Öz
Amaç: Obezite; insülin direnci, tip 2 diyabet ve pek çok metabolik sendromun altında yatan baskın risk faktörlerinden biridir. Bu çalışmada obez hastalarda
inflamasyon parametrelerini, bu parametrelerin insülin direnci (İD) ve kan grupları ile ilişkisi araştırmayı amaçladık.
Gereç ve Yöntemler: Hasta ve kontrol grubunun demografik özellikleri, vücut kitle indeksleri (VKİ), biyokimya, hemogram, C-reaktif proteinin (CRP) ve
kan grupları kayıt edilerek gruplar arasında karşılaştırıldı.
Bulgular: Obez hastaların yaş ortalaması 37.37±11.43 yıldı ve %41.8’inde (n=77) insülin direnci vardı. Obez ve İD olan grubun nötrofil ve monosit düzeyleri
İD olmayan kontrol ve obez gruplardan anlamlı derecede yüksekti (p<0.001). İD olan obezlerde nötrofil/lenfosit oranı (NLO), monosit/HDL oranı
(MHO) ve sistemik immün-inflamatuar indeks (Sİİ) düzeyleri İD olamayan obezlerden anlamlı derecede yüksekti. B kan grubunda olan obezlerde İD ve
nötrofil oranları O kan grubundakilere göre anlamlı derecede yüksek bulundu (p=0.023).
Sonuç: Obez ve İD olan grupta hematolojik inflamatuar parametreleri ve NLO, MHO ve Sİİ gibi sistemik kronik inflamasyonu gösteren oranları yüksek
bulduk. Çalışmamızın artmış yağ dokusunun neden olduğu inflamasyon ve obezlerde İD gelişimi arasındaki ilişkiyi gösterdiğini, gelecekte bu konuda yapılacak
çalışmaların erken teşhis ve tedavilerin tasarlanmasında yardımcı olacağını düşünüyoruz
Anahtar Kelimeler
Destekleyen Kurum
yok
Kaynakça
- World Health Organization. Obesity and overweight. [(accessed May 5, 2013)]. Available online: http://www.who.int/mediacentre/factsheets/fs311/en/
- Carr DB, Utzschneider KM, Hull RL, Kodama K, Retzlaff BM, Brunzell JD et al. Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes. 2004;53(8):2087-2094.
- Sok Lee Y, Olefsky J. Chronic tissue inflammation and metabolic disease. 2021;35(5-6):307–328.
- Qatanani M, Lazar MA. Mechanisms of obesity-associated insulin resistance: Many choices on the menu. Genes and Development. 2007;21(12):1443–1455.
- Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415–445.
- Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell. 2014;156:20–44.
- Kojta I, Chacińska M, Błachnio-Zabielska A. Obesity, bioactive lipids, and adipose tissue ınflammation in ınsulin resistance. Nutrients. 2020;12(5):1305.
- Ewald DR, Sumner SC. Blood type biochemistry and human disease. Wiley Interdiscip Rev Syst Biol Med. 2016;8:517–535.
- Liumbruno GM, Franchini M. Beyond immunohaematology: The role of the ABO blood group in human diseases. Blood Transfus.2013;11:491–499.
- Feng JF, Chen S, Yang X. Systemic immuneinflammation index (SII) is a useful prognostic indicator for patients with squamous cell carcinoma of the esophagus. Medicine (Baltimore).2017;96(4):e5886.
- Topsakal S, Yerlikaya E, Akin F, Kaptanoglu B, Erürker T. Relation with HOMA-IR and thyroid hormones in obese Turkish women with metabolic syndrome. Eat Weight Disord 2012;17(1):e57-61.
- Goran MI, Lane C, Toledo-Corral C, Weigensberg MJ. Persistence of pre-diabetes in overweight and obese hispanic children; Association with progressive insulin resistance, Poor β-cell function, and increasing visceral fat. Diabetes.2008;57(11):3007–3012.
