Otofaji: Bir Hücresel Stres Yanıtı ve Ölüm Mekanizması

Devrim Öz Arslan; Gözde Korkmaz; Devrim Gözüaçık

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Otofaji: Bir Hücresel Stres Yanıtı ve Ölüm Mekanizması

Öz

Otofaji uzun ömürlü proteinlerin, organellerin ve sitoplazmik parçacıkların parçalanmasından sorumlu fizyolojik bir fenomendir. Otofaji, lizozomal parçalanmadan sonra hücresel geridönüşümü sağlar ve hücrenin açlık, büyüme faktörü yokluğu ve oksidatif stres gibi çeşitli koşullarda hayatta kalmasına yardımcı olur. Paradoksal olarak bazı koşullar altında otofaji hücreyi kaspaz bağımsız yolak üzerinden, apoptotik olmayan hücre ölümüyle, öldürebilmektedir Tip II hücre ölümü ya da otofajik hücre ölümü . Birçok veri, klasik apoptoz ile otofaji arasında doğrudan bir bağlantı olduğunu işaret etmektedir ve bu bağlantı moleküler düzeyde aydınlatılmaya başlanmıştır. Apoptoz ve otofaji arasındaki karşılıklı etkileşim oldukça karışık gibi gözükmektedir. Fakat bu alandaki araştırmalar kanser, enfeksiyonlar ve nörodejenaratif hastalıklar gibi sağlık problemleri için yeni tanı, takip ve tedavi yöntemlerine yol açma potansiyeli nedeniyle çok büyük önem arz etmektedir

Anahtar Kelimeler

Otofaji,apoptoz,hayatta kalım,sinyal iletimi

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Turkish

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Devrim Öz Arslan

Gözde Korkmaz

Devrim Gözüaçık

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December 1, 2011

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Year 2011 Number: 4

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https://izlik.org/JA92FX68AY

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Arslan DÖ, Korkmaz G, Gözüaçık D (December 1, 2011) Otofaji: Bir Hücresel Stres Yanıtı ve Ölüm Mekanizması. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 4 184–194.

Otofaji: Bir Hücresel Stres Yanıtı ve Ölüm Mekanizması

Otofaji: Bir Hücresel Stres Yanıtı ve Ölüm Mekanizması

Öz

Anahtar Kelimeler

Autophagy: a Cellular Stres and Cell Death Mechanism

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