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Corneal Thickness and Topography Indices After Collagen Cross-Linking For Keratoconus: 18 Months Follow-Up and Literature Review

Year 2018, Issue: 1, 43 - 51, 01.03.2018

Ayşe Ebru Kılavuzoğlu Ali Rıza Cenk Çelebi Cemile Banu Coşar Asım Bozkurt Şener

Abstract

Amaç: Keratokonusun çapraz bağlama tedavisi sonrası korneal topografi indekslerinde ve kornea kalınlığında görülen değişikliklerin değerlendirilmesi. Çalışma Planı: Retrospektif Gözlemsel Çalışma Hastalar ve Yöntemler: Keratokonus tedavisi için korneal kollajen çapraz bağlama tedavisi uygulanan hastaların verileri toplandı. Santral kornea kalınlığı SKK , maksimum ve ortalama keratometri Kmax Kort , değerleri ve topografi indeksleri: index of surface variance ISV , index of vertical asymmetry IVA , keratoconus index KI , central keratoconus index CKI , minimum radius of curvature Rmin , index of height asymmetry IHA ve index of height decentration IHD Pentacam ve Wavelight-Allegretto Wave Topolyzer cihazlarının çıktılarından elde edildi. Takip süresi 18 aydı. Bulgular: Çalışmada keratokonus hastalığı olan 10 hastanın 15 gözü değerlendirildi. Santral kornea kalınlığı ameliyattan 1 ay sonra istatistiksel olarak anlamlı şekilde azaldı p=0,003 fakat son takip değerlerinde ameliyat öncesi değerlere göre istatistiksel olarak anlamlı bir fark yoktu p>0,05 . Kmax ve Kort değerleri son kontrollerde ameliyat öncesi değerlere göre istatistiksel olarak farklı değildi p>0,05 . Korneal topografi indekslerinin birçoğu ameliyat sonrası 6. aydan sonra istatistiksel olarak anlamlı şekilde düzeldi p

