Research Article

Can Cellular Differentiation and Microvascular Invasion in Hepatocellular Carcinoma be Predicted by Contrast-Enhanced Computed Tomography?

Volume: 14 Number: 4 October 1, 2023
Acıbadem Üniversitesi Sağlık Bilimleri Dergisi Cover
Acıbadem Üniversitesi Sağlık Bilimleri Dergisi
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Can Cellular Differentiation and Microvascular Invasion in Hepatocellular Carcinoma be Predicted by Contrast-Enhanced Computed Tomography?

Abstract

Objective The purpose of our study was to examine the contrast-enhanced computed tomography (CECT) characteristics of hepatocellular carcinoma (HCC) in explanted liver, the association between microvascular invasion (MVI) and cellular differentiation, and to predict the severity of HCC. Material and Methods: CECT images of 54 surgically proven HCCs were evaluated with abdominal radiologist. Our CECT protocol was composed of precontrast, arterial, portal and delayed venous phases. The radiologist analysed the CT images for; tumor size, tumor margin, presence of intratumoral vessels; presence of capsule; intratumoral fat accumulation; and macroinvasion. The imaging features were correlated with cellular differentiation and MVI using Fisher's exact test or the χ2 test. Results: The results of our study indicated that there was a significant inverse correlation between the presence of capsule and MVI (p<0,05) and the grade of HCC (p=0,001) while a significant positive correlation was observed between macroinvasion and the grade of HCC (p=0,02). Conclusion: Patients with cirrhosis and HCC will be better managed if imaging techniques can predict tumor and MVI grade prior to treatment without necessitating a sample. MVI can be used to decide on treatment strategies and offer a more precise prognosis. For the preoperative prediction of MVI and tumor grade, the CECT-observed incomplete tumor capsule and the macroinvasion are crucial.

Keywords

References

  1. 1. Chou CT, Chen RC, Lin WC, et al. Prediction of microvascular invasion of hepatocellular carcinoma: preoperative CT and histopathologic correlation. AJR Am J Roentgenol. 2014 Sep;203(3): W253-9. doi: 10.2214/AJR.13.10595. 
  2. 2. Lim KC, Chow PK, Allen JC, et al. Microvascular invasion is a better predictor of tumor recurrence and overall survival following surgical resection for hepatocellular carcinoma compared to the Milan criteria. Ann Surg. 2011 Jul;254(1):108-13. doi: 10.1097/SLA.0b013e31821ad884.

Details

Primary Language

English

Subjects

Radiology and Organ Imaging

Journal Section

Research Article

Authors

Early Pub Date

August 21, 2023

Publication Date

October 1, 2023

Submission Date

August 11, 2022

Acceptance Date

August 3, 2023

Published in Issue

Year 2023 Volume: 14 Number: 4

DOI

https://doi.org/10.31067/acusaglik.1160673

IZ

https://izlik.org/JA66TJ32MP

Cite

RIS / Bibtex
EndNote
Altan Kus A, Koyuncu Sökmen B (October 1, 2023) Can Cellular Differentiation and Microvascular Invasion in Hepatocellular Carcinoma be Predicted by Contrast-Enhanced Computed Tomography? Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 14 4 587–593.