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Plasma netrin-1 levels in Familial Mediterranean fever: a potential biomarker?

Yıl 2022, Cilt: 39 Sayı: 4, 1202 - 1206, 29.10.2022

Öz

Netrins are primarily defined as being of guidance in axonal cell migration in the embryonic period. Cell migration has an important role in the occurrence of organogenesis and inflammation. In the etiopathogenesis of autoimmune diseases, there is said to be tissue destruction associated with uncontrolled activation of the immune system and uncontrolled migration of inflammatory cells to tissues. We aimed to determine whether netrin-1 has a role in the etiopathogenesis of the FMF disease. This study included 42 patients with Familial Mediterranean Fever (FMF) and 44 healthy control subjects. The plasma netrin 1 levels were measured, and relationships were examined between the netrin levels and demographic data, clinical findings and laboratory test results in both groups. No significant difference was determined between the groups in respect of the plasma netrin levels. The lack of difference between the two groups in this study in respect of plasma netrin levels could suggest that netrin-1 does not have an important role in the etiopathogenesis of FMF. There is a need for further in vivo and in vitro studies to examine netrin-1 and receptors in inflammation tissue samples and in normal tissue.

Kaynakça

  • 1. Rajasekharan S, Kennedy TE. The netrin protein family. Genome Biol. 2009; 10:239.
  • 2. Maruyama K, Takemura N, Martino MM, Kondo T, Akira S. Netrins as prophylactic targets in skeletal diseases: A double-edged sword? Pharmacol Res. 2017; 122:46–52. 3. Ly A, Nikolaev A, Suresh G, Zheng Y, Tessier-Lavigne M, Stein E. DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell. 2008; 133:1241–1254.
  • 4. Ramesh G. Role of Netrin-1 Beyond the Brain: From Biomarker of Tissue Injury to Therapy for Inflammatory Diseases. Recent Pat Biomark. 2012; 2:202–208.
  • 5. Schubert T, Denk A, Mägdefrau U, Kaufmann S, Bastone P, Lowin T, et al. Role of the netrin system of repellent factors on synovial fibroblasts in rheumatoid arthritis and osteoarthritis. Int J Immunopathol Pharmacol. 2009; 22:715–722.
  • 6. Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, et al. The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue. Neuron. 2014; 83:839–849.
  • 7. Moore KJ, Fisher EA. Macrophages, atherosclerosis and the potential of netrin-1 as a novel target for future therapeutic intervention. Future Cardiol. 2012; 8:349–352. 8. Mediero A, Ramkhelawon B, Perez-Aso M, Moore KJ, Cronstein BN. Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation. J Bone Miner Res. 2015; 30:837–854.
  • 9. Matsugaki A, Yamazaki D, Nakano T. Selective patterning of netrin-1 as a novel guiding cue for anisotropic dendrogenesis in osteocytes. Mater Sci Eng C Mater Biol Appl. 2020; 108:110391. Epub 2019.11.05.
  • 10. Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, et al. Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. J Biol Chem. 2013, 288:2210–2222.
  • 11. Akino T, Han X, Nakayama H, McNeish B, Zurakowski D, Mammoto A, et al. Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and demonstrates elevated expression in tumor tissue and urine of patients with pediatric medulloblastoma. Cancer Res. 2014; 74:3716–3726.
  • 12. Ly NP, Komatsuzaki K, Fraser IP, Tseng AA, Prodhan P, Moore KJ, et al. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc Natl Acad Sci U S A. 2005; 102:14729–14734.
  • 13. Dalvin S, Anselmo MA, Prodhan P, Komatsuzaki K, Schnitzer JJ, Kinane TB. Expression of Netrin-1 and its two receptors DCC and UNC5H2 in the developing mouse lung. Gene Expr Patterns. 2003; 3:279–283.
  • 14. Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, et al. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004; 432:179–186.
  • 15. Yıldız M, Haşlak F, Adrovic A, Barut K, Kasapçopur Ö. Autoinflammatory Diseases in Childhood. Balkan Med J. 2020 Aug 11;37(5):236-246.
  • 16. Claro V, Ferro A. Netrin-1: Focus on its role in cardiovascular physiology and atherosclerosis. JRSM Cardiovasc Dis. 2020; 9:2048004020959574.Epub 2020.11.25.
  • 17. Mirakaj V, Thix CA, Laucher S, Henes J, Unertl KE, Köhler D, Rosenberger P, et al. Netrin-1 dampens pulmonary inflammation during acute lung injury. Am J Respir Crit Care Med. 2010; 181:815–824.
  • 18. Mirakaj V, Gatidou D, Pötzsch C, König K, Rosenberger P. Netrin-1 signaling dampens inflammatory peritonitis. J Immunol. 2011; 186:549–555.
  • 19. Tadagavadi RK, Wang W, Ramesh G. Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. J Immunol. 2010; 185:3750–3758.
  • 20. Chen J, Cai Q-P, Shen P-J, Yan RL, Wang CM, Yang DJ, et al. Netrin-1 protects against L-Arginine-induced acute pancreatitis in mice. PLoS One. 2012; 7:e46201. Epub 2012.09.27
  • 21. Aherne CM, Collins CB, Masterson JC, Tizzano M, Boyle TA, Westrich JA, et al. Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis. Gut. 2012; 61:695–705.
  • 22. Rosenberger P, Schwab JM, Mirakaj V, Masekowsky E, Mager A, Morote-Garcia JC, Unertl K, et al. Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia. Nat Immunol 2009; 10:195–202.
  • 23. Mediero A, Ramkhelawon B, Wilder T, Purdue PE, Goldring SR, Dewan MZ, et al. Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis. Ann Rheum Dis. 2016; 75:1706–1713.
  • 24. van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ramkhelawon B, Ray TD, Rayner KJ, et al. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nat Immunol. 2012; 13:136–143.
  • 25. Joseph BB, Quan PD. The neuroimmune guidance cue netrin-1: a new therapeutic target in cardiovascular disease. Am J Cardiovasc Dis. 2013; 3:129–134.
  • 26. Ramkhelawon B, Hennessy EJ, Ménager M, Ray TD, Sheedy FJ, Hutchison S, et al. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Nat Med. 2014; 20:377–384.
  • 27. Paradisi A, Maisse C, Coissieux M-M, et al. Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression. Proc Natl Acad Sci U S A. 2009; 106:17146–17151.
  • 28. Tu T, Zhang C, Yan H, Luo Y, Kong R, Wen P, et al. CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. Cell Res. 2015; 25:275–287.
Yıl 2022, Cilt: 39 Sayı: 4, 1202 - 1206, 29.10.2022

