Correlation Between Pet/ct Primary Tumor Fdg Uptake Levels and Lymph Node Metastases In Patients With Cervical Cancer
Abstract
Objectives: The aim of this study was to determine the correlation between Positron Emission Tomography/Computed Tomography PET/CT primary tumor FDG uptake levels and lymph node metastases in cervical cancer patients.Materials and methods: One hundred and three 103 cervical cancer patients who had pretreatment staging PET/CT were included in the study. Primary tumor maximum standard uptake value SUVmax levels, maximum tumor diameter measured on PET/CT, FDGavid pelvic and paraaortic lymph nodes and SUVmax values for FDG-avid lymph nodes were recorded for every patient. Correlation between SUVmax levels and lymph node metastases were evaluated. Statistical analysis was done using SPSS. Results: Median age was 56 years range 31-91 years . Mean SUVmax levels for primary tumor and for lymph nodes were 14,3±6,3 range; 3,9-34,2 and 8,6±3,9 range; 2,8-19,3 , respectively. SUVmax levels for the patients with FDG-avid lymph nodes and non FDG-avid patients were 15,9 range; 4,1-34,2 and11,9 range; 3,9-25,5 p 4 cm there were lymph node metastases. Two groups were statistically different according to the SUVmax levels and lymph node metastases p
Keywords
References
- Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin, 2011; 61: 69-90.
- Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol, 2006; 24: 2137-50.
- National Comprehensive Cancer Network. Cervical Cancer. (Version 1.2016). http://www.nccn.org/professionals/physician_gls/pdf/ cervical.pdf. Erişim tarihi 4 Mart 2016.
- Kjær SK, Frederiksen K, Munk C, Iftner T. Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistence. J Natl Cancer Inst. 2010; 102: 1478-88.
- International Collaboration of Epidemiological Studies of Cervical Cancer. Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies. Int J Cancer, 2007; 120: 885-91.
- Kidd EA, Siegel BA, Dehdashti F, Grigsby PW. Pelvic lymph node F-18 fluorodeoxyglucose uptake as a prognostic biomarker in newly diagnosed patients with locally advanced cervical cancer. Cancer, 2010; 116: 1469-75.
- Tinga DJ, Timmer PR, Bouma J, Aalders JG. Prognostic significance of single versus multiple lymph node metastases in cervical carcinoma stage IB. Gynecol Oncol, 1990; 39: 175-80.
- Stehman FB, Bundy BN, DiSaia PJ, Keys HM, Larson JE, Fowler WC. Carcinoma of the cervix treated with radiation therapy. I. A multi- variate analysis of prognostic variables in the Gynecologic Oncology Group. Cancer, 1991; 67: 2776-85.
- Pecorelli S, Zigliani L, Odicino F. Revised FIGO staging for carcinoma of the cervix. Int J Gynaecol Obstet, 2009; 105: 107-8.
- Kidd EA, Siegel BA, Dehdashti F, Rader JS, Mutch DG, Powell MA, ve ark. Lymph node staging by positron emission tomography in cervical cancer: relationship to prognosis. J Clin Oncol, 2010; 28: 2108-13.
- Scheidler J, Hricak H, Yu KK, Subak L, Segal MR. Radiological evaluation of lymph node metastases in patients with cervical cancer. A meta-analysis. JAMA, 1997; 278: 1096-101.
- Juweid ME, Cheson BD. Positron-emission tomography and assessment of cancer therapy. N Engl J Med. 2006; 354: 496-507.
- Cox BL, Mackie TR, Eliceiri KW. The sweet spot: FDG and other 2-carbon glucose analogs for multi-modal metabolic imaging of tumor metabolism.Am J Nucl Med Mol Imaging. 2014; 5: 1-13.
- Higashi K, Clavo AC, Wahl RL. Does FDG uptake measure proliferative activity of human cancer cells? in vitro comparison with DNA flow cytometry and tritiated thymidine uptake. J Nucl Med, 1993; 34: 414-19.
- Grigsby PW, Siegel BA, Dehdashti F. Lymph node staging by positron emission tomography in patients with carcinoma of the cervix. J Clin Oncol, 2001; 19: 3745-49.
