Relationship Between GRK4 Polymorphisms and Essential Hypertension. A Study in A Group of Turkish Subjects

Hale Yıldız; Beki Kan; Oya Orun; Cevdet Nacar; Yüksel Doğan; Özlem Güneysel; Hulya Cabadak

doi:10.31067/acusaglik.1351877

EN

Relationship Between GRK4 Polymorphisms and Essential Hypertension. A Study in A Group of Turkish Subjects

Abstract

Background/Purpose: G protein-coupled receptor kinase (GRK4) is associated with essential hypertension (EHT). GRK4 regulates sodium balance in the proximal tubules of the kidney. In this study, the possible roles of A142V and A486V polymorphisms in the development of hypertension were investigated in a Turkish population. Methods: Genomic DNA was obtained from white blood cells using the standard DNA isolation kit (Roche). Genotypes of variants of GRK4 were determined by Polymerase chain reaction (PCR) - Restriction fragment length polymorphism (RFLP) analysis. Results: In this study, GRKA142V and A486V polymorphisms were found to be associated with EHT in the Turkish population (P<0.05). The relationship between EHT and the A142V polymorphism was found to be more significant in men than in women. Conclusion: Our results show that A142V and A486V polymorphisms of the GRK4 were associated with EHT in a Turkish population. As far as we know, this is the first study on the association between the GRK4 A142V and A486V gene polymorphisms and essential hypertension in the Turkish population. GRK4 could be a new therapeutic target for hypertension

Keywords

Supporting Institution

Marmara Üniversitesi

Project Number

Marmara University Scientific Research Projects Coordination Unit (Istanbul/Turkey) under grant number SAG-C-YLP-171209-0333

Ethical Statement

Etik kurul beyanı eklenmiştir

Thanks

This work has been supported by Marmara University Scientific Research Projects Coordination Unit. We would like to thank Ph.D. student Zehra Kanlı for the Graphical abstract and Fig.1-2 figure format preparation

References

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Details

Primary Language

English

Subjects

Biochemistry and Cell Biology (Other)

Journal Section

Research Article

Authors

Hale Yıldız
0009-0005-9041-0496
Türkiye

Beki Kan
0000-0002-2738-9680
Türkiye

Oya Orun
0000-0003-1581-2207
Türkiye

Cevdet Nacar
0000-0002-8293-1495
Türkiye

Yüksel Doğan
0009-0004-0538-2068
Türkiye

Özlem Güneysel
0000-0002-1833-2199
Türkiye

Hulya Cabadak ^*
0000-0001-5757-2198
Türkiye

Publication Date

January 31, 2024

Submission Date

August 31, 2023

Acceptance Date

October 17, 2023

Published in Issue

Year 1970 Volume: 15 Number: 1

DOI

https://doi.org/10.31067/acusaglik.1351877

IZ

https://izlik.org/JA66BU24FH

Cite

RIS / Bibtex

EndNote

Yıldız H, Kan B, Orun O, Nacar C, Doğan Y, Güneysel Ö, Cabadak H (January 1, 2024) Relationship Between GRK4 Polymorphisms and Essential Hypertension. A Study in A Group of Turkish Subjects. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 15 1 1–7.