- Petersen MC, Shulman GI. Mechanisms of insulin action and ınsulin resistance. Physiol Rev.2018;98(4):2133–2223.
- Andersen CJ, Murphy KE, Fernandez ML. Impact of obesity and metabolic syndrome on immunity. Adv Nutr.2016;7(1):66-75.
- Cruz-Pineda WD, Parra-Rojas I, Rodríguez-Ruíz HA, Illades-Aguiar B, Matia-García I, Garibay-Cerdenares OL. The regulatory role of insulin in energy metabolism and leukocyte functions. J Leukoc Biol.2022;111(1):197-208.
- Hernandez Vera R, Vilahur G, Badimon L. Obesity with insulin resistance increase thrombosis in wild-type and bone marrow-transplanted Zucker Fatty rats. Thromb Haemost. 2013;109(2):319-327.
- Yang M, Qiu S, He Y, Li L, Wu T, Ding N et al. Genetic ablation of C-reactive protein gene confers resistance to obesity and insulin resistance in rats. Diabetologia. 2021;64(5):1169-1183.
- Aydin M, Yilmaz A, Donma MM, Tulubas F, Demirkol M, Erdogan M et al. Neutrophil/lymphocyte ratio in obese adolescents. North Clin Istanb. 2015;2(2):87-91.
- Liu H, Zhan F, Wang Y. Evaluation of monocyte-to-high-density lipoprotein cholesterol ratio and monocyte-to-lymphocyte ratio in ischemic stroke. J Int Med Res.2020;48(7):0300060520933806.
- Jin M, Yuan S, Yuan Y, Yi L. prognostic and clinicopathological significance of the systemic immune-inflammation ındex in patients with renal cell carcinoma: A meta-analysis. Front Oncol.2021;11:735803.
- Liu N, Mao J, Tao P, Chi H, Jia W, Dong C. The relationship between NLR/PLR/LMR levels and survival prognosis in patients with non-small cell lung carcinoma treated with immune checkpoint inhibitors. Medicine (Baltimore)202221;101(3):e28617.
- Karakaya S, Altay M, Kaplan Efe F, Karadağ I, Ünsal O, Bulur O et al. The neutrophil-lymphocyte ratio and its relationship with insulin resistance in obesity. Turk J Med Sci.2019;49(1):245–248.
- Erdal E, İnanir M. Platelet-to-lymphocyte ratio (PLR) and Plateletcrit (PCT) in young patients with morbid obesity. Rev Assoc Med Bras (1992).2019;65(9):1182-1187.
- Furuncuoğlu Y, Tulgar S, Dogan AN, Cakar S, Tulgar YK, Cakiroglu B. How obesity affects the neutrophil/lymphocyte and platelet/lymphocyte ratio, systemic immune-inflammatory index and platelet indices: a retrospective study. Eur Rev Med Pharmacol Sci.2016;20(7):1300-1306.
- Yu JY, Choi WJ, Lee HS, Lee JW. Relationship between inflammatory markers and visceral obesity in obese and overweight Korean adults: An observational study. Medicine (Baltimore)2019;98(9):e14740.
- Battaglia S, Scialpi N, Berardi E, Antonica G. Gender, BMI and fasting hyperglycaemia influence Monocyte to-HDL ratio (MHR) index in metabolic subjects. PLoS One.2020; 15(4):e0231927.
- Parveen N, Rehman J, Hassan SH, Hassan Z, Rehman M. Different blood groups association with body mass index in medical students of Karachi. Professional Medical Journal.2016;23(8):1001–1004.
- Fagherazzi G, Gusto G, Clavel-Chapelon F, Balkau B, Bonnet F. ABO and Rhesus blood groups and risk of type 2 diabetes: evidence from the large E3N cohort study. Diabetologia.2015;58(3):519-22.
- Sukalingam K, Ganesan K. Rhesus blood groups associated with risk to obesity and diabetes mellitus: A report on Punjabi population in Selangor, Malaysia. International Journal of Integrative Medical Sciences.2015;2(4):105–109.