- Kidd EA, Siegel BA, Dehdashti F, Grigsby PW. The standardized uptake value for F-18 fluorodeoxyglucose is a sensitive predictive biomarker for cervical cancer treatment response and survival. Cancer. 2007; 110: 1738-44.
- Parker K, Gallop-Evans E, Hanna L, Adams M. Five years’ experience treating locally advanced cervical cancer with concurrent chemoradiotherapy and high-dose-rate brachytherapy: results from a single institution. Int J Radiat Oncol Biol Phys. 2009; 74: 140-46.
- Yeh LS, Hung YC, Shen YY, Kao CH, Lin CC, Lee CC. Detecting para- aortic lymph nodal metastasis by positron emission tomography of 18F-fluorodeoxyglucose in advanced cervical cancer with negative magnetic resonance imaging findings. Oncol Rep, 2002; 9: 1289-92.
- Sun SS, Chen TC, Yen RF, Shen YY, Changlai SP, Kao A. Value of whole body 18F-fluoro-2-deoxyglucose positron emission tomography in the evaluation of recurrent cervical cancer. Anticancer Res, 2001; 21: 2957-61.
- Alan Selçuk N, Selçuk H, Halaç M, Türkmen C, Sönmezoğlu K. Jinekolojik kanserlerde pozitron emisyon tomografisi uygulamaları. Türk Onkoloji Dergisi, 2012; 27: 150-62.
- Lee YY, Choi CH, Kim CJ, Kang H, Kim TJ, Lee JW, ve ark. The prognostic significance of the SUVmax (maximum standardized uptake value for F-18 fluorodeoxyglucose) of the cervical tumor in PET imaging for early cervical cancer: preliminary results. Gynecol Oncol, 2009; 115: 65-8.
- Chung HH, Kim JW, Han KH, Eo JS, Kang KW, Park NH, ve ark. Prognostic value of metabolic tumor volume measured by FDG-PET/ CT in patients with cervical cancer. Gynecol Oncol, 2011; 120: 270-4.
- Herrera FG, Breuneval T, Prior JO, Bourhis J, Ozsahin M. [(18)F]FDG- PET/CT metabolic parameters as useful prognostic factors in cervical cancer patients treated with chemo-radiotherapy. Radiat Oncol, 2016; 16; 11:43.
- Delikgoz Soykut E, Ozsahin EM, Yukselen Guney Y, Aytac Arslan S, Derinalp Or O, Altundag MB, ve ark. The use of PET/CT in radiotherapy planning: contribution of deformable registration. Front Oncol. 2013;12;3:33.
- Elicin O, Callaway S, Prior JO, Bourhis J, Ozsahin M, Herrera FG. [(18) F]FDG-PET standard uptake value as a metabolic predictor of bone marrow response to radiation: impact on acute and late hematological toxicity in cervical cancer patients treated with chemoradiation therapy. Int J Radiat Oncol Biol Phys, 2014; 90: 1099-107.
- Fleming S, Cooper RA, Swift SE, Thygesen HH, Chowdhury FU, Scarsbrook AF, ve ark. Clin Radiol. Clinical impact of FDG PET-CT on the management of patients with locally advanced cervical carcinoma. 2014; 69: 1235-43.
- Sandvik RM, Jensen PT, Hendel HW, Palle C. Positron emission tomography-computed tomography has a clinical impact for patients with cervical cancer. Dan Med Bull, 2011; 58: A4240.
- Yildirim Y, Sehirali S, Avci ME, Yilmaz C, Ertopcu K, Tinar S, ve ark. Integrated PET/CT for the evaluation of para-aortic nodal metastasis in locally advanced cervical cancer patients with negative conventional CT findings. Gynecol Oncol, 2008; 108: 154-9.
