Research Article
Year 2025,
Issue: Kabul Edilen Makaleler
Abstract
References
- 1. She J, Jiang J, Ye L, Hu L, Bai C, Song Y. 2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies. Clin Transl Med. 2020;9(1).
- 2. Qu JM, Cao B, Chen RC. Clinical features of COVID-19. Covid-19. 2021;13–39.
- 3. Conde Cardona G, Quintana Pájaro LD, Quintero Marzola ID, Ramos Villegas Y, Moscote Salazar LR. Neurotropism of SARS-CoV 2: Mechanisms and manifestations. J Neurol Sci. 2020;412.
- 4. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-280.e8.
- 5. Iroegbu JD, Ifenatuoha CW, Ijomone OM. Potential neurological impact of coronaviruses: implications for the novel SARS-CoV-2. Neurological Sciences. 2020;41(6):1329–37.
- 6. Almufarrij I, Munro KJ. One year on: an updated systematic review of SARS-CoV-2, COVID-19 and audio-vestibular symptoms. Int J Audiol. 2021;60(12):935–45.
- 7. De Santis G. SARS-CoV-2: A new virus but a familiar inflammation brain pattern. Brain Behav Immun. 2020;87:95–6.
- 8. Öztürk B, Kavruk H, Aykul A. Audiological findings in individuals diagnosed with COVID-19. American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 2022;43(3).
- 9 Jerger J. Clinical experience with impedance audiometry. Arch Otolaryngol. 1970 Oct;92(4):311–24.
- 10 Grais EM, Wang X, Wang J, Zhao F, Jiang W, Cai Y, et al. Analysing wideband absorbance immittance in normal and ears with otitis media with effusion using machine learning. Sci Rep. 2021;11(1).
- 11 Kalcioglu MT, Sallavaci S, Hrncic N, Beishenova M, Davcheva Cakar M, Vlaski L, et al. Prevalence of and factors affecting otitis media with effusion in children in the region from Balkans to Caspian basin; A multicentric cross-sectional study. Int J Pediatr Otorhinolaryngol. 2021;143.
- 12 G CJ. Uses and abuses of hearing loss classification. ASHA. 1981;23(7):493–500.
- 13 Harris FP. Distortion-product otoacoustic emissions in humans with high frequency sensorineural hearing loss. J Speech Hear Res. 1990;33(3):594–600.
- 14 Yong SJ. Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis. ACS Chem Neurosci. 2021;12(4):573–80.
- 15 George D, Mallery P. IBM SPSS Statistics 26 Step by Step. IBM SPSS Statistics 26 Step by Step. Routledge; 2019.
- 16. Abramovich S, Prasher DK. Electrocochleography and Brain-Stem Potentials in Ramsay Hunt Syndrome. Arch Otolaryngol Head Neck Surg. 1986;112(9):925–8.
- 17 Cohen BE, Durstenfeld A, Roehm PC. Viral Causes of Hearing Loss: A Review for Hearing Health Professionals. Trends Hear. 2014 Oct;18:233121651454136.
- 18 Lamounier P, Gonçalves VF, Ramos HVL, Gobbo DA, Teixeira RP, Dos Reis PC, et al. A 67-year-old woman with sudden hearing loss associated with SARS-CoV-2 infection. American Journal of Case Reports. 2020;21:1–6.
- 19 Brzycki M, Richard R, Burwick N, Graf S, O’Brien C, Wu D, et al. Autologous hematopoietic transplantation following COVID-19 infection. Clin Case Rep. 2021;9(3):1167–70.
- 20 Sağlam S. Audiological Evaluation of Healed Covid-19 Patients. Gelisim University, Istanbul.; 2021.
- 21 Groiss SJ, Balloff C, Elben S, Brandenburger T, Müttel T, Kindgen-Milles D, et al. Prolonged Neuropsychological Deficits, Central Nervous System Involvement, and Brain Stem Affection After COVID-19—A Case Series. Front Neurol. 2020;11.
- 22 Gedik O, Hüsam H, Başöz M, Tas N, Aksoy F. The effect of coronavirus disease 2019 on the hearing system. Journal of Laryngology and Otology. 2021;135(9):810–4.
- 23 Mustafa MWM. Audiological profile of asymptomatic Covid-19 PCR-positive cases. American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 2020;41(3).
- 24 Dorobisz, K., Pazdro-Zastawny, K., Misiak, P., Kruk-Krzemień, A., & Zatoński, T. Sensorineural Hearing Loss in Patients with Long-COVID-19: Objective and Behavioral Audiometric Findings. Infection and Drug Resistance. 2023; 16:1931–1939. https://doi.org/10.2147/IDR.S398126
- 25. Celesia GG. Hearing disorders in brainstem lesions. In: Handbook of Clinical Neurology. 2015. p. 509–36.
Year 2025,
Issue: Kabul Edilen Makaleler
Abstract
Purpose: The aim of this study was to investigate whether auditory pathways at the brainstem level are affected in volunteers with normal hearing infected with SARS-CoV-2 virus, which is thought to localize in the brainstem and cause symptoms such as loss of smell and taste.
Methods: A total of 60 volunteers (120 ears), 30 (21 females and 9 males; M: 24.5±5.5) infected (study group) and 30 (18 females and 12 males; M: 20.7±2) never infected (control group), aged 17-45 years, were included in the study. The study group consisted of individuals who had Covid-19 and had at least one of the symptoms known to occur with the localization of the virus in the brainstem, such as nausea-vomiting, loss of smell-taste, weakness-fatigue.
The latency and amplitude values of auditory brainstem responses elicited at 80 dB nHL with LS-CE chirp stimuli were compared between the two groups. I, III, and V-wave latencies, I-III, III-V, and I-V interpic latencies, I, III, and V-wave amplitudes, and V/I amplitude ratio parameters were evaluated in the ABR test.
Results: Although no statistically significant difference (p>0.05) was observed between the study group and the control group in all parameters, it was found that the amplitudes of the waves were lower in the study group compared to the control group.
Conclusion: Although the findings did not show any significant results, the study group's worse amplitudes may indicate the presence of brainstem damage.
References
- 1. She J, Jiang J, Ye L, Hu L, Bai C, Song Y. 2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies. Clin Transl Med. 2020;9(1).
- 2. Qu JM, Cao B, Chen RC. Clinical features of COVID-19. Covid-19. 2021;13–39.
- 3. Conde Cardona G, Quintana Pájaro LD, Quintero Marzola ID, Ramos Villegas Y, Moscote Salazar LR. Neurotropism of SARS-CoV 2: Mechanisms and manifestations. J Neurol Sci. 2020;412.
- 4. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-280.e8.
- 5. Iroegbu JD, Ifenatuoha CW, Ijomone OM. Potential neurological impact of coronaviruses: implications for the novel SARS-CoV-2. Neurological Sciences. 2020;41(6):1329–37.
- 6. Almufarrij I, Munro KJ. One year on: an updated systematic review of SARS-CoV-2, COVID-19 and audio-vestibular symptoms. Int J Audiol. 2021;60(12):935–45.
- 7. De Santis G. SARS-CoV-2: A new virus but a familiar inflammation brain pattern. Brain Behav Immun. 2020;87:95–6.
- 8. Öztürk B, Kavruk H, Aykul A. Audiological findings in individuals diagnosed with COVID-19. American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 2022;43(3).
- 9 Jerger J. Clinical experience with impedance audiometry. Arch Otolaryngol. 1970 Oct;92(4):311–24.
- 10 Grais EM, Wang X, Wang J, Zhao F, Jiang W, Cai Y, et al. Analysing wideband absorbance immittance in normal and ears with otitis media with effusion using machine learning. Sci Rep. 2021;11(1).
- 11 Kalcioglu MT, Sallavaci S, Hrncic N, Beishenova M, Davcheva Cakar M, Vlaski L, et al. Prevalence of and factors affecting otitis media with effusion in children in the region from Balkans to Caspian basin; A multicentric cross-sectional study. Int J Pediatr Otorhinolaryngol. 2021;143.
- 12 G CJ. Uses and abuses of hearing loss classification. ASHA. 1981;23(7):493–500.
- 13 Harris FP. Distortion-product otoacoustic emissions in humans with high frequency sensorineural hearing loss. J Speech Hear Res. 1990;33(3):594–600.
- 14 Yong SJ. Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis. ACS Chem Neurosci. 2021;12(4):573–80.
- 15 George D, Mallery P. IBM SPSS Statistics 26 Step by Step. IBM SPSS Statistics 26 Step by Step. Routledge; 2019.
- 16. Abramovich S, Prasher DK. Electrocochleography and Brain-Stem Potentials in Ramsay Hunt Syndrome. Arch Otolaryngol Head Neck Surg. 1986;112(9):925–8.
- 17 Cohen BE, Durstenfeld A, Roehm PC. Viral Causes of Hearing Loss: A Review for Hearing Health Professionals. Trends Hear. 2014 Oct;18:233121651454136.
- 18 Lamounier P, Gonçalves VF, Ramos HVL, Gobbo DA, Teixeira RP, Dos Reis PC, et al. A 67-year-old woman with sudden hearing loss associated with SARS-CoV-2 infection. American Journal of Case Reports. 2020;21:1–6.
- 19 Brzycki M, Richard R, Burwick N, Graf S, O’Brien C, Wu D, et al. Autologous hematopoietic transplantation following COVID-19 infection. Clin Case Rep. 2021;9(3):1167–70.
- 20 Sağlam S. Audiological Evaluation of Healed Covid-19 Patients. Gelisim University, Istanbul.; 2021.
- 21 Groiss SJ, Balloff C, Elben S, Brandenburger T, Müttel T, Kindgen-Milles D, et al. Prolonged Neuropsychological Deficits, Central Nervous System Involvement, and Brain Stem Affection After COVID-19—A Case Series. Front Neurol. 2020;11.
- 22 Gedik O, Hüsam H, Başöz M, Tas N, Aksoy F. The effect of coronavirus disease 2019 on the hearing system. Journal of Laryngology and Otology. 2021;135(9):810–4.
- 23 Mustafa MWM. Audiological profile of asymptomatic Covid-19 PCR-positive cases. American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 2020;41(3).
- 24 Dorobisz, K., Pazdro-Zastawny, K., Misiak, P., Kruk-Krzemień, A., & Zatoński, T. Sensorineural Hearing Loss in Patients with Long-COVID-19: Objective and Behavioral Audiometric Findings. Infection and Drug Resistance. 2023; 16:1931–1939. https://doi.org/10.2147/IDR.S398126
- 25. Celesia GG. Hearing disorders in brainstem lesions. In: Handbook of Clinical Neurology. 2015. p. 509–36.
There are 25 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Audiology |
| Journal Section | Clinical Research |
| Authors | |
| Early Pub Date | December 10, 2024 |
| Publication Date | |
| Submission Date | January 3, 2024 |
| Acceptance Date | September 26, 2024 |
| Published in Issue | Year 2025Issue: Kabul Edilen Makaleler |