Evaluating the Impact of Dienogest on Quality of Life in Turkish Patients with Endometriosis: A Clinical Study

Tevfik Berk Bıldacı; Yasemin Ozgunayer Atmaca; Can Ata; Ufuk Atlıhan; Hüseyin Aytuğ Avşar; Selçuk Erkılınç

doi:10.31067/acusaglik.1668799

Research Article

Year 2025, Volume: 16 Issue: 4, 534 - 539, 01.10.2025

Tevfik Berk Bıldacı , Yasemin Ozgunayer Atmaca , Can Ata , Ufuk Atlıhan , Hüseyin Aytuğ Avşar , Selçuk Erkılınç

https://doi.org/10.31067/acusaglik.1668799

Abstract

References

1. Chapron C, Marcellin L, Borghese B, et al. Rethinking mechanisms, diagnosis and management of endometriosis. Nat Rev Endocrinol. 2019;15(11):666-82. Epub 20190905. doi: 10.1038/s41574-019- 0245-z. PubMed PMID: 31488888.
2. Vitale SG, Capriglione S, Peterlunger I, et al. The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner. Oxid Med Cell Longev. 2018;2018:7924021. Epub 20180321. doi: 10.1155/2018/7924021. PubMed PMID: 29743986; PubMed Central PMCID: PMC5883985.
3. Parasar P, Ozcan P, Terry KL. Endometriosis: Epidemiology, Diagnosis and Clinical Management. Curr Obstet Gynecol Rep. 2017;6(1):34-41. Epub 20170127. doi: 10.1007/s13669-017-0187-1. PubMed PMID: 29276652; PubMed Central PMCID: PMC5737931.
4. Koninckx PR, Fernandes R, Ussia A, et al. Pathogenesis Based Diagnosis and Treatment of Endometriosis. Front Endocrinol (Lausanne). 2021;12:745548. Epub 20211125. doi: 10.3389/ fendo.2021.745548. PubMed PMID: 34899597; PubMed Central PMCID: PMC8656967.
5. Laganà AS, La Rosa VL, Rapisarda AMC, et al. Anxiety and depression in patients with endometriosis: impact and management challenges. Int J Womens Health. 2017;9:323-30. Epub 20170516. doi: 10.2147/ ijwh.S119729. PubMed PMID: 28553145; PubMed Central PMCID: PMC5440042.
6. Jia SZ, Leng JH, Shi JH, et al. Health-related quality of life in women with endometriosis: a systematic review. J Ovarian Res. 2012;5(1):29. Epub 20121018. doi: 10.1186/1757-2215-5-29. PubMed PMID: 23078813; PubMed Central PMCID: PMC3507705.
7. Grundström H, Gerdle B, Alehagen S, et al. Reduced pain thresholds and signs of sensitization in women with persistent pelvic pain and suspected endometriosis. Acta Obstet Gynecol Scand. 2019;98(3):327-36. Epub 20181230. doi: 10.1111/aogs.13508. PubMed PMID: 30472739.
8. Marques A, Bahamondes L, Aldrighi JM, et al. Quality of life in Brazilian women with endometriosis assessed through a medical outcome questionnaire. J Reprod Med. 2004;49(2):115-20. PubMed PMID: 15018440.
9. Jones G, Kennedy S, Barnard A, et al. Development of an endometriosis quality-of-life instrument: The Endometriosis Health Profile-30. Obstet Gynecol. 2001;98(2):258-64. doi: 10.1016/s0029- 7844(01)01433-8. PubMed PMID: 11506842.
10. Vincent K, Kennedy S, Stratton P. Pain scoring in endometriosis: entry criteria and outcome measures for clinical trials. Report from the Art and Science of Endometriosis meeting. Fertil Steril. 2010;93(1):62- 7. Epub 20081105. doi: 10.1016/j.fertnstert.2008.09.056. PubMed PMID: 18990378; PubMed Central PMCID: PMC2940106.
11. Oettel M, Breitbarth H, Elger W, et al. The pharmacological profile of dienogest. The European Journal of Contraception & Reproductive Health Care. 1999;4(sup1):2-13. doi: 10.3109/13625189909085259.
12. Strowitzki T, Marr J, Gerlinger C, et al. Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial. Human Reproduction. 2010;25(3):633-41. doi: 10.1093/humrep/ dep469.
13. Falcone T, Flyckt R. Clinical Management of Endometriosis. Obstetrics & Gynecology. 2018;131(3).
14. El Taha L, Abu Musa A, Khalifeh D, et al. Efficacy of dienogest vs combined oral contraceptive on pain associated with endometriosis: Randomized clinical trial. Eur J Obstet Gynecol Reprod Biol. 2021;267:205-12. Epub 20211030. doi: 10.1016/j.ejogrb.2021.10.029. PubMed PMID: 34826668.
15. Darici E, Kemahlı MNC, Bahat PY, et al. Validation of the Turkish version of Endometriosis Health Profile questionnaire (EHP-30) to evaluate the quality of life in women with endometriosis. Facts Views Vis Obgyn. 2023;15(2):131-6. doi: 10.52054/fvvo.15.2.079. PubMed PMID: 37436049; PubMed Central PMCID: PMC10410650.
16. Techatraisak K, Hestiantoro A, Ruey S, et al. Effectiveness of dienogest in improving quality of life in Asian women with endometriosis (ENVISIOeN): interim results from a prospective cohort study under real-life clinical practice. BMC Womens Health. 2019;19(1):68. Epub 20190516. doi: 10.1186/s12905-019-0758-6. PubMed PMID: 31096979; PubMed Central PMCID: PMC6524261.
17. Schindler AE. Dienogest in long-term treatment of endometriosis. Int J Womens Health. 2011;3:175-84. Epub 20110706. doi: 10.2147/ ijwh.S5633. PubMed PMID: 21792339; PubMed Central PMCID: PMC3140813.
18. Techatraisak K, Hestiantoro A, Soon R, et al. Impact of Long- Term Dienogest Therapy on Quality of Life in Asian Women with Endometriosis: the Prospective Non-Interventional Study ENVISIOeN. Reprod Sci. 2022;29(4):1157-69. Epub 20220202. doi: 10.1007/s43032-021-00787-w. PubMed PMID: 35112299; PubMed Central PMCID: PMC8907083.

