Stabil Kronik Obstrüktif Akciğer Hastalığında İnflamatuar Belirteçler ve Hastalık Ağırlığı ile Karotis Arter İntima-Media Kalınlığının İlişkisi

Engin Aynacı; Birsen Pınar Yıldız; Aysun Aynacı; Gönenç Ortaköylü; Fırat Çetinkaya; Emel Çağlar

The Comparison of Carotid Artery Intima Media Thickness and Inflamatory Markers In Patients With Copd

Yıl 2011, Sayı: 3, 146 - 151, 01.09.2011

Engin Aynacı Birsen Pınar Yıldız Aysun Aynacı Gönenç Ortaköylü Fırat Çetinkaya Emel Çağlar

Öz

Aim: The aim of the study was to evaluate the relationship between intimamedia thickness of carotid artery and inflammatory markers and severity of disease in patients with COPD. Materials and method: Fifty-three stable COPD patients 38males/15females with median age 56,9±54 years old were included. Right and left carotid arteries were examined with a duplex scanner. Intima-media thickness IMT measurements of the carotid artery are compared to levels of CRP, fibrinojen, leucocyte counts, BMI, and stage of the disease. Results: There is significant relationship between the stage of COPD and the levels of CRP elevation p=0.01 . But no relationship was found between intima media thickness and the parameters we have investigated, including CRP. Conclusion: There have to be made new extended studies, to examine the effects of COPD, as a systemic inflamatory disease, on vasculer system

Anahtar Kelimeler

Inflammation, Chronic obstructive lung disease, intima media thickness, Carotid artery

