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An Overview To Cytokeratin Pattern of Cholesteatoma

Year 2015, Issue: 1, 1 - 6, 01.03.2015

Ahmet Koç Emrah Emre

Abstract

Cholesteatoma is a destructive pathology characterized with progressive and chronic infiltration of keratinized squamous epithelium that can be seen the middle ear and mastoid regions of temporal bone. It has serious intra and extracranial complications which can be difficult to manage. Embryologic remnants of squamous epithelium, squamous metaplasia of middle ear epithelium, migration of epidermal cells from external ear canal and tympanic membrane and cell seeding because of middle ear surgery or trauma were all stated as causes of cholesteatoma. Cytokeratins are important markers of cell differentiation. The patterns of cytokeratin expression correlate well with the state of keratinocyte proliferation, migration and differentiation. These patterns are known to be affected during the formation of cholesteatoma. Increasing our knowledge about cytokeratin patterns may help us understand the unknown formation of cholesteatoma. In this review article, a literature survey was done about cytokeratin patterns of cholesteatoma

Keywords

cholesteatoma cytokeratin

References

  • Gray D. The treatment of cholesteatoma in children. Proceedings of the Royal Society of Medicine, London, 1964;57: 769-771
  • Osma C, Cureoglu S, Hosoglu S. The complications of chronic otitis media: report of 93 cases. J Laryngol Otol 2000;114:97-100
  • Sennaroglu L, Sozeri B. Otogenic brain abscess: review of 41 cases. Otolarygol Head Neck Surg 2000;123:751-755
  • Yetiser S, Tosun F, Kazkayasi M. Facial nevre paralysis due to chronic otitis media. Otol Neurotol 2002;23:580-588
  • Sade J. Middle ear mucosa. Arch Otolaryngol 1966;84:137
  • Jansen C. Posterior tympanotomy: access to the middle ear with preservation of the external ear canal. Arch Klin Exp Ohren Kehlkopfheilkd 1967;188:558-9
  • Sheehy JL, Patterson MR. Intact canal wall tympanoplasty with mastoidectomy. A review of eight years’ experience. Laryngoscope 1967;77:1502-1542
  • Portmann M. Open or closed technique in surgery of the middle ear. Ann Otol Rhinol Laryngol 1968;77:927-937
  • Inanlı S, Ozturk O, Batman C, Tutkun A, Uneri C, Sehitoglu MA. Clinical importance of supratubal recess in cholesteatoma surgery. Otol Neurotol 2001;22:754-760
  • Gocmen H, Kılıc R, Ozdek A, Kızılkaya Z, Safak MA; Samim E. Surgical treatment of cholesteatoma in children. Int J Pediatr Otorhinolaryngol 2003;67:867-872
  • Derlacki E, Clemis JD. Congenital cholesteatoma of the middle ear and mastoid. Ann Otol Rhinol Laryngol 1965;74:706-725
  • Sade J, Babiacki A, Pinkus G. The metaplastic and congenital origin of cholesteatoma. Acta Otolaryngol 1983;96:119-129
  • Ruedi L. Pathogenesis and surgical treatment of the middle ear cholesteatoma. Acta Otolaryngol (Stockh) Suppl 1979;361:1-45
  • Tseng SCG, Jarvinen MG, Nelson WG, Huang JW, Woodcock-Mitchell J, Sun TT. Correlation of spesific keratins with different types of epithelial differentiation: monoclonal antibody studies. Cell 1982;30:361-372
  • Sun TT, Eichner R, Nelson WG, Tsengf SCG, Weiss RA, Jarvinen M, Woodcock-Mitchell J. Keratin classes: molecular markers for different types of epithelial differentiation. J Invest Dermatol 1983;81:109-115
  • Eichner R, Sun TT, Aebi U. The role of keratin subfamilies and keratin pairs in the formation of human epidermal intermediate filaments. J Cell Biol 1986;102:1767-1777
  • Young R, Rowles P. The spatial organization of keratinocytes in acquired middle ear cholesteatoma resembles that of external auditory canal skin and pars flaccida. Acta Otolaryngol 1990;110:115-119
  • Moll R, Schiller DL, Franke WW. Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. J Cell Biol 1990;111:567-580
  • O’Donoghue GM. The migration theory of cholesteatoma formation: some experimental observations. J Laryngol Otol 1986;100:395-398
  • Broekaert D, Cornille A, Eto E, Leigh I, Ramaekers F, Van Muijen G, Coucke P, De Bersaques J, Kluyskens P, Gillis E. A comparative immunohistochemical analysis of the cytokeratin and vimentin expression in middle ear mucosa and cholesteatoma and in epidermis. Virchows Arch Pathol Anat 1988;413:39-51
  • Huang CC, Shi GS, Yi ZX. Experimental induction of middle ear cholesteatoma in rats. Am J Otolaryngol 1988;9:165-172
  • Chao WY, Huang CC. An immunocytochemical study of
  • cytokeratin expression in human middle ear cholesteatoma. Arch Otorhinolaryngol 1989;246:37-42
  • Masaki M, Wright CG, Meyerhoff WL. Experimental cholesteatoma: epidermal ingrowth through tympanic membrane following middle ear application of propylene glycol. Acta Otolaryngol 1989;108:113-121
