Derleme
Yıl 2020,
Cilt: 17 Sayı: 3, 478 - 482, 30.09.2020
Öz
Mikrobiyotanın kadın ve erkek fertilitesi üzerinde önemli etkilere sahip olduğu düşünülmektedir. Bu derlemenin amacı mikrobiyota ile infertilite arasındaki ilişkiyi inceleyen çalışmaları incelemek ve bu konuda sağlık bakım profesyonellerinin farkındalığını arttırmaktır. Yapılan çalışmalar kadın ve erkek genital organlarında birçok patojen ve nonpatojen etkenin yer aldığını ve baskın florayı oluşturan Lactobacillus’un fertilitenin korunmasında önemli etkileri olduğunu kanıtlamaktadır. Ayrıca ovarian follikül sıvındaki mikrobiyal etkenlerin gebelik sonuçlarıyla ilişkili olduğu gösterilmiştir. Bunun yanı sıra oral sağlığın da üreme sağlığı, gebeliğin oluşması ve fetal gelişim üzerine etkileri olduğu ortaya çıkartılmıştır. Erkek genitoüriner sistemine ait mikrobiyotanın üreme sistemi sağlığı ve fertilite üzerine etkileri olduğu çalışmalarda görülmüştür. Ancak seminal mayide yer alan patojenlerin kökeni net bir şekilde açıklanamamıştır. Üreme sağlığı açısından probiyotiklerin kullanımının fayda sağlayabileceği çalışmalarla desteklenmektedir. Mikrobiyotanın fertilite üzerine etkileri konusunda sağlık profesyonellerinin farkındalığının artması ve toplumun eğitilmesi gerekmektedir.
Anahtar Kelimeler
Kaynakça
- 1. Consortium HMP. A framework for human microbiome research. Nature. 2012;486(7402):215-21. 2. Stumpf RM, Wilson BA, Rivera A, Yildirim S, Yeoman CJ, Polk JD, et al. The primate vaginal microbiome: comparative context and implications for human health and disease. American journal of physical anthropology. 2013;152 Suppl 57:119-34. 3. Weng SL, Chiu CM, Lin FM, Huang WC, Liang C, Yang T, et al. Bacterial communities in semen from men of infertile couples: metagenomic sequencing reveals relationships of seminal microbiota to semen quality. PloS one. 2014;9(10):e110152. 4. Bilgiç D, Yüksel P, Gülhan H, Şirin F, Uygun H. Üniversitede Yurtta Kalan Kız Öğrencilerin Genital Hijyen Davranışları ve Sağlık Sonuçları. ACU Sağlık Bil Derg. 2018. 5. Topuz Ş, Büyükkayacı-Duman N, Güneş A. Sağlık Bilimleri Fakültesi Birinci Sınıftaki Kız Öğrencilerin Genital Hijyen Uygulamaları. Turkish Journal of Clinics and Laboratory. 2015;6(3):85-90. 6. Aslan E, Bektaş H, Başgöl Ş, Demir S, Vural PI. Üniversite Öğrencilerinin Cinsel Sağlık Konusundaki Bilgi Düzeyleri ve Davranışları. STED. 2014;23(5):174-82. 7. Yurttaş A, Gültekin Ü, Ejder-Apay S. İdrar Yolu Enfeksiyonu Geçiren 15-49 Yaş Arası Kadınların Perine Bakımı Uygulamalarının İncelenmesi. ACU Sağlık Bil Derg. 2018;9(3):297-301. 8. Taş BG, Öztürk GZ, Maç ÇE, Egici MT, Toprak D. Sağlık Çalışanları İle Mikrobiyota ve Probiyotik Üzerine Kesitsel Çalışma. JAREN. 2018:1-7. 9. Kroon SJ, Ravel J, Huston WM. Cervicovaginal microbiota, women's health, and reproductive outcomes. Fertility and sterility. 2018;110(3):327-36. 10. Ravel J, Gajer P, Abdo Z, Schneider GM, Koenig SS, McCulle SL, et al. Vaginal microbiome of reproductive-age women. Proceedings of the National Academy of Sciences of the United States of America. 2011;108 Suppl 1:4680-7. 11. Reid G, Younes JA, Van der Mei HC, Gloor GB, Knight R, Busscher HJ. Microbiota restoration: natural and supplemented recovery of human microbial communities. Nature reviews Microbiology. 2011;9(1):27-38. 12. O'Hanlon DE, Moench TR, Cone RA. Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota. PloS one. 2013;8(11):e80074. 13. Smith SB, Ravel J. The vaginal microbiota, host defence and reproductive physiology. The Journal of physiology. 2017;595(2):451-63. 14. Sirota I, Zarek SM, Segars JH. Potential influence of the microbiome on infertility and assisted reproductive technology. Seminars in reproductive medicine. 2014;32(1):35-42. 