Abstract
Randomize kontrollü çalışmamızın amacı luteal faz desteğinin başlamasında farklı zaman sürelerinin in vitro fertilizasyon IVF siklüslerinde klinik sonuçlar üzerine etkisini araştırmaktır. Ardışık 180 IVF siklüsünün 92’si A grubu, 88’i B grubu olarak düzenlendi. Grup A’da luteal faz vajinal mikronize progesteron, oosit toplanmasından OPU hemen sonra, grup B’de ise OPU sonrası 48. saatte başlandı. Her iki grupta da transfer başına klinik gebelik oranı ve embriyo başına implantasyon oranı benzer bulundu sırasıyla %34.ve %35.4, p:1.00; %13.8 ve %15.3, p:0.59 . Çalışma gruplarındaki abortus oranları arasında fark izlenmedi. IVF siklüslerinde progesteron desteğinin OPU günü ya da 48 saat sonra başlanması klinik sonuçları değiştirmemektedir
Keywords
References
- Soliman S, Daya S, Collins J, et al.: The role of luteal phase support in infertility treatment: a meta-analysis of randomized trials. Fertil Steril 1994; 61:1068-1076.
- Pritts EA, Atwood AK: Luteal phase support in infertility treatment: a meta-analysis of the randomized trials. Hum Reprod. 2002; 17: 2287-2299.
- Ludwig M, Diedrich K.: Evaluation of an optimal luteal phase support protocol in IVF. Acta Obstet Gynecol Scand. 2001; 80: 452-466.
- Fanchin R, Righini C, Olivennes F, et al.: Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization. Hum Reprod. 1998; 13:1968-1974.
- Nikas G.:Pinopodes as markers of endometrial receptivity in clinical practive. Hum Reprod. 1999; 14(Supple.2): 99-106.
- Chang SY, Soong YK, Chang MY, et al.: Immediate versus delayed progesterone supplementation in gamete intrafallopian transfer. J In Vitro Fert Embryo Transfer. 1989; 6: 275-279.
- Williams SC, Oehninger S, Gibbons WE, et al. : Delaying the initiation of progesterone supplementation results in decreased pregnancy rates after in vitro fertilization: a randomized, prospective study. Fertil Steril. 2001; 76: 1140-1143.
Abstract
The purpose of the current prospective randomized controlled study is to investigate whether the different time periods for the initiation of luteal phase support modify the clinical outcomes in in vitro fertilization IVF cycles. Out of 180 consecutive cycles, 92 were assigned to group A and 88 were assigned to group B. In group A, luteal phase was supplemented with intravaginal micronized progesterone starting right after the follicular puncture, while in group B, the same dose was started intravaginally 48 hours after the oocyte retrieval. The clinical pregnancy rate per transfer and implantation rate per embryo were similar in groups A and B 34.8% and 35.4%, p:1.00; 13.8% and 15.3%, p:0.59; respectively . Abortion rates were also comparable between the two study groups. Initiation of the progesterone supplementation either on the day of oocyte retrieval or 48 hours later does not alter clinical outcomes in IVF cycles
References
- Soliman S, Daya S, Collins J, et al.: The role of luteal phase support in infertility treatment: a meta-analysis of randomized trials. Fertil Steril 1994; 61:1068-1076.
- Pritts EA, Atwood AK: Luteal phase support in infertility treatment: a meta-analysis of the randomized trials. Hum Reprod. 2002; 17: 2287-2299.
- Ludwig M, Diedrich K.: Evaluation of an optimal luteal phase support protocol in IVF. Acta Obstet Gynecol Scand. 2001; 80: 452-466.
- Fanchin R, Righini C, Olivennes F, et al.: Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization. Hum Reprod. 1998; 13:1968-1974.
- Nikas G.:Pinopodes as markers of endometrial receptivity in clinical practive. Hum Reprod. 1999; 14(Supple.2): 99-106.
- Chang SY, Soong YK, Chang MY, et al.: Immediate versus delayed progesterone supplementation in gamete intrafallopian transfer. J In Vitro Fert Embryo Transfer. 1989; 6: 275-279.
- Williams SC, Oehninger S, Gibbons WE, et al. : Delaying the initiation of progesterone supplementation results in decreased pregnancy rates after in vitro fertilization: a randomized, prospective study. Fertil Steril. 2001; 76: 1140-1143.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 1, 2010 |
| Published in Issue | Year 2010Issue: 4 |