Research Article
BibTex RIS Cite

Evaluation of Pneumonia Severity and Lung Computed Tomography Findings in Covid-19 Patients

Year 2024, Volume: 15 Issue: 3, 194 - 203, 01.07.2024

Melek Cihanbeylerden Çağla Şafak Cihat Tek Muhammed Savran

https://doi.org/10.31067/acusaglik.1362545

Abstract

Purpose: Early recognition of corona virus disease 2019 (COVID-19) cases is the key to reducing mortality. In this study, we aimed to describe the relationship between the clinical, laboratory, and lung computed tomography (LCT) characteristics of patients with COVID-19 pneumonia and determine the severity of pneumonia in these patients.
Methods: The pneumonia severity index (PSI) score system, LCT images, and laboratory parameters at the time of first presentation to the emergency department were examined to assess the severity of COVID-19 pneumonia in 225 adult patients.
Results: In this study, a significant relationship was found between COVID-19-associated mortality and male gender (p=0.045), advanced age (p<0.001), a high neutrophil count in peripheral blood (p<0.001), a low eosinophil count (p<0.001), 5-49% lung involvement on LCT (p<0.001), and PSI Groups IV and V (p<0.001).
Conclusion: Using the multivariate logistic regression analysis, we determined the most significant factors for mortality as advanced age, low eosinophil and lymphocyte counts, increased lactate and ferritin levels, and PSI Group V.

Keywords

Corona virus disease 2019 Pneumonia severity index Computed tomography Prognosis Mortality

References

  • 1. Loeffelholz MJ, Tang Y-W. Laboratory diagnosis of emerging human coronavirus infections–the state of the art. EMi, 2020;9(1):747-56. DOI: 10.1080/22221751.2020.1745095
  • 2. Xu X-W, Wu X-X, Jiang X-G, et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ. 2020;368. DOI: 10.1136/bmj.m606
  • 3. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-42. DOI: 10.1001/jama.2020.2648
  • 4. Pan L, Mu M, Yang P, et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. The AJG. 2020;115. DOI: 10.14309/ajg.0000000000000620
  • 5. Li K, Wu J, Wu F, et al. The clinical and chest CT features associated with severe and critical COVID-19 pneumonia. Invest Radiol. 2020. DOI: 10.1097/RLI.0000000000000672
  • 6. Liu R, Han H, Liu F, et al. Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020. CCA. 2020;505:172-5. DOI: 10.1016/j.cca.2020.03.009
  • 7. Control CfD, Prevention. Research use only real-time RT-PCR protocol for identification of 2019-nCoV. 2020.
  • 8. Wang S, Kang B, Ma J, et al. A deep learning algorithm using CT images to screen for Corona Virus Disease (COVID-19). ESR. 2021;31:6096-104. DOI: 10.1007/s00330-021-07715-1
  • 9. Hansell DM, Bankier AA, MacMahon H, et al. Fleischner Society: glossary of terms for thoracic imaging. Radiol. 2008;246(3):697-722. DOI: 10.1148/radiol.2462070712
  • 10. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. DOI: 10.1001/jama.2020.1585
  • 11. Guan W-j, Ni Z-y, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. NEJM. 2020;382(18):1708-20. DOI: 10.1056/NEJMoa2002032
  • 12. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. DOI: 10.1016/ S0140-6736(20)30183-5
  • 13. Li J, He X, Yuan Y, et al. Meta-analysis investigating the relationship between clinical features, outcomes, and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. AJIC. 2021;49(1):82-9. DOI: 10.1016/j.ajic.2020.06.008
  • 14. Qin C, Zhou L, Hu Z, et al. Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China. CID. 2020;71(15):762-8. DOI: 10.1093/cid/ciaa248
  • 15. Taylor Jr FB, Toh C-H, Hoots KW, et al. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. JTH. 2001;86(11):1327-30. DOI: 10.1055/s-0037-1616068
  • 16. Tang N, Li D, Wang X, et al. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. JTH. 2020;18(4):844-7. DOI: 10.1111/jth.14768
  • 17. Zou Z, Yang Y, Chen J, et al. Prognostic factors for severe acute respiratory syndrome: a clinical analysis of 165 cases. CID .2004;38(4):483-9. DOI: 10.1086/380973
  • 18. Colombi D, Bodini FC, Petrini M, et al. Well-aerated lung on admitting chest CT to predict adverse outcome in COVID-19 pneumonia. Radiol. 2020;296(2):E86-E96. DOI: 10.1148/radiol.2020201433
  • 19. Wang Y, Dong C, Hu Y, et al. Temporal changes of CT findings in 90 patients with COVID-19 pneumonia: a longitudinal study. Radiol. 2020;296(2):E55-E64. DOI: 10.1148/radiol.2020200843
  • 20. Bernheim A, Mei X, Huang M, et al. Chest CT findings in coronavirus disease-19 (COVID-19): relationship to duration of infection. Radiol. 2020;295(3):685-91. DOI: 10.1148/radiol.2020200463
  • 21. Chon Y, Kim JY, Suh YJ, et al. Adverse initial CT findings associated with poor prognosis of coronavirus disease. J Korean Med Sci . 2020;35(34). DOI: 10.3346/jkms.2020.35.e316
  • 22. Kim M-A, Park JS, Lee CW, et al. Pneumonia severity index in viral community acquired pneumonia in adults. PONE. 2019;14(3):e0210102. DOI: 10.1371/journal.pone.0210102

