Abstract
Aim: Lichen planus is a lymphocytic inflammatory disorder of unknown origin mediated by cellular immunity. The reports documenting contact hypersensitivity to certain antigens are increasing in number mainly in oral but also in cutaneous lichen planus as well. However, there are only a few studies questioning whether there is any alteration in contact hypersensitivity response in this patient group due to T-cell mediated changes. Methods: The purpose of this study is to find out the prevalence of contact hypersensitivity to standard contact allergens in cutaneous lichen planus patients. In the present study 43 cutaneous lichen planus patients and 33 controls were patch tested by T.R.U.E test methodology. Resulst: A positive patch test reaction was found in 11.6% of the lichen planus patients while the control group showed a percentage of 30.3%. Statistically, the difference between the two groups was not significant Fischer test p=0.07 . Conclusions: This is the first study examining into the standard patch test positivity in cutaneous lichen planus patients the results showed no difference from the control
References
- Shiohara T, Kono Y. Lichen planus and lichenoid dermatoses, in Dermatology. Bolognia JL, Jorizzo JL, Schaffer JV Eds. China, Elsevier Inc. 2013, p. 183-196.
- Kawamura T, Fukuda S, Ohtake N, Furue M, Tamaki K. Lichen planus-like dermatitis due to methacrylic acid esters. Br J Dermatol 1996;134:358-360.
- Liden C. Lichen planus in relation to occupational and non- occupational exposure to chemicals. Br J Dermatol 1986;115:23-31.
- Sasaki G, Yokozeki H, Katayama I, Nishioka K. Three cases of linear lichen planus caused by dental metal compounds. J Dermatol 1996;23:890-892.
- Scalf L A, Fowler J F, Morgan KW, Looney SW. Dental metal allergy in patients with oral, cutaneous, and genital lichenoid reactions. Am J Contact Dermatitis 2001;12:146-150.
- Yiannias JA, el-Azhary RA, Hand JH Pakzad SY, Rogers RS. Relevant contact sensitivities in patients with the diagnosis oral lichen planus. J Am Acad Dermatol 2000;42:177-182.
- Rietschel RL, Fowler JF. Fisher’s Contact Dermatitis. Philadelphia: Lippincott Williams & Wilkins, 2001: pp.76-77.
- Schäfer T, Böhler E, Ruhdorfer S, Weigl L, Wessner D, Filipiak B et al. Epidemiology of contact allergy in adults. Allergy 2001;56:1192-1196.
- Dunsche A, Kastel I, Terheyden H, Springer IN, Christophers I, Brasch J. Oral lichenoid reactions associated with amalgam. Improvement after amalgam removal. Br J Dermatol 2003;148:70-7.
- Rees JL, Matthews JNS, Friedman PS. Delayed type hypersensitivity is abnormal in patients with lichen planus. Arch Dermatol Res 1992;284:132-134.
- Ertam I, Türkmen M, Alper S. Patch-test results of an academic department in Izmir, Turkey. Dermatitis. 2008;19:213-5.
- Onder M, Adisen E. Patch test results in a Turkish paediatric population. Contact Dermatitis. 2008;58:63-5.
- Greig JE, Carson CF, Stuckey MS, Riley TV. Prevalence of delayed hypersensitivity to the European standard series in a self-selected population. Australas J Dermatol 2000;41:86-89.
- Mangelsdorf HC, Fleischer AB, Sherertz EF. Patch testing in an aged population without dermatitis: high prevalence of patch test positivity. Am J Contact Dermat 1996;7:155-157.
- Ingber A, Trattner A, Cohen I R, Mekori YA. Low doses of low molecular weight heparin in vivo inhibit the elicitation of contact hypersensitivity. Acta Derm Venereol (Stockh) 1994;74:454-456.
- Norlind K. Modulating effects of heparin preparations on the DNA synthesis response of human peripheral blood T lymphocytes activated by mercuric chloride and nichel sulfate. Int Arch Allergy Appl Immunol 1987;84:156-158.
- Rockwell S, Irvin CG, Neaderland MH. Inhibition of delayed hypersensitivity by metronidazole and misonidazole. Int J Radiat Oncol Biol Phys 1983;9:701-706.
- Fischer MD, Maibach HI. Easier patch testing with T.R.U.E.Test. J Am Acad Dermatol 1989;20:447-453.