Hematological and Inflammatory Parameters Effective on Inflammation and Insulin Resistance in Obesity
Öz
Objective: Obesity is one of the predominant risk factors associated with insulin resistance (IR), type 2 diabetes, and many metabolic syndromes. In this
study, we aimed to investigate inflammatory parameters and their relationship with IR and blood groups in obese individuals.
Materials and Methods: The demographic characteristics, body mass index (BMI), biochemical parameters, hemogram values, and blood group types of
individuals in the obesity and control groups were recorded and compared.
Results: The mean age was 37.37±11.43 years in obese individuals and 41.8% (n=77) of them had IR. Neutrophil and monocyte counts of the obese individuals
with IR were significantly higher than those of the individuals without IR in the control and the obesity groups (p<0.001). The neutrophil/lymphocyte
ratio (NLR), the monocyte/high-density lipoprotein cholesterol ratio (MHR), and the systemic immune-inflammation index (SII) were significantly higher
in obese individuals with IR compared to obese individuals without IR. IR was more common and neutrophil ratios were significantly higher in obese individuals
with B blood type compared to those with O blood type (p=0.023).
Conclusion: We found that the values of hematological inflammatory parameters and the levels of NLR, MHR, and SII as indicators of systemic chronic
inflammation were increased in obese individuals with IR. We think that our study shows the relationship between inflammation due to excess adipose tissue
and the development of IR in obese individuals. We are of the opinion that future studies investigating this subject will help to develop processes for early
diagnosis and treatment.
Anahtar Kelimeler
Kaynakça
- World Health Organization. Obesity and overweight. [(accessed May 5, 2013)]. Available online: http://www.who.int/mediacentre/factsheets/fs311/en/
- Carr DB, Utzschneider KM, Hull RL, Kodama K, Retzlaff BM, Brunzell JD et al. Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes. 2004;53(8):2087-2094.
- Sok Lee Y, Olefsky J. Chronic tissue inflammation and metabolic disease. 2021;35(5-6):307–328.
- Qatanani M, Lazar MA. Mechanisms of obesity-associated insulin resistance: Many choices on the menu. Genes and Development. 2007;21(12):1443–1455.
- Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415–445.
- Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell. 2014;156:20–44.
- Kojta I, Chacińska M, Błachnio-Zabielska A. Obesity, bioactive lipids, and adipose tissue ınflammation in ınsulin resistance. Nutrients. 2020;12(5):1305.
- Ewald DR, Sumner SC. Blood type biochemistry and human disease. Wiley Interdiscip Rev Syst Biol Med. 2016;8:517–535.
- Liumbruno GM, Franchini M. Beyond immunohaematology: The role of the ABO blood group in human diseases. Blood Transfus.2013;11:491–499.
- Feng JF, Chen S, Yang X. Systemic immuneinflammation index (SII) is a useful prognostic indicator for patients with squamous cell carcinoma of the esophagus. Medicine (Baltimore).2017;96(4):e5886.
- Topsakal S, Yerlikaya E, Akin F, Kaptanoglu B, Erürker T. Relation with HOMA-IR and thyroid hormones in obese Turkish women with metabolic syndrome. Eat Weight Disord 2012;17(1):e57-61.
- Goran MI, Lane C, Toledo-Corral C, Weigensberg MJ. Persistence of pre-diabetes in overweight and obese hispanic children; Association with progressive insulin resistance, Poor β-cell function, and increasing visceral fat. Diabetes.2008;57(11):3007–3012.
- Petersen MC, Shulman GI. Mechanisms of insulin action and ınsulin resistance. Physiol Rev.2018;98(4):2133–2223.
- Andersen CJ, Murphy KE, Fernandez ML. Impact of obesity and metabolic syndrome on immunity. Adv Nutr.2016;7(1):66-75.
