Is there Any Relationship Between Long-Term Mortality of Acute Pulmonary Embolism and Complete Blood Count Analysis?

Fatma Tokgöz Akyıl; Gökhan Söğüt; Murat Erdal Ozantürk; Ahmet Topbaş; Hasan Tütüncüler; Mustafa Akyıl; Tülin Sevim

doi:10.31067/acusaglik.832714

EN TR

Is there Any Relationship Between Long-Term Mortality of Acute Pulmonary Embolism and Complete Blood Count Analysis?

Abstract

Purpose:Acute pulmonary embolism (PE) is a challenging disease as the third most common cause of cardiovascular death. Despite various scoring systems and blood parameters, more simple and practical predictors are being investigated. The objective of this study is to investigate the relationship between hospital and long-term mortality and complete blood count parameters, neutrophil-to-lymphocyte ratio (PLR) and platelet-to-lymphocyte ratio (PLR) in patients with acute PE. Patients and Methods:The present study is a retrospective observational study. Between June 2016 and June 2018, patients hospitalised in our chest diseases clinic with evident PE were included. Demographics, baseline complete blood count, D-dimer (mg/L) and C-reaktif protein (mg/L) values were recorded. In-hospital mortality and long-term mortality were investigated and predictors of mortality were analyzed. Results:Of all the 74 pateints, 36 (49%) were male and the mean age was 65±18 (20-89). Embolus was localised in main pulmonary artery in 51%, right heart dysfunction were noted in 8 (10%) patients. Baseline NLR was significantly higher in patients who died in hospital (9.8±7.1 vs. 5.3±4.8, respectively) (P=0.037). Additionally NLR was found as a predictor of long-term mortality (P=.,047). The other predictors for long-term mortality were male gender (P=0.002), advanced age (P=0.023) and lower hemoglobin (P=0.013) values. Conclusion:Acute PE may lead mortality and require close follow-up of patients. Higher NLR values relate both in-hospital and long-term mortality and may be used as a cheap, simple and useful prognostic predictor in patients with PE.

Keywords

Akut Pulmoner Embolide Uzun Dönem Mortalite ile Tam Kan Sayımı Parametrelerinin İlişkisi Var mıdır?

Öz

Amaç:Akut pulmoner emboli (PE) kardiyovasküler hastalıklar içinde üçüncü sıklıkta ölüme neden olan önemli bir hastalıktır. Prognoz tayininde çeşitli skorlamalar ve periferik kan belirteçleri tanımlanmış olsa da daha pratik ve kolay ulaşılabilecek belirteçlerin arayışı devam etmektedir. Bu çalışmanın amacı akut PE hastalarında tam kan sayımı parametreleri, nötrofillerin lenfositlere oranı (NLO) ve plateletlerin lenfositlere oranı (PLO) ile hastane ve uzun dönem mortalitesi arasındaki ilişkiyi araştırmaktır. Hastalar ve Yöntem:Çalışma retrospektif, gözlemsel bir çalışmadır. Haziran 2016- Haziran 2018 tarihleri arasında göğüs hastalıkları kliniğimizde PE tanısı ile yatışı olan ve tanısı doğrulanan 74 hasta çalışmaya dahil edildi. Hastaların demografik özellikleri, bazal tam kan sayımı, D-dimer (mg/L) ve C-reaktif protein (mg/L) değerleri kaydedildi. Hastane ve uzun dönem mortalitesi ile ilişkili faktörler araştırıldı. Bulgular:Çalışmaya dahil edilen 74 hastanın yaş ortalaması 65±18 (20-89) ve 36’sı erkek (%49) idi. Emboli lokalizasyonu hastaların %51’inde ana pulmoner arterdeydi ve sağ kalp yüklenme bulguları 8 (%10) hastada eşlik etmekteydi. NLO ortalaması hastanede ölen hastalarda 9,8±7,1 saptanırken taburcu edilenlerden anlamlı olarak daha yüksekti (NLO=5,3±4,8) (P=0,037). Yüksek NLO değerleri uzun dönem takiplerde mortalite ile ilişkili bulundu (P=0,047). Uzun dönem mortalitesi ile ilişkili diğer faktörler erkek cinsiyet (P=0,002), düşük hemoglobin (P=0,013) ve ileri yaş (P=0,023) olarak saptandı. Sonuç:Akut PE yakın takip gerektiren mortalitesi yüksek bir hastalıktır. Yüksek NLO değerleri kısa ve uzun dönem mortalite ile ilişkilidir ve yüksek riskli hastaları belirlemek için kullanılabilecek ucuz, basit ve kullanışlı bir parametredir.

Anahtar Kelimeler

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Details

Primary Language

English

Subjects

Clinical Sciences

Journal Section

Research Article

Authors

Fatma Tokgöz Akyıl ^*
Türkiye

Gökhan Söğüt
Türkiye

Murat Erdal Ozantürk
Türkiye

Ahmet Topbaş
Türkiye

Hasan Tütüncüler
Türkiye

Mustafa Akyıl
Türkiye

Tülin Sevim
Türkiye

Publication Date

December 16, 2020

Submission Date

July 11, 2019

Acceptance Date

October 9, 2019

Published in Issue

Year 2021 Volume: 12 Number: 1

DOI

https://doi.org/10.31067/acusaglik.832714

IZ

https://izlik.org/JA34PG66KS

Cite

RIS / Bibtex

EndNote

Tokgöz Akyıl F, Söğüt G, Ozantürk ME, Topbaş A, Tütüncüler H, Akyıl M, Sevim T (December 1, 2020) Is there Any Relationship Between Long-Term Mortality of Acute Pulmonary Embolism and Complete Blood Count Analysis? Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 12 1 44–49.