Evaluating the Impact of Dienogest on Quality of Life in Turkish Patients with Endometriosis: A Clinical Study

Year 2025, Volume: 16 Issue: 4, 534 - 539, 01.10.2025

Tevfik Berk Bıldacı , Yasemin Ozgunayer Atmaca , Can Ata , Ufuk Atlıhan , Hüseyin Aytuğ Avşar , Selçuk Erkılınç

https://doi.org/10.31067/acusaglik.1668799

Abstract

Purpose
This study aimed to evaluate the effectiveness of dienogest in alleviating the negative effects associated with endometriosis in Turkish patients. The impact of the treatment on health-related quality of life (HRQoL) was assessed using the validated Turkish version of the Endometriosis Health Profile-30 (EHP-30) questionnaire.
Methods
A total of 119 patients with a confirmed diagnosis of endometrioma characterized by a unilocular cyst with homogeneous ground-glass echogenicity were included in this study, conducted at a tertiary care center. All participants were prescribed or already have been prescribed a continuous regimen of 2 mg/day dienogest for symptom control. Each patient completed the core section of the EHP-30 questionnaire twice: before treatment initiation and after a defined treatment period.
Results
A significant improvement was observed in total EHP-30 scores (from 96.92 to 52.03, p < .001). Notable improvements were also found in the pain (p < .001), self-image (p < .001), and emotional well-being (p < .001) subdomains. Changes in EHP-30 scores were not found to be significantly correlated with treatment duration, reduction in endometrioma size, or changes in CA125 levels.
Conclusion
Dienogest significantly improves quality of life even with short-term use and stands out as an effective treatment option for endometriosis.