Serviks Kanserli Hastalarda PET/BT Tetkikinde Primer Tümörün FDG Tutulum Derecesi ile Lenf Nodu Metastazı Arasındaki İlişki
Abstract
Amaç: Bu çalışmada, serviks kanserli hastalarda Pozitron Emisyon Tomografisi/Bilgisayarlı Tomografi PET/BT tetkikinde primer tümörün FDG tutulum derecesi ile lenf nodu metastazı arasındaki ilişkinin saptanması amaçlandı.Gereç ve yöntem: Tedavi öncesi evreleme amacıyla PET/BT tetkiki yapılan 103 hasta çalışmaya dahil edildi. Primer tümörün maksimum standart uptake SUVmaks değeri, PET/BT tetkikinde ölçülen maksimum tümör çapı, pelvik ve paraaortik lenf nodlarında FDG tutulumu olup olmadığı ve FDG tutulumu olan lenf nodlarında SUVmaks değerleri her hasta için kaydedildi. SUVmaks değerlerinin lenf nodu metastazı ile ilişkisi araştırıldı. İstatistiksel analiz SPSS programı ile yapıldı. Bulgular: Ortanca yaş 56 idi 31-91 arası . SUVmaks ortalama değerleri primer tümör için 14,3±6,3 3,9-34,2 arası ve lenf nodları için 8,6±3,9 2,8-19,3 arası idi. Lenf nodu tutulumu olan ve olmayan hastalarda SUVmaks ortalama değerleri sırasıyla 15,9 4,1-34,2 arası ve 11,9 3,9-25,5 arası idi p 4 cm olan hastaların %66’sında lenf nodu tutulumu vardı. SUVmaks değerleri ve lenf nodu FDG tutulumu açısından iki grup arasındaki fark istatistiksel olarak anlamlıydı p
Keywords
References
- Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin, 2011; 61: 69-90.
- Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol, 2006; 24: 2137-50.
- National Comprehensive Cancer Network. Cervical Cancer. (Version 1.2016). http://www.nccn.org/professionals/physician_gls/pdf/ cervical.pdf. Erişim tarihi 4 Mart 2016.
- Kjær SK, Frederiksen K, Munk C, Iftner T. Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistence. J Natl Cancer Inst. 2010; 102: 1478-88.
- International Collaboration of Epidemiological Studies of Cervical Cancer. Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies. Int J Cancer, 2007; 120: 885-91.
- Kidd EA, Siegel BA, Dehdashti F, Grigsby PW. Pelvic lymph node F-18 fluorodeoxyglucose uptake as a prognostic biomarker in newly diagnosed patients with locally advanced cervical cancer. Cancer, 2010; 116: 1469-75.
- Tinga DJ, Timmer PR, Bouma J, Aalders JG. Prognostic significance of single versus multiple lymph node metastases in cervical carcinoma stage IB. Gynecol Oncol, 1990; 39: 175-80.
- Stehman FB, Bundy BN, DiSaia PJ, Keys HM, Larson JE, Fowler WC. Carcinoma of the cervix treated with radiation therapy. I. A multi- variate analysis of prognostic variables in the Gynecologic Oncology Group. Cancer, 1991; 67: 2776-85.
- Pecorelli S, Zigliani L, Odicino F. Revised FIGO staging for carcinoma of the cervix. Int J Gynaecol Obstet, 2009; 105: 107-8.
- Kidd EA, Siegel BA, Dehdashti F, Rader JS, Mutch DG, Powell MA, ve ark. Lymph node staging by positron emission tomography in cervical cancer: relationship to prognosis. J Clin Oncol, 2010; 28: 2108-13.
- Scheidler J, Hricak H, Yu KK, Subak L, Segal MR. Radiological evaluation of lymph node metastases in patients with cervical cancer. A meta-analysis. JAMA, 1997; 278: 1096-101.
- Juweid ME, Cheson BD. Positron-emission tomography and assessment of cancer therapy. N Engl J Med. 2006; 354: 496-507.
- Cox BL, Mackie TR, Eliceiri KW. The sweet spot: FDG and other 2-carbon glucose analogs for multi-modal metabolic imaging of tumor metabolism.Am J Nucl Med Mol Imaging. 2014; 5: 1-13.
- Higashi K, Clavo AC, Wahl RL. Does FDG uptake measure proliferative activity of human cancer cells? in vitro comparison with DNA flow cytometry and tritiated thymidine uptake. J Nucl Med, 1993; 34: 414-19.
