The Effect of Hashimoto's Thyroiditis on the Development of Thyroid Carcinoma

Sezin Doğan Çakır; Özlem Çelik; Özer Açbay

doi:10.31067/acusaglik.1394223

EN

The Effect of Hashimoto's Thyroiditis on the Development of Thyroid Carcinoma

Abstract

Background/Purpose: Our aim was to investigate whether Hashimoto’s Thyroiditis (HT) effects the development of thyroid carcinoma or not. Methods: We examined 772 patients’ file between january 2000 and december 2010 retrospectively at Istanbul University Cerrahpasa Medical School Endocrinology and Metabolism Clinic, whom fine-needle aspiration biopsy (FNAB) were applied. We noted patient’s demographic findings, anti-thyroglobulin antibody (anti-TG) and anti-thyroperoxidase antibody (anti-TPO) levels, ultrasonography (US) and cytology reports. We compared findings of HT patients with nonhashimoto control group. Results: 393 patients with mean age 46.11 ± 12.53 of whom 39 male and 354 female with HT and thyroid nodules (HT group) were compared with 379 patients with mean age 47.5 ± 12.6 of whom 53 male and 326 female with nonautoimmune thyroid disease and nodules (control group). We found the prevalance of differentiated thyroid carcinoma 6.6% in the HT group and backwards 12.9% in the control group (p=0.03). There were not any distinguishing US findings between groups. Anti-TPO positivity was significantly higher in benign nodules (p=0.008). Conclusion: Our findings did not point out an increased risk of Hashimoto’s nodules in terms of differentiated thyroid carcinoma development.

Keywords

References

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Details

Primary Language

English

Subjects

Endocrinology

Journal Section

Research Article

Authors

Sezin Doğan Çakır ^*
0000-0001-6641-7827
Türkiye

Özlem Çelik
0000-0002-7254-0757
Türkiye

Özer Açbay
0000-0003-4892-0626
Türkiye

Early Pub Date

March 27, 2024

Publication Date

April 1, 2024

Submission Date

November 21, 2023

Acceptance Date

January 31, 2024

Published in Issue

Year 2024 Volume: 15 Number: 2

DOI

https://doi.org/10.31067/acusaglik.1394223

IZ

https://izlik.org/JA72MW95MD

Cite

RIS / Bibtex

EndNote

Doğan Çakır S, Çelik Ö, Açbay Ö (April 1, 2024) The Effect of Hashimoto’s Thyroiditis on the Development of Thyroid Carcinoma. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 15 2 152–158.