Abstract
Amaç: Liken planus, lenfositik enflamasyonla karakterize hücresel immün sistemin rol oynadığı nedeni bilinmeyen bir hastalıktır. Belirli antijenlere karşı kontakt aşırı duyarlılığın başta oral liken planus olmak üzere kütanöz liken planusta da bulunduğunu gösteren çalışmalar giderek artmaktadır. Buna karşın T hücre aracılı bu hastalıkta kontakt aşırı duyarlılık cevabında herhangi bir değişiklik olup olmadığını sorgulayan az sayıda çalışma mevcuttur. Hastalar ve Yöntem: Bu çalışmanın amacı kütanöz liken planuslu hastalarda standart kontakt allerjenlere karşı oluşan aşırı duyarlılık reaksiyonlarının prevalansını saptamaktır. Bu çalışmada kütanöz liken planus tanısı konulan 43 kişilik hasta grubuna ve 33 kişilik kontrol grubuna T.R.U.E test metolojisi ile yama testi uygulanmıştır. Bulgular: Hasta grubunda yama testi pozitifliği %11.6, kontrol grubunda %30.3 olarak bulunmuştur. İki grup arasındaki fark istatistiki olarak anlamlı değildir. Fischer testi p=0.07 . Sonuç: Bu çalışma kütanöz liken planusta yama testi pozitifliğini araştıran ilk çalışmadır ve hasta grubunun kontrol grubundan farklı olmadığı sonucuna varılmıştır
References
- Shiohara T, Kono Y. Lichen planus and lichenoid dermatoses, in Dermatology. Bolognia JL, Jorizzo JL, Schaffer JV Eds. China, Elsevier Inc. 2013, p. 183-196.
- Kawamura T, Fukuda S, Ohtake N, Furue M, Tamaki K. Lichen planus-like dermatitis due to methacrylic acid esters. Br J Dermatol 1996;134:358-360.
- Liden C. Lichen planus in relation to occupational and non- occupational exposure to chemicals. Br J Dermatol 1986;115:23-31.
- Sasaki G, Yokozeki H, Katayama I, Nishioka K. Three cases of linear lichen planus caused by dental metal compounds. J Dermatol 1996;23:890-892.
- Scalf L A, Fowler J F, Morgan KW, Looney SW. Dental metal allergy in patients with oral, cutaneous, and genital lichenoid reactions. Am J Contact Dermatitis 2001;12:146-150.
- Yiannias JA, el-Azhary RA, Hand JH Pakzad SY, Rogers RS. Relevant contact sensitivities in patients with the diagnosis oral lichen planus. J Am Acad Dermatol 2000;42:177-182.
- Rietschel RL, Fowler JF. Fisher’s Contact Dermatitis. Philadelphia: Lippincott Williams & Wilkins, 2001: pp.76-77.
- Schäfer T, Böhler E, Ruhdorfer S, Weigl L, Wessner D, Filipiak B et al. Epidemiology of contact allergy in adults. Allergy 2001;56:1192-1196.
- Dunsche A, Kastel I, Terheyden H, Springer IN, Christophers I, Brasch J. Oral lichenoid reactions associated with amalgam. Improvement after amalgam removal. Br J Dermatol 2003;148:70-7.
- Rees JL, Matthews JNS, Friedman PS. Delayed type hypersensitivity is abnormal in patients with lichen planus. Arch Dermatol Res 1992;284:132-134.
- Ertam I, Türkmen M, Alper S. Patch-test results of an academic department in Izmir, Turkey. Dermatitis. 2008;19:213-5.
- Onder M, Adisen E. Patch test results in a Turkish paediatric population. Contact Dermatitis. 2008;58:63-5.
- Greig JE, Carson CF, Stuckey MS, Riley TV. Prevalence of delayed hypersensitivity to the European standard series in a self-selected population. Australas J Dermatol 2000;41:86-89.
- Mangelsdorf HC, Fleischer AB, Sherertz EF. Patch testing in an aged population without dermatitis: high prevalence of patch test positivity. Am J Contact Dermat 1996;7:155-157.
- Ingber A, Trattner A, Cohen I R, Mekori YA. Low doses of low molecular weight heparin in vivo inhibit the elicitation of contact hypersensitivity. Acta Derm Venereol (Stockh) 1994;74:454-456.
- Norlind K. Modulating effects of heparin preparations on the DNA synthesis response of human peripheral blood T lymphocytes activated by mercuric chloride and nichel sulfate. Int Arch Allergy Appl Immunol 1987;84:156-158.
- Rockwell S, Irvin CG, Neaderland MH. Inhibition of delayed hypersensitivity by metronidazole and misonidazole. Int J Radiat Oncol Biol Phys 1983;9:701-706.
- Fischer MD, Maibach HI. Easier patch testing with T.R.U.E.Test. J Am Acad Dermatol 1989;20:447-453.
Details
| Primary Language | English |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | March 1, 2014 |
| Published in Issue | Year 2014Issue: 1 |