Year 2020,
Issue: 3, 434 - 438, 01.09.2020
Abstract
Purpose: Migraine is associated with serious social and economic burdens. Migraine attacks are associated with trigeminal nerve stimulation and neurogenic inflammation. It has been reported that the frequency of the attacks and disease progression are related to certain inflammatory indicators. Neutrophils are the paramount cells in causing inflammatory response during acute phase reactions. Neutrophil/Lymphocytes ratio N/L has been associated with the prognosis and mortality of several diseases.Methods and Materials: The patients and control group in the age range of 18–45 years were included in the study. The relationship between N/L ratio in patients and control group was investigated.Results: There was a statistically significant difference between the N/L ratios determined during the migraine attacks and the N/L ratio values obtained in the control group. But the non-attacks were not different compared to those of the control group. No statistically significant relationships of N/L ratio were detected with any of the clinical features of migraine, VAS and MIDAS.Conclusions: The N/L ratio is associated with a migraine attack. However, with N/L ratio, disease duration, attack duration, pain frequency and pain severity; the disease disability cannot be predicted
References
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- 5. Ceylan M, Yalcin A. Coexistence of Symptoms Associated with Trigeminal Pathways in Chronic and Episodic Migraine and the Effects on Quality of Life. Pain Med 2019;20:172–9. [CrossRef]
- 6. Vanmolkot FH, de Hoon JN. Increased C-reactive protein in young adult patients with migraine. Cephalalgia 2007;27:843–6. [CrossRef ]
- 7. Tietjen GE, Khubchandani J, Herial N, Palm-Meinders IH, Koppen H, Terwindt GM, et al. Migraine and vascular disease biomarkers: A population-based case-control study. Cephalalgia 2018;38:511–8. [CrossRef]
- 8. de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care 2010;14: R192. [CrossRef]
- 9. Ear T, McDonald PP. Cytokine generation, promoter activation, and oxidant-independent NF-kappaB activation in a transfectable human neutrophilic cellular model. BMC Immunol 2008;9:14. [CrossRef]
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- 12. Gomez D, Farid S, Malik HZ, Young AL, Toogood GJ, Lodge JP, Prasad KR. Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg 2008;32:1757–62. [CrossRef]
- 13. Azab B, Bhatt VR, Phookan J, Murukutla S, Kohn N, Terjanian T, Widmann WD. Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients. Ann Surg Oncol 2012;19:217–24. [CrossRef]
- 14. Neeb L, Hellen P, Boehnke C, Hoffmann J, Schuh-Hofer S, Dirnagl U, Reuter U. IL-1β stimulates COX-2 dependent PGE₂ synthesis and CGRP release in rat trigeminal ganglia cells. PLoS ONE 2011;6:e17360. [CrossRef]
- 15. Sommer C, Kress M. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci Lett 2004;361:184–7. [CrossRef]
- 16. Williamson DJ, Hargreaves RJ. Neurogenic inflammation in the context of migraine. Microsc Res Tech 2001;53:167–78. [CrossRef]
- 17. Walkowiak B, Kozubski W, Pawlowska Z, Prusinski A, Cierniewski CS. Expression of fibrinogen receptors in platelets of migraine patients --correlation with platelet GPIIb content and plasma cholesterol. Thromb Haemost 1989;61:419–22. [CrossRef]
- 18. Bianchi A, Pitari G, Amenta V, Giuliano F, Gallina M, Costa R, Ferlito S. Endothelial, haemostatic and haemorheological modifications in migraineurs. Artery 1996;22:93–100.
- 19. Turan H, Horasanli B, Ugur M, Arslan H. Procalcitonin levels in migraine patients. Can J Neurol Sci 2011;38:124–8. [CrossRef]
- 20. Ceylan M, Bayraktutan OF, Becel S, Atis Ö, Yalcin A. Kotan D. Serum levels of pentraxin-3 and other inflammatory biomarkers in migraine: Association with migraine characteristics. Cephalalgia 2016;36:518–25. [CrossRef]
- 21. Jilma B, Blann A, Pernerstorfer T, Stohlawetz P, Eichler HG, Vondrovec B, et al. Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin. Am J Respir Crit Care Med 1999;159:857–63. [CrossRef]
- 22. Dionigi R, Dominioni L, Benevento A, Giudice G, Cuffari S, Bordone N, et al. Effects of surgical trauma of laparoscopic vs. open cholecystectomy. Hepatogastroenterology 1994;41:471–6.
