Nöro-Oftalmolojik Hastalıklarda Optik Koherens Tomografisi

Abdulbaki Mudun

EN TR

Nöro-Oftalmolojik Hastalıklarda Optik Koherens Tomografisi

Öz

Optik Koherens Tomografisi OKT klinisyenlere optik sinir hastalıklarına yaklaşımda önemli bilgiler veren retina sinir lifi tabakası RSLT kalınlığını kantitatif olarak ölçme olanağı tanır. OKT cihazları artan tarama hızları sonucu gelişerek retina katlarının görüntülemesinde olağanüstü bir ayrıntıya ve hassasiyete ulaşılmıştır. OKT günümüzde çeşitli nöro-oftalmik durumlarda kullanılmaya başlanmıştır. Bunların arasında anterior iskemik optik nöropati AİON , toksik ve inflamatuar diğer optik nöropatiler, multiple sklerozis, nöromyelitis optika, psödotumor serebri, migren, optic sinir başı druseni, Leber’in herediter optik nöropatisi LHON , Alzheimer hastalığı ve Friedrich hastalığı yer almaktadır. Bu derlemenin amacı nöro-oftalmolojik hastalıklarda OKT kullanımı ile ilgili varolan yayınların gözden geçirilmesi ve klinik uygulamada kullanımını artırmaktır. OKT’nin optik sinir ve görme sistemi hastalıklarının değerlendirilmesinde yaygın kullanımı, nöro-oftalmolojik hastalıklardaki yargılarımızı, yaklaşımımızı, araştırmalarımızı ve anlayışımızı kökten değiştirmektedir

Anahtar Kelimeler

nörodejeneratif hastalıklar,optik koherens tomografisi,optik nöropati,retina sinir lifi tabakası

References

Frisen L, Hoyt WF. Insidious atrophy of retinal nerve fi bers in multiple sclerosis. Funduscopic identifi cation in patients with and without visual complaints. Arch Ophthalmol 1974; 92: 91–97.
Elbol P, Work K. Retinal nerve fi ber layer in multiple sclerosis. Acta Ophthalmol (Copenh) 1990; 68: 481–486.
Honrubia F, Calonge B. Evaluation of the nerve fi ber layer and peripapillary atrophy in ocular hypertension. Int Ophthalmol 1989; 13: 57–62.
Quigley HA, Addicks EM. Quantitative studies of retinal nerve fi ber layer defects. Arch Ophthalmol 1982; 100: 807–814.
Leigh RJ and Wolinsky JS. Keeping eye on MS. Neurology 2001; 57:751-752.
Traboulsee A, Dehmeshki J, Peters KR, Griffi n CM, Brex PA, Silver N, Ciccarrelli O, Chard DT, Barker GJ, Thompson AJ, Miller DH. Disability in multiple sclerosis is related to normal appearing brain tissue MTR histogram abnormalities. Mult Scler 2003; 9:566-573.
Frohman EM, Zhang H, Kramer PD, Fleckenstein J, Hawker K, Racke MK, Frohman TC. MRI characteristics of the MLF in MS patients with chronic internuclear ophthalmoparesis. Neurology 2001; 57:762-768.
Frohman EM, Frohman TC, O’Suilleabhain P, Zhang H, Hawker K, Racke MK, Frawley W, Phillips JT, Kramer PD. Quantitative oculographic characterization of internuclear ophthalmoparesis in multiple sclerosis:the versional dysconjugacy index Z score. J Neurol Neurosurg Psychiatry 2002; 73:51-55.

