Öz
Hepatoid adenocarcinoma is a rare extrahepatic tumor, resembling hepatocellular carcinoma. It resembles hepatocytes both morphologically and functionally. Serum level of AFP is high in most cases. They reveal positive immunostaining with AFP, CEA, CK-8 and CK-18. To make the diagnosis of Hepatoid adenocarcinoma, hepatocellular carcinoma should be ruled out. Although it has an aggressive natural history, some cases like ours may show slower course, and recur in distant sites. In this article, we present a case of ovarian Hepatoid adenocarcinoma who presented with tumor in gallbladder having similar histopathology after 3 years of initial diagnosis
Anahtar Kelimeler
Kaynakça
- Ishikura H, Fukasawa Y, Ogasawara K, Natori T, Tsukada Y, Aizawa M: An AFP- producing gastric carcinoma with features of hepatic differentiation. A case report. Cancer 1985; 56:840-8.
- Higuchi Y, Kouno T, Teshima H, Akizuki S, Kikuta M, Ohyumi M, et al. Serous papillary cyst adenocarcinoma associated with alfa- fetoprotein production. Arch Pathol Lab Med 1984;108:710–2.
- Watanabe M, Hori Y, Nojima T, Kato H, Taketa K, Isogawa S, et al Alpha-fetoprotein producing carcinoma of the gallbladder. Dig Dis Sci 1993;38:561–4.
- Bakir T, Aliyazicioglu Y, Bektas A, Siviloglu C, Ozgur O. Hepatoid adenocarcinoma of the stomach: report of five cases and review of the literature. Acta Gastroenterol Belg. 2006;69(3):330-7.
- Watanabe Y, Umemoto M, Ueda H, Nakai H, Hoshiai H, Noda K. Cytopathologic and clinicopathologic features of ovarian hepatoid carcinoma. A case report. Acta Cytol 2003; 47:78-82.
- Augustin G, Jelincic Z, Tentor D, Majerovic M, Matosevic P. Hepatoid adenocarcinoma of the stomach: case report and short notes on immunohistochemical markers. Acta Gastroenterol Belg 2009;72:253-6.
- Metzgeroth G, Ströbel P, Baumbusch T, Reiter A, Hastka J. Hepatoid adenocarcinoma- Review of the literature illustrated by a rare case originating in the peritoneal cavity. Onkologie 2010; 33:263-9
- Pandey M, Trica C. Hepatoid carcinoma of the ovary. JCO 2011; 29:446-448.
Öz
Hepatoid adenokarsinom, hepatoselüler karsinoma benzeyen ve nadir görülen ekstrahepatik bir tümördür. Tümör hücreleri hem fonksiyonel hemde morfololojik olarak hepatositlere benzer. Çoğu olguda AFP serum düzeyi yüksektir. Tümör hücreleri AFP, CEA, CK-8 ve CK-18 ile positif immünboyanma gösterirler. Hepatoid adenokarsinom tanısı için hepatoselüler karsinom ekarte edilmelidir. Agresif bir doğal seyri olmasına rağmen bazen yavaş seyirli olabilir ve uzak yerlere metastazla hastalık tekrarlayabilir. Bu yazımızda over Hepatoid adenokarsinomu nedeni ile opere edilen ve 3 yıl sonra safra kesesinde Hepatoid adenokarsinom nüksü olan olguyu sunuyoruz
Anahtar Kelimeler
Kaynakça
- Ishikura H, Fukasawa Y, Ogasawara K, Natori T, Tsukada Y, Aizawa M: An AFP- producing gastric carcinoma with features of hepatic differentiation. A case report. Cancer 1985; 56:840-8.
- Higuchi Y, Kouno T, Teshima H, Akizuki S, Kikuta M, Ohyumi M, et al. Serous papillary cyst adenocarcinoma associated with alfa- fetoprotein production. Arch Pathol Lab Med 1984;108:710–2.
- Watanabe M, Hori Y, Nojima T, Kato H, Taketa K, Isogawa S, et al Alpha-fetoprotein producing carcinoma of the gallbladder. Dig Dis Sci 1993;38:561–4.
- Bakir T, Aliyazicioglu Y, Bektas A, Siviloglu C, Ozgur O. Hepatoid adenocarcinoma of the stomach: report of five cases and review of the literature. Acta Gastroenterol Belg. 2006;69(3):330-7.
- Watanabe Y, Umemoto M, Ueda H, Nakai H, Hoshiai H, Noda K. Cytopathologic and clinicopathologic features of ovarian hepatoid carcinoma. A case report. Acta Cytol 2003; 47:78-82.
- Augustin G, Jelincic Z, Tentor D, Majerovic M, Matosevic P. Hepatoid adenocarcinoma of the stomach: case report and short notes on immunohistochemical markers. Acta Gastroenterol Belg 2009;72:253-6.
- Metzgeroth G, Ströbel P, Baumbusch T, Reiter A, Hastka J. Hepatoid adenocarcinoma- Review of the literature illustrated by a rare case originating in the peritoneal cavity. Onkologie 2010; 33:263-9
- Pandey M, Trica C. Hepatoid carcinoma of the ovary. JCO 2011; 29:446-448.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Case Report |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Aralık 2013 |
| Yayımlandığı Sayı | Yıl 2013Sayı: 4 |