Kaynakça

1. Bartu Saryal S, Acıcan T. (eds) Epidemiyoloji ve risk faktörleri. In: Güncel Bilgiler Işığında KOAH, Bilimsel Tıp Kitabevi, Ankara 2003;s:12-32.
2. Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO Global Iniative for chronic obstructive lung disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001; 163:1256 -1276.
3. In: Fishman AP, Elias JA et al. Fishman’s Pulmonary Disease and Disorders. 3.ED, McGraw-Hill, 1998.
4. Sin DD, Wu L, Man SF. The relationship between reduced lung function and cardiovascular mortality. Chest 2005; 127: 1952-9.
5. Sin DD, Man SF. Proc. Am. Thorac. Soc. 2005; 2: 8-11.
6. O’Leary DH, Polak JF. Intima-media thickness: a tool for atherosclerosis. Am. J. Cardiol 2002; 90:18-21.
7. Raggi P, Bellasi A, Ratti C. Diabetes Care 2005; 28: 2787-2794.
8. Türk toraks derneği 6. kış okulu kitabı sayfa:77; 2007.
9. 73-Gavin C. Donaldson, Terence A. R. Seemungal, Irem S. Airway and Systemic Inflammation and Decline in Lung Function in Patients with COPD.
10. Wedzicha JA, Seemungal TA, MacCallum PK, et al. Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinojen and serum IL-6 levels. Thromb Haemost 2000;84:210-15.
11. Folsom AR. Epidemiology of fibrinogen. Eur Heart J1995;16(suppl A):21-24.
12. De Maat MP, Pietersma A, Kofflard M, et al. Association of plasma fibrinogen levels with coronary artery disease, smoking and inflammatory markers. Atherosclerosis 1996;121:185-191.
13. American Journal of Respiratory and Critical Care Medicine Vol 172. pp. 625-630, 2005. Kenji Minoguchi, Takuya Yokoe, Toshiyuki Tazaki. Increased Carotid Intima-Media Thickness and Serum İnflammatory Markers in Obstructive Sleep Apnea.
14. Am J Cardiol . 2007 Jun 1 ; 99 (11) : 1598-602.Epub 2007m Apr 18.
15. Hiroyasu I, Shimamoto T, Sato S. Passive Smoking and Plasma Fibrinojen Concentrations. Am J Epidemiol 1996;144:1151-4.
16. Ridker PM, Rifai N, Rose LL, Buring JE, Cook NR. Comparison of C reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002;347:1557 1565.
17. Gan Wq, Man SFP, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic rewiew and meta-analysis. Thorax 2004; 59:574-580.
18. Mannino DM, Ford ES, Redd SC. Obstructive and restrictive lung disease and markers of inflammation:data from the third National Health and Nutrition Examination. Am J Med 2003;114:758-762.
19. Nascetti S, Elosua R, Pena A, et al. Variables associated with fibrinojen in a population-based study: Interaction between smoking and age on fibrinojen concentration. European Journal of Epidemiology 2001;17:953-58.
20. Scarabin PY, Bara L, Ricard S, et al. Genetic variation at the b-fibrinogen locus in relation to plasma concentrations and risk of myocardial infarction. Atherosclerosis Thromb 1993;13:886-91.
21. Taylor HD, Jacobs DR, Schhucker b, et al. A questionnaire for the assassment of leisure time physical activities. J Chronic Disease 1978;31:741-55.
22. Cooper J, Douglas AS. Fibrinogen level as a predictor of mortality infarction. Fibrinolysis 1991;5:105-8.
23. Cook NS, Ubben D. Fibrinogen as a major risk factor in cardiovascular disease. Trends Pharmacol Sci. 1990;11:444-51.
24. Sin Don D, Man SF. Why Are Patients With Chronic Obstructive Pulmonary Disease at Increased Risk of Cardiovascular Diseases? Circulation 2000;107:1514.
25. Cytokine. 2007 Jan;37(1): 44-50. Epub 2007 Mar 26.
26. Trends in Pharmacological sciences volume 28, ıssue 10, october 2007, pages 544-550.
27. Suzuki T, Nakano H, Maekawa J, Okomato Y, Ohnishi Y, Yamauchi M, Kimura H. Obstructive sleep apnea and carotid-artery intima- media thicness. Sleep .2004 Feb 1;27(1):129-33.
28. Baguet JP, Hammer L, Levy P, Pierre H, Launois S, Mallion JM, Pepin JL. The severity of oxygen desaturation is predictive of carotid wall thickening and plaque occurrence. Chest . 2005 Nov;128(5):3407-12.
29. Diez-Roux AV, Nieto FJ, Comstock GW, Howard G, Szklo m. The relationship of active and passive smoking to carotid atherosclerosis 12-14 years later. Prev Med. 1995 Jan ; 24 (1):48-55.
30. Howard G, Burke GL, Szklo M, Tell GS, Eckfeldt J, Evans G, Heiss. Active and passive smoking are associated with increased carotid wall thickness. The atherosclerosis Risk in Communities Study. Arch İntern Med. 1994Jun13;154(11):1277-82.
31. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ.Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987; 316:1371-1375.
32. O’Leary DH et al. Carotid artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. New Engl J Med 1999;340:14-22.
33. Gostomzyk JG, Heller WD, Gerhardt et al. B-scan ultrasound examination of the carotid arteries within a representative population (MONICA Project Augsburg). Klin Wochenschr. 1988;66(suppl 11):58-65.
34. Geroulakos G, O’Gorman D, Nicolaides A, et al. Carotid intima-media thickness: correlation with the British regional heart study risk score. J Intern Med. 1994;235:431-433.
35. Grobbee DE, Bots ML. Carotid artery intima-media thickness as an indicator of generalized atherosclerosis. J Intern Med. 1994;236:567–573.

