Wernicke Encephalopathy, Miller Fisher Syndrome; Differential Diagnostic Details In The Context of Case Presentation

Wernicke Encephalopathy WE is a treatable neurological disorder known since 1881 and has a high mortality and morbidity rate if left untreated. Although the classical triad of symptoms are confusion, ataxia and ophtalmoparesis, different findings such as decreased deep tendon reflexes, areflexia or weakness has been reported. Another neurological disorder, Miller Fisher Syndrome MFS has a similar triad of ataxia, ophtalmoparesis and areflexia and reports of patients who have been mistakenly diagnosed with one of the two conditions are noteworthy in the medical literature. In this report we describe a patient who was initially considered as MFS and later was diagnosed with WE. We discuss the striking similarities and differential diagnosis of WE and MFS

Wernicke ensefalopatisi WE , 1881 yılından beri bilinen mortalitesi ve morbiditesi yüksek, tedavisi mümkün nörolojik bir hastalıktır. Hastalığın klinik triadı konfüzyon, ataksi, oftalmoparezi olmakla birlikte derin tendon reflekslerinde azalma, arefleksi ve kas güçsüzlüğü de ek klinik bulgular olarak bildirilmiştir. Miller Fisher sendromunun klasik triadı ise ataksi, oftalmoparezi, arefleksidir ve benzer klinik bulguları içeren bu iki klinik tanının karıştırıldığına dair literatür dikkat çekicidir. Bu yazıda, başlangıçta Miller Fisher Sendromu düşünülüp daha sonra Wernicke Ensefalopatisi teşhisi konan olgu eşliğinde klinik yanılsama durumu tartışılmıştır