Abstract
References
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- 16. Henry BM, Aggarwal G, Wong J, et al. Lactate dehydrogenase levels predict coronavirus disease 2019 (COVID-19) severity and mortality: A pooled analysis. Am J Emerg Med. 2020;38(9):1722-6. DOI: 10.1016/j.ajem.2020.05.073.
The Effect of Clinical, Laboratory Findings and Parenchymal Infiltration Features on the Diameter of the Main Pulmonary Artery in COVID-19 Pneumonia
Abstract
Purpose: The main pulmonary artery diameter is an indirect indicator of pulmonary vascular bed resistance. In this study, it was aimed to reveal which parameters are associated with respiratory distress by evaluating the parameters affecting the diameter of the main pulmonary artery in cases with COVID-19 pneumonia.
Methods: The relationship between comorbid diseases, clinical findings, laboratory values, pulmonary infiltration features, and main pulmonary artery diameter (MPAD) was statistically evaluated.
Results: When MPAD 27.5 mm was considered as enlargement; it was significantly wider in smokers in COVID-19 pneumonia (p<0.05). It was statistically shown that there was not association with diabetes, hypertension, asthma, or COPD and MPAD (p>0.05). It was observed that MPAD was associated with shortness of breath (p=0.039; p<0.05) but not with cough and fever (p>0.05). Also, it was found that MPAD was significantly wider in cases with high CRP and LDH values (p=0.008; p<0.01, p=0.011; p<0.05, respectively). While MPAD did not differ significantly in those with ground-glass infiltration; MPAD was significantly larger in those with infiltration in the form of crazy-paving or consolidation (p<0.05). While there is no significant variation in MPAD in those with periferobasal involvement; MPAD was significantly wider in cases with central or mixed infiltration (p<0.05).
Conclusion: It is possible to indirectly predict respiratory distress in COVID-19 patients by measuring MPAD, which is associated with respiratory distress. Smoking, CRP and LDH values, central infiltration in the pattern of crazy-paving or consolidation are related with increased MPAD in COVID-19 pneumonia.
Keywords
COVID-19 SARS-CoV-2 respiratory distress main pulmonary artery diameter chest CT crazy-paving ground-glass opacity
References
- 1. WHO Coronavirus (COVID-19) Dashboard https://covid19.who.int/ access date 10.04.2021
- 2. Batah SS and Fabro AT. Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians. Respir Med. 2021;176:106239. DOI: 10.1016/j.rmed.2020.106239.
- 3. van Eijk LE, Binkhorst M, Bourgonje AR, et al. COVID-19: immunopathology, pathophysiological mechanisms, and treatment options. J Pathol. 2021:10.1002/path.5642. DOI: 10.1002/path.5642.
- 4. Chen X, Liu K, Wang Z, et al. Computed tomography measurement of pulmonary artery for diagnosis of COPD and its comorbidity pulmonary hypertension. Int J Chron Obstruct Pulmon Dis. 2015;10:2525-33. DOI: 10.2147/COPD.S94211.
- 5. Truong QA, Massaro JM, Rogers IS, et al. Reference values for normal pulmonary artery dimensions by noncontrast cardiac computed tomography: the Framingham Heart Study. Circ Cardiovasc Imaging. 2012;5:147-54. DOI:10.1161/CIRCIMAGING.111.968610
- 6. Bhalla V, Blish CA and South AM. A historical perspective on ACE2 in the COVID-19 era. J Hum Hypertens. 2020;1-5. DOI: 10.1038/s41371-020-00459-3
- 7. Tekcan Sanli DE, Yildirim D, Sanli AN, et al. Predictive value of CT imaging findings in COVID-19 pneumonia at the time of first-screen regarding the need for hospitalization or intensive care unit. Diagn Interv Radiol. 2020. DOI: 10.5152/dir.2020.20421.
- 8. Sanli DET, Yildirim D, Sanli AN, et al. A practical approach to imaging characteristics and standardized reporting of COVID-19: a radiologic review. Mil Med Res. 2021;8:7. DOI: 10.1186/s40779-021-00301-y.
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- 10. Santamarina MG, Boisier D, Contreras R, et al. COVID-19: a hypothesis regarding the ventilation-perfusion mismatch. Crit Care. 2020;24:395. DOI: 10.1186/s13054-020-03125-9.
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Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | March 15, 2022 |
| Submission Date | May 1, 2021 |
| Published in Issue | Year 2022 |