Stabil Kronik Obstrüktif Akciğer Hastalığında İnflamatuar Belirteçler ve Hastalık Ağırlığı ile Karotis Arter İntima-Media Kalınlığının İlişkisi

Yıl 2011, Sayı: 3, 146 - 151, 01.09.2011

Engin Aynacı Birsen Pınar Yıldız Aysun Aynacı Gönenç Ortaköylü Fırat Çetinkaya Emel Çağlar

Öz

Amaç: Çalışmamızda Kronik Obstrüktif Akciğer Hastalığı KOAH olgularında inflamatuar markerlar ve hastalığın şiddeti ile karotis arter intima-media kalınlaşması İMK arasında ilişki olup olmadığı araştırıldı.Gereç ve yöntem: Çalışmaya stabil durumda KOAH’ı olan 53 38erkek/15kadın hasta alındı. Hastaların yaş ortalaması 56,9±54 idi. Hastaların sağ ve sol karotis arterleri duplex scanner ile incelendi. Karotis İMK’nın ölçümleri; hastaların sigara içme alışkanlığı, KOAH’ın evresi, CRP ve fibrinojen seviyeleri, lökosit sayısı, BMİ ile karşılaştırıldı.Bulgular: Çalışmamızda KOAH evresi ile CRP düzeyi arasında anlamlı ilişki olduğu görüldü p=0.01 . Fakat İMK ile CRP de dahil olmak üzere diğer parametreler arasında ilişki saptanmadı.Sonuç: KOAH’lı hastalarda vasküler sistem üzerine sistemik inflamatuar hastalık olan KOAH’ın etkisini belirlemek üzere daha geniş çalışmalara ihtiyaç vardır

Anahtar Kelimeler

İnflamasyon, Kronik obstrüktif akciğer hastalığı, intima-media kalınlaşması, karotis arter

