Abstract
Amaç:Pelvis kemik halka, kemik metastazının en yaygın görüldüğü bölgelerinden biridir. Bu çalışmanın amacı pelvik halkayı oluşturan anatomik bölgelerin metastazlarını ve pelvis kemik metastazlarının primer kanserlere göre dağılım özelliklerini incelemek ve pelvis kemik metastazına eşlik edebilecek ek kemik metastazlarının özelliklerini ortaya koymaktır.
Hastalar ve Yöntem:2015-2019 yılları arasında İstanbul Onkoloji Hastanesinde kanser tanısı ile takip edilen hastaların verileri retrospektif olarak incelendi. Visseral organ metastazı olmadan pelvis kemik metastazı olan 151 hasta çalışmaya dahil edilme ve çalışmadan dışlanma kriterleri göz önünde bulundurularak çalışmaya dahil edildi. 151 hastanın klinik verileri, patolojik tanı raporları ve PET-BT sonuçları değerlendirildi. Hastalar yaş, cinsiyet, pelvis kemik metastaz sayısı (tek odak, çoklu odak) ve pelvik kemik metastazının (sakroiliak eklem, sakrum, ilium, ischium, pubis, asetabulum) lokalizasyonu açısından değerlendirildi.
Bulgular:Çalışmaya dahil edilen 151 hastanın ortalama yaşı 65.16 ± 12.01 (35-96)di. Çoklu pelvis kemik metastaz sıklığı kadınlarda (% 80.00) erkeklere (% 61.46) göre anlamlı derecede yüksekti (p = 0.030). Metastazın en sık görüldüğü yer her iki cinsiyet için de ilium idi. Metastazın en sık yerleşim yeri meme (% 61.76), prostat (% 44.44) ve jinekolojik (% 66.67) kanserler için ilium idi. Solunum sistemi kanseri metastazının en sık görüldüğü yerler sakrum (% 54.29) ve ilium (% 54.29) idi. Asetabulum gastrointestinal (% 72.73) ve üriner (% 58.33) sistem kanserleri için en yaygın metastaz bölgesiydi.
Sonuç:Bu çalışmanın sonucu olarak ilium, pelvisin en yaygın metastatik kemik bölgesidir. Primer kanserler genellikle pelvik halkaya çoklu metastaz yapma eğilimindedir. Pelvik halkanın metastazlarının daha fazla sayıda vaka ile değerlendirilmesi primeri bilinmeyen tümörlerin bulunmasında ipuçları sağlayabilir.
Keywords
References
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- 2-Coleman RE. Metastatic bone disease: clinical features, pathophysiology and treatment strategies, Cancer Treat. Rev. 2001;27:165–176, https://doi.org/10.1053/ctrv.2000.0210.
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- 4-Janjan N. Bone metastases: approaches to management. Semin Oncol 2001;28:28—34. DOI: 10.1016/s0093-7754(01)90229-5
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Abstract
Purpose:The aim of this stduy is to examine the distribution properties of pelvic bone metastases according to primary cancers and to reveal the properties of additional bone metastases that may accompany pelvic bone metastasis.
Patients and Methods:151 patients with pelvic bone metastases and without visceral metastases were included in the study. Clinical data, pathological diagnostic reports and PET-CT results of 151 patients were evaluated. The patients were evaluated in terms of age, gender, number of pelvic bone metastases (single focus, multiple focus) and localization of pelvic bone metastasis(sacroiliac joint, sacrum, ilium, ischium, pubis, acetabulum).
Results:Multiple pelvic metastasis frequency was significantly higher in the females (80.00%) than in the males (61.46%) (p=0.030). The most common location of the metastasis was ilium for both genders. The most common location of the metastasis was ilium for the breast (61.76%), prostate (44.44%) and gynecologic (66.67%) cancers. The most common locations of respiratory system cancers metastasis were sacrum (54.29%) and ilium (54.29%). Acetabulum was the most common metastasis location for gastrointestinal (72.73%) and urinary (58.33%) tract cancers.
Conclusion:As the result of this study the ilium is the the most common metastatic bone region of the pelvis. Primary cancers often tend to cause multiple metastases to the pelvic bone. Evaluating the metastases of the pelvic ring with larger number of cases may provide clues in finding the tumors of unknown primary.
