Research Article

The Role of Mitral Annular Calcification in Predicting One-Month Mortality in Patients with STEMI Undergoing Primary Percutaneous Coronary Intervention

Volume: 14 Number: 4 October 1, 2023
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The Role of Mitral Annular Calcification in Predicting One-Month Mortality in Patients with STEMI Undergoing Primary Percutaneous Coronary Intervention

Abstract

Purpose: Numerous cardiovascular disorders have been related to mitral annular calcification (MAC). This study looked at the effects of mitral annular calcification on one-month mortality in ST-segment elevation myocardial infarction (STE-MI) patients. Methods: This single-center, retrospective observational study was carried out between 2017 and 2021. The study included 1541 patients who presented to the Dr. Siyami Ersek Hospital emergency department with a diagnosis of STE-MI and underwent primary percutaneous intervention. The patients' clinical and demographic characteristics were investigated. Images taken during percutaneous intervention using angiography were used to assess the presence of MAC in patients. According to death, the patients were split into two groups, and a statistical analysis was done. Results: The median age of 1541 STE-MI patients included in the study was 59 years (51, 68) and 78% were male. While MAC was present in 134 patients (8.7%) in the whole group, the frequency of MAC was significantly higher in the deceased compared to the survivors (19% vs. 7.8%, p<0.001). The presence of MAC (OR = 2.84, 95% CI 1.68-4.63, p<0.001) was associated with death. In multivariable analysis hypertension (OR = 1.6, 95% CI 1.02-2.54, p = 0.043), platelet count (OR = 1, 95% CI 1.00-1.01, p = 0.02), LVEF (OR = 0.98, 95% CI 0.96-) 1.00, p = 0.024) and MAC (OR = 2.68, 95% CI 1.55- 4.50, p<0.001) were found to be independent predictors of death. Conclusion: In STE-MI patients, increased one-month mortality is strongly correlated with the presence of MAC during fluoroscopic primary percutaneous intervention.

Keywords

References

  1. GBD 2019 Stroke Collaborators. “Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.” The Lancet. Neurology vol. 20,10 (2021): 795-820. DOI:10.1016/S1474-4422(21)00252-0
  2. Nestico PF, Depace NL, Morganroth J et al. Mitral annular calcification: clinical, pathophysiology, and echocardiographic review. Am Heart J. 1984 May;107(5 Pt 1):989-96. DOI:10.1016/0002-8703(84)90840-8
  3. Adler Y, Fink N, Spector D et al. Mitral annulus calcification--a window to diffuse atherosclerosis of the vascular system. Atherosclerosis. 2001 Mar;155(1):1-8. DOI:10.1016/s0021-9150(00)00737-1
  4. Kanjanauthai S, Nasir K, Katz R, et al. Relationships of mitral annular calcification to cardiovascular risk factors: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2010 Dec;213(2):558-62. DOI:10.1016/j.atherosclerosis.2010.08.072
  5. Hamirani YS, Nasir K, Blumenthal RS et al. Relation of mitral annular calcium and coronary calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Am J Cardiol. 2011 May 1;107(9):1291-4. DOI:10.1016/j.amjcard.2011.01.005
  6. Abramowitz Y, Jilaihawi H, Chakravarty T et al. Mitral Annulus Calcification. J Am Coll Cardiol. 2015 Oct 27;66(17):1934-41. DOI:10.1016/j.jacc.2015.08.872
  7. Willens HJ, Chirinos JA, Schob A et al. The relation between mitral annular calcification and mortality in patients undergoing diagnostic coronary angiography. Echocardiography. 2006 Oct;23(9):717-22. DOI:10.1111/j.1540-8175.2006.00300.x
  8. Domienik-Karłowicz J, Kupczyńska K, Michalski B, et al. Fourth universal definition of myocardial infarction. Selected messages from the European Society of Cardiology document and lessons learned from the new guidelines on ST-segment elevation myocardial infarction and non-ST-segment elevation-acute coronary syndrome. Cardiol J. 2021;28(2):195-201. DOI: 10.5603/CJ.a2021.0036

Details

Primary Language

English

Subjects

Cardiovascular Medicine and Haematology (Other)

Journal Section

Research Article

Authors

Early Pub Date

September 21, 2023

Publication Date

October 1, 2023

Submission Date

August 16, 2023

Acceptance Date

August 30, 2023

Published in Issue

Year 2023 Volume: 14 Number: 4

DOI

https://doi.org/10.31067/acusaglik.1344156

IZ

https://izlik.org/JA24XX23NC

Cite

RIS / Bibtex
EndNote
Ceylan US, Karabay CY (October 1, 2023) The Role of Mitral Annular Calcification in Predicting One-Month Mortality in Patients with STEMI Undergoing Primary Percutaneous Coronary Intervention. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 14 4 528–533.