Generic Cyclosporine in the Treatment of Dry Eye Disease

C: Banu Coşar; Ayşe Ebru Kılavuzoğlu; Ali Riza Cenk Celebi; Uğur Emrah Altıparmak

doi:10.31067/acusaglik.871316

EN

Generic Cyclosporine in the Treatment of Dry Eye Disease

Abstract

Objectives: To investigate the efficacy and safety of a generic Cyclosporine 0.05% ophthalmic emulsion in chronic dry eye disease. Materails and Methods: Thirty patients with dry eye disease were included in this observational, prospective study. Patients were examined at baseline, at month -1,-3 and 6 of the study. The following were evaluated at each visit: CDVA (corrected distance visual acuity), corneal and conjunctival staining (Oxford) score, TBUT (tear break-up time), Schirmer-2 score, OSDI (Ocular Surface Disease Index) score, patient’s subjective rating scale of ocular discomfort, daily use of concomittant artificial tears, the researcher's assessment of the global treatment response, and IOP (intraocular pressure). In addition, drug-related side effects were evaluated individually in each examination. When initiating dry eye treatment, cyclosporine was combined with topical loteprednol etabonate 0.5%. Results: There was a statistically significant improvement from baseline in corneal and conjunctival staining (decrease in mean Oxford score), TBUT, Schirmer-2 values, OSDI score, patient’s subjective rating score for ocular discomfort, and mean physician’s subjective assessment of global response to treatment at all follow-up visits (p<0.001). The mean daily use of artifical drops decreased statistically at all time points (<0.001). The most commonly reported adverse events were ocular burning (6.7%), followed by stinging (3.3%), conjunctival hyperemia (3.3%), foreign body sensation (3.3%), and visual disturbance (3.3%). Conclusion: Generic cyclosporine 0.05% ophthalmic emulsion with loteprednol etabonate 0.5% on initiation treatment has well-tolerability and improves subjective and objective measures of dry eye disease.

Keywords

References

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Details

Primary Language

English

Subjects

Ophthalmology

Journal Section

Research Article

Authors

C: Banu Coşar ^*
0000-0002-4018-9798
Türkiye

Ayşe Ebru Kılavuzoğlu
0000-0001-8990-9365
Türkiye

Ali Riza Cenk Celebi
0000-0002-7952-1241
Türkiye

Uğur Emrah Altıparmak
0000-0002-3262-5959
Türkiye

Publication Date

March 15, 2022

Submission Date

May 17, 2021

Acceptance Date

December 10, 2021

Published in Issue

Year 2022 Volume: 13 Number: 2

DOI

https://doi.org/10.31067/acusaglik.871316

IZ

https://izlik.org/JA59BB24ZG

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RIS / Bibtex

EndNote

Coşar CB, Kılavuzoğlu AE, Celebi ARC, Altıparmak UE (March 1, 2022) Generic Cyclosporine in the Treatment of Dry Eye Disease. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 13 2 241–246.

Öz

Generic Cyclosporine in the Treatment of Dry Eye Disease

Abstract

Keywords

References

Details

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Publication Date

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Acceptance Date

Published in Issue

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