Öz

Kaynakça

  • 1. Rajasekharan S, Kennedy TE. The netrin protein family. Genome Biol. 2009; 10:239.
  • 2. Maruyama K, Takemura N, Martino MM, Kondo T, Akira S. Netrins as prophylactic targets in skeletal diseases: A double-edged sword? Pharmacol Res. 2017; 122:46–52. 3. Ly A, Nikolaev A, Suresh G, Zheng Y, Tessier-Lavigne M, Stein E. DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell. 2008; 133:1241–1254.
  • 4. Ramesh G. Role of Netrin-1 Beyond the Brain: From Biomarker of Tissue Injury to Therapy for Inflammatory Diseases. Recent Pat Biomark. 2012; 2:202–208.
  • 5. Schubert T, Denk A, Mägdefrau U, Kaufmann S, Bastone P, Lowin T, et al. Role of the netrin system of repellent factors on synovial fibroblasts in rheumatoid arthritis and osteoarthritis. Int J Immunopathol Pharmacol. 2009; 22:715–722.
  • 6. Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, et al. The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue. Neuron. 2014; 83:839–849.
  • 7. Moore KJ, Fisher EA. Macrophages, atherosclerosis and the potential of netrin-1 as a novel target for future therapeutic intervention. Future Cardiol. 2012; 8:349–352. 8. Mediero A, Ramkhelawon B, Perez-Aso M, Moore KJ, Cronstein BN. Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation. J Bone Miner Res. 2015; 30:837–854.
  • 9. Matsugaki A, Yamazaki D, Nakano T. Selective patterning of netrin-1 as a novel guiding cue for anisotropic dendrogenesis in osteocytes. Mater Sci Eng C Mater Biol Appl. 2020; 108:110391. Epub 2019.11.05.
  • 10. Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, et al. Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. J Biol Chem. 2013, 288:2210–2222.
  • 11. Akino T, Han X, Nakayama H, McNeish B, Zurakowski D, Mammoto A, et al. Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and demonstrates elevated expression in tumor tissue and urine of patients with pediatric medulloblastoma. Cancer Res. 2014; 74:3716–3726.
  • 12. Ly NP, Komatsuzaki K, Fraser IP, Tseng AA, Prodhan P, Moore KJ, et al. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc Natl Acad Sci U S A. 2005; 102:14729–14734.
  • 13. Dalvin S, Anselmo MA, Prodhan P, Komatsuzaki K, Schnitzer JJ, Kinane TB. Expression of Netrin-1 and its two receptors DCC and UNC5H2 in the developing mouse lung. Gene Expr Patterns. 2003; 3:279–283.
  • 14. Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, et al. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004; 432:179–186.
  • 15. Yıldız M, Haşlak F, Adrovic A, Barut K, Kasapçopur Ö. Autoinflammatory Diseases in Childhood. Balkan Med J. 2020 Aug 11;37(5):236-246.
  • 16. Claro V, Ferro A. Netrin-1: Focus on its role in cardiovascular physiology and atherosclerosis. JRSM Cardiovasc Dis. 2020; 9:2048004020959574.Epub 2020.11.25.
  • 17. Mirakaj V, Thix CA, Laucher S, Henes J, Unertl KE, Köhler D, Rosenberger P, et al. Netrin-1 dampens pulmonary inflammation during acute lung injury. Am J Respir Crit Care Med. 2010; 181:815–824.
  • 18. Mirakaj V, Gatidou D, Pötzsch C, König K, Rosenberger P. Netrin-1 signaling dampens inflammatory peritonitis. J Immunol. 2011; 186:549–555.
  • 19. Tadagavadi RK, Wang W, Ramesh G. Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. J Immunol. 2010; 185:3750–3758.
  • 20. Chen J, Cai Q-P, Shen P-J, Yan RL, Wang CM, Yang DJ, et al. Netrin-1 protects against L-Arginine-induced acute pancreatitis in mice. PLoS One. 2012; 7:e46201. Epub 2012.09.27
  • 21. Aherne CM, Collins CB, Masterson JC, Tizzano M, Boyle TA, Westrich JA, et al. Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis. Gut. 2012; 61:695–705.
  • 22. Rosenberger P, Schwab JM, Mirakaj V, Masekowsky E, Mager A, Morote-Garcia JC, Unertl K, et al. Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia. Nat Immunol 2009; 10:195–202.
  • 23. Mediero A, Ramkhelawon B, Wilder T, Purdue PE, Goldring SR, Dewan MZ, et al. Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis. Ann Rheum Dis. 2016; 75:1706–1713.
  • 24. van Gils JM, Derby MC, Fernandes LR, Ramkhelawon B, Ramkhelawon B, Ray TD, Rayner KJ, et al. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nat Immunol. 2012; 13:136–143.
  • 25. Joseph BB, Quan PD. The neuroimmune guidance cue netrin-1: a new therapeutic target in cardiovascular disease. Am J Cardiovasc Dis. 2013; 3:129–134.
  • 26. Ramkhelawon B, Hennessy EJ, Ménager M, Ray TD, Sheedy FJ, Hutchison S, et al. Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity. Nat Med. 2014; 20:377–384.
  • 27. Paradisi A, Maisse C, Coissieux M-M, et al. Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression. Proc Natl Acad Sci U S A. 2009; 106:17146–17151.
  • 28. Tu T, Zhang C, Yan H, Luo Y, Kong R, Wen P, et al. CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. Cell Res. 2015; 25:275–287.
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Clinical Research
Yazarlar