Year 2024, Volume: 15 Issue: 3, 194 - 203, 01.07.2024

Melek Cihanbeylerden Çağla Şafak Cihat Tek Muhammed Savran

https://doi.org/10.31067/acusaglik.1362545

Abstract

References

  • 1. Loeffelholz MJ, Tang Y-W. Laboratory diagnosis of emerging human coronavirus infections–the state of the art. EMi, 2020;9(1):747-56. DOI: 10.1080/22221751.2020.1745095
  • 2. Xu X-W, Wu X-X, Jiang X-G, et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ. 2020;368. DOI: 10.1136/bmj.m606
  • 3. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-42. DOI: 10.1001/jama.2020.2648
  • 4. Pan L, Mu M, Yang P, et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. The AJG. 2020;115. DOI: 10.14309/ajg.0000000000000620
  • 5. Li K, Wu J, Wu F, et al. The clinical and chest CT features associated with severe and critical COVID-19 pneumonia. Invest Radiol. 2020. DOI: 10.1097/RLI.0000000000000672
  • 6. Liu R, Han H, Liu F, et al. Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020. CCA. 2020;505:172-5. DOI: 10.1016/j.cca.2020.03.009
  • 7. Control CfD, Prevention. Research use only real-time RT-PCR protocol for identification of 2019-nCoV. 2020.
  • 8. Wang S, Kang B, Ma J, et al. A deep learning algorithm using CT images to screen for Corona Virus Disease (COVID-19). ESR. 2021;31:6096-104. DOI: 10.1007/s00330-021-07715-1
  • 9. Hansell DM, Bankier AA, MacMahon H, et al. Fleischner Society: glossary of terms for thoracic imaging. Radiol. 2008;246(3):697-722. DOI: 10.1148/radiol.2462070712
  • 10. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. DOI: 10.1001/jama.2020.1585
  • 11. Guan W-j, Ni Z-y, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. NEJM. 2020;382(18):1708-20. DOI: 10.1056/NEJMoa2002032
  • 12. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. DOI: 10.1016/ S0140-6736(20)30183-5
  • 13. Li J, He X, Yuan Y, et al. Meta-analysis investigating the relationship between clinical features, outcomes, and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. AJIC. 2021;49(1):82-9. DOI: 10.1016/j.ajic.2020.06.008
  • 14. Qin C, Zhou L, Hu Z, et al. Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China. CID. 2020;71(15):762-8. DOI: 10.1093/cid/ciaa248
  • 15. Taylor Jr FB, Toh C-H, Hoots KW, et al. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. JTH. 2001;86(11):1327-30. DOI: 10.1055/s-0037-1616068
  • 16. Tang N, Li D, Wang X, et al. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. JTH. 2020;18(4):844-7. DOI: 10.1111/jth.14768
  • 17. Zou Z, Yang Y, Chen J, et al. Prognostic factors for severe acute respiratory syndrome: a clinical analysis of 165 cases. CID .2004;38(4):483-9. DOI: 10.1086/380973
  • 18. Colombi D, Bodini FC, Petrini M, et al. Well-aerated lung on admitting chest CT to predict adverse outcome in COVID-19 pneumonia. Radiol. 2020;296(2):E86-E96. DOI: 10.1148/radiol.2020201433
  • 19. Wang Y, Dong C, Hu Y, et al. Temporal changes of CT findings in 90 patients with COVID-19 pneumonia: a longitudinal study. Radiol. 2020;296(2):E55-E64. DOI: 10.1148/radiol.2020200843
  • 20. Bernheim A, Mei X, Huang M, et al. Chest CT findings in coronavirus disease-19 (COVID-19): relationship to duration of infection. Radiol. 2020;295(3):685-91. DOI: 10.1148/radiol.2020200463
  • 21. Chon Y, Kim JY, Suh YJ, et al. Adverse initial CT findings associated with poor prognosis of coronavirus disease. J Korean Med Sci . 2020;35(34). DOI: 10.3346/jkms.2020.35.e316
  • 22. Kim M-A, Park JS, Lee CW, et al. Pneumonia severity index in viral community acquired pneumonia in adults. PONE. 2019;14(3):e0210102. DOI: 10.1371/journal.pone.0210102
There are 22 citations in total.

Details

Primary Language English
Subjects Infectious Diseases, ​Internal Diseases
Journal Section Research Articles
Authors

Melek Cihanbeylerden 0000-0002-0810-087X

Çağla Şafak 0000-0003-0451-2225

Cihat Tek 0000-0001-6673-1373

Muhammed Savran 0000-0003-2688-6930

Publication Date July 1, 2024
Submission Date September 19, 2023
Published in Issue Year 2024Volume: 15 Issue: 3

Cite

EndNote Cihanbeylerden M, Şafak Ç, Tek C, Savran M (July 1, 2024) Evaluation of Pneumonia Severity and Lung Computed Tomography Findings in Covid-19 Patients. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 15 3 194–203.
 Download Cover Image