Keywords

Cornea corneal topography keratoconus

References

  • Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 2003;135:620–7.
  • Wollensak G. Crosslinking treatment of progressive keratoconus: new hope. Curr Opin Ophthalmol 2006;17:356–60. https://doi. org/10.1097/01.icu.0000233954.86723.25
  • Spoerl E, Wollensak G, Seiler T. Increased resistance of crosslinked cornea against enzymatic digestion. Curr Eye Res 2004;29:35–40. https://doi.org/10.1080/02713680490513182
  • Caporossi A, Baiocchi S, Mazzotta C, Traversi C, Caporossi T. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian study. J Cataract Refract Surg 2006;32:837–45. https://doi.org/10.1016/j.jcrs.2006.01.091
  • Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg 2008;34:795–801. https://doi. org/10.1016/j.jcrs.2007.12.039
  • Greenstein SA, Fry KL, Hersh PS. Corneal topography indices after corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results. J Cataract Refract Surg 2011;37:1282–90. https:// doi.org/10.1016/j.jcrs.2011.01.029
  • Arbelaez MC, Sekito MB, Vidal C, Choudhury SA. Collagen cross- linking with riboflavin and ultraviolet-A light in keratoconus: one-year results. Oman J Ophthalmol 2009;2:33–8. https://doi. org/10.4103/0974-620X.48420
  • (TMS-4; Tomey, Erlangen, Germany) 43±0.08 Vinciguerra 2009 02 83 61 23 09 62
  • Wollensak G, Spoerl E, Seiler T. Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross- linking. J Cataract Refract Surg 2003;29:1780–85.
  • Toprak I, Yildirim C. Scheimpflug parameters after corneal collagen crosslinking for keratoconus. Eur J Ophthalmol 2013;23:793–8. https://doi.org/10.5301/ejo.5000313
  • Vinciguerra P, Albe E, Trazza S, Rosetta P, Vinciguerra R, Seiler T, Epstein D. Refractive, topographic, tomographic and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology 2009;116:369–78. https://doi.org/10.1016/j. ophtha.2008.09.048
  • Caporossi A, Mazzotta C, Baiocchi S, Caporossi T. Long- term results of riboflavin ultraviolet A corneal collagen cross- linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol ;149:585–93. https://doi.org/10.1016/j.ajo.2009.10.021
  • Vinciguerra P, Camesasca FI, Albe E, Trazza S. Corneal collagen cross-linking for ectasia after excimer laser refractive surgery:1-year results. J Refract Surg 2010;26:486–97. https://doi.org/10.3928/1081 X-20090910-02
  • Richoz O, Mavrakanas N, Pajic B, Hafezi F. Corneal collagen cross- linking for ectasia after LASIK and photorefractive keratectomy. Ophthalmology 2013;120:1354–9. https://doi.org/10.1016/j. ophtha.2012.12.027
  • Kanellopoulos AJ, Asimellis G. Revisiting keratoconus diagnosis and progression classification based on evaluation of corneal asymmetry indices, derived from Scheimpflug imaging in keratoconic and suspect cases. Clin Ophthalmol 2013;7:1539–48. https://doi. org/10.2147/OPTH.S44741
  • Wittig-Silva C, Chan E, Islam FM, Wu T, Whiting M, Snibson GR. A randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus: three-year results. Ophthalmology ;121:812–21. https://doi.org/10.1016/j.ophtha.2013.10.028
  • Ghanem RC, Santhiago MR, Berti T, Netto MV, Ghanem VC. Topographic, corneal wavefront, and refractive outcomes 2 years after collagen crosslinking for progressive keratoconus. Cornea ;33:43–8. https://doi.org/10.1097/ICO.0b013e3182a9fbdf
  • Toprak I, Yaylalı V, Yildirim C. Factors affecting outcomes of corneal collagen crosslinking treatment. Eye (Lond) 2014;28:41–6. https:// doi.org/10.1038/eye.2013.224
  • Goldich Y, Barkana Y, Wussuku Lior O, Marcovich AL, Hirsh A, Avni I, Zadok D. Corneal collagen cross-linking for the treatment of progressive keratoconus:3-year prospective outcome. Can J Ophthalmol 2014;49:54–9. https://doi.org/10.1016/j.jcjo.2013.09.002
  • Sloot F, Soeters N, van der Valk R, Tahzib NG. Effective corneal collagen crosslinking in advanced cases of progressive keratoconus. J Cataract Refract Surg 2013;39:1141–5. https://doi.org/10.1016/j.jcrs.2013.01.045
  • Toprak I, Yildirim C. Effects of corneal collagen crosslinking on corneal topographic indices in patients with keratoconus. Eye Contact Lens ;39:385–7. https://doi.org/10.1097/ICL.0b013e31829e907f
  • Poli M, Cornut PL, Balmitgere T, Aptel F, Janin H, Burillon C. Prospective study of corneal collagen cross-linking efficacy and tolerance in the treatment of keratoconus and corneal ectasia: 3-year results. Cornea ;32:583–90. https://doi.org/10.1097/ICO.0b013e31825e8414
  • Hashemi H, Seyedian MA, Miraftab M, Fotouhi A, Asgari S. Corneal collagen cross-linking with riboflavin and ultraviolet a irradiation for keratoconus: long-term results. Ophthalmology 2013;120:1515–20. https://doi.org/10.1016/j.ophtha.2013.01.012
  • Viswanathan D, Males J. Prospective longitudinal study of corneal collagen cross-linking in progressive keratoconus. Clin Exp Ophthalmol 2013;41:531–6. https://doi.org/10.1111/ceo.12035
  • Goldich Y, Marcovich AL, Barkana Y, Mandel Y, Hirsh A, Morad Y, et al. Clinical and corneal biomechanical changes after collagen cross-linking with riboflavin and UV irradiation in patients with progressive keratoconus: results after 2 years of follow-up. Cornea ;31:609–14. https://doi.org/10.1097/ICO.0b013e318226bf4a
  • Asri D, Touboul D, Fournie P, Malet F, Garra C, Gallois A, et al. Corneal collagen crosslinking in progressive keratoconus: multicenter results from the French National Reference Center for Keratoconus. J Cataract Refract Surg 2011;37):2137–43. https://doi.org/10.1016/j. jcrs.2011.08.026
  • Koller T, Pajic B, Vinciguerra P, Seiler T. Flattening of the cornea after collagen crosslinking for keratoconus. J Cataract Refract Surg ;37:1488–92. https://doi.org/10.1016/j.jcrs.2011.03.041
  • Hersh PS, Greenstein SA, Fry KL. Corneal collagen crosslinking for keratoconus and corneal ectasia: One-year results. J Cataract Refract Surg 2011;37:149–60. https://doi.org/10.1016/j.jcrs.2010.07.030
  • Greenstein SA, Shah VP, Fry KL, Hersh PS. Corneal thickness changes after corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results. J Cataract Refract Surg 2011;37:691–700. https://doi.org/10.1016/j.jcrs.2010.10.052
  • O’Brart DP, Chan E, Samaras K, Patel P, Shah SP. A randomized, prospective study to investigate the efficacy of riboflavin/ultraviolet A (370 nm) corneal collagen cross-linkage to halt the progression of keratoconus. Br J Ophthalmol 2011;95:1519–24. https://doi. org/10.1136/bjo.2010.196493
  • Henriquez MA, Izquierdo L Jr, Bernilla C, Zakrzewski PA, Mannis M. Riboflavin/Ultraviolet A corneal collagen cross-linking for the treatment of keratoconus: visual outcomes and Scheimpflug analysis. Cornea 2011;30:281–6. https://doi.org/10.1097/ ICO.0b013e3181eeaea1
  • Coskunseven E, Jankov MR 2nd, Hafezi F. Contralateral eye study of corneal collagen cross-linking with riboflavin and UVA irradiation in patients with keratoconus. J Refract Surg 2009;25:371–6.
  • Grewal DS, Brar GS, Jain R, Sood V, Singla M, Grewal SP. Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging. J Cataract Refract Surg 2009;35:425–32. https://doi.org/10.1016/j. jcrs.2008.11.046
  • Vinciguerra P, Albe E, Trazza S, Seiler T, Epstein D. Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus. Arch Ophthalmol 2009;127:1258–65. https://doi.org/10.1001/archophthalmol.2009.205
  • Agrawal VB. Corneal collagen cross-linking with riboflavin and ultraviolet - a light for keratoconus: results in Indian eyes. Indian J Ophtthalmol 2009;57:111–4.
  • Wittig-Silva C, Whiting M, Lamoureux E, Lindsay RG, Sullivan LJ, Snibson GR. A randomized controlled trial of corneal collagen cross- linking in progressive keratoconus: preliminary results. J Refract Surg 2008;24:S720–5.

