Pre-operative predictive factors of grade II and III meningiomas

Mustafa Güdük; Baran Bozkurt; Murat Şakir Ekşi; Murat İmre Usseli; Mustafa Necmettin Pamir

doi:10.31067/acusaglik.834505

EN TR

Pre-operative predictive factors of grade II and III meningiomas

Abstract

Purpose:Meningiomas are the most common primary intracranial tumors. They are graded into three pathologic grades. Surgical gross total resection is the definitive treatment of meningiomas, but follow-up or stereotactic radiosurgery is sometimes advised for asymptomatic, incidentally diagnosed meningiomas. For a decision making, pre-operative prediction of Grade II and III meningiomas which are more aggressive clinically, is important. We have reviewed our intracranial meningioma series, based on their clinical, radiological, and location, to analyze the predictive factors of Grade II and III meningiomas. Patients and Methods:The clinical, radiological, operative and pathological reports of patients who were operated for intracranial meningiomas between September 1986 and July 2019 have been reviewed retrospectively from our patient database. Their age, sex, tumor location, absence or presence of peritumoral edema, and the pathological grade of meningiomas have been noted. The predictive effect of age, sex, peritumoral edema and location of tumor is analyzed statistically for pathological grade. Results:There were 1401 patients with intracranial meningiomas, 1015 of them were female, 386 were male (female/male=2.6). Their mean age was 52.2 years. There were 1219 Grade I, 164 Grade II, and 18 Grade III meningiomas. Male sex, and non-skull base location were predictive for Grade II and III meningiomas. Conclusion:While advising conservative treatment (follow-up, or stereotactic radiosurgery) for asymptomatic, incidental meningiomas, it should be kept in mind that male sex, and/or non-skull base location are risk factors for the more aggressive Grade II and III meningiomas.

Keywords

Derece II ve III meningiomların preoperatif prediktif faktörleri

Öz

Amaç:Meningiomlar en sık görülen primer intrakranyal patolojilerdir. Patolojik olarak üç dereceleri vardır. Cerrahi ile total rezeksiyon belirleyici tedavi olmakla beraber, özellikle asemptomatik ve insidental vakalarda, yakın takip veya stereotaktik radyocerrahi tercih edilebilmektedir. Cerrahi tedavi ile konservatif tedavi arasında karar verebilmek açısından, daha agresif klinik seyir gösterebilen Derece II ve III meningiomların, ön görülebilmesi önem taşımaktadır. Çalışmamızda, meningiom serimizde kayıtlı hastaların klinik, radyolojik ve yerleşim özelliklerine göre patolojik derecelerinde prediktif olabilecek etkenleri araştırdık. Hastalar ve Yöntem:İntrakranyal meningiom veri tabanımıza kayıtlı, Eylül 1986 ile Temmuz 2019 arasında opere edilen hastaların klinik, radyolojik, cerrahi ve patolojik raporları retrospektif olarak tarandı. Yaş, cinsiyet, tümör yerleşimi, peritümöral ödem olup olmaması, patolojik derecesi not edildi. Patoloji dereceleri açısından yaşın, cinsiyetin, ödemin ve tümör yerleşiminin prediktif olup olmadığı istatistiki yöntemler ile araştırıldı. Bulgular:Veri tabanımızda 1401 intrakranyal meningiom hastası tespit edildi. Hastaların 1015’i kadın, 386’sı erkekti (kadın/erkek=2,6). Ortalama yaşları 52,2 yıl idi. Bin iki yüz on dokuz Derece I, 164 Derece II, 18 Derece III meningiom vardı. Erkek cinsiyeti ve/veya kafa tabanı dışı yerleşim Derece II ve III meningiomlar için prediktif olarak tespit edildi. Sonuç:Asemptomatik, insidental olarak tespit edilen meningiomlarda, konservatif tedavi (yakın takip veya stereotaktik radyocerrahi) tercih edildiğinde, erkek ve/veya kafa tabanı dışı yerleşimli olanların, daha agresif davranışlı olan Derece II veya III olma ihtimalinin daha yüksek olduğu unutulmamalıdır.

Anahtar Kelimeler

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Details

Primary Language

English

Subjects

Clinical Sciences

Journal Section

Research Article

Authors

Mustafa Güdük ^*
Türkiye

Baran Bozkurt
Türkiye

Murat Şakir Ekşi
Türkiye

Murat İmre Usseli
Türkiye

Mustafa Necmettin Pamir
Türkiye

Publication Date

December 16, 2020

Submission Date

October 5, 2020

Acceptance Date

-

Published in Issue

Year 2021 Volume: 12 Number: 1

DOI

https://doi.org/10.31067/acusaglik.834505

IZ

https://izlik.org/JA45AD24KH

Cite

RIS / Bibtex

EndNote

Güdük M, Bozkurt B, Ekşi MŞ, Usseli Mİ, Pamir MN (December 1, 2020) Pre-operative predictive factors of grade II and III meningiomas. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 12 1 1–6.

Cited By

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Journal of Clinical Neuroscience

https://doi.org/10.1016/j.jocn.2021.07.022