Diagnostic Role of Scd14-Subtype As a Sepsis Biomarker In Febrile Neutropenic Pediatric Oncology Patients

Şebnem Kuter; Cengiz Canpolat; Kaan Yılancıoğlu

EN TR

Diagnostic Role of Scd14-Subtype As a Sepsis Biomarker In Febrile Neutropenic Pediatric Oncology Patients

Abstract

Introduction and Objective: Febrile neutropenia FN is one of the most common complications of cancer chemotherapy and requires urgent treatment. Upon diagnosis of childhood FN, culture samples should be obtained and a broad spectrum antibiotherapy should be administered immediately. However, bacterial infections are not the only cause of fever in neutropenic pediatric patients; chemotherapeutics, the disease itself, as well as viral and fungal agents can also be the cause of fever. Various biomarkers have been studied to differentiate the cause of fever to date. Infections are mostly lethal in neutropenic patients, early stage differential biomarkers are, therefore, of utmost importance. It is the aim of this study to assess the potential of presepsin as an additional diagnostic tool for the detection of bacteremia/sepsis in childhood Febrile Neutropenia FN patients. Methods: Twenty-four pediatric patients, with a total 29 febrile neutropenic episodes were enrolled in this study. One patient with 3 FN episodes, three patients with 2 FN episodes were admitted to our clinic during the study. Patients were classified into bacteremia/sepsis and fever without origin groups. Serum samples were collected after confirmation of FN and analyzed for presepsin, c-reactive protein CRP and procalcitonin PCT according to instructions of manufacturers. Results: Biomarkers failed to display a discriminative value between bacteremia/sepsis and fever without origin groups, whereas presepsin was found to be an indicator of the presence of bacterial growth in hemoculture and was shown to have a potential diagnostic value.Conclusion: Presepsin might be used as an additional diagnostic tool for the detection of bacteremia/sepsis in childhood FN patients

Keywords

Biomarker,Febrile Neutropenia,Presepsin,sCD14-subtype

ATEŞLI NÖTROPENIK PEDIATRIK ONKOLOJI HASTALARINDA SCD14 ALT TIPININ SEPSIS BIYOBELIRTECI OLARAK TANIDAKI ROLÜ

Öz

Giriş ve Amaç: Bu çalışmada, Çocukluk çağında gelişen Febril Nötropeni FN hastalarında presepsin’in bakteriyemi/sepsisin saptanmasında ek bir tanı aracı olarak potansiyelini değerlendirmek amaçlanmıştır. Febril nötropeni kanser kemoterapisinin en yaygın komplikasyonlarından biridir ve acilen bir tedavi gerektirir. FN’ de kültür örnekleri alınmalı ve hızlı bir şekilde geniş spektrumlu antibiyoterapi uygulanmalıdır. Nötropenik hastalarda ateşin tek nedeni bakteriyel enfeksiyon değildir. Kemoterapötikler, hastalığın kendisi, viral ve fungal ajanlar ateşin diğer sebepleri olabilir. Ateş nedenini ayırt etmek için çeşitli biyolojik belirteçler araştırılmaktadır. Enfeksiyonlar nötropenik hastalarda çoğunlukla öldürücüdür, bu nedenle erken evredeki farklı biyobelirteçler bulunması son derece önemlidir.Yöntem: Toplam 29 febril nötropenik atak ve 24 pediatrik hasta çalışmaya alındı. Hastalar, bakteriemi/sepsis ve odağı olmayan ateş grubu olarak sınıflandırıldı. Serum örnekleri, FN teşhisi sonrasında toplandı ve presepsin, c-reaktif protein CRP ve prokalsitonin PCT konsantrasyonları analiz edildi.Bulgular: Bilinen biyolojik belirteçler, bakteriemi/sepsis ile odağı olmayan ateş grubu arasında ayırt edici bir değer göstermezken, presepin, hemokültürde bakteri gelişiminin bir göstergesi olarak anlamlı bulundu ve potansiyel bir tanısal değeri olduğu gösterildi.Sonuç: Presepsin, çocukluk çağı FN’li hastalarda bakteriyemi/sepsis tespiti için ilave bir tanı aracı olarak kullanılabilir

Anahtar Kelimeler

Biyobelirteç, Febril Nötropeni, Presepsin, sCD14-alt tipi

References

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Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Şebnem Kuter

Cengiz Canpolat

Kaan Yılancıoğlu

Publication Date

December 1, 2018

Submission Date

-

Acceptance Date

-

Published in Issue

Year 2018 Number: 4

IZ

https://izlik.org/JA88HA48HK

Cite

RIS / Bibtex

EndNote

Kuter Ş, Canpolat C, Yılancıoğlu K (December 1, 2018) Diagnostic Role of Scd14-Subtype As a Sepsis Biomarker In Febrile Neutropenic Pediatric Oncology Patients. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 4 395–400.