Fox RJ, McColl RW, Lee JC, Frohman T, Sakaie K, Frohman E. A preliminary validation study of diff usion tensor imaging as a measure of functional brain injury. Arch Neurol 2008; 65:1179-1184.
Comi G, Filippi M, Barkhof F, Durelli L, Edan G, Fernández O, Hartung H, Seeldrayers P, Sİrensen PS, Rovaris M, Martinelli V, Hommes OR; Early Treatment of Multiple Sclerosis Study Group. Eff ect of early interferon treatment on conversion to defi nite multiple sclerosis:a randomised study. Lancet 2001; 357:1576-1582.
Jacobs LD, Beck RW, Simon JH, Kinkel RP, Brownscheidle CM, Murray TJ, Simonian NA, Slasor PJ, Sandrock AW. Intramuscular interferon beta-1a therapy initiated during a fi rst demyelinating event in multiple sclerosis. CHAMPS Study Group. N Engl J Med 2000; 343:898-904.
Kappos L, Polman CH, Freedman MS, Edan G, Hartung HP, Miller DH, Montalban X, Barkhof F, Bauer L, Jakobs P, Pohl C, Sandbrink R. Treatment with interferon beta-1b delays conversion to clinically defi nite and McDonald MS in patients with clinically isolated syndromes. Neurology 2006; 67:1242-1249.
Kinkel RP, Kollman C, O’Connor P, Murray TJ, Simon J, Arnold D, Bakshi R, Weinstock-Gutman B, Brod S, Cooper J, Duquette P, Eggenberger E, Felton W, Fox R, Freedman M, Galetta S, Goodman A, Guarnaccia J, Hashimoto S, Horowitz S, Javerbaum J, Kasper L, Kaufman M, Kerson L, Mass M, Rammohan K, Reiss M, Rolak L, Rose J, Scott T, Selhorst J, Shin R, Smith C, Stuart W, Thurston S, Wall M; CHAMPIONS Study Group. IM interferon beta-1a delays defi nite multiple sclerosis 5 years after a fi rst demyelinating event. Neurology 2006; 66:678-684.
Frohman EM, Goodin DS, Calabresi PA, Corboy JR, Coyle PK, Filippi M, Frank JA, Galetta SL, Grossman RI, Hawker K, Kachuck NJ, Levin MC, Phillips JT, Racke MK, Rivera VM, Stuart WH. The utility of MRI in suspected MS: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2003;61:602–611.
Balcer LJ. Clinical practice: optic neuritis. N Engl J Med 2006; 354:1273-80.
Ikuta F, Zimmerman HM. Distribution of plaques in seventy autopsy cases of multiple sclerosis in the United States. Neurology 1976; 26:26–28.
Toussaint D, Périer O, Verstappen A, Bervoets S. Clinicopathological study of the visual pathways, eyes, and cerebral hemispheres in 32 cases of disseminated sclerosis. J Clin Neuroophthalmol 1983;3:211–220.
Frohman EM, Frohman TC, Zee DS, McColl R, Galetta S.The neuro-ophthalmology of multiple sclerosis. Lancet Neurol 2005; 4:111–121.
Toledo J, Sepulcre J, Salinas-Alaman A, García-Layana A, Murie-Fernandez M, Bejarano B, Villoslada P. Retinal nerve fi ber layer atrophy is associated with physical and cognitive disability in multiple sclerosis. Mult Scler. 2008; 14(7):906-12.
Fisher JB, Jacobs DA, Markowitz CE, Galetta SL, Volpe NJ, Nano-Schiavi ML, Baier ML, Frohman EM, Winslow H, Frohman TC, Calabresi PA, Maguire MG, Cutter GR, Balcer LJ. Relation of visual function to retinal nerve fi ber layer thickness in multiple sclerosis. Ophthalmology 2006; 113:324-332.
Costello F, Hodge W, Pan YI, Metz L, Kardon RH. Retinal nerve fi ber layer and future risk of multiple sclerosis. Can J Neurol Sci. 2008; 35:482-7.
Gordon-Lipkin E, Chodkowski B, Reich DS, Smith SA, Pulicken M, Balcer LJ, Frohman EM, Cutter G, Calabresi PA. Retinal nerve fi ber layer is associated with brain atrophy in multiple sclerosis. Neurology. 2007; 69:1603-9.
Naismith RT, Tutlam NT, Xu J, Shepherd JB, Klawiter EC, Song SK, Cross AH. Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis. Neurology 2009;73:46–52.
Siger M, Dziegielewski K, Jasek L, Bieniek M, Nicpan A, Nawrocki J, Selmaj K. Optical coherence tomography in multiple sclerosis: thickness of the retinal nerve fi ber layer as a potential measure of axonal loss and brain atrophy. J Neurol. 2008; 255:1555-60.