Keywords

Dienogest , Endometriosis , Pain , Quality of Life , Questionnaires

References

1. Chapron C, Marcellin L, Borghese B, et al. Rethinking mechanisms, diagnosis and management of endometriosis. Nat Rev Endocrinol. 2019;15(11):666-82. Epub 20190905. doi: 10.1038/s41574-019- 0245-z. PubMed PMID: 31488888.
2. Vitale SG, Capriglione S, Peterlunger I, et al. The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner. Oxid Med Cell Longev. 2018;2018:7924021. Epub 20180321. doi: 10.1155/2018/7924021. PubMed PMID: 29743986; PubMed Central PMCID: PMC5883985.
3. Parasar P, Ozcan P, Terry KL. Endometriosis: Epidemiology, Diagnosis and Clinical Management. Curr Obstet Gynecol Rep. 2017;6(1):34-41. Epub 20170127. doi: 10.1007/s13669-017-0187-1. PubMed PMID: 29276652; PubMed Central PMCID: PMC5737931.
4. Koninckx PR, Fernandes R, Ussia A, et al. Pathogenesis Based Diagnosis and Treatment of Endometriosis. Front Endocrinol (Lausanne). 2021;12:745548. Epub 20211125. doi: 10.3389/ fendo.2021.745548. PubMed PMID: 34899597; PubMed Central PMCID: PMC8656967.
5. Laganà AS, La Rosa VL, Rapisarda AMC, et al. Anxiety and depression in patients with endometriosis: impact and management challenges. Int J Womens Health. 2017;9:323-30. Epub 20170516. doi: 10.2147/ ijwh.S119729. PubMed PMID: 28553145; PubMed Central PMCID: PMC5440042.
6. Jia SZ, Leng JH, Shi JH, et al. Health-related quality of life in women with endometriosis: a systematic review. J Ovarian Res. 2012;5(1):29. Epub 20121018. doi: 10.1186/1757-2215-5-29. PubMed PMID: 23078813; PubMed Central PMCID: PMC3507705.
7. Grundström H, Gerdle B, Alehagen S, et al. Reduced pain thresholds and signs of sensitization in women with persistent pelvic pain and suspected endometriosis. Acta Obstet Gynecol Scand. 2019;98(3):327-36. Epub 20181230. doi: 10.1111/aogs.13508. PubMed PMID: 30472739.
8. Marques A, Bahamondes L, Aldrighi JM, et al. Quality of life in Brazilian women with endometriosis assessed through a medical outcome questionnaire. J Reprod Med. 2004;49(2):115-20. PubMed PMID: 15018440.
9. Jones G, Kennedy S, Barnard A, et al. Development of an endometriosis quality-of-life instrument: The Endometriosis Health Profile-30. Obstet Gynecol. 2001;98(2):258-64. doi: 10.1016/s0029- 7844(01)01433-8. PubMed PMID: 11506842.
10. Vincent K, Kennedy S, Stratton P. Pain scoring in endometriosis: entry criteria and outcome measures for clinical trials. Report from the Art and Science of Endometriosis meeting. Fertil Steril. 2010;93(1):62- 7. Epub 20081105. doi: 10.1016/j.fertnstert.2008.09.056. PubMed PMID: 18990378; PubMed Central PMCID: PMC2940106.
11. Oettel M, Breitbarth H, Elger W, et al. The pharmacological profile of dienogest. The European Journal of Contraception & Reproductive Health Care. 1999;4(sup1):2-13. doi: 10.3109/13625189909085259.
12. Strowitzki T, Marr J, Gerlinger C, et al. Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial. Human Reproduction. 2010;25(3):633-41. doi: 10.1093/humrep/ dep469.
13. Falcone T, Flyckt R. Clinical Management of Endometriosis. Obstetrics & Gynecology. 2018;131(3).
14. El Taha L, Abu Musa A, Khalifeh D, et al. Efficacy of dienogest vs combined oral contraceptive on pain associated with endometriosis: Randomized clinical trial. Eur J Obstet Gynecol Reprod Biol. 2021;267:205-12. Epub 20211030. doi: 10.1016/j.ejogrb.2021.10.029. PubMed PMID: 34826668.
15. Darici E, Kemahlı MNC, Bahat PY, et al. Validation of the Turkish version of Endometriosis Health Profile questionnaire (EHP-30) to evaluate the quality of life in women with endometriosis. Facts Views Vis Obgyn. 2023;15(2):131-6. doi: 10.52054/fvvo.15.2.079. PubMed PMID: 37436049; PubMed Central PMCID: PMC10410650.
16. Techatraisak K, Hestiantoro A, Ruey S, et al. Effectiveness of dienogest in improving quality of life in Asian women with endometriosis (ENVISIOeN