Serbest Mitokondriyal DNA’nın Sistemik Dolaşımdaki Rolü ve Hastalıkların Patogenezine Etkisi

Ayşe Tülay Aydınoğlu; Evrim Aksu Mengeş; Burcu Balcı Hayta

EN TR

Serbest Mitokondriyal DNA’nın Sistemik Dolaşımdaki Rolü ve Hastalıkların Patogenezine Etkisi

Abstract

Mitokondri, oksidatif fosforilasyon ile ATP üretiminin yanı sıra üstlendiği görevler ile hücre canlılığının sürdürülebilmesinde merkezi öneme sahip çok işlevli bir organeldir. Organelin hücre canlılığına katkıda bulunmasında rol oynayan en temel özelliklerinden biri de kendine özgül genetik sistemidir. Mitokondriyal DNA mtDNA ’nın normal fizyolojik koşullarda organelin matriks kısmında bulunduğu, fakat gerek organel gerekse hücre hasarı olduğu durumda hücre dışı matrise salınarak serbest dolaşıma katıldığı belirtilmiştir. Özellikle son yıllarda mtDNA’ya ilişkin yapılan çalışmalar, organel genomunun dolaşımda üstlendiği roller ve hastalıklarla ilişkisi üzerine yoğunlaşmıştır. Sistemik dolaşımda serbest halde bulunan mtDNA’lar [circulating cell free mtDNA ccf-mtDNA ] bağışıklık sisteminde görevli Kalıp Tanıma Reseptörleri [Pattern Recognition Receptors PRRs ] tarafından Hasarla İlişkili Moleküler Yapılar [Damage Associated Molecular Patterns DAMPs ] olarak algılanarak pro-inflamatuar yanıt oluşumunda temel bir rol üstlenmektedir. Bu derlemede, ccf-mtDNA’nın sistemik dolaşıma katılma mekanizmaları ve etkileşimde bulunduğu yolakların detayına inilerek, bağışıklık sisteminin bir uyaranı olarak görev almasına ve hastalıklarla ilişkisine dair bilgiler özetlenmiştir

Keywords

ccf-mtDNA,sistemik dolaşım,inflamasyon

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Turkish

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Authors

Ayşe Tülay Aydınoğlu

Evrim Aksu Mengeş

Burcu Balcı Hayta

Publication Date

September 1, 2020

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Year 2020 Number: 3

IZ

https://izlik.org/JA54ZB23RK

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RIS / Bibtex

APA

Aydınoğlu, A. T., Mengeş, E. A., & Hayta, B. B. (2020). Serbest Mitokondriyal DNA’nın Sistemik Dolaşımdaki Rolü ve Hastalıkların Patogenezine Etkisi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 3, 372-379. https://izlik.org/JA54ZB23RK

AMA

1.Aydınoğlu AT, Mengeş EA, Hayta BB. Serbest Mitokondriyal DNA’nın Sistemik Dolaşımdaki Rolü ve Hastalıkların Patogenezine Etkisi. Acibadem Univ Saglik Bilim Derg. 2020;(3):372-379. https://izlik.org/JA54ZB23RK

Chicago

Aydınoğlu, Ayşe Tülay, Evrim Aksu Mengeş, and Burcu Balcı Hayta. 2020. “Serbest Mitokondriyal DNA’nın Sistemik Dolaşımdaki Rolü Ve Hastalıkların Patogenezine Etkisi”. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, nos. 3: 372-79. https://izlik.org/JA54ZB23RK.

EndNote

Aydınoğlu AT, Mengeş EA, Hayta BB (September 1, 2020) Serbest Mitokondriyal DNA’nın Sistemik Dolaşımdaki Rolü ve Hastalıkların Patogenezine Etkisi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 3 372–379.

IEEE

[1]A. T. Aydınoğlu, E. A. Mengeş, and B. B. Hayta, “Serbest Mitokondriyal DNA’nın Sistemik Dolaşımdaki Rolü ve Hastalıkların Patogenezine Etkisi”, Acibadem Univ Saglik Bilim Derg, no. 3, pp. 372–379, Sept. 2020, [Online]. Available: https://izlik.org/JA54ZB23RK

ISNAD

Aydınoğlu, Ayşe Tülay - Mengeş, Evrim Aksu - Hayta, Burcu Balcı. “Serbest Mitokondriyal DNA’nın Sistemik Dolaşımdaki Rolü Ve Hastalıkların Patogenezine Etkisi”. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi. 3 (September 1, 2020): 372-379. https://izlik.org/JA54ZB23RK.

JAMA

1.Aydınoğlu AT, Mengeş EA, Hayta BB. Serbest Mitokondriyal DNA’nın Sistemik Dolaşımdaki Rolü ve Hastalıkların Patogenezine Etkisi. Acibadem Univ Saglik Bilim Derg. 2020;:372–379.

MLA

Aydınoğlu, Ayşe Tülay, et al. “Serbest Mitokondriyal DNA’nın Sistemik Dolaşımdaki Rolü Ve Hastalıkların Patogenezine Etkisi”. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, no. 3, Sept. 2020, pp. 372-9, https://izlik.org/JA54ZB23RK.

Vancouver

1.Ayşe Tülay Aydınoğlu, Evrim Aksu Mengeş, Burcu Balcı Hayta. Serbest Mitokondriyal DNA’nın Sistemik Dolaşımdaki Rolü ve Hastalıkların Patogenezine Etkisi. Acibadem Univ Saglik Bilim Derg [Internet]. 2020 Sep. 1;(3):372-9. Available from: https://izlik.org/JA54ZB23RK

The Role of Circulating Cell-Free Mitochondrial Dna In Systemic Circulation and Its Effect On Diseases Pathogenesis

Abstract

Keywords

Serbest Mitokondriyal DNA’nın Sistemik Dolaşımdaki Rolü ve Hastalıkların Patogenezine Etkisi

Abstract

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