Frohman EM, Dwyer MG, Frohman T, Cox JL, Salter A, Greenberg BM, Hussein S, Conger A, Calabresi P, Balcer LJ, Zivadinov R. Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fi ber layer thickness, as assessed by OCT and GDx: a pilot study. J Neurol Sci. 2009 15; 282:96-105.
Salter A, Conger A, Frohman T, Zivadinov R, Eggenberger E, Calabresi P, Cutter G, Balcer L, Frohman E Retinal architecture predicts pupillary refl ex metrics in MS. Mult Scler. 2008.
Contreras I, Noval S, Rebolleda G, Muñoz-Negrete FJ. Follow-up of nonarteritic anterior ischemic optic neuropathy with optical coherence tomography. Ophthalmology. 2007; 114:2338-44.
Deleón-Ortega J, Carroll KE, Arthur SN, Girkin CA. Correlations between retinal nerve fi ber layer and visual fi eld in eyes with nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol. 2007;143:288-294.
Alasil T, Tan O, Lu AT, Huang D, Sadun AA. Correlation of Fourier domain optical coherence tomography retinal nerve fi ber layer maps with visual fi elds in nonarteritic ischemic optic neuropathy. Ophthalmic Surg Lasers Imaging. 2008; 39:71-9.
E. Marziani, P. Ramolfo, C. Mariani, S. Pomati, A. Giani, M. Cigada, G. Staurenghi. Evaluation of Retinal Nerve Fibre Layer and Ganglion Layer Cells Thickness as Biologic Marker of Alzheimer’s Disease Presentation Start/End Time: Sunday, May 03, 2009, 2:45 PM - 4:30 PM Location: Hall B/C Reviewing Code: 242 Imaging of the Retina in Health and Disease (Poster Only) - MOI Author Block: . AEye Clinic, BNeurology Clinic, 1University of Milan - Sacco Hospital, Milan, Italy.
Valenti DA. Neuroimaging of retinal nerve fi ber layer in AD using optical coherence tomography. Neurology. 2007; 69:1060.
Chai SJ, Foroozan R. Decreased retinal nerve fi bre layer thickness detected by optical coherence tomography in patients with ethambutol-induced optic neuropathy. Br J Ophthalmol. 2007; 91:895-7.
Fortuna F, Barboni P, Liguori R, Valentino ML, Savini G, Gellera C, Mariotti C, Rizzo G, Tonon C, Manners D, Lodi R, Sadun AA, Carelli V. Visual system involvement in patients with Friedreich’s ataxia. Brain. 2009;132:116-23.
de Seze J, Blanc F, Jeanjean L, Zéphir H, Labauge P, Bouyon M, Ballonzoli L, Castelnovo G, Fleury M, Defoort S, Vermersch P, Speeg C. Optical coherence tomography in neuromyelitis optica. Arch Neurol. 2008; 65: 920-3.
Choi SS, Zawadzki RJ, Keltner JL, Werner JS. Changes in cellular structures revealed by ultra-high resolution retinal imaging in optic neuropathies. Invest Ophthalmol Vis Sci. 2008; 49: 2103-19.
Barboni P, Carbonelli M, Savini G, Ramos C do VF, Carta A, Berezovsky A, Salomao SR, Carelli V,Sadun AA. Natural History of Leber’s Hereditary Optic Neuropathy: Longitudinal Analysis of the Retinal Nerve Fiber Layer by Optical Coherence Tomography Ophthalmology 2010;117:623–627.
Jafri MS, Tang R, Tang CM. Optical coherence tomography guided neurosurgical procedures in small rodents. J Neurosci Methods. 2009;176:85-95.

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Abdulbaki Mudun

Publication Date

March 1, 2011

Submission Date

-

Acceptance Date

-

Published in Issue

Year 2011 Number: 1

IZ

https://izlik.org/JA85YT43ME

Cite

RIS / Bibtex

EndNote

Mudun A (March 1, 2011) Nöro-Oftalmolojik Hastalıklarda Optik Koherens Tomografisi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 1 5–9.

Nöro-Oftalmolojik Hastalıklarda Optik Koherens Tomografisi

Optical Coherence Tomography In Neuro-Ophthalmological Diseases

Abstract

Keywords

Nöro-Oftalmolojik Hastalıklarda Optik Koherens Tomografisi

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

IZ

Cite