15. Wee BA, Thomas M, Sweeney EL, Frentiu FD, Samios M, Ravel J, et al. A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women. The Australian & New Zealand journal of obstetrics & gynaecology. 2018;58(3):341-8. 16. Haahr T, Jensen JS, Thomsen L, Duus L, Rygaard K, Humaidan P. Abnormal vaginal microbiota may be associated with poor reproductive outcomes: a prospective study in IVF patients. Human reproduction (Oxford, England). 2016;31(4):795-803. 17. Tamarelle J, Thiebaut ACM, de Barbeyrac B, Bebear C, Ravel J, Delarocque-Astagneau E. The vaginal microbiota and its association with human papillomavirus, Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections: a systematic review and meta-analysis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2018. 18. Pelzer ES, Allan JA, Waterhouse MA, Ross T, Beagley KW, Knox CL. Microorganisms within human follicular fluid: effects on IVF. PloS one. 2013;8(3):e59062. 19. Moreno I, Codoner FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazan J, et al. Evidence that the endometrial microbiota has an effect on implantation success or failure. American journal of obstetrics and gynecology. 2016;215(6):684-703. 20. Tsypurdeeva ND, Shipitsyna EV, Savicheva AM, Gzgzyan AM, Kogan IY. Composition of endometrial microbiota and chronic endometritis severity in patients with in vitro fertilization failures. Is there any connection? Journal Of Obstetrics and Women's Diseases. 2018;67(2):5-15. 21. Kyono K, Hashimoto T, Nagai Y, Sakuraba Y. Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single‐center pilot study. Reproductive Medicine and Biology. 2018;17(3):297-306. 22. Graspeuntner S, Bohlmann MK, Gillmann K, Speer R, Kuenzel S, Mark H, et al. Microbiota-based analysis reveals specific bacterial traits and a novel strategy for the diagnosis of infectious infertility. PloS one. 2018;13(1):e0191047. 23. Mukherjee S, Maitra A. Molecular & genetic factors contributing to insulin resistance in polycystic ovary syndrome. Indian J Med Res. 2010;131:743-60. 24. Akcali A, Bostanci N, Ozcaka O, Ozturk-Ceyhan B, Gumus P, Buduneli N, et al. Association between polycystic ovary syndrome, oral microbiota and systemic antibody responses. PloS one. 2014;9(9):e108074. 25. Nwhator SO, Opeodu OI, Ayanbadejo PO, Umeizudike KA, Olamijulo JA, Alade GO, et al. Could Periodontitis Affect Time to Conception? Ann Med Health Sci Res. 2014;4(5):817-22. 26. Shanthi V, Vanka A, Bhambal A, Saxena V, Saxena S, Kumar SS. Association of pregnant women periodontal status to preterm and low-birth weight babies: A systematic and evidence-based review. Dent Res J (Isfahan). 2012;9(4):368-80. 27. Hart R, Doherty DA, Pennell CE, Newnham IA, Newnham JP. Periodontal disease: a potential modifiable risk factor limiting conception. Human reproduction (Oxford, England). 2012;27(5):1332-42. 28. Santos CM, Pires MC, Leao TL, Hernandez ZP, Rodriguez ML, Martins AK, et al. Selection of Lactobacillus strains as potential probiotics for vaginitis treatment. Microbiology (Reading, England). 2016;162(7):1195-207. 29. Mandar R, Turk S, Korrovits P, Ausmees K, Punab M. Impact of sexual debut on culturable human seminal microbiota. Andrology. 2018;6(3):510-2. 30. Hou D, Zhou X, Zhong X, Settles ML, Herring J, Wang L, et al. Microbiota of the seminal fluid from healthy and infertile men. Fertility and sterility. 2013;100(5):1261-9. 31. Zozaya M, Ferris MJ, Siren JD, Lillis R, Myers L, Nsuami MJ, et al. Bacterial communities in penile skin, male urethra, and vaginas of heterosexual couples with and without bacterial vaginosis. Microbiome. 2016;4:16. 32. Liu CM, Hungate BA, Tobian AA, Ravel J, Prodger JL, Serwadda D, et al. Penile Microbiota and Female Partner Bacterial Vaginosis in Rakai, Uganda. mBio. 2015;6(3):e00589.