KERATOKONUSUN KOLLAJEN ÇAPRAZ BAĞLAMA TEDAVISI SONRASI KORNEA KALINLIĞI VE TOPOGRAFI INDEKSLERI: 18 AYLIK TAKIP VE LITERATÜR ÖZETI

Year 2018, Issue: 1, 43 - 51, 01.03.2018

Ayşe Ebru Kılavuzoğlu Ali Rıza Cenk Çelebi Cemile Banu Coşar Asım Bozkurt Şener

Abstract

Amaç: Keratokonusun çapraz bağlama tedavisi sonrası korneal topografi indekslerinde ve kornea kalınlığında görülen değişikliklerin değerlendirilmesi. Çalışma Planı: Retrospektif Gözlemsel Çalışma Hastalar ve Yöntemler: Keratokonus tedavisi için korneal kollajen çapraz bağlama tedavisi uygulanan hastaların verileri toplandı. Santral kornea kalınlığı SKK , maksimum ve ortalama keratometri Kmax Kort , değerleri ve topografi indeksleri: index of surface variance ISV , index of vertical asymmetry IVA , keratoconus index KI , central keratoconus index CKI , minimum radius of curvature Rmin , index of height asymmetry IHA ve index of height decentration IHD Pentacam ve Wavelight-Allegretto Wave Topolyzer cihazlarının çıktılarından elde edildi. Takip süresi 18 aydı. Bulgular: Çalışmada keratokonus hastalığı olan 10 hastanın 15 gözü değerlendirildi. Santral kornea kalınlığı ameliyattan 1 ay sonra istatistiksel olarak anlamlı şekilde azaldı p=0,003 fakat son takip değerlerinde ameliyat öncesi değerlere göre istatistiksel olarak anlamlı bir fark yoktu p>0,05 . Kmax ve Kort değerleri son kontrollerde ameliyat öncesi değerlere göre istatistiksel olarak farklı değildi p>0,05 . Korneal topografi indekslerinin birçoğu ameliyat sonrası 6. aydan sonra istatistiksel olarak anlamlı şekilde düzeldi p

