Araştırma Makalesi
Yıl 2024,
Cilt: 37 Sayı: 1, 11 - 17, 28.01.2024
Öz
Objective: The study aims to investigate the use of pulmonary artery stiffness (PAS) parameter in early diagnosis of systemic sclerosis
(SSc) and pulmonary hypertension in SSc patients.
Patients and Methods: The study involved 102 SSc patients and 45 control group patients, who underwent transthoracic
echocardiographic evaluations.
Results: Pulmonary artery stiffness was measured as 25.7±7.6 (Hz/msn) in the SSc cases and 13.7 ±1.6 (Hz/msn) in the healthy
subjects (P< 0.001). TAPSE/sPAP ratio, which we used as an indicator of RV-PA coupling, was calculated as 0.65+0.28 in SSc cases and
1.12+0.33 in the control group (P<0.001).
When we evaluated PAS values of subgroups PAS was significantly higher in SScPH(-) patients without pulmonary hypertension than
control subjects (respectively; 21.67 ± 3.9; 13.7 ± 1.6, P<0.001). The relationship of PAS with the parameters in which pulmonary
hypertension and right ventricular functions were evaluated, there was a positive correlation with sPAP( r: – 0.396, P <0.001), while a
negative correlation was observed with TAPSE/sPAP (r: 0.456, P<0.001).
Conclusion: We observed higher PAS values in SScPH(-) patients compared to the control group and found a positive correlation
between the increase in PAS and sPAP and a negative correlation between them and TAPSE/sPAP.
Anahtar Kelimeler
Pulmonary hypertension Systemic sclerosis Transthoracic Echocardiography Pulmonary arterial stiffness TAPSE/sPAP ratio
Kaynakça
- Mukerjee D, George DS, Coleiro B, et al. Prevalence and outcome in systemic sclerosis-associated pulmonary arterial hypertension: application of a registry approach. Ann Rheum Dis 2003; 62:1088-93. doi: 10.1136/ard.62.11.1088
- Humbert M, Kovacs G, Hoeper M, et al. ESC/ERS Scientific Document Group. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J 2022; 43:3618-731. doi: 10.1093/eurheartj/ehac237
- Coghlan JG, Denton CP, Grünig E, et al. Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Ann Rheum Dis 2014; 73:1340- 9. doi: 10.1136/annrheumdis-2013-203301.
- Rangarajan V, Matiasz R, Freed BH et al. Cardiac complications of systemic sclerosis and management: recent progress. Curr Opin Rheumatol 2017; 9: 574–84. doi:10.1097/ BOR.000.000.0000000439.
- Brown Z, Proudman S, Morrisroe K, et al. Screening for the early detection of pulmonary arterial hypertension in patients with systemic sclerosis: A systematic review and meta-analysis of long-term outcomes. Semin Arthritis Rheum 2021;51:495- 512. doi:10.1016/j.semarthrit.2021.03.011
- Horvat D, Zlibut A, Orzan RI, et al. Aging influences pulmonary artery flow and stiffness in healthy individuals: non-invasive assessment using cardiac MRI. Clin Radiol 2021;76:161.e19-161.e28. doi:10.1016/j.crad.2020.09.021
- van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. Ann Rheum Dis 2013;72:1747-55. doi:10.1136/annrheumdis-2013-204424
- Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiograph endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr 2010;23:685-788. doi:10.1016/j. echo.2010.05.010
- Colalillo A, Grimaldi MC, Vaiarello V, et al. In systemic sclerosis, the TAPSE/sPAP ratio can be used in addition to the DETECT algorithm for pulmonary arterial hypertension diagnosis. Rheumatology (Oxford) 2022;61:2450-56. doi:10.1093/rheumatology/keab748
- Görgülü S, Eren M, Yildirim A, et al. A new echocardiographic approach in assessing pulmonary vascular bed in patients with congenital heart disease: pulmonary artery stiffness. Anadolu Kardiyol Derg 2003;3:92-97.
