Predictive Value of the Intestinal Free Fatty Acid Binding Protein in Celiac Disease

Pınar Gökçen; Erol Çakmak; Gupse Adalı; Halef Dogan; Hatice Özer; Oguzhan Ozturk; Hamdi Levent Doğanay; Kamil Ozdil

doi:10.31067/acusaglik.979140

EN

Predictive Value of the Intestinal Free Fatty Acid Binding Protein in Celiac Disease

Abstract

Purpose: Non-invasive tests used in the screening and follow-up of celiac disease (CD) are currently below expectations because they show false negatives/positives and are not always correlated with duodenal histology. We aimed to investigate the predictive value of intestinal free fatty acid binding protein (FABP-I) which can easily be released into the circulation in the presence of enterocyte damage in a short time in CD. Methods: This study included 59 patients with CD who were not on gluten free diet (GFD)(n=24) and who were on GFD(n=35) and 52 healthy controls. Demographic variables, complete blood count, ferritin, vitamin D, calcium, phosphorus, vitamin B12, prothrombin time, INR, and serum FABP-I levels were recorded for all groups. Results: There was no difference between the groups in terms of complete blood count, ferritin, calcium, phosphorus, vitamin B12, prothrombin time and INR (all p>0.05). Mean serum FABP-I was determined as 499.2±33.3 ng/L for patients with CD who were not on GFD and as 487.7±48.0 ng/L for who were on GFD, and these values were significantly higher when compared to the healthy controls 432.2±63.8 ng/L(p<0.001). The sensitivity, specificity, positive predictive value, and negative predictive value of FABP-I for a cut-off value of 456.8 ng/L were 84.7%, 69.2%, 10.2% and 61.5%, respectively(AUC=0.785). Conclusion: This study has shown that FABP-I can serve as a non-invasive predictive marker for CD diagnosis. Overlooked diagnosis in serology-negative patients and false serology positivity for reasons other than CD will be prevented with its use in clinical practice since FABP-I directly reflects intestinal damage.

Keywords

Supporting Institution

This work is supported by the Scientific Research Project Fund of Cumhuriyet University

Project Number

T-762.

References

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Details

Primary Language

English

Subjects

Gastroenterology and Hepatology

Journal Section

Research Article

Authors

Pınar Gökçen ^*
Türkiye

Erol Çakmak
0000-0002-6468-3483
Türkiye

Gupse Adalı
0000-0002-6468-3483
Türkiye

Halef Dogan
0000-0001-8738-0760
Türkiye

Hatice Özer
0000-0001-6479-3626
Türkiye

Oguzhan Ozturk
0000-0002-7718-8684
Türkiye

Hamdi Levent Doğanay
0000-0002-2263-6689
Türkiye

Kamil Ozdil
0000-0003-2556-3064
Türkiye

Publication Date

January 1, 2022

Submission Date

August 6, 2021

Acceptance Date

November 16, 2021

Published in Issue

Year 2022 Volume: 13 Number: 1

DOI

https://doi.org/10.31067/acusaglik.979140

IZ

https://izlik.org/JA47CP26NX

Cite

RIS / Bibtex

EndNote

Gökçen P, Çakmak E, Adalı G, Dogan H, Özer H, Ozturk O, Doğanay HL, Ozdil K (January 1, 2022) Predictive Value of the Intestinal Free Fatty Acid Binding Protein in Celiac Disease. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 13 1 30–35.