Keywords

Kornea kornea topografisi keratokonus

References

  • Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 2003;135:620–7.
  • Wollensak G. Crosslinking treatment of progressive keratoconus: new hope. Curr Opin Ophthalmol 2006;17:356–60. https://doi. org/10.1097/01.icu.0000233954.86723.25
  • Spoerl E, Wollensak G, Seiler T. Increased resistance of crosslinked cornea against enzymatic digestion. Curr Eye Res 2004;29:35–40. https://doi.org/10.1080/02713680490513182
  • Caporossi A, Baiocchi S, Mazzotta C, Traversi C, Caporossi T. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian study. J Cataract Refract Surg 2006;32:837–45. https://doi.org/10.1016/j.jcrs.2006.01.091
  • Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg 2008;34:795–801. https://doi. org/10.1016/j.jcrs.2007.12.039
  • Greenstein SA, Fry KL, Hersh PS. Corneal topography indices after corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results. J Cataract Refract Surg 2011;37:1282–90. https:// doi.org/10.1016/j.jcrs.2011.01.029
  • Arbelaez MC, Sekito MB, Vidal C, Choudhury SA. Collagen cross- linking with riboflavin and ultraviolet-A light in keratoconus: one-year results. Oman J Ophthalmol 2009;2:33–8. https://doi. org/10.4103/0974-620X.48420
  • (TMS-4; Tomey, Erlangen, Germany) 43±0.08 Vinciguerra 2009 02 83 61 23 09 62
  • Wollensak G, Spoerl E, Seiler T. Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross- linking. J Cataract Refract Surg 2003;29:1780–85.
  • Toprak I, Yildirim C. Scheimpflug parameters after corneal collagen crosslinking for keratoconus. Eur J Ophthalmol 2013;23:793–8. https://doi.org/10.5301/ejo.5000313
  • Vinciguerra P, Albe E, Trazza S, Rosetta P, Vinciguerra R, Seiler T, Epstein D. Refractive, topographic, tomographic and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology 2009;116:369–78. https://doi.org/10.1016/j. ophtha.2008.09.048
  • Caporossi A, Mazzotta C, Baiocchi S, Caporossi T. Long- term results of riboflavin ultraviolet A corneal collagen cross- linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol ;149:585–93. https://doi.org/10.1016/j.ajo.2009.10.021
  • Vinciguerra P, Camesasca FI, Albe E, Trazza S. Corneal collagen cross-linking for ectasia after excimer laser refractive surgery:1-year results. J Refract Surg 2010;26:486–97. https://doi.org/10.3928/1081 X-20090910-02
  • Richoz O, Mavrakanas N, Pajic B, Hafezi F. Corneal collagen cross- linking for ectasia after LASIK and photorefractive keratectomy. Ophthalmology 2013;120:1354–9. https://doi.org/10.1016/j. ophtha.2012.12.027
  • Kanellopoulos AJ, Asimellis G. Revisiting keratoconus diagnosis and progression classification based on evaluation of corneal asymmetry indices, derived from Scheimpflug imaging in keratoconic and suspect cases. Clin Ophthalmol 2013;7:1539–48. https://doi. org/10.2147/OPTH.S44741
  • Wittig-Silva C, Chan E, Islam FM, Wu T, Whiting M, Snibson GR. A randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus: three-year results. Ophthalmology ;121:812–21. https://doi.org/10.1016/j.ophtha.2013.10.028
  • Ghanem RC, Santhiago MR, Berti T, Netto MV, Ghanem VC. Topographic, corneal wavefront, and refractive outcomes 2 years after collagen crosslinking for progressive keratoconus. Cornea ;33:43–8. https://doi.org/10.1097/ICO.0b013e3182a9fbdf
  • Toprak I, Yaylalı V, Yildirim C. Factors affecting outcomes of corneal collagen crosslinking treatment. Eye (Lond) 2014;28:41–6. https:// doi.org/10.1038/eye.2013.224
  • Goldich Y, Barkana Y, Wussuku Lior O, Marcovich AL, Hirsh A, Avni I, Zadok D. Corneal collagen cross-linking for the treatment of progressive keratoconus:3-year prospective outcome. Can J Ophthalmol 2014;49:54–9. https://doi.org/10.1016/j.jcjo.2013.09.002
  • Sloot F, Soeters N, van der Valk R, Tahzib NG. Effective corneal collagen crosslinking in advanced cases of progressive keratoconus. J Cataract Refract Surg 2013;39:1141–5. https://doi.org/10.1016/j.jcrs.2013.01.045
  • Toprak I, Yildirim C. Effects of corneal collagen crosslinking on corneal topographic indices in patients with keratoconus. Eye Contact Lens ;39:385–7. https://doi.org/10.1097/ICL.0b013e31829e907f
