Pluta RM, Hansen-Schwartz J, Dreier J, et al. Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought. Neurol Res 2009;31(2):151-158.
  • Referans 12. Vikman P, Beg S, Khurana TS, et al. Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in the rat. J Neurosurg 2006;105(3):438-444.
  • Referans 13. Quraishi SA, McCarthy C, Blum L, et al. Plasma 25-Hydroxyvitamin D Levels at Initiation of Care and Duration of Mechanical Ventilation in Critically Ill Surgical Patients. J Parenter Enteral Nutr 2016;40(2):273-278.
Toplam 13 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Sedat Yaşin 0000-0001-8067-8388

Halil Ay 0000-0001-7233-7698

Yayımlanma Tarihi 28 Ağustos 2022
Gönderilme Tarihi 27 Şubat 2022
Kabul Tarihi 18 Nisan 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 19 Sayı: 2

Kaynak Göster

Vancouver Yaşin S, Ay H. Endovasküler Tedavi Uygulanmış Subaraknoid Kanama Hastalığı ile Vitamin D Düzeyleri Arasındaki İlişkinin Araştırılması. Harran Üniversitesi Tıp Fakültesi Dergisi. 2022;19(2):378-81.

Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty