Evaluating the Impact of Dienogest on Quality of Life in Turkish Patients with Endometriosis: A Clinical Study

Tevfik Berk Bıldacı; Yasemin Ozgunayer Atmaca; Can Ata; Ufuk Atlıhan; Hüseyin Aytuğ Avşar; Selçuk Erkılınç

doi:10.31067/acusaglik.1668799

EN

Evaluating the Impact of Dienogest on Quality of Life in Turkish Patients with Endometriosis: A Clinical Study

Abstract

Purpose This study aimed to evaluate the effectiveness of dienogest in alleviating the negative effects associated with endometriosis in Turkish patients. The impact of the treatment on health-related quality of life (HRQoL) was assessed using the validated Turkish version of the Endometriosis Health Profile-30 (EHP-30) questionnaire. Methods A total of 119 patients with a confirmed diagnosis of endometrioma characterized by a unilocular cyst with homogeneous ground-glass echogenicity were included in this study, conducted at a tertiary care center. All participants were prescribed or already have been prescribed a continuous regimen of 2 mg/day dienogest for symptom control. Each patient completed the core section of the EHP-30 questionnaire twice: before treatment initiation and after a defined treatment period. Results A significant improvement was observed in total EHP-30 scores (from 96.92 to 52.03, p < .001). Notable improvements were also found in the pain (p < .001), self-image (p < .001), and emotional well-being (p < .001) subdomains. Changes in EHP-30 scores were not found to be significantly correlated with treatment duration, reduction in endometrioma size, or changes in CA125 levels. Conclusion Dienogest significantly improves quality of life even with short-term use and stands out as an effective treatment option for endometriosis.

Keywords

References

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Details

Primary Language

English

Subjects

Obstetrics and Gynaecology

Journal Section

Research Article

Authors

Tevfik Berk Bıldacı ^*
0000-0002-6432-6777
Türkiye

Yasemin Ozgunayer Atmaca
0009-0009-2633-634X
Türkiye

Can Ata
0000-0002-0841-0480
Türkiye

Ufuk Atlıhan
0000-0002-2109-1373
Türkiye

Hüseyin Aytuğ Avşar
0000-0003-0636-3104
Türkiye

Selçuk Erkılınç
0000-0002-6512-9070
Türkiye

Early Pub Date

September 15, 2025

Publication Date

October 1, 2025

Submission Date

April 1, 2025

Acceptance Date

June 24, 2025

Published in Issue

Year 2025 Volume: 16 Number: 4

DOI

https://doi.org/10.31067/acusaglik.1668799

IZ

https://izlik.org/JA75TT25MW

Cite

RIS / Bibtex

EndNote

Bıldacı TB, Ozgunayer Atmaca Y, Ata C, Atlıhan U, Avşar HA, Erkılınç S (October 1, 2025) Evaluating the Impact of Dienogest on Quality of Life in Turkish Patients with Endometriosis: A Clinical Study. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 16 4 534–539.

Öz

Evaluating the Impact of Dienogest on Quality of Life in Turkish Patients with Endometriosis: A Clinical Study

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Early Pub Date

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite