Research Article

Geriatric Syndromes in Polymyalgia Rheumatica: A Cross-Sectional Study

Volume: 16 Number: 3 July 1, 2025
EN

Geriatric Syndromes in Polymyalgia Rheumatica: A Cross-Sectional Study

Abstract

Background/Purpose: Polymyalgia rheumatica (PMR) is a common inflammatory disorder in the elderly. Geriatric syndromes as losses in activities of daily living, fraility, nutritional deficits and sarcopenia were conditions that become increasingly prevalent with age. Whilist PMR is a disease mostly affects geriatric population, there is a scarce data about PMR and possible accompanying geriatric syndromes. We examined prevalence of the accompanying geriatric syndromes in PMR patients and compare with age (±<5years) and sex matched controls. Methods: Ten patients (8 female/2 male) diagnosed with PMR according to ACR/EULAR 2012 provisional PMR criteria and ten healthy controls were included to present study. Losses in activities of daily living was evaluated with Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs) Nutritional status were assessed with Mini-Nutritional Assessment Short Form. Muscle strength evaluated with hand grip test. Patients with lowered muscle strength were labeled as probable sarcopenia according to The European Working Group on Sarcopenia in Older People (EWGSOP2) 2018. Results: The mean age was 75±7,9 for patients and 75,7±7,9 6,6 for controls (p=0.9). Mean hand grip strength was significantly lower in PMR patients (p=0.04) and probable sarcopenia was strikingly more common in patient group (p=0.01). Difference between the groups in terms of activities of daily living, nutritional status was non-significant. Conclusion: Higher prevalence of sarcopenia was disclosed at immune mediated rheumatic disease patients in the previous studies. Current study indicates that PMR patients were significantly more prone to probable sarcopenia. Further efforts are needed to ameliorate the patients’ care, quality of life and well-being.

Keywords

References

  1. 1- Gazitt T, Zisman D, Gardner G. Polymyalgia Rheumatica: a Common Disease in Seniors. Curr Rheumatol Rep. 2020 Jun 19;22(8):40.
  2. 2- González-Gay MA, Matteson EL, Castañeda S. Polymyalgia rheumatica. Lancet. 2017 Oct 7;390(10103):1700-1712.
  3. 3- Nakajima S, Chiba A, Makiyama A et al. Association of mucosal-associated invariant T cells with different disease phases of polymyalgia rheumatica. Rheumatology (Oxford). 2020 Oct 1;59(10):2939-2946
  4. 4- Alvarez-Rodríguez L, Lopez-Hoyos M, Mata C et al.. Circulating cytokines in active polymyalgia rheumatica. Ann Rheum Dis. 2010 Jan;69(1):263-9
  5. 5- Salvarani C, Gabriel SE, O'Fallon WM, Hunder GG. Epidemiology of polymyalgia rheumatica in Olmsted County, Minnesota, 1970-1991. Arthritis Rheum. 1995 Mar;38(3):369-73.
  6. 6- Fulop T, Larbi A, Dupuis G et al. Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? Front Immunol. 2018 Jan 10;8:1960.
  7. 7- Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013). Frailty in elderly people. The Lancet, 381(9868), 752-762.
  8. 8- Dasgupta B, Cimmino MA, Maradit-Kremers H et. Al.. 2012 provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Ann Rheum Dis. 2012 Apr;71(4):484-92. doi: 10.1136/annrheumdis-2011-200329. PMID: 22388996; PMCID: PMC3298664.

Details

Primary Language

English

Subjects

Geriatrics and Gerontology , Rheumatology and Arthritis

Journal Section

Research Article

Early Pub Date

June 18, 2025

Publication Date

July 1, 2025

Submission Date

December 14, 2024

Acceptance Date

December 27, 2024

Published in Issue

Year 2025 Volume: 16 Number: 3

EndNote
Öztaş M, Suzan V (July 1, 2025) Geriatric Syndromes in Polymyalgia Rheumatica: A Cross-Sectional Study. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 16 3 376–380.