- Grigsby PW, Siegel BA, Dehdashti F. Lymph node staging by positron emission tomography in patients with carcinoma of the cervix. J Clin Oncol, 2001; 19: 3745-49.
- Kidd EA, Siegel BA, Dehdashti F, Grigsby PW. The standardized uptake value for F-18 fluorodeoxyglucose is a sensitive predictive biomarker for cervical cancer treatment response and survival. Cancer. 2007; 110: 1738-44.
- Parker K, Gallop-Evans E, Hanna L, Adams M. Five years’ experience treating locally advanced cervical cancer with concurrent chemoradiotherapy and high-dose-rate brachytherapy: results from a single institution. Int J Radiat Oncol Biol Phys. 2009; 74: 140-46.
- Yeh LS, Hung YC, Shen YY, Kao CH, Lin CC, Lee CC. Detecting para- aortic lymph nodal metastasis by positron emission tomography of 18F-fluorodeoxyglucose in advanced cervical cancer with negative magnetic resonance imaging findings. Oncol Rep, 2002; 9: 1289-92.
- Sun SS, Chen TC, Yen RF, Shen YY, Changlai SP, Kao A. Value of whole body 18F-fluoro-2-deoxyglucose positron emission tomography in the evaluation of recurrent cervical cancer. Anticancer Res, 2001; 21: 2957-61.
- Alan Selçuk N, Selçuk H, Halaç M, Türkmen C, Sönmezoğlu K. Jinekolojik kanserlerde pozitron emisyon tomografisi uygulamaları. Türk Onkoloji Dergisi, 2012; 27: 150-62.
- Lee YY, Choi CH, Kim CJ, Kang H, Kim TJ, Lee JW, ve ark. The prognostic significance of the SUVmax (maximum standardized uptake value for F-18 fluorodeoxyglucose) of the cervical tumor in PET imaging for early cervical cancer: preliminary results. Gynecol Oncol, 2009; 115: 65-8.
- Chung HH, Kim JW, Han KH, Eo JS, Kang KW, Park NH, ve ark. Prognostic value of metabolic tumor volume measured by FDG-PET/ CT in patients with cervical cancer. Gynecol Oncol, 2011; 120: 270-4.
- Herrera FG, Breuneval T, Prior JO, Bourhis J, Ozsahin M. [(18)F]FDG- PET/CT metabolic parameters as useful prognostic factors in cervical cancer patients treated with chemo-radiotherapy. Radiat Oncol, 2016; 16; 11:43.
- Delikgoz Soykut E, Ozsahin EM, Yukselen Guney Y, Aytac Arslan S, Derinalp Or O, Altundag MB, ve ark. The use of PET/CT in radiotherapy planning: contribution of deformable registration. Front Oncol. 2013;12;3:33.
- Elicin O, Callaway S, Prior JO, Bourhis J, Ozsahin M, Herrera FG. [(18) F]FDG-PET standard uptake value as a metabolic predictor of bone marrow response to radiation: impact on acute and late hematological toxicity in cervical cancer patients treated with chemoradiation therapy. Int J Radiat Oncol Biol Phys, 2014; 90: 1099-107.
- Fleming S, Cooper RA, Swift SE, Thygesen HH, Chowdhury FU, Scarsbrook AF, ve ark. Clin Radiol. Clinical impact of FDG PET-CT on the management of patients with locally advanced cervical carcinoma. 2014; 69: 1235-43.
- Sandvik RM, Jensen PT, Hendel HW, Palle C. Positron emission tomography-computed tomography has a clinical impact for patients with cervical cancer. Dan Med Bull, 2011; 58: A4240.
- Yildirim Y, Sehirali S, Avci ME, Yilmaz C, Ertopcu K, Tinar S, ve ark. Integrated PET/CT for the evaluation of para-aortic nodal metastasis in locally advanced cervical cancer patients with negative conventional CT findings. Gynecol Oncol, 2008; 108: 154-9.
There are 28 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | September 1, 2016 |
| Published in Issue | Year 2016Issue: 3 |