Öz
Objective: Low intake of Vitamin B12 (vit B 12) with malabsorptions are the most critical factors causing the deficiency. Vit B 12 deficiency has also been associated with Helicobacter pylori (HP) gastritis in previous studies. This study’s main goal is to find a similar relation with recent studies or an opposite conclusion. For this purpose we choose the most suitable group; patients with the same two diseases HP gastritis and vit B 12 deficiency.
Methods: The whole study was conducted retrospectively. İn the study we included 19 patients (mean age: 15.6 ± 1.3 years ). The B12 levels of patients undergoing upper gastroscopy for any reason were studied. We tried to figure out whether B12 deficiency and HP positivity were statistically significant. The Electrochemiluminescence immunoassay method has been used for serum vit B12 level measurement.
Results: There are 15 (62.5%) patients with neurological symptoms and 6 (25.0%) patients with fatigue and weakness. Only 3 (12.5 %) patients have no symptoms. There was no statistical significance between these groups (p=0.224). There are 18 (75%) patients with HP positivity. HP positive and negative patients have levels of B12 108.6 ± 31.1 pg/mL and 113.5 ± 41.2 pg/mL respectively (p=973).
Conclusion: There were no statistical significance with vitamin B 12 levels in HP-positive patients and HP-negative patients. İt sure be beneficial to use a bigger aspect patients group to have better results between HP infection and vitamin B 12 deficiency relation.
Anahtar Kelimeler
Teşekkür
Thanks to Kahraman Kılavuz for proofreading. https://orcid.org/0000-0002-6625-4105
Kaynakça
- Choe YH, Kwon YS, Jung MK, Kang SK, Hwang TS, Hong YC. Helicobacter pylori–associated iron-deficiency anemia in adolescent female athletes. The journal of Pediatrics. 2001;139(1):100-4.
- Mehata S, Parajuli KR, Pant ND, Rayamajhee B, Yadav UN, Mehta RK, et al. Prevalence and correlates of Helicobacter pylori infection among under-five children, adolescent and non-pregnant women in Nepal: Further analysis of Nepal national micronutrient status survey 2016. PLoS neglected tropical diseases. 2021;15(6):e0009510.
- Mišak Z, Hojsak I, Despot R, Jadrešin O, Kolaček S, Konjik V, et al. Recommendation on diagnosis and treatment of Helicobacter pylori infection in children and adolescents. Liječnički vjesnik. 2022;144(7-8):197-206.
- Kato S, Gold BD, Kato A. Helicobacter pylori-Associated Iron Deficiency Anemia in Childhood and Adolescence-Pathogenesis and Clinical Management Strategy. Journal of Clinical Medicine. 2022;11(24):7351.
- Mubaraki MA, Alalhareth AS, Aldawood E, Albouloshi A, Aljarah MS, Hafiz TA, et al. The iron deficiency anemia in association to Helicobacter pylori infection in Najran city, Saudi Arabia. Journal of King Saud University-Science. 2022;34(8):102353.
- Ding S-Z. Global whole family based-Helicobacter pylori eradication strategy to prevent its related diseases and gastric cancer. World Journal of Gastroenterology. 2020;26(10):995.
- Hussain A, Nadeem M, Khan R, Khalid M, Iqbal K, Ishfaq M. Prevalence of Iron Deficiency Anemia Amongst Patients Infected with Helicobacter Pylori at Tertiary Care Hospital. Pakistan Journal of Medical & Health Sciences. 2022;16(07):919.
- Mehrabani S. Helicobacter pylori infection in children: a comprehensive review. Maedica. 2019;14(3):292.
- Borka Balas R, Meliț LE, Mărginean CO. Worldwide Prevalence and Risk Factors of Helicobacter pylori Infection in Children. Children. 2022;9(9):1359.
- Patel RR, Sachdeva PD. A Systematic Review of Anemia among Adolescents Girls. National Journal of Medical Research. 2021;11(03):109-13.
- Liu C, Wang Y, Shi J, Zhang C, Nie J, Li S, et al. The status and progress of first-line treatment against Helicobacter pylori infection: a review. Therapeutic Advances in Gastroenterology. 2021;14:1756284821989177.
- Elsaadany E, Amin S, Abdel-Hafez M, El Amrousy D, Kasem S, Abd Elaziz D, et al. Study of Serum Ferritin, Zinc, and Copper Levels in Children With Helicobacter pylori Gastritis and the Effect of the Treatment. Journal of Pediatric Gastroenterology and Nutrition. 2022;75(5):e88-e93.
- Anaya-Loyola MA, Brito A, Vergara-Castañeda H, Sosa C, Rosado JL, Allen LH. Low serum B12 concentrations are associated with low B12 dietary intake but not with Helicobacter pylori infection or abnormal gastric function in rural Mexican women. Nutrients. 2019;11(12):2922.
- Sadiq A, Hameed JA, Khan MR, Mushtaq M, Yasmin R, Khan MS. Frequency of Iron Deficiency Anemia (IDA) Among Patients with Helicobacter Pylori Infection. Pakistan Journal of Medical & Health Sciences. 2022;16(10):885.
- Elsaghier AM, Abdel Aal FH, Abu Faddan NH, Farghaly HS, Hassan MA-E, Sherif MF. Serum level of some micronutrients in children infected with Helicobacter pylori. Egyptian Pediatric Association Gazette. 2020;68(1):1-14.
Öz
Amaç: Malabsorbsyon B12 eksikliği sebeplerindendir. B12 vitamin eksikliğine neden olan beslenme yetersizliği yada uygunsuz diyet sebeplerden sayılabilir. Yapılan pek çok çalışmada B12 vitaminin eksikliği Helikobakter pilori (HP) ile ilişkilendirilmiştir. Bu çalışmadaki amacımız eksikliği olan adolesanlarda B12 ve HP birlikteliğinin araştırılmasıdır.
Yöntem: Çalışma kaynak teşkil eden veriler retrospektif olarak hasta dosyalarının meslektaşlarımız tarafından taranması yolu ile elde edilmiştir. Meslektaşlarımızın çalışmakta bulunduğu merkezlerde üst gastrointestinal sistem endoskopisi ve hızlı üreaz testleri ile HP tanısı almış hastaların B12 düzeyleri taranarak çalışmaya dahil edilmişlerdir. Çalışmaya 19 hasta (ortalama yaş: 16.2 ±2.3 yıl) dâhil olmuş bu hastaların B12 vitamini düzeyi elektrokemiluminesens immunoassay ile ölçülmüştür.
Bulgular: Çalışmamızda hastaların 17’sinin (%58.5) nörolojik semptomlar ile başvurduğu görüldü. Başka sebepler ile tetkik edilen diğer hastaların üçünde (%13.5) B12 vitamini eksikliği tespit edildi.Bazı hastalarda ise 8 (%25.0) yorgunluk ve halsizlik şikâyetlerin ana şikayetlerini oluşturduğu görüldü. B12 düzeyleri kıyaslandığında semptomatik ve asemtomatik hasta gruplarının B12 vitamini düzeyleri arasındaki fark anlamlı bulunmadı.(p=0.224). Hastaların onsekizinde (%75) HP pozitifliği saptanırken HP pozitif hastaların vitamin B12 düzeyleri ile HP negatif hastaların B12 düzeyleri kıyaslandığında sırasıyla 103.4 ± 34.3 pg/mL ve 117.5 ± 43.2 pg/mL değerlerine ulaşıldı. (p=973).
Sonuç: B12 vitamini düzeyleri kıyaslandığında HP enfeksiyonu pozitif olan çocuklarda düzeyler daha düşük olmakla beraber HP negatif hastalarla arasındaki fark anlamlı bulunmamıştır. Bu birlikteliğin gösterilebilmesi için geniş hasta grupları ile daha büyük ölçekte çalışmaların yapılması yararlı olabilir.
Anahtar Kelimeler
Kaynakça
- Choe YH, Kwon YS, Jung MK, Kang SK, Hwang TS, Hong YC. Helicobacter pylori–associated iron-deficiency anemia in adolescent female athletes. The journal of Pediatrics. 2001;139(1):100-4.
- Mehata S, Parajuli KR, Pant ND, Rayamajhee B, Yadav UN, Mehta RK, et al. Prevalence and correlates of Helicobacter pylori infection among under-five children, adolescent and non-pregnant women in Nepal: Further analysis of Nepal national micronutrient status survey 2016. PLoS neglected tropical diseases. 2021;15(6):e0009510.
- Mišak Z, Hojsak I, Despot R, Jadrešin O, Kolaček S, Konjik V, et al. Recommendation on diagnosis and treatment of Helicobacter pylori infection in children and adolescents. Liječnički vjesnik. 2022;144(7-8):197-206.
- Kato S, Gold BD, Kato A. Helicobacter pylori-Associated Iron Deficiency Anemia in Childhood and Adolescence-Pathogenesis and Clinical Management Strategy. Journal of Clinical Medicine. 2022;11(24):7351.
- Mubaraki MA, Alalhareth AS, Aldawood E, Albouloshi A, Aljarah MS, Hafiz TA, et al. The iron deficiency anemia in association to Helicobacter pylori infection in Najran city, Saudi Arabia. Journal of King Saud University-Science. 2022;34(8):102353.
- Ding S-Z. Global whole family based-Helicobacter pylori eradication strategy to prevent its related diseases and gastric cancer. World Journal of Gastroenterology. 2020;26(10):995.
- Hussain A, Nadeem M, Khan R, Khalid M, Iqbal K, Ishfaq M. Prevalence of Iron Deficiency Anemia Amongst Patients Infected with Helicobacter Pylori at Tertiary Care Hospital. Pakistan Journal of Medical & Health Sciences. 2022;16(07):919.
- Mehrabani S. Helicobacter pylori infection in children: a comprehensive review. Maedica. 2019;14(3):292.
- Borka Balas R, Meliț LE, Mărginean CO. Worldwide Prevalence and Risk Factors of Helicobacter pylori Infection in Children. Children. 2022;9(9):1359.
- Patel RR, Sachdeva PD. A Systematic Review of Anemia among Adolescents Girls. National Journal of Medical Research. 2021;11(03):109-13.
- Liu C, Wang Y, Shi J, Zhang C, Nie J, Li S, et al. The status and progress of first-line treatment against Helicobacter pylori infection: a review. Therapeutic Advances in Gastroenterology. 2021;14:1756284821989177.
- Elsaadany E, Amin S, Abdel-Hafez M, El Amrousy D, Kasem S, Abd Elaziz D, et al. Study of Serum Ferritin, Zinc, and Copper Levels in Children With Helicobacter pylori Gastritis and the Effect of the Treatment. Journal of Pediatric Gastroenterology and Nutrition. 2022;75(5):e88-e93.
- Anaya-Loyola MA, Brito A, Vergara-Castañeda H, Sosa C, Rosado JL, Allen LH. Low serum B12 concentrations are associated with low B12 dietary intake but not with Helicobacter pylori infection or abnormal gastric function in rural Mexican women. Nutrients. 2019;11(12):2922.
- Sadiq A, Hameed JA, Khan MR, Mushtaq M, Yasmin R, Khan MS. Frequency of Iron Deficiency Anemia (IDA) Among Patients with Helicobacter Pylori Infection. Pakistan Journal of Medical & Health Sciences. 2022;16(10):885.
- Elsaghier AM, Abdel Aal FH, Abu Faddan NH, Farghaly HS, Hassan MA-E, Sherif MF. Serum level of some micronutrients in children infected with Helicobacter pylori. Egyptian Pediatric Association Gazette. 2020;68(1):1-14.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Kadın Hastalıkları ve Doğum |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Temmuz 2023 |
| Gönderilme Tarihi | 13 Ocak 2023 |
| Kabul Tarihi | 23 Ocak 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 5 Sayı: 2 |
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