Yıl 2020,
Cilt: 17 Sayı: 3, 478 - 482, 30.09.2020
Öz
Kaynakça
- 1. Consortium HMP. A framework for human microbiome research. Nature. 2012;486(7402):215-21. 2. Stumpf RM, Wilson BA, Rivera A, Yildirim S, Yeoman CJ, Polk JD, et al. The primate vaginal microbiome: comparative context and implications for human health and disease. American journal of physical anthropology. 2013;152 Suppl 57:119-34. 3. Weng SL, Chiu CM, Lin FM, Huang WC, Liang C, Yang T, et al. Bacterial communities in semen from men of infertile couples: metagenomic sequencing reveals relationships of seminal microbiota to semen quality. PloS one. 2014;9(10):e110152. 4. Bilgiç D, Yüksel P, Gülhan H, Şirin F, Uygun H. Üniversitede Yurtta Kalan Kız Öğrencilerin Genital Hijyen Davranışları ve Sağlık Sonuçları. ACU Sağlık Bil Derg. 2018. 5. Topuz Ş, Büyükkayacı-Duman N, Güneş A. Sağlık Bilimleri Fakültesi Birinci Sınıftaki Kız Öğrencilerin Genital Hijyen Uygulamaları. Turkish Journal of Clinics and Laboratory. 2015;6(3):85-90. 6. Aslan E, Bektaş H, Başgöl Ş, Demir S, Vural PI. Üniversite Öğrencilerinin Cinsel Sağlık Konusundaki Bilgi Düzeyleri ve Davranışları. STED. 2014;23(5):174-82. 7. Yurttaş A, Gültekin Ü, Ejder-Apay S. İdrar Yolu Enfeksiyonu Geçiren 15-49 Yaş Arası Kadınların Perine Bakımı Uygulamalarının İncelenmesi. ACU Sağlık Bil Derg. 2018;9(3):297-301. 8. Taş BG, Öztürk GZ, Maç ÇE, Egici MT, Toprak D. Sağlık Çalışanları İle Mikrobiyota ve Probiyotik Üzerine Kesitsel Çalışma. JAREN. 2018:1-7. 9. Kroon SJ, Ravel J, Huston WM. Cervicovaginal microbiota, women's health, and reproductive outcomes. Fertility and sterility. 2018;110(3):327-36. 10. Ravel J, Gajer P, Abdo Z, Schneider GM, Koenig SS, McCulle SL, et al. Vaginal microbiome of reproductive-age women. Proceedings of the National Academy of Sciences of the United States of America. 2011;108 Suppl 1:4680-7. 11. Reid G, Younes JA, Van der Mei HC, Gloor GB, Knight R, Busscher HJ. Microbiota restoration: natural and supplemented recovery of human microbial communities. Nature reviews Microbiology. 2011;9(1):27-38. 12. O'Hanlon DE, Moench TR, Cone RA. Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota. PloS one. 2013;8(11):e80074. 13. Smith SB, Ravel J. The vaginal microbiota, host defence and reproductive physiology. The Journal of physiology. 2017;595(2):451-63. 14. Sirota I, Zarek SM, Segars JH. Potential influence of the microbiome on infertility and assisted reproductive technology. Seminars in reproductive medicine. 2014;32(1):35-42. 15. Wee BA, Thomas M, Sweeney EL, Frentiu FD, Samios M, Ravel J, et al. A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women. The Australian & New Zealand journal of obstetrics & gynaecology. 2018;58(3):341-8. 16. Haahr T, Jensen JS, Thomsen L, Duus L, Rygaard K, Humaidan P. Abnormal vaginal microbiota may be associated with poor reproductive outcomes: a prospective study in IVF patients. Human reproduction (Oxford, England). 2016;31(4):795-803. 17. Tamarelle J, Thiebaut ACM, de Barbeyrac B, Bebear C, Ravel J, Delarocque-Astagneau E. The vaginal microbiota and its association with human papillomavirus, Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections: a systematic review and meta-analysis. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2018. 