Kronik Lenfositik Lösemide PD-1/PD-L1 Ekspresyon Düzeyleri ve Prognostik Önemi

Ayfer Gedük; Özgür Mehtap; Elif Birtaş Ateşoğlu; Pinar Tarkun; Esra Terzi Demirsoy; Meral Uluköylü Mengüç; Serkan Ünal; Sinan Mersin; Abdullah Hacıhanefioğlu; Tülin Burhanoğlu; Gülçin Gacar

doi:10.31067/acusaglik.850893

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Kronik Lenfositik Lösemide PD-1/PD-L1 Ekspresyon Düzeyleri ve Prognostik Önemi

Öz

Amaç:Çalışmamızda, kronik lenfositik lösemide (KLL) programlı hücre ölümü 1 (PD-1) ve programlı hücre ölümü ligandı 1 (PD-L1) ekspresyon düzeylerinin belirlenmesi ve prognoz üzerine etkilerinin değerlendirilmesi amaçlandı. Hastalar ve Yöntem:Kliniğimizde takip edilmiş ve tanı anında periferik kandan akım sitometrisi çalışılmış 92 hasta bu çalışmaya dahil edildi. Lenfositlerde %20 ve üzeri hücrede PD-1/PD-L1 boyanma varlığı pozitif olarak kabul edildi Bulgular:Hastaların ortanca takip süresi 31 (1-114) aydı. PD-1 pozitifliği hastaların 44’ünde (%47.8), PD-L1 pozitifliği ise 8’inde (%8.7) tespit edildi. Tüm kohortta ortalama PD-1 düzeyi %22.13±15.39, PD-L1 düzeyi ise %8.4±13.12 olarak saptandı. Ortanca genel sağkalıma ulaşılamamış olmakla birlikte 60. ayda PD-1 pozitif hastaların %69.1’i hayattayken, PD-1 negatif grupta bu oran %79’du (p=0.723). Yine 60. ayda PD-L1 pozitif hastaların %75’i hayattayken, PD-L1 negatif grupta bu oran %73.6’ydı (p=0.849). PD-1 negatif grupta ilk dizi tedavi sonrası kısmi yanıt ve üstü 18 (%85.7) hastada mevcutken, PD-1 pozitif grupta 10 (%71.4) hastada mevcuttu (p=0.401). Ortanca progresyonsuz sağkalım, PD-1 pozitif grupta 16 ay [ %95 GA,10.68-21.31] iken PD-1 negatif grupta 18 ay [%95 GA, 5.23-30.76] olarak tespit edildi (p=0.432). PD-1 pozitif hastalarda ikinci dizi tedaviye geçiş süresi 2 (0-25) ay iken, PD-1 negatif hastalarda 7 (0-80) ay olarak tespit edildi (p=0.372). Sonuç:KLL’de periferik kanda lenfositler üzerinde PD-1 ekspresyonu tespit edilmiş olup PD-L1 ekspresyon düzeyi oldukça düşük düzeyde saptandı. PD-1 ve PD-L1 pozitifliğinin prognoz üzerinde net bir etkisi gözlemlenmedi

Anahtar Kelimeler

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Details

Primary Language

Turkish

Subjects

Internal Diseases

Journal Section

Research Article

Authors

Ayfer Gedük ^*
Türkiye

Özgür Mehtap
Türkiye

Elif Birtaş Ateşoğlu
Türkiye

Pinar Tarkun
Türkiye

Esra Terzi Demirsoy
Türkiye

Meral Uluköylü Mengüç
Türkiye

Serkan Ünal
Türkiye

Sinan Mersin
Türkiye

Abdullah Hacıhanefioğlu
Türkiye

Tülin Burhanoğlu
Türkiye

Gülçin Gacar
Türkiye

Publication Date

April 1, 2021

Submission Date

April 17, 2020

Acceptance Date

-

Published in Issue

Year 1970 Volume: 12 Number: 2

DOI

https://doi.org/10.31067/acusaglik.850893

IZ

https://izlik.org/JA59WP65RT

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Gedük A, Mehtap Ö, Ateşoğlu EB, Tarkun P, Terzi Demirsoy E, Uluköylü Mengüç M, Ünal S, Mersin S, Hacıhanefioğlu A, Burhanoğlu T, Gacar G (April 1, 2021) Kronik Lenfositik Lösemide PD-1/PD-L1 Ekspresyon Düzeyleri ve Prognostik Önemi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 12 2 197–203.

PD-1/PD-L1 Expression Levels and Prognostic Significance in Chronic Lymphocytic Leukemia

Kronik Lenfositik Lösemide PD-1/PD-L1 Ekspresyon Düzeyleri ve Prognostik Önemi

Öz

Anahtar Kelimeler

PD-1/PD-L1 Expression Levels and Prognostic Significance in Chronic Lymphocytic Leukemia

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