- Koh ET, Lee P, Gladman DD, Abu-Shakra M. Pulmonary hypertension in systemic sclerosis: an analysis of 17 patients. Br J Rheumatol 1996;35:989-93. doi:10.1093/ rheumatology/35.10.989
- Belin RJ, Varga J, Collins JD, Freed BH. Right ventricular cardiomyopathy in systemic sclerosis. Rheumatology (Oxford) 2017;56:1045-47. doi:10.1093/rheumatology/kew494
- Demirci M, Ozben B, Sunbul M, et al. The evaluation of right ventricle dyssynchrony by speckle tracking echocardiography in systemic sclerosis patients. J Clin Ultrasound 2021;49:895- 902. doi:10.1002/jcu.23041
- Chemla D, Weatherald J, Lau EMT, et al. Clinical and hemodynamic correlates of pulmonary arterial stiffness in incident, untreated patients with idiopathic pulmonary arterial hypertension. Chest 2018;154:882-92. doi:10.1016/j. chest.2018.06.015
- Kang KW, Chang HJ, Kim YJ, et al. Cardiac magnetic resonance imaging-derived pulmonary artery distensibility index correlates with pulmonary artery stiffness and predicts functional capacity in patients with pulmonary arterial hypertension. Circ J 2011;75:2244-51. doi:10.1253/circj.cj-10- 1310
- Yaşar S, Unlu M, Görmel S, et al. Evaluation of the relationship between pulmonary artery stiffness and right ventricular function in patients with Behçet’s disease using transthoracic echocardiography. Authorea 2021: 2232-36. doi 10.22541/ au.163615.894.48445737/v1
- Ozkececi G, Ulasli SS, Akci O, et al. Assessment of pulmonary arterial stiffness in obstructive sleep apnea. Int J Cardiovasc Imaging 2016;32:799-805. doi:10.1007/s10554.016.0841-0
- Baysal SS, Has M. Evaluation of pulmonary artery stiffness in newly diagnosed adult patients with asthma. Echocardiography 2019;36:870-76. doi:10.1111/echo.14309
- Abacioglu OO, Gulumsek E, Sumbul H, Kaplan M, Yavuz F. Increased pulmonary arterial stiffness and impaired right ventricle-pulmonary artery coupling in PCOS. Arq Bras Cardiol 2021;116:806-11. doi:10.36660/abc.20190762
- Öz A, Çınar T, Taş E, Çağan Efe S, Ayça B, Karabağ T. Assessment of pulmonary arterial stiffness in patients with cirrhosis: A prospective cohort study. Echocardiography 2021;38:57-63. doi:10.1111/echo.14935
- Yenerçağ M, Arslan U, Dereli S, Çoksevim M, Doğduş M, Kaya A. Effects of angiotensin receptor neprilysin inhibition on pulmonary arterial stiffness in heart failure with reduced ejection fraction. Int J Cardiovasc Imaging 2021;37:165-73. doi:10.1007/s10554.020.01973-8
- Duman D, Masatlıoğlu S, Demirtunç R,Karadağ B Increased pulmonary artery stiffness and its relation to right ventricular function in patients with systemic lupus erythematosus. Turk Kardiyoloji Dernegi Arsivi 2008; 36,2:82-9.
- Cerik IB, Meric M, Gulel O, et al. Echocardiographic assessment of pulmonary arterial stiffness in human immunodeficiency virus-infected patients. Echocardiography 2019;36:1123-31. doi:10.1111/echo.14349
- Hoffmann-Vold AM, Fretheim H, Midtvedt Q, et al. Frequencies of borderline pulmonary hypertension before and after the DETECT algorithm: results from a prospective systemic sclerosis cohort. Rheumatology (Oxford) 2018;57:480-87. doi:10.1093/rheumatology/kex435
- Colalillo A, Hoffmann-Vold AM, Pellicano C, et al. The role of TAPSE/sPAP ratio in predicting pulmonary hypertension and mortality in the systemic sclerosis EUSTAR cohort. Autoimmun Rev 2023;22:113-19. doi:10.1016/j. autrev.2023.103290
- Baptista R, Serra S, Martins R, et al. Exercise echocardiography for the assessment of pulmonary hypertension in systemic sclerosis: a systematic review. Arthritis Res Ther 2016;18:153. doi:10.1186/s13075.016.1051-9
Yıl 2024,
Cilt: 37 Sayı: 1, 11 - 17, 28.01.2024
Öz
Kaynakça
- Mukerjee D, George DS, Coleiro B, et al. Prevalence and outcome in systemic sclerosis-associated pulmonary arterial hypertension: application of a registry approach. Ann Rheum Dis 2003; 62:1088-93. doi: 10.1136/ard.62.11.1088
- Humbert M, Kovacs G, Hoeper M, et al. ESC/ERS Scientific Document Group. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J 2022; 43:3618-731. doi: 10.1093/eurheartj/ehac237
- Coghlan JG, Denton CP, Grünig E, et al. Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study. Ann Rheum Dis 2014; 73:1340- 9. doi: 10.1136/annrheumdis-2013-203301.
- Rangarajan V, Matiasz R, Freed BH et al. Cardiac complications of systemic sclerosis and management: recent progress. Curr Opin Rheumatol 2017; 9: 574–84. doi:10.1097/ BOR.000.000.0000000439.
- Brown Z, Proudman S, Morrisroe K, et al. Screening for the early detection of pulmonary arterial hypertension in patients with systemic sclerosis: A systematic review and meta-analysis of long-term outcomes. Semin Arthritis Rheum 2021;51:495- 512. doi:10.1016/j.semarthrit.2021.03.011
- Horvat D, Zlibut A, Orzan RI, et al. Aging influences pulmonary artery flow and stiffness in healthy individuals: non-invasive assessment using cardiac MRI. Clin Radiol 2021;76:161.e19-161.e28. doi:10.1016/j.crad.2020.09.021
- van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. Ann Rheum Dis 2013;72:1747-55. doi:10.1136/annrheumdis-2013-204424
- Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiograph endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr 2010;23:685-788. doi:10.1016/j. echo.2010.05.010
- Colalillo A, Grimaldi MC, Vaiarello V, et al. In systemic sclerosis, the TAPSE/sPAP ratio can be used in addition to the DETECT algorithm for pulmonary arterial hypertension diagnosis. Rheumatology (Oxford) 2022;61:2450-56. doi:10.1093/rheumatology/keab748
- Görgülü S, Eren M, Yildirim A, et al. A new echocardiographic approach in assessing pulmonary vascular bed in patients with congenital heart disease: pulmonary artery stiffness. Anadolu Kardiyol Derg 2003;3:92-97.