  • Poli M, Cornut PL, Balmitgere T, Aptel F, Janin H, Burillon C. Prospective study of corneal collagen cross-linking efficacy and tolerance in the treatment of keratoconus and corneal ectasia: 3-year results. Cornea ;32:583–90. https://doi.org/10.1097/ICO.0b013e31825e8414
  • Hashemi H, Seyedian MA, Miraftab M, Fotouhi A, Asgari S. Corneal collagen cross-linking with riboflavin and ultraviolet a irradiation for keratoconus: long-term results. Ophthalmology 2013;120:1515–20. https://doi.org/10.1016/j.ophtha.2013.01.012
  • Viswanathan D, Males J. Prospective longitudinal study of corneal collagen cross-linking in progressive keratoconus. Clin Exp Ophthalmol 2013;41:531–6. https://doi.org/10.1111/ceo.12035
  • Goldich Y, Marcovich AL, Barkana Y, Mandel Y, Hirsh A, Morad Y, et al. Clinical and corneal biomechanical changes after collagen cross-linking with riboflavin and UV irradiation in patients with progressive keratoconus: results after 2 years of follow-up. Cornea ;31:609–14. https://doi.org/10.1097/ICO.0b013e318226bf4a
  • Asri D, Touboul D, Fournie P, Malet F, Garra C, Gallois A, et al. Corneal collagen crosslinking in progressive keratoconus: multicenter results from the French National Reference Center for Keratoconus. J Cataract Refract Surg 2011;37):2137–43. https://doi.org/10.1016/j. jcrs.2011.08.026
  • Koller T, Pajic B, Vinciguerra P, Seiler T. Flattening of the cornea after collagen crosslinking for keratoconus. J Cataract Refract Surg ;37:1488–92. https://doi.org/10.1016/j.jcrs.2011.03.041
  • Hersh PS, Greenstein SA, Fry KL. Corneal collagen crosslinking for keratoconus and corneal ectasia: One-year results. J Cataract Refract Surg 2011;37:149–60. https://doi.org/10.1016/j.jcrs.2010.07.030
  • Greenstein SA, Shah VP, Fry KL, Hersh PS. Corneal thickness changes after corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results. J Cataract Refract Surg 2011;37:691–700. https://doi.org/10.1016/j.jcrs.2010.10.052
  • O’Brart DP, Chan E, Samaras K, Patel P, Shah SP. A randomized, prospective study to investigate the efficacy of riboflavin/ultraviolet A (370 nm) corneal collagen cross-linkage to halt the progression of keratoconus. Br J Ophthalmol 2011;95:1519–24. https://doi. org/10.1136/bjo.2010.196493
  • Henriquez MA, Izquierdo L Jr, Bernilla C, Zakrzewski PA, Mannis M. Riboflavin/Ultraviolet A corneal collagen cross-linking for the treatment of keratoconus: visual outcomes and Scheimpflug analysis. Cornea 2011;30:281–6. https://doi.org/10.1097/ ICO.0b013e3181eeaea1
  • Coskunseven E, Jankov MR 2nd, Hafezi F. Contralateral eye study of corneal collagen cross-linking with riboflavin and UVA irradiation in patients with keratoconus. J Refract Surg 2009;25:371–6.
  • Grewal DS, Brar GS, Jain R, Sood V, Singla M, Grewal SP. Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging. J Cataract Refract Surg 2009;35:425–32. https://doi.org/10.1016/j. jcrs.2008.11.046
  • Vinciguerra P, Albe E, Trazza S, Seiler T, Epstein D. Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus. Arch Ophthalmol 2009;127:1258–65. https://doi.org/10.1001/archophthalmol.2009.205
  • Agrawal VB. Corneal collagen cross-linking with riboflavin and ultraviolet - a light for keratoconus: results in Indian eyes. Indian J Ophtthalmol 2009;57:111–4.
  • Wittig-Silva C, Whiting M, Lamoureux E, Lindsay RG, Sullivan LJ, Snibson GR. A randomized controlled trial of corneal collagen cross- linking in progressive keratoconus: preliminary results. J Refract Surg 2008;24:S720–5.
There are 36 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Ayşe Ebru Kılavuzoğlu

Ali Rıza Cenk Çelebi

Cemile Banu Coşar

Asım Bozkurt Şener

Publication Date March 1, 2018
Published in Issue Year 2018Issue: 1

Cite

EndNote Kılavuzoğlu AE, Çelebi ARC, Coşar CB, Şener AB (March 1, 2018) KERATOKONUSUN KOLLAJEN ÇAPRAZ BAĞLAMA TEDAVISI SONRASI KORNEA KALINLIĞI VE TOPOGRAFI INDEKSLERI: 18 AYLIK TAKIP VE LITERATÜR ÖZETI. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 1 43–51.