- 23. O’Mahony JB, Palder SB, Wood JJ, McIrvine A, Rodrick ML, Demling RH, Mannick JA. Depression of cellular immunity after multiple trauma in the absence of sepsis. J Trauma 1984;24:869–75. [CrossRef]
- 24. Karabulut KU, Egercioglu TU, Uyar M, Ucar Y. The change of neutrophils/lymphocytes ratio in migraine attacks: A case-controlled study. Ann Med Surg (Lond) 2016;10:52–6. [CrossRef]
- 25. Yücel M, Kotan D, Gurol Çiftçi G, Çiftçi IH, Cikriklar HI. Serum levels of endocan, claudin-5 and cytokines in migraine. Eur Rev Med Pharmacol Sci 2016;20:930–6. https://www.europeanreview.org/article/10441
Year 2020,
Issue: 3, 434 - 438, 01.09.2020
Abstract
Giriş: Migrenin ciddi sosyal ve ekonomik etkisi vardır. Migren atakları trigeminal sinir uyarılması ve nörojenik inflamasyonla ilişkilidir. Atak sıklığının bazı enflamatuar belirteçlerle ilişkili olduğu bildirilmiştir. Nötrofiller akut faz reaksiyonlarında inflamatuar cevaba yol açan en önemli hücrelerdir. Nötrofil/Lenfosit oranının N/L birçok hastalıkta prognoz ve mortalite ile ilişkili olduğu bildirilmiştir. Materyal-Metod: Çalışmaya 18–45 yaş arası hastalar ve kontrol grupları dâhil edildi. Hasta ve kontrol grupları ile N/L oranı arasında ilişki araştırıldı. Bulgular: Migren atak ile kontrol grubu N/L oranı arasında istatistiksel olarak anlamlı fark vardı, ancak non-atak ile kontrol grupları karşılaştırıldığında farklı tespit edilmedi. Migren klinik özellikleri, VAS ve MIDAS ile N/L arasında ilişki tespit edilmedi. Tartışma: N/L oranı migren atakları ile ilişkilidir. Ancak, N/L oranı ile hastalık süresi, atak süresi ve ağrı sıklığı, ağrı şiddeti ve hastalık disabilitesi tahmin edilemez.
References
- 1. Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2163–96. [CrossRef]
- 2. Steiner TJ, Stovner LJ, Birbeck GL. Migraine: the seventh disabler. Cephalalgia 2013;33:289–90. [CrossRef]
- 3. Diener HC, Solbach K, Holle D, Gaul C. Integrated care for chronic migraine patients: epidemiology, burden, diagnosis and treatment options. Clin Med (Lond) 2015;15:344–50. [CrossRef]
- 4. Yu S, Liu R, Zhao G, Yang X, Qiao X, Feng J, et al. The prevalence and burden of primary headaches in China: a population-based door-todoor survey. Headache 2012;52:582–91. [CrossRef]
- 5. Ceylan M, Yalcin A. Coexistence of Symptoms Associated with Trigeminal Pathways in Chronic and Episodic Migraine and the Effects on Quality of Life. Pain Med 2019;20:172–9. [CrossRef]
- 6. Vanmolkot FH, de Hoon JN. Increased C-reactive protein in young adult patients with migraine. Cephalalgia 2007;27:843–6. [CrossRef ]
- 7. Tietjen GE, Khubchandani J, Herial N, Palm-Meinders IH, Koppen H, Terwindt GM, et al. Migraine and vascular disease biomarkers: A population-based case-control study. Cephalalgia 2018;38:511–8. [CrossRef]
- 8. de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care 2010;14: R192. [CrossRef]
- 9. Ear T, McDonald PP. Cytokine generation, promoter activation, and oxidant-independent NF-kappaB activation in a transfectable human neutrophilic cellular model. BMC Immunol 2008;9:14. [CrossRef]
- 10. Robertson CM, Coopersmith CM. The systemic inflammatory response syndrome. Microbes Infect 2006;8:1382–9. [CrossRef]
- 11. Zahorec R. Ratio of neutrophil to lymphocyte counts --rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001;102:5–14.