18. Pelzer ES, Allan JA, Waterhouse MA, Ross T, Beagley KW, Knox CL. Microorganisms within human follicular fluid: effects on IVF. PloS one. 2013;8(3):e59062. 19. Moreno I, Codoner FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazan J, et al. Evidence that the endometrial microbiota has an effect on implantation success or failure. American journal of obstetrics and gynecology. 2016;215(6):684-703. 20. Tsypurdeeva ND, Shipitsyna EV, Savicheva AM, Gzgzyan AM, Kogan IY. Composition of endometrial microbiota and chronic endometritis severity in patients with in vitro fertilization failures. Is there any connection? Journal Of Obstetrics and Women's Diseases. 2018;67(2):5-15. 21. Kyono K, Hashimoto T, Nagai Y, Sakuraba Y. Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single‐center pilot study. Reproductive Medicine and Biology. 2018;17(3):297-306. 22. Graspeuntner S, Bohlmann MK, Gillmann K, Speer R, Kuenzel S, Mark H, et al. Microbiota-based analysis reveals specific bacterial traits and a novel strategy for the diagnosis of infectious infertility. PloS one. 2018;13(1):e0191047. 23. Mukherjee S, Maitra A. Molecular & genetic factors contributing to insulin resistance in polycystic ovary syndrome. Indian J Med Res. 2010;131:743-60. 24. Akcali A, Bostanci N, Ozcaka O, Ozturk-Ceyhan B, Gumus P, Buduneli N, et al. Association between polycystic ovary syndrome, oral microbiota and systemic antibody responses. PloS one. 2014;9(9):e108074. 25. Nwhator SO, Opeodu OI, Ayanbadejo PO, Umeizudike KA, Olamijulo JA, Alade GO, et al. Could Periodontitis Affect Time to Conception? Ann Med Health Sci Res. 2014;4(5):817-22. 26. Shanthi V, Vanka A, Bhambal A, Saxena V, Saxena S, Kumar SS. Association of pregnant women periodontal status to preterm and low-birth weight babies: A systematic and evidence-based review. Dent Res J (Isfahan). 2012;9(4):368-80. 27. Hart R, Doherty DA, Pennell CE, Newnham IA, Newnham JP. Periodontal disease: a potential modifiable risk factor limiting conception. Human reproduction (Oxford, England). 2012;27(5):1332-42. 28. Santos CM, Pires MC, Leao TL, Hernandez ZP, Rodriguez ML, Martins AK, et al. Selection of Lactobacillus strains as potential probiotics for vaginitis treatment. Microbiology (Reading, England). 2016;162(7):1195-207. 29. Mandar R, Turk S, Korrovits P, Ausmees K, Punab M. Impact of sexual debut on culturable human seminal microbiota. Andrology. 2018;6(3):510-2. 30. Hou D, Zhou X, Zhong X, Settles ML, Herring J, Wang L, et al. Microbiota of the seminal fluid from healthy and infertile men. Fertility and sterility. 2013;100(5):1261-9. 31. Zozaya M, Ferris MJ, Siren JD, Lillis R, Myers L, Nsuami MJ, et al. Bacterial communities in penile skin, male urethra, and vaginas of heterosexual couples with and without bacterial vaginosis. Microbiome. 2016;4:16. 32. Liu CM, Hungate BA, Tobian AA, Ravel J, Prodger JL, Serwadda D, et al. Penile Microbiota and Female Partner Bacterial Vaginosis in Rakai, Uganda. mBio. 2015;6(3):e00589.
Toplam 1 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Kadın Hastalıkları ve Doğum |
| Bölüm | Derleme |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Eylül 2020 |
| Gönderilme Tarihi | 20 Ocak 2020 |
| Kabul Tarihi | 24 Şubat 2020 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 17 Sayı: 3 |