Keywords
References
- 1-Mundy GR. Metastasis to bone: causes, consequences and therapeutic opportunities, Nat. Rev. Cancer 2002;2:584–593 https://doi.org/10.1038/nrc867.
- 2-Coleman RE. Metastatic bone disease: clinical features, pathophysiology and treatment strategies, Cancer Treat. Rev. 2001;27:165–176, https://doi.org/10.1053/ctrv.2000.0210.
- 3-Papagelopoulos PJ, Mavrogenis AF, Soucacos PN. Evaluation and treatment of pelvis metastases. Injury. 2007 Apr;38(4):509-520 https://doi.org/10.1016/j.injury.2007.01.008
- 4-Janjan N. Bone metastases: approaches to management. Semin Oncol 2001;28:28—34. DOI: 10.1016/s0093-7754(01)90229-5
- 5-Memon AG, Jaleel A, Aftab J. Patten of prostatic carcinoma metastases in bones detected by bone scans using Technitium 99m methyl dipohsphate (Tc99m MDP) imaging technique. Pak J Med Sci 2006; 22: 180–183.
- 6-Morgan JWM, Adcock KM, Donohue RE. Distribution of skeletal metastases in prostatic and lung cancer. Urology 1990; 36: 31–34. doi: 10.1016/0090-4295(90)80308-a.
- 7-Müller DA, Capanna R. The Surgical Treatment of Pelvic Bone Metastases. Advances in Orthopedics. 2015. https://doi.org/10.1155/2015/525363
- 8-Mingyu Z, Xin L, Yuan Q, et al. Bone metastasis pattern of cancer patients with bone metastasis but no visceral metastasis. J Bone Oncol. 2019;Apr; 15: 100219. DOI: 10.1016/j.jbo.2019.100219
- 9-Boyce BF, Yoneda T, Guise TA. Factors regulating the growth of metastatic cancer in bone, Endocr. Relat. Cancer. 1999;6:333–347. DOI: 10.1677/erc.0.0060333
- 10-Rubens RD. Bone metastases – the clinical problem, Eur. J. Cancer.1998;34: 210–213. DOI: 10.1016/s0959-8049(97)10128-9
- 11-Yin JJ, Pollock CB, Kelly K. Mechanisms of cancer metastasis to the bone, Cell Res. 15 (2005) 57–62, https://doi.org/10.1038/sj.cr.7290266.
- 12- Picci P, Manfrini M, Fabbri N et al. Atlas of Musculoskeletal Tumors and Tumorlike Lesions, Springer, Berlin, Germany, 2014.
- 13-W. Enneking W, Dunham M, Gebhardt M, et al. A system for the classification of skeletal resections. La Chirurgia degli Organi di Movimento. 1990;75(1): 217-240.
- 14-Kakhki VRD, Anvari K, Sadeghi R, et al. Pattern and distribution of bone metastases in common malignant tumors. Nuclear Medicine Review 2013,;16(2): 66–69. DOI: 10.5603/NMR.2013.0037
- 15-Wang CY, Shen Y, Zhu SB. Distribution features of skeletal metastases: a comparative study between pulmonary and prostate cancers, Plos One 2015;10, https://doi.org/10.1371/journal.pone.0143437
- 16-Kawamura H, Yamaguchi T, Yano Y, et al. Characteristics and Prognostic Factors of Bone Metastasis in Patients With Colorectal Cancer. Dis Colon Rectum. 2018 Jun;61(6):673-678. doi: 10.1097/DCR.0000000000001071.
- 17- Zhang L, Gong Z. Clinical Characteristics and Prognostic Factors in Bone Metastases from Lung Cancer. Med Sci Monit, 2017; Aug 24;23:4087-4094. DOI: 10.12659/msm.902971
- 18- C. Wang, Y. Shen, Study on the distribution features of bone metastases in prostate cancer. Nucl. Med. Commun. 2012;33: 379–383. DOI: 10.1097/MNM.0b013e3283504528
Details
| Primary Language | English |
|---|---|
| Subjects | Orthopaedics |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | April 1, 2021 |
| Submission Date | September 7, 2020 |
| Published in Issue | Year 2021 |