- 12. Gomez D, Farid S, Malik HZ, Young AL, Toogood GJ, Lodge JP, Prasad KR. Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J Surg 2008;32:1757–62. [CrossRef]
- 13. Azab B, Bhatt VR, Phookan J, Murukutla S, Kohn N, Terjanian T, Widmann WD. Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients. Ann Surg Oncol 2012;19:217–24. [CrossRef]
- 14. Neeb L, Hellen P, Boehnke C, Hoffmann J, Schuh-Hofer S, Dirnagl U, Reuter U. IL-1β stimulates COX-2 dependent PGE₂ synthesis and CGRP release in rat trigeminal ganglia cells. PLoS ONE 2011;6:e17360. [CrossRef]
- 15. Sommer C, Kress M. Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci Lett 2004;361:184–7. [CrossRef]
- 16. Williamson DJ, Hargreaves RJ. Neurogenic inflammation in the context of migraine. Microsc Res Tech 2001;53:167–78. [CrossRef]
- 17. Walkowiak B, Kozubski W, Pawlowska Z, Prusinski A, Cierniewski CS. Expression of fibrinogen receptors in platelets of migraine patients --correlation with platelet GPIIb content and plasma cholesterol. Thromb Haemost 1989;61:419–22. [CrossRef]
- 18. Bianchi A, Pitari G, Amenta V, Giuliano F, Gallina M, Costa R, Ferlito S. Endothelial, haemostatic and haemorheological modifications in migraineurs. Artery 1996;22:93–100.
- 19. Turan H, Horasanli B, Ugur M, Arslan H. Procalcitonin levels in migraine patients. Can J Neurol Sci 2011;38:124–8. [CrossRef]
- 20. Ceylan M, Bayraktutan OF, Becel S, Atis Ö, Yalcin A. Kotan D. Serum levels of pentraxin-3 and other inflammatory biomarkers in migraine: Association with migraine characteristics. Cephalalgia 2016;36:518–25. [CrossRef]
- 21. Jilma B, Blann A, Pernerstorfer T, Stohlawetz P, Eichler HG, Vondrovec B, et al. Regulation of adhesion molecules during human endotoxemia. No acute effects of aspirin. Am J Respir Crit Care Med 1999;159:857–63. [CrossRef]
- 22. Dionigi R, Dominioni L, Benevento A, Giudice G, Cuffari S, Bordone N, et al. Effects of surgical trauma of laparoscopic vs. open cholecystectomy. Hepatogastroenterology 1994;41:471–6.
- 23. O’Mahony JB, Palder SB, Wood JJ, McIrvine A, Rodrick ML, Demling RH, Mannick JA. Depression of cellular immunity after multiple trauma in the absence of sepsis. J Trauma 1984;24:869–75. [CrossRef]
- 24. Karabulut KU, Egercioglu TU, Uyar M, Ucar Y. The change of neutrophils/lymphocytes ratio in migraine attacks: A case-controlled study. Ann Med Surg (Lond) 2016;10:52–6. [CrossRef]
- 25. Yücel M, Kotan D, Gurol Çiftçi G, Çiftçi IH, Cikriklar HI. Serum levels of endocan, claudin-5 and cytokines in migraine. Eur Rev Med Pharmacol Sci 2016;20:930–6. https://www.europeanreview.org/article/10441
There are 25 citations in total.
Details
| Primary Language | English |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | September 1, 2020 |
| Published in Issue | Year 2020Issue: 3 |