Kaynakça

1. Bartu Saryal S, Acıcan T. (eds) Epidemiyoloji ve risk faktörleri. In: Güncel Bilgiler Işığında KOAH, Bilimsel Tıp Kitabevi, Ankara 2003;s:12-32.
2. Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO Global Iniative for chronic obstructive lung disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001; 163:1256 -1276.
3. In: Fishman AP, Elias JA et al. Fishman’s Pulmonary Disease and Disorders. 3.ED, McGraw-Hill, 1998.
4. Sin DD, Wu L, Man SF. The relationship between reduced lung function and cardiovascular mortality. Chest 2005; 127: 1952-9.
5. Sin DD, Man SF. Proc. Am. Thorac. Soc. 2005; 2: 8-11.
6. O’Leary DH, Polak JF. Intima-media thickness: a tool for atherosclerosis. Am. J. Cardiol 2002; 90:18-21.
7. Raggi P, Bellasi A, Ratti C. Diabetes Care 2005; 28: 2787-2794.
8. Türk toraks derneği 6. kış okulu kitabı sayfa:77; 2007.
9. 73-Gavin C. Donaldson, Terence A. R. Seemungal, Irem S. Airway and Systemic Inflammation and Decline in Lung Function in Patients with COPD.
10. Wedzicha JA, Seemungal TA, MacCallum PK, et al. Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinojen and serum IL-6 levels. Thromb Haemost 2000;84:210-15.
11. Folsom AR. Epidemiology of fibrinogen. Eur Heart J1995;16(suppl A):21-24.
12. De Maat MP, Pietersma A, Kofflard M, et al. Association of plasma fibrinogen levels with coronary artery disease, smoking and inflammatory markers. Atherosclerosis 1996;121:185-191.
13. American Journal of Respiratory and Critical Care Medicine Vol 172. pp. 625-630, 2005. Kenji Minoguchi, Takuya Yokoe, Toshiyuki Tazaki. Increased Carotid Intima-Media Thickness and Serum İnflammatory Markers in Obstructive Sleep Apnea.
14. Am J Cardiol . 2007 Jun 1 ; 99 (11) : 1598-602.Epub 2007m Apr 18.
15. Hiroyasu I, Shimamoto T, Sato S. Passive Smoking and Plasma Fibrinojen Concentrations. Am J Epidemiol 1996;144:1151-4.
16. Ridker PM, Rifai N, Rose LL, Buring JE, Cook NR. Comparison of C reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002;347:1557 1565.
17. Gan Wq, Man SFP, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic rewiew and meta-analysis. Thorax 2004; 59:574-580.
18. Mannino DM, Ford ES, Redd SC. Obstructive and restrictive lung disease and markers of inflammation:data from the third National Health and Nutrition Examination. Am J Med 2003;114:758-762.
19. Nascetti S, Elosua R, Pena A, et al. Variables associated with fibrinojen in a population-based study: Interaction between smoking and age on fibrinojen concentration. European Journal of Epidemiology 2001;17:953-58.
20. Scarabin PY, Bara L, Ricard S, et al. Genetic variation at the b-fibrinogen locus in relation to plasma concentrations and risk of myocardial infarction. Atherosclerosis Thromb 1993;13:886-91.
21. Taylor HD, Jacobs DR, Schhucker b, et al. A questionnaire for the assassment of leisure time physical activities. J Chronic Disease 1978;31:741-55.
22. Cooper J, Douglas AS. Fibrinogen level as a predictor of mortality infarction. Fibrinolysis 1991;5:105-8.
23. Cook NS, Ubben D. Fibrinogen as a major risk factor in cardiovascular disease. Trends Pharmacol Sci. 1990;11:444-51.
24. Sin Don D, Man SF. Why Are Patients With Chronic Obstructive Pulmonary Disease at Increased Risk of Cardiovascular Diseases? Circulation 2000;107:1514.
25. Cytokine. 2007 Jan;37(1): 44-50. Epub 2007 Mar 26.
26. Trends in Pharmacological sciences volume 28, ıssue 10, october 2007, pages 544-550.
27. Suzuki T, Nakano H, Maekawa J, Okomato Y, Ohnishi Y, Yamauchi M, Kimura H. Obstructive sleep apnea and carotid-artery intima- media thicness. Sleep .2004 Feb 1;27(1):129-33.
28. Baguet JP, Hammer L, Levy P, Pierre H, Launois S, Mallion JM, Pepin JL. The severity of oxygen desaturation is predictive of carotid wall thickening and plaque occurrence. Chest . 2005 Nov;128(5):3407-12.
29. Diez-Roux AV, Nieto FJ, Comstock GW, Howard G, Szklo m. The relationship of active and passive smoking to carotid atherosclerosis 12-14 years later. Prev Med. 1995 Jan ; 24 (1):48-55.
30. Howard G, Burke GL, Szklo M, Tell GS, Eckfeldt J, Evans G, Heiss. Active and passive smoking are associated with increased carotid wall thickness. The atherosclerosis Risk in Communities Study. Arch İntern Med. 1994Jun13;154(11):1277-82.
31. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ.Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987; 316:1371-1375.
32. O’Leary DH et al. Carotid artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. New Engl J Med 1999;340:14-22.
33. Gostomzyk JG, Heller WD, Gerhardt et al. B-scan ultrasound examination of the carotid arteries within a representative population (MONICA Project Augsburg). Klin Wochenschr. 1988;66(suppl 11):58-65.
34. Geroulakos G, O’Gorman D, Nicolaides A, et al. Carotid intima-media thickness: correlation with the British regional heart study risk score. J Intern Med. 1994;235:431-433.
35. Grobbee DE, Bots ML. Carotid artery intima-media thickness as an indicator of generalized atherosclerosis. J Intern Med. 1994;236:567–573.

Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Bölüm	Research Article
Yazarlar	Engin Aynacı Birsen Pınar Yıldız Aysun Aynacı Gönenç Ortaköylü Fırat Çetinkaya Emel Çağlar
Yayımlanma Tarihi	1 Eylül 2011
Yayımlandığı Sayı	Yıl 2011Sayı: 3

Kaynak Göster

EndNote	Aynacı E, Yıldız BP, Aynacı A, Ortaköylü G, Çetinkaya F, Çağlar E (01 Eylül 2011) Stabil Kronik Obstrüktif Akciğer Hastalığında İnflamatuar Belirteçler ve Hastalık Ağırlığı ile Karotis Arter İntima-Media Kalınlığının İlişkisi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 3 146–151.

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