- Cruz-Pineda WD, Parra-Rojas I, Rodríguez-Ruíz HA, Illades-Aguiar B, Matia-García I, Garibay-Cerdenares OL. The regulatory role of insulin in energy metabolism and leukocyte functions. J Leukoc Biol.2022;111(1):197-208.
- Hernandez Vera R, Vilahur G, Badimon L. Obesity with insulin resistance increase thrombosis in wild-type and bone marrow-transplanted Zucker Fatty rats. Thromb Haemost. 2013;109(2):319-327.
- Yang M, Qiu S, He Y, Li L, Wu T, Ding N et al. Genetic ablation of C-reactive protein gene confers resistance to obesity and insulin resistance in rats. Diabetologia. 2021;64(5):1169-1183.
- Aydin M, Yilmaz A, Donma MM, Tulubas F, Demirkol M, Erdogan M et al. Neutrophil/lymphocyte ratio in obese adolescents. North Clin Istanb. 2015;2(2):87-91.
- Liu H, Zhan F, Wang Y. Evaluation of monocyte-to-high-density lipoprotein cholesterol ratio and monocyte-to-lymphocyte ratio in ischemic stroke. J Int Med Res.2020;48(7):0300060520933806.
- Jin M, Yuan S, Yuan Y, Yi L. prognostic and clinicopathological significance of the systemic immune-inflammation ındex in patients with renal cell carcinoma: A meta-analysis. Front Oncol.2021;11:735803.
- Liu N, Mao J, Tao P, Chi H, Jia W, Dong C. The relationship between NLR/PLR/LMR levels and survival prognosis in patients with non-small cell lung carcinoma treated with immune checkpoint inhibitors. Medicine (Baltimore)202221;101(3):e28617.
- Karakaya S, Altay M, Kaplan Efe F, Karadağ I, Ünsal O, Bulur O et al. The neutrophil-lymphocyte ratio and its relationship with insulin resistance in obesity. Turk J Med Sci.2019;49(1):245–248.
- Erdal E, İnanir M. Platelet-to-lymphocyte ratio (PLR) and Plateletcrit (PCT) in young patients with morbid obesity. Rev Assoc Med Bras (1992).2019;65(9):1182-1187.
- Furuncuoğlu Y, Tulgar S, Dogan AN, Cakar S, Tulgar YK, Cakiroglu B. How obesity affects the neutrophil/lymphocyte and platelet/lymphocyte ratio, systemic immune-inflammatory index and platelet indices: a retrospective study. Eur Rev Med Pharmacol Sci.2016;20(7):1300-1306.
- Yu JY, Choi WJ, Lee HS, Lee JW. Relationship between inflammatory markers and visceral obesity in obese and overweight Korean adults: An observational study. Medicine (Baltimore)2019;98(9):e14740.
- Battaglia S, Scialpi N, Berardi E, Antonica G. Gender, BMI and fasting hyperglycaemia influence Monocyte to-HDL ratio (MHR) index in metabolic subjects. PLoS One.2020; 15(4):e0231927.
- Parveen N, Rehman J, Hassan SH, Hassan Z, Rehman M. Different blood groups association with body mass index in medical students of Karachi. Professional Medical Journal.2016;23(8):1001–1004.
- Fagherazzi G, Gusto G, Clavel-Chapelon F, Balkau B, Bonnet F. ABO and Rhesus blood groups and risk of type 2 diabetes: evidence from the large E3N cohort study. Diabetologia.2015;58(3):519-22.
- Sukalingam K, Ganesan K. Rhesus blood groups associated with risk to obesity and diabetes mellitus: A report on Punjabi population in Selangor, Malaysia. International Journal of Integrative Medical Sciences.2015;2(4):105–109.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Erken Görünüm Tarihi | 10 Temmuz 2023 |
| Yayımlanma Tarihi | 12 Temmuz 2023 |
| Gönderilme Tarihi | 10 Mayıs 2022 |
| Kabul Tarihi | 12 Eylül 2022 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 18 Sayı: 2 |
