High Mobility Group Box 1 ve Kanser

Mustafa Yıldırım; Dinç Süren; Özlem Demirpençe; Vildan Kaya

EN TR

High Mobility Group Box 1 ve Kanser

Öz

Amaç: High mobility group box HMGB proteinler hücrede çok farklı fonksiyonları olan non-histon nükleer proteinlerdir. HMGB1 bu ailenin en önemli üyesidir. DNA’nın küçük oluğuna nonspesifik şekilde bağlanarak p53, steroid hormon reseptörleri de dahil olmak üzere bazı transkripsiyon faktörlerinin DNA ile etkileşimini modifiye eder. HMGB1‘in nekrotik hücrelerden pasif, inflamatuar hücrelerden aktif olarak sekrete edilerek en önemli reseptörü olan RAGE receptor for advanced glycation end products ’e bağlanır. HMGB1 Hücre farklılaşması, hücre göçü, tümör metastazı ve inflamasyonda da rol oynamaktadır. Kanser progresyonunda, anjiogenezde, invazyon ve metastaz gelişiminde HMGB1 rolü ile ilgili kanıtlar giderek artmaktadır. Yapılan çalışmalar HMGB1‘in kanser gelişiminde önemli bir role sahip olabileceğini düşündürmektedir. Bu nedenle HMGB1 ve reseptörü RAGE önemli bir tedavi hedefi olmaya başlamıştır. Bu nedenle HMGB1’in tedaviyi predikte etme ve prognozu belirlemedeki rolünü aydınlatacak çalışmaların hangi kanserlerin hedeflenebileceğini göstermesi açısından önemli olduğunu düşünüyoruz

Anahtar Kelimeler

high mobility group box B1,kanser,apoptozis,anjiogenez,hedef tedaviler

References

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Turkish

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Mustafa Yıldırım

Dinç Süren

Özlem Demirpençe

Vildan Kaya

Publication Date

September 1, 2014

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-

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Year 2014 Number: 3

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https://izlik.org/JA42TA93UB

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EndNote

Yıldırım M, Süren D, Demirpençe Ö, Kaya V (September 1, 2014) High Mobility Group Box 1 ve Kanser. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 3 182–186.

High Mobility Group Box 1 ve Kanser

High Mobility Group Box 1 and Cancer

Abstract

Keywords

High Mobility Group Box 1 ve Kanser

Öz

Anahtar Kelimeler

References

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Subjects

Journal Section

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Submission Date

Acceptance Date

Published in Issue

IZ

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