- Koh ET, Lee P, Gladman DD, Abu-Shakra M. Pulmonary hypertension in systemic sclerosis: an analysis of 17 patients. Br J Rheumatol 1996;35:989-93. doi:10.1093/ rheumatology/35.10.989
- Belin RJ, Varga J, Collins JD, Freed BH. Right ventricular cardiomyopathy in systemic sclerosis. Rheumatology (Oxford) 2017;56:1045-47. doi:10.1093/rheumatology/kew494
- Demirci M, Ozben B, Sunbul M, et al. The evaluation of right ventricle dyssynchrony by speckle tracking echocardiography in systemic sclerosis patients. J Clin Ultrasound 2021;49:895- 902. doi:10.1002/jcu.23041
- Chemla D, Weatherald J, Lau EMT, et al. Clinical and hemodynamic correlates of pulmonary arterial stiffness in incident, untreated patients with idiopathic pulmonary arterial hypertension. Chest 2018;154:882-92. doi:10.1016/j. chest.2018.06.015
- Kang KW, Chang HJ, Kim YJ, et al. Cardiac magnetic resonance imaging-derived pulmonary artery distensibility index correlates with pulmonary artery stiffness and predicts functional capacity in patients with pulmonary arterial hypertension. Circ J 2011;75:2244-51. doi:10.1253/circj.cj-10- 1310
- Yaşar S, Unlu M, Görmel S, et al. Evaluation of the relationship between pulmonary artery stiffness and right ventricular function in patients with Behçet’s disease using transthoracic echocardiography. Authorea 2021: 2232-36. doi 10.22541/ au.163615.894.48445737/v1
- Ozkececi G, Ulasli SS, Akci O, et al. Assessment of pulmonary arterial stiffness in obstructive sleep apnea. Int J Cardiovasc Imaging 2016;32:799-805. doi:10.1007/s10554.016.0841-0
- Baysal SS, Has M. Evaluation of pulmonary artery stiffness in newly diagnosed adult patients with asthma. Echocardiography 2019;36:870-76. doi:10.1111/echo.14309
- Abacioglu OO, Gulumsek E, Sumbul H, Kaplan M, Yavuz F. Increased pulmonary arterial stiffness and impaired right ventricle-pulmonary artery coupling in PCOS. Arq Bras Cardiol 2021;116:806-11. doi:10.36660/abc.20190762
- Öz A, Çınar T, Taş E, Çağan Efe S, Ayça B, Karabağ T. Assessment of pulmonary arterial stiffness in patients with cirrhosis: A prospective cohort study. Echocardiography 2021;38:57-63. doi:10.1111/echo.14935
- Yenerçağ M, Arslan U, Dereli S, Çoksevim M, Doğduş M, Kaya A. Effects of angiotensin receptor neprilysin inhibition on pulmonary arterial stiffness in heart failure with reduced ejection fraction. Int J Cardiovasc Imaging 2021;37:165-73. doi:10.1007/s10554.020.01973-8
- Duman D, Masatlıoğlu S, Demirtunç R,Karadağ B Increased pulmonary artery stiffness and its relation to right ventricular function in patients with systemic lupus erythematosus. Turk Kardiyoloji Dernegi Arsivi 2008; 36,2:82-9.
- Cerik IB, Meric M, Gulel O, et al. Echocardiographic assessment of pulmonary arterial stiffness in human immunodeficiency virus-infected patients. Echocardiography 2019;36:1123-31. doi:10.1111/echo.14349
- Hoffmann-Vold AM, Fretheim H, Midtvedt Q, et al. Frequencies of borderline pulmonary hypertension before and after the DETECT algorithm: results from a prospective systemic sclerosis cohort. Rheumatology (Oxford) 2018;57:480-87. doi:10.1093/rheumatology/kex435
- Colalillo A, Hoffmann-Vold AM, Pellicano C, et al. The role of TAPSE/sPAP ratio in predicting pulmonary hypertension and mortality in the systemic sclerosis EUSTAR cohort. Autoimmun Rev 2023;22:113-19. doi:10.1016/j. autrev.2023.103290
- Baptista R, Serra S, Martins R, et al. Exercise echocardiography for the assessment of pulmonary hypertension in systemic sclerosis: a systematic review. Arthritis Res Ther 2016;18:153. doi:10.1186/s13075.016.1051-9
Toplam 26 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Cerrahi (Diğer) |
| Bölüm | Original Research |
| Yazarlar | |
| Yayımlanma Tarihi | 28 Ocak 2024 |
| Yayımlandığı Sayı | Yıl 2024 Cilt: 37 Sayı: 1 |
