The Correlation Between Serum Adiponectin Levels and Proinflammatory Cytokines" Levels, Apache-Ii Scores and Mortality In Patients With Intra-Abdominal Sepsis

Kürşat Dikmen; Tonguç Utku Yılmaz; Mustafa Kerem; Hasan Bostancı; Asiye Dikmen Uğraş; Özge Paşaoğlu; Öge Taşçılar; Tarkan Karakan

EN TR

The Correlation Between Serum Adiponectin Levels and Proinflammatory Cytokines" Levels, Apache-Ii Scores and Mortality In Patients With Intra-Abdominal Sepsis

Abstract

Objectives: Adiponectin is an anti-inflammatory cytokine that is abundantly produced by adipocytes and have a wide range of effects in sepsis pathophysiology. This study was conducted to investigate whether there is a correlation between serum adiponectin, proinflammatory cytokines’ levels, APACHE-II scores and mortality rates of the patients with sepsis, severe sepsis and septic shock. Patients and Methods: Forty-five patients who met the criteria for sepsis n=18 , severe sepsis n=14 and septic shock n=13 were included in this prospective study. Patients who underwent elective abdominal surgery without sepsis were identified as the control group. After the diagnosis of sepsis, blood samples were taken on the following 5 days for adiponectin, IL-6, IL-1β, TNF-α and procalcitonin levels. APACHE-II scores of the patients were calculated daily. All patients were followed for 28 days and mortalities were observed. Results: Ten of the patients died within 28 days. The serum adiponectin levels of the patients in the study group were statistically higher than those in the control group. Statistically, the adiponectin levels of the patients in the septic shock group were markedly lower than those of the patients in sepsis and severe sepsis groups. Serum adiponectin levels inversely correlated with blood levels of IL-6, IL-1β, TNF-α, procalcitonin, lactate and APACHE-II scores. Serum adiponectin levels were significantly higher in survivors. Conclusion: Adiponectin levels reveal differences between sepsis, severe sepsis and septic shock groups. In patients with septic shock, serum adiponectin levels were associated with mortality among patients. Serum adiponectin levels might be a negative predictive marker in patients with sepsis, severe sepsis and septic shock.

Keywords

Adiponectin,sepsis,APACHE,survival

İNTRABDOMINAL SEPSISLI HASTALARDA SERUM ADIPONEKTIN SEVIYELERI ILE PROINFLAMATUAR SITOKIN DÜZEYLERI, APACHE-II SKORLARI VE MORTALITE ARASINDAKI ILIŞKI

Öz

Amaç: Adiponektin, adipositler tarafından salgılanan anti-inflamatuar bir sitokindir ve sepsis fizyopatolojisinde geniş etkilere sahiptir. Sepsis, ciddi sepsis ve septik şoklu hastalarda serum adiponektin, proinflamatuar sitokin seviyeleri, APACHE-II skorları ve mortalite arasında ilişki olup olmadığını incelemek için bu çalışma hazırlanmıştır. Hastalar ve Yöntemler: Bu prospektif çalışmaya sepsis n=18 , ciddi sepsis n=14 ve septik şok n=13 kriterlerine uyan 45 hasta dahil edildi. Elektif karın ameliyatı geçiren ama sepsis tanısı olmayan hastalar control grubu olarak belirlendi. Sepsis tanısı konulduktan sonra takip eden 5 gün boyunca hastalardan serum adiponektin, interlökin-6 IL , IL-1β, Tümör Nekrozis Faktör-α ve prokalsitonin ölçümü için kan örneği alındı. Hastalara ait APACHE-II skorları günlük kayıt edildi. Hastalar 28 gün boyunca takip edilip mortaliteler izlendi. Bulgular: Takip edilen 28 gün boyunca 10 hasta öldü. Çalışma grubundaki hastaların serum adiponektin düzeyleri kontrol grubundaki hastalara göre istatistiksel olarak yüksekti. Septik şok grubundaki hastaların adiponektin düzeyleri sepsis ve ciddi sepsis grubundaki hastalardan istatistiksel olarak belirgin düşüktü. Serum adiponektin düzeyleri ile serum IL-6, IL-1β, TNF-α, prolaktin ve laktat düzeyleri ters orantılı bulundu. Hayatta kalan hastalarda serum adiponektin seviyesi istatistiksel olarak belirgin yüksek bulundu. Sonuç: Adiponektin seviyeleri sepsis, ciddi sepsis ve septik şok gruplarında değişiklik göstermektedir. Septik şoklu hastalarda serum adiponektin seviyeleri mortalite ile ilişkiliydi. Sepsis, ciddi sepsis ve septik şoklu hastalarda serum adiponektin düzeyi negative prediktif bir belirteç olabilir.

Anahtar Kelimeler

Adiponektin,sepsis,APACHE-II,sağkalım

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Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Kürşat Dikmen

Tonguç Utku Yılmaz

Mustafa Kerem

Hasan Bostancı

Asiye Dikmen Uğraş

Özge Paşaoğlu

Öge Taşçılar

Tarkan Karakan

Publication Date

June 1, 2019

Submission Date

-

Acceptance Date

-

Published in Issue

Year 2019 Number: 2

IZ

https://izlik.org/JA27JW33SD

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RIS / Bibtex

EndNote

Dikmen K, Yılmaz TU, Kerem M, Bostancı H, Uğraş AD, Paşaoğlu Ö, Taşçılar Ö, Karakan T (June 1, 2019) The Correlation Between Serum Adiponectin Levels and Proinflammatory Cytokines" Levels, Apache-Ii Scores and Mortality In Patients With Intra-Abdominal Sepsis. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2 288–294.