Abstract
Purpose: Duodenitis is the inflammation of the duodenal mucosa and is classified as specific and non-specific. Currently, the effect of Helicobacter pylori H. pylori in the etiology of nonspecific duodenitis NSD remains unclear. In this study, the importance of H. pylori infection in NSD pathogenesis was examined. Patients and Methods: In our study, patients who underwent upper gastrointestinal endoscopy between 2013- 2016 were included in the study. 137 patients with NSD were included in the study. Age, sex, gastritis status, presence of H. pylori, duodenitis and histopathological results were recorded as data. Results: The female / male ratio of the patients included in the study was 1/1 and the mean age was 41.9 years. 59.12% n = 81 of the patients had chronic gastritis; 91.97% n = 126 had chronic duodenitis. In all patients, 58.39% n = 80 had H. pylori in the gastric mucosa. Of the patients with active chronic duodenitis, 90.91% n = 10 had H. pylori in the gastric mucosa and 72.73% n = 8 had active chronic gastritis. Conclusion: In our study, we found that chronic duodenitis was significantly associated with chronic gastritis and H. pylori. Considering this situation in the planning and treatment planning of patients, we believe that it can be important in the use of resources in terms of both treatment and examination of the patient.
References
- Taş A, Koklu S, Beyazit Y, et al. The endoscopic course of scattered white spots in the descending duodenum: a prospective study. Gastroenterol Hepatol. 2012;35:57-64. [CrossRef]
- Wang CX, Liu LJ, Guan J, Zhao XL. Ultrastructural changes in non- specific duodenitis. World J Gastroenterol. 2005;11:686-9. [CrossRef]
- http://id.who.int/icd/entity/1595026136 (18 June 2018)
- Konorev MR, Litviakov AM, Matveenko ME, et al. Principles of current classification of duodenitis. Klin Med (Mosk). 2003; 81:15-20.
- Moayyedi P. The health economics of Helicobacter pylori infection. Best Pract Res Clin Gastroenterol. 2007;21:347-61. [CrossRef]
- Sugano K, Tack J, Kuipers EJ, et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut 2015;64:1353–67. [CrossRef]
- Suzuki H, Franceschi F, Nishizawa T, Gasbarrini A. Extragastric manifestations of Helicobacter pylori infection. Helicobacter. 2011;16:65–9. [CrossRef]
- Sipponen P, Price AB. The Sydney System for classification of gastritis 20 years ago. J Gastroenterol Hepatol. 2011;26 Suppl 1:31-4. [CrossRef]
- Mirbagheri SA, Khajavirad N, Rakhshani N, et al. Impact of Helicobacter pylori infection and microscopic duodenal histopathological changes on clinical symptoms of patients with functional dyspepsia. Dig Dis Sci. 2012;57:967-72. [CrossRef]
- Kreuning J, vd Wal AM, Kuiper G, Lindeman J. Chronic nonspecific duodenitis. A multiple biopsy study of the duodenal bulb in health and disease. Scand J Gastroenterol Suppl. 1989;167:16-20.
- Peura DA, Malfertheiner P. Chairmen’s summary: dichotomies and directions in acid-related disorders. Aliment Pharmacol Ther. 2004;19:77-80.
- Voutilainen M, Juhola M, Färkkilä M, Sipponen P. Gastric metaplasia and chronic inflammation at the duodenal bulb mucosa. Dig Liver Dis. 2003;35:94-8.
- Caselli M, Gaudio M, Chiamenti CM, et al. Histologic findings and Helicobacter pylori in duodenal biopsies. J Clin Gastroenterol. 1998;26:74-80.
- Hsu CT, Yeh C, Cheng HH. Helicobacter pylori, gastritis and duodenitis in the healing process of duodenal ulcer. J Formos Med Assoc. 1992;91:81-4.
- Carmack SW, Genta RM. The diagnostic value of the duodenal biopsy: a clinico-pathologic analysis of 28,000 patients. Dig Liver Dis. 2010; 42:485-9. [CrossRef]
- Sahin A, Cihangiroglu G, Bilgic Y, Calhan T, Cengiz M. Is duodenal biopsy appropriate in areas endemic for Helicobacter pylori?. North Clin Istanb. 2017;4:13-21. [CrossRef]
- Ozdil K, Sahin A, Kahraman R, et al. Current prevalence of intestinal metaplasia and Helicobacter pylori inf ection in dyspeptic adult patients from Turkey. Hepatogastroenterology. 2010;57:1563–6.
- Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally-representative, cross- sectional, screening with the ¹³C-Urea breath test. BMC Public Health. 2013;13:1215. [CrossRef]
- Alim A, Ataş AD, Güneş T, ve ark. Sivas ili merkezinde semptomatik ve asemptomatik yetişkin bireylerde Helicobacter pylori seroprevalansı. CÜ Tıp Fak Derg 2004;26:75- 80.
- Demirtas L, İlyas Sayar İ, Akbas EM ve ark. Endoskopi yapılan hastalarda Helicobacter pylori sıklığı ve yerleşim yerinin yaş ve cinsiyete göre dağılımı. Dicle Med J. 2014;41: 507-11. [CrossRef]
Abstract
Amaç: Duodenit, duodenum mukozanın inflamasyonu olup spesifik ve nonspesifik olarak ele alınır. Günümüzde nonspesifik duodenit NSD etyolojisinde Helikobakter pilorinin H. pylori etkisi hala netleşmemiştir. Bu çalışmamızda, NSD patogenezinde H. pylori enfeksiyonunun önemi incelendi. Hastalar ve Yöntem: Araştırmamızda, 2013-2016 yılları arasında, üst sindirim sistemi endoskopisi yapılan hastalar incelemeye alındı. NSD tanısı olan 137 hasta çalışmaya dahil edildi. Hastalara ait retrospektif dosyalardan, hastaların yaşı, cinsiyeti, gastrit durumu, mide mukozasında H. pylori varlığı, duodenit ve histopatolojik sonuçları veri olarak değerlendirilerek kayıt altına alındı. Bulgular: Çalışmaya dahil edilen hastaların kadın/erkek oranı: 1/1 olup ortalama yaşları 41,9 yıl idi. Hastaların %59,12 n=81 ’sinde kronik gastrit; %91,97 n=126 ’sinde kronik duodenit saptandı. Tüm hastaların %58,39 n=80 ’unda mide mukozasında H. pylori saptandı. Aktif kronik duodenit bulunan hastaların %90,91 n=10 ’inin mide mukozasında H. pylori, %72,73 n=8 ’ünde ise aktif kronik gastrit tespit edilmiştir. Sonuç: Çalışmamızda kronik duodenitin belirgin bir şekilde kronik gastrit ve H. pylori ile birlikte olduğu belirlenmiş olup, tetkik ve tedavi planlamalarında bu durumun göz önüne alınmasının hem hastanın tedavisi hem de tetkik etmek açısından kaynakların yerinde kullanımında önemli olabileceği kanaatindeyiz.
References
- Taş A, Koklu S, Beyazit Y, et al. The endoscopic course of scattered white spots in the descending duodenum: a prospective study. Gastroenterol Hepatol. 2012;35:57-64. [CrossRef]
- Wang CX, Liu LJ, Guan J, Zhao XL. Ultrastructural changes in non- specific duodenitis. World J Gastroenterol. 2005;11:686-9. [CrossRef]
- http://id.who.int/icd/entity/1595026136 (18 June 2018)
- Konorev MR, Litviakov AM, Matveenko ME, et al. Principles of current classification of duodenitis. Klin Med (Mosk). 2003; 81:15-20.
- Moayyedi P. The health economics of Helicobacter pylori infection. Best Pract Res Clin Gastroenterol. 2007;21:347-61. [CrossRef]
- Sugano K, Tack J, Kuipers EJ, et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut 2015;64:1353–67. [CrossRef]
- Suzuki H, Franceschi F, Nishizawa T, Gasbarrini A. Extragastric manifestations of Helicobacter pylori infection. Helicobacter. 2011;16:65–9. [CrossRef]
- Sipponen P, Price AB. The Sydney System for classification of gastritis 20 years ago. J Gastroenterol Hepatol. 2011;26 Suppl 1:31-4. [CrossRef]
- Mirbagheri SA, Khajavirad N, Rakhshani N, et al. Impact of Helicobacter pylori infection and microscopic duodenal histopathological changes on clinical symptoms of patients with functional dyspepsia. Dig Dis Sci. 2012;57:967-72. [CrossRef]
- Kreuning J, vd Wal AM, Kuiper G, Lindeman J. Chronic nonspecific duodenitis. A multiple biopsy study of the duodenal bulb in health and disease. Scand J Gastroenterol Suppl. 1989;167:16-20.
- Peura DA, Malfertheiner P. Chairmen’s summary: dichotomies and directions in acid-related disorders. Aliment Pharmacol Ther. 2004;19:77-80.
- Voutilainen M, Juhola M, Färkkilä M, Sipponen P. Gastric metaplasia and chronic inflammation at the duodenal bulb mucosa. Dig Liver Dis. 2003;35:94-8.
- Caselli M, Gaudio M, Chiamenti CM, et al. Histologic findings and Helicobacter pylori in duodenal biopsies. J Clin Gastroenterol. 1998;26:74-80.
- Hsu CT, Yeh C, Cheng HH. Helicobacter pylori, gastritis and duodenitis in the healing process of duodenal ulcer. J Formos Med Assoc. 1992;91:81-4.
- Carmack SW, Genta RM. The diagnostic value of the duodenal biopsy: a clinico-pathologic analysis of 28,000 patients. Dig Liver Dis. 2010; 42:485-9. [CrossRef]
- Sahin A, Cihangiroglu G, Bilgic Y, Calhan T, Cengiz M. Is duodenal biopsy appropriate in areas endemic for Helicobacter pylori?. North Clin Istanb. 2017;4:13-21. [CrossRef]
- Ozdil K, Sahin A, Kahraman R, et al. Current prevalence of intestinal metaplasia and Helicobacter pylori inf ection in dyspeptic adult patients from Turkey. Hepatogastroenterology. 2010;57:1563–6.
- Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally-representative, cross- sectional, screening with the ¹³C-Urea breath test. BMC Public Health. 2013;13:1215. [CrossRef]
- Alim A, Ataş AD, Güneş T, ve ark. Sivas ili merkezinde semptomatik ve asemptomatik yetişkin bireylerde Helicobacter pylori seroprevalansı. CÜ Tıp Fak Derg 2004;26:75- 80.
- Demirtas L, İlyas Sayar İ, Akbas EM ve ark. Endoskopi yapılan hastalarda Helicobacter pylori sıklığı ve yerleşim yerinin yaş ve cinsiyete göre dağılımı. Dicle Med J. 2014;41: 507-11. [CrossRef]
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | September 1, 2020 |
| Published in Issue | Year 2020Issue: 3 |