Ebru Atalar 0000-0003-2708-0373

Kevser Gök 0000-0001-8639-751X

Esra Fırat Oğuz 0000-0002-8147-5379

Ahmet Kor 0000-0002-5794-6951

Yüksel Maraş 0000-0001-9319-0955

Yayımlanma Tarihi 29 Ekim 2022
Gönderilme Tarihi 4 Temmuz 2022
Kabul Tarihi 12 Temmuz 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 39 Sayı: 4

Kaynak Göster

APA Atalar, E., Gök, K., Fırat Oğuz, E., Kor, A., vd. (2022). Plasma netrin-1 levels in Familial Mediterranean fever: a potential biomarker?. Journal of Experimental and Clinical Medicine, 39(4), 1202-1206.
AMA Atalar E, Gök K, Fırat Oğuz E, Kor A, Maraş Y. Plasma netrin-1 levels in Familial Mediterranean fever: a potential biomarker?. J. Exp. Clin. Med. Ekim 2022;39(4):1202-1206.
Chicago Atalar, Ebru, Kevser Gök, Esra Fırat Oğuz, Ahmet Kor, ve Yüksel Maraş. “Plasma Netrin-1 Levels in Familial Mediterranean Fever: A Potential Biomarker?”. Journal of Experimental and Clinical Medicine 39, sy. 4 (Ekim 2022): 1202-6.
EndNote Atalar E, Gök K, Fırat Oğuz E, Kor A, Maraş Y (01 Ekim 2022) Plasma netrin-1 levels in Familial Mediterranean fever: a potential biomarker?. Journal of Experimental and Clinical Medicine 39 4 1202–1206.
IEEE E. Atalar, K. Gök, E. Fırat Oğuz, A. Kor, ve Y. Maraş, “Plasma netrin-1 levels in Familial Mediterranean fever: a potential biomarker?”, J. Exp. Clin. Med., c. 39, sy. 4, ss. 1202–1206, 2022.
ISNAD Atalar, Ebru vd. “Plasma Netrin-1 Levels in Familial Mediterranean Fever: A Potential Biomarker?”. Journal of Experimental and Clinical Medicine 39/4 (Ekim 2022), 1202-1206.
JAMA Atalar E, Gök K, Fırat Oğuz E, Kor A, Maraş Y. Plasma netrin-1 levels in Familial Mediterranean fever: a potential biomarker?. J. Exp. Clin. Med. 2022;39:1202–1206.
MLA Atalar, Ebru vd. “Plasma Netrin-1 Levels in Familial Mediterranean Fever: A Potential Biomarker?”. Journal of Experimental and Clinical Medicine, c. 39, sy. 4, 2022, ss. 1202-6.
Vancouver Atalar E, Gök K, Fırat Oğuz E, Kor A, Maraş Y. Plasma netrin-1 levels in Familial Mediterranean fever: a potential biomarker?. J. Exp. Clin. Med. 2022;39(4):1202-6.