  • Van Blitterswijk CA, Grote JJ, Lutgert RW, Hesseling SC, Out CJ, Van Muijen GN, Fransen JA. Cytokeratin patterns of tissues related to cholesteatoma pathogenesis. Ann Otol Rhinol Laryngol 1989;98:635-640
  • Vennix PP, Kuijpers W, Tonnaer E, Peters TA, Ramaekers FC. Cytokeratins in induced epidermoid formation and cholesteatoma lesions. Arch Otolaryngol Head Neck Surg 1990;116:560-565
  • Broekaert D, Coucke P, Leperque S, Ramaekers F, Van Muijen G, Boedts D, Leigh I, Lane B. Immunohistochemical analysis of the cytokeratin expression in middle ear cholesteatoma and related epithelial tissues. Ann Otol Rhinol Laryngol 1992;101:931-938
  • Buija J, schilling V, Holly A, Stammberger M, Kastanbauer E. Hyperproliferation associated keratin expression in human middle ear cholesteatoma. Acta Otolaryngol 1993;113:364-368
  • Sudhoff H, Bujia J, Borkowshi G, Koc C, Holly A, Hildmann H, Fisseler- Eckhoff A. Basement membrane in middle ear cholesteatoma: immunohistochemical and ultrastructural observations. Ann Otol Rhinol Laryngol 1996;105:804-810
  • Vennix PP, Kuijpers W, Peters TA, Tonnaer E, Ramaekers F. Keratinocyte differentiation in acquired cholesteatoma and perforated tympanic membranes. Arch Otolaryngol Head Neck Surg 1996;122:825-832
  • Goycoolea MV, Hueb MM, Muchow D, Paparella MM. The theory of the trigger, the bridge and the transmigration in the pathogenesis of acquired cholesteatoma. Acta Otolaryngol 1999;119:244-248
  • Kim CS, Chung JW. Morphologic and biologic changes of experimentally induced cholesteatoma in Mongolian gerbils with anticytokeratin and lectin study. Am J Otol 1999;20:13-18
  • Lee RJ, Sidey CM, Narula AA, McKenzie IC, James RFL. Keratin patterns in aural epithelia and cholesteatoma cell culture. In Cholesteatoma and Mastoid Surgery, Proceedings of the Fourth International Conference, Nakano Y (ed), Kugler Publications, Amsterdam / New York, 1993;pp 167-171
  • Woodcock-Mitchell J, Eichner R, Nelson WG, Sun TT.
  • Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J Cell Biol 1982;95:580-588
  • Sasaki H, Huang CC. Cytokeratin expression in cholesteatoma, meatal skin and tympanic membrane. In: Cholesteatoma and Mastoid Surgery, Proceedings of the Fourth International Conference, Nakano Y (ed), Kugler Publications, Amsterdam / New York, 1993;pp 143-150
  • Mare DS, Jong DE, Van Erp PEJ, Van de Kerkhof PCM. Markers for proliferation and keratinization in the magrin of the active psoriatic lesion. Br J Dermatol 1990;122:469-475
  • Ergun S, Zheng X, Carlsöö B. Antigen expression of epithelial markers, collagen IV and Ki67 in middle ear cholesteatoma. An immunohistochemical study. Acta Otolaryngol 1994;114,295-302
  • Lepercque S, Broekaert D, Van Cauwenberge P. Cytokeratin expression patterns in the human tympanic membrane and external ear canal. Eur Arch Otorhinolaryngol 1993;250,78-81
  • Sasaki H, Huang CC. Expression of cytokeratins 13 and 16 in middle ear cholesteatoma. Otolaryngol Head Neck Surg 1994;110:310-317
  • Olszewska E, Lautermann J, Koc C, Schwaab M, Dazert S, Hildmann H, Sudhoff H. Cytokeratin expression pattern in congenital and acquired pediatric cholesteatoma. Eur Arch Otorhinolaryngol 2005;262:731-736
  • Rosenfeld RM, Moura RL, Bluestone CD. Predictors of residual – recurrent cholesteatoma in children. Arch Otolaryngol Head Neck Surg 1992;118:384-439
  • Liang JN, Chrobok V, Michaels L, Wright A. Incidence and cytokeratin analysis of the epidermal formation. Registry 2000;8:1-4
  • Kim HJ, Tinling SP, Chole RA. Expression patterns of cytokeratins in cholesteatomas: evidence of increased migration and proliferation. J Korean Med Sci 2002;17:381-388
  • Weiss RA, Eichner R, Sun T. Monoclonal antibody analysis of keratin expression in epidermal disease: a 48- and 56-k Dalton keratin as molecular markers for hyperproliferative keratinocytes. J Cell Biol 1984;98:1397-1406
  • Weiss RA, Guillet GYA, Freedberg IM, Farmer ER, Small EA, Weiss MM, Sun TT. The use of monoclonal antibody to keratin in human epidermal disease: alterations in immunohistochemical staining pattern. J Invest Dermatol 1983;81:224-230
  • Shinkawa H, Hozawa J, Usami S. Immunohistochemical study on CK and vimentin expression in congenital cholesteatoma. In: Nakano Y (ed). Cholesteatoma and Mastoid Surgery. Kugler, Amsterdam, 1993;pp 155-166
  • Kim HJ, Tinling SP, Chole RA. Expression patterns of
  • cytokeratins in retraction pocket cholesteatoma. Laryngoscope 2001;111:1032-1036
  • Olsewska E, Sudhoff H. Comparative cytokeratin distribution patterns in cholesteatoma epithelium. Histol Histopathol 2007;22:37-42
  • Lifton WB. Epidermal migration in the ear: the location and characteristics of the generation center revealed by utilizing a radio-active desoxyribose nucleic acid precursor. Acta Otolaryngol (Stockh) (Suppl) 1968;240:-39

KOLESTEATOMADA SİTOKERATİN PATERNİNE GENEL BİR BAKIŞ

Year 2015, Issue: 1, 1 - 6, 01.03.2015

Ahmet Koç Emrah Emre

Abstract

Kolesteatoma, temporal kemiğin özellikle orta kulak ve mastoid bölgele- rinde görülen, keratinize yassı epitelin ilerleyici ve kronik infiltrasyonu ile karakterize tahrip edici bir patolojidir. Tedavisi güç olabilen ciddi kafa içi ve kafa dışı komplikasyonları vardır. Kolesteatoma oluşumunda; yassı epitelin embryolojik kalıntıları, orta kulak epitelinin yassı epitel metaplazisi, dış kulak yolu ve kulak zarından epidermal hücrelerin göç etmesi ve orta kulak cerrahisi yada travma nedeniyle hücre ekimi gibi nedenler suçlanmaktadır. Sitokeratinler, hücre farklılaşmasında önemli belirleyicilerdir. Sitokeratin oluşum paternleri; keratinosit proliferasyonu, göç ve farklılaşma ile yüksek oranda ilişkilidir. Bu paternlerin, kolesteatoma oluşumu sırasında etkili ol- duğu bilinmektedir. Sitokeratin paternleri hakkında bilgilerimiz arttıkça, kolesteatoma oluşumu hakkındaki bilgilerimiz de artacaktır. Bu makalede, kolesteatomada sitokeratin paternleri hakkında bir literatür taraması yapıl- mıştır

Keywords

kolesteatoma sitokeratin

References

  • Gray D. The treatment of cholesteatoma in children. Proceedings of the Royal Society of Medicine, London, 1964;57: 769-771
  • Osma C, Cureoglu S, Hosoglu S. The complications of chronic otitis media: report of 93 cases. J Laryngol Otol 2000;114:97-100
  • Sennaroglu L, Sozeri B. Otogenic brain abscess: review of 41 cases. Otolarygol Head Neck Surg 2000;123:751-755
  • Yetiser S, Tosun F, Kazkayasi M. Facial nevre paralysis due to chronic otitis media. Otol Neurotol 2002;23:580-588
  • Sade J. Middle ear mucosa. Arch Otolaryngol 1966;84:137
  • Jansen C. Posterior tympanotomy: access to the middle ear with preservation of the external ear canal. Arch Klin Exp Ohren Kehlkopfheilkd 1967;188:558-9
  • Sheehy JL, Patterson MR. Intact canal wall tympanoplasty with mastoidectomy. A review of eight years’ experience. Laryngoscope 1967;77:1502-1542
  • Portmann M. Open or closed technique in surgery of the middle ear. Ann Otol Rhinol Laryngol 1968;77:927-937
  • Inanlı S, Ozturk O, Batman C, Tutkun A, Uneri C, Sehitoglu MA. Clinical importance of supratubal recess in cholesteatoma surgery. Otol Neurotol 2001;22:754-760
  • Gocmen H, Kılıc R, Ozdek A, Kızılkaya Z, Safak MA; Samim E. Surgical treatment of cholesteatoma in children. Int J Pediatr Otorhinolaryngol 2003;67:867-872
  • Derlacki E, Clemis JD. Congenital cholesteatoma of the middle ear and mastoid. Ann Otol Rhinol Laryngol 1965;74:706-725
  • Sade J, Babiacki A, Pinkus G. The metaplastic and congenital origin of cholesteatoma. Acta Otolaryngol 1983;96:119-129
  • Ruedi L. Pathogenesis and surgical treatment of the middle ear cholesteatoma. Acta Otolaryngol (Stockh) Suppl 1979;361:1-45
  • Tseng SCG, Jarvinen MG, Nelson WG, Huang JW, Woodcock-Mitchell J, Sun TT. Correlation of spesific keratins with different types of epithelial differentiation: monoclonal antibody studies. Cell 1982;30:361-372
  • Sun TT, Eichner R, Nelson WG, Tsengf SCG, Weiss RA, Jarvinen M, Woodcock-Mitchell J. Keratin classes: molecular markers for different types of epithelial differentiation. J Invest Dermatol 1983;81:109-115
  • Eichner R, Sun TT, Aebi U. The role of keratin subfamilies and keratin pairs in the formation of human epidermal intermediate filaments. J Cell Biol 1986;102:1767-1777
  • Young R, Rowles P. The spatial organization of keratinocytes in acquired middle ear cholesteatoma resembles that of external auditory canal skin and pars flaccida. Acta Otolaryngol 1990;110:115-119
  • Moll R, Schiller DL, Franke WW. Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. J Cell Biol 1990;111:567-580
  • O’Donoghue GM. The migration theory of cholesteatoma formation: some experimental observations. J Laryngol Otol 1986;100:395-398
  • Broekaert D, Cornille A, Eto E, Leigh I, Ramaekers F, Van Muijen G, Coucke P, De Bersaques J, Kluyskens P, Gillis E. A comparative immunohistochemical analysis of the cytokeratin and vimentin expression in middle ear mucosa and cholesteatoma and in epidermis. Virchows Arch Pathol Anat 1988;413:39-51
  • Huang CC, Shi GS, Yi ZX. Experimental induction of middle ear cholesteatoma in rats. Am J Otolaryngol 1988;9:165-172
  • Chao WY, Huang CC. An immunocytochemical study of
  • cytokeratin expression in human middle ear cholesteatoma. Arch Otorhinolaryngol 1989;246:37-42
  • Masaki M, Wright CG, Meyerhoff WL. Experimental cholesteatoma: epidermal ingrowth through tympanic membrane following middle ear application of propylene glycol. Acta Otolaryngol 1989;108:113-121
  • Van Blitterswijk CA, Grote JJ, Lutgert RW, Hesseling SC, Out CJ, Van Muijen GN, Fransen JA. Cytokeratin patterns of tissues related to cholesteatoma pathogenesis. Ann Otol Rhinol Laryngol 1989;98:635-640
  • Vennix PP, Kuijpers W, Tonnaer E, Peters TA, Ramaekers FC. Cytokeratins in induced epidermoid formation and cholesteatoma lesions. Arch Otolaryngol Head Neck Surg 1990;116:560-565
  • Broekaert D, Coucke P, Leperque S, Ramaekers F, Van Muijen G, Boedts D, Leigh I, Lane B. Immunohistochemical analysis of the cytokeratin expression in middle ear cholesteatoma and related epithelial tissues. Ann Otol Rhinol Laryngol 1992;101:931-938
  • Buija J, schilling V, Holly A, Stammberger M, Kastanbauer E. Hyperproliferation associated keratin expression in human middle ear cholesteatoma. Acta Otolaryngol 1993;113:364-368
  • Sudhoff H, Bujia J, Borkowshi G, Koc C, Holly A, Hildmann H, Fisseler- Eckhoff A. Basement membrane in middle ear cholesteatoma: immunohistochemical and ultrastructural observations. Ann Otol Rhinol Laryngol 1996;105:804-810
  • Vennix PP, Kuijpers W, Peters TA, Tonnaer E, Ramaekers F. Keratinocyte differentiation in acquired cholesteatoma and perforated tympanic membranes. Arch Otolaryngol Head Neck Surg 1996;122:825-832
  • Goycoolea MV, Hueb MM, Muchow D, Paparella MM. The theory of the trigger, the bridge and the transmigration in the pathogenesis of acquired cholesteatoma. Acta Otolaryngol 1999;119:244-248
  • Kim CS, Chung JW. Morphologic and biologic changes of experimentally induced cholesteatoma in Mongolian gerbils with anticytokeratin and lectin study. Am J Otol 1999;20:13-18
  • Lee RJ, Sidey CM, Narula AA, McKenzie IC, James RFL. Keratin patterns in aural epithelia and cholesteatoma cell culture. In Cholesteatoma and Mastoid Surgery, Proceedings of the Fourth International Conference, Nakano Y (ed), Kugler Publications, Amsterdam / New York, 1993;pp 167-171
  • Woodcock-Mitchell J, Eichner R, Nelson WG, Sun TT.
  • Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J Cell Biol 1982;95:580-588
  • Sasaki H, Huang CC. Cytokeratin expression in cholesteatoma, meatal skin and tympanic membrane. In: Cholesteatoma and Mastoid Surgery, Proceedings of the Fourth International Conference, Nakano Y (ed), Kugler Publications, Amsterdam / New York, 1993;pp 143-150
  • Mare DS, Jong DE, Van Erp PEJ, Van de Kerkhof PCM. Markers for proliferation and keratinization in the magrin of the active psoriatic lesion. Br J Dermatol 1990;122:469-475
  • Ergun S, Zheng X, Carlsöö B. Antigen expression of epithelial markers, collagen IV and Ki67 in middle ear cholesteatoma. An immunohistochemical study. Acta Otolaryngol 1994;114,295-302
  • Lepercque S, Broekaert D, Van Cauwenberge P. Cytokeratin expression patterns in the human tympanic membrane and external ear canal. Eur Arch Otorhinolaryngol 1993;250,78-81
  • Sasaki H, Huang CC. Expression of cytokeratins 13 and 16 in middle ear cholesteatoma. Otolaryngol Head Neck Surg 1994;110:310-317
  • Olszewska E, Lautermann J, Koc C, Schwaab M, Dazert S, Hildmann H, Sudhoff H. Cytokeratin expression pattern in congenital and acquired pediatric cholesteatoma. Eur Arch Otorhinolaryngol 2005;262:731-736
  • Rosenfeld RM, Moura RL, Bluestone CD. Predictors of residual – recurrent cholesteatoma in children. Arch Otolaryngol Head Neck Surg 1992;118:384-439
  • Liang JN, Chrobok V, Michaels L, Wright A. Incidence and cytokeratin analysis of the epidermal formation. Registry 2000;8:1-4
  • Kim HJ, Tinling SP, Chole RA. Expression patterns of cytokeratins in cholesteatomas: evidence of increased migration and proliferation. J Korean Med Sci 2002;17:381-388
  • Weiss RA, Eichner R, Sun T. Monoclonal antibody analysis of keratin expression in epidermal disease: a 48- and 56-k Dalton keratin as molecular markers for hyperproliferative keratinocytes. J Cell Biol 1984;98:1397-1406
  • Weiss RA, Guillet GYA, Freedberg IM, Farmer ER, Small EA, Weiss MM, Sun TT. The use of monoclonal antibody to keratin in human epidermal disease: alterations in immunohistochemical staining pattern. J Invest Dermatol 1983;81:224-230
  • Shinkawa H, Hozawa J, Usami S. Immunohistochemical study on CK and vimentin expression in congenital cholesteatoma. In: Nakano Y (ed). Cholesteatoma and Mastoid Surgery. Kugler, Amsterdam, 1993;pp 155-166
  • Kim HJ, Tinling SP, Chole RA. Expression patterns of
  • cytokeratins in retraction pocket cholesteatoma. Laryngoscope 2001;111:1032-1036
  • Olsewska E, Sudhoff H. Comparative cytokeratin distribution patterns in cholesteatoma epithelium. Histol Histopathol 2007;22:37-42
  • Lifton WB. Epidermal migration in the ear: the location and characteristics of the generation center revealed by utilizing a radio-active desoxyribose nucleic acid precursor. Acta Otolaryngol (Stockh) (Suppl) 1968;240:-39
There are 51 citations in total.

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Primary Language English
Journal Section Collection
Authors

Ahmet Koç

Emrah Emre

Publication Date March 1, 2015
Published in Issue Year 2015Issue: 1

Cite

EndNote Koç A, Emre E (March 1, 2015) An Overview To Cytokeratin Pattern of Cholesteatoma. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 1 1–6.