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The Disease of All Times: A Retrospective Study of 272 Syphilis Cases

Year 2024, , 8 - 14, 31.01.2024
https://doi.org/10.31067/acusaglik.1269980

Abstract

Purpose: This study aimed to investigate the changes in our syphilis cases over the years, their demographic and clinical characteristics, and their laboratory findings.
Methods: The study included patients diagnosed with syphilis between 2018 and 2022 at a tertiary hospital's Dermatology and Infectious Diseases (ID) outpatient clinics. Patients'; demographic, clinical, and laboratory data evaluated at the time of diagnosis. The Statistical Package for the Social Sciences (SPSS) 20.0 program was used to analyze the data.
Results: A total of 272 syphilis cases were included in the study. Among these cases, 82.4% were male, and 39.6% were 41–60 years old. In total, 7.4% were anti-HIV, and 2.9% were positive for HBsAg. The rates of the cases diagnosed at primary and secondary stages were 74.4%. Syphilis cases were detected more in 2018 than in other years (except 2020) and fewer in 2022 than in other years (p< 0.001). Anti-HIV positive cases were diagnosed more frequently at ID outpatient clinics, and cases with clinical findings were diagnosed more at dermatology outpatient clinics (p< 0.001). The rate of sexual partners not tested for syphilis was significantly higher in males than in females (p= 0.027). The rates of syphilis cases in the study and Turkey as a whole were similar in 2018–2019 but significantly different in 2020-2021-2022 (p< 0.001).
Conclusion: Reporting syphilis is essential to identify the at-risk population prevent complications, and reduce transmission. Monitoring the profile of syphilis cases admitted to the hospital can increase the detection rate of syphilis cases.

References

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  • 18. Xie N, Hu X, Yan H et al. Effects of Case Management on Risky Sexual Behaviors and Syphilis Among HIV-Infected Men Who Have Sex With Men in China: A Randomized Controlled Study. Sex Transm Dis. 2022;49:22-8.
  • DOI: 10.1097/OLQ.0000000000001502
Year 2024, , 8 - 14, 31.01.2024
https://doi.org/10.31067/acusaglik.1269980

Abstract

References

  • 1. Syphilis: Epidemiology, pathophysiology, and clinical manifestations in patients without HIV. https://www.uptodate.com/contents/syphilis-epidemiology-pathophysiology-and-clinical-manifestations-in-patients-without-hiv/. Accessed 03 March 2023
  • 2. Syphilis - STD information from CDC. https://www.cdc.gov/std/syphilis/default.htm/. Accessed 10 March 2023
  • 3. Rowley J, Vander Hoorn S, Korenromp E et al. Chlamydia, gonorrhea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016. Bull World Health Organ. 2019;97:548-562. DOI: 10.2471/BLT.18.228486
  • 4. Sifiliz https://hsgm.saglik.gov.tr/tr/bulasici-hastaliklar/sifiliz/sifiliz-liste/sifiliz-istatistik.html/. Accessed 7 March 2023
  • 5. Romanowski B, Sutherland R, Fick GH et al. Serologic response to treatment of infectious syphilis. Ann Intern Med. 1991;114:1005-1009. DOI: 10.7326/0003-4819-114-12-1005
  • 6. Brown ST, Zaidi A, Larsen SA et al. Serological response to syphilis treatment. A new analysis of old data. JAMA. 1985;253:1296-1299.
  • 7. Workowski KA, Bachmann LH, Chan PA et al. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR. 2021;70:1-187. DOI: 10.15585/mmwr.rr7004a1
  • 8. Adişen E, Öztaş M, Gürer MA. Demographic Characteristics of Syphilis Patients Followed Between 1994 and 2006. Türkderm 2008;42:9-12.
  • 9. Wong NS, Chen L, Tucker JD et al. Distribution of reported syphilis cases in South China: spatiotemporal analysis. Sci Rep.2018;8:9090. DOI: 10.1038/s41598-018-27173-y
  • 10. Hook EW. Syphilis. The Lancet. 2017;389:1550-1557. DOI: 10.1016/S0140-6736(16)32411-4
  • 11. Akalpler Ö, Eroğlu K. University Students’ Sexual Behavior and Knowledge Levels on Common Sexually Transmitted Infections in the Turkish Republic of Northern Cyprus. Hacet Üniversitesi Hemşire Fakültesi Derg. 2015;2:1-19.
  • 12. Ross MW. A community level syphilis prevention programme: outcome data from a controlled trial. Sex Transm Infect. 2004;80:100-104. DOI: 10.1136/sti.2003.006171.
  • 13. Topçu W, Söyletir G , Doğanay M, Enfeksiyon Hastalıkları ve Mikrobiyolojisi. Publishing; 2017. p.341-427
  • 14. Laga M, Manoka A, Kivuvu M et al. Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS Lond Engl. 7:95-102. DOI: 10.1097/00002030-199301000-00015
  • 15. Management of syphilis in the HIV-infected patient: facts and controversies. https://pubmed.ncbi.nlm.nih.gov/20797515/. Accessed 7 March 2023
  • 16. Körber A, Dissemond J, Lehnen M et al. Syphilis with HIV coinfection. J Dtsch Dermatol Ges.2004;2:833-40. DOI: 10.1046/j.1439-0353.2004.04071.x
  • 17. HIV-AIDS İstatistik. https://hsgm.saglik.gov.tr/tr/bulasici-hastaliklar/hiv-aids/hiv-aids-liste/hiv-aids-istatislik.html. Accessed 8 March 2023
  • 18. Xie N, Hu X, Yan H et al. Effects of Case Management on Risky Sexual Behaviors and Syphilis Among HIV-Infected Men Who Have Sex With Men in China: A Randomized Controlled Study. Sex Transm Dis. 2022;49:22-8.
  • DOI: 10.1097/OLQ.0000000000001502
There are 19 citations in total.

Details

Primary Language English
Subjects Infectious Diseases
Journal Section Clinical Research
Authors

Tülay Ünver Ulusoy 0000-0002-0172-2326

Aslı Haykır Solay 0000-0002-8684-687X

Hacer Demirköse 0000-0003-4564-0792

Semanur Kuzi 0000-0001-6496-1773

Can Huseyin Hekımoglu 0000-0002-2156-4636

İrfan Şencan 0000-0003-0465-5090

Publication Date January 31, 2024
Submission Date March 23, 2023
Published in Issue Year 2024

Cite

EndNote Ünver Ulusoy T, Haykır Solay A, Demirköse H, Kuzi S, Hekımoglu CH, Şencan İ (January 1, 2024) The Disease of All Times: A Retrospective Study of 272 Syphilis Cases. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 15 1 8–14.