Norethisteron Induced Cholestasis: A Case Report

Number: 2 June 1, 2014
  • Elif Yorulmaz
  • Serhat Özçelik
  • Ahmet Engin Atay
  • Muhammed Kızılgül
  • Önder Peker
  • İlyas Tuncer
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Norethisteron Induced Cholestasis: A Case Report

Abstract

Norethisteron is a progesterone-only oral contraceptive OCS that is widely used in some gynecological disorders. The side effects of the drug are nausea, vomiting, thromboembolia and hypertension, however rarely do these lead to cholestasis. We present a 42-year-old female patient admitted with fatigue, jaundice, dark urine, itching subsequent to use of norethisteron for amenorrhea. Due to sustained elevation of bilirubin and cholestasis enzymes, the patient underwent a liver biopsy. Histopathologic examination revealed canalicular cholestasis which is usually observed subsequent to administration of steroidal drugs. The patient responded well to steroid administration, and clinical and biochemical recovery were achieved on the 6th month of therapy

Keywords

References

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Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Elif Yorulmaz

Serhat Özçelik

Ahmet Engin Atay

Muhammed Kızılgül

Önder Peker

İlyas Tuncer

Publication Date

June 1, 2014

Submission Date

-

Acceptance Date

-

Published in Issue

Year 1970 Number: 2

IZ

https://izlik.org/JA62LC65FD

Cite

RIS / Bibtex
EndNote
Yorulmaz E, Özçelik S, Atay AE, Kızılgül M, Peker Ö, Tuncer İ (June 1, 2014) NORETHİSTERONA BAĞLI KOLESTAZ: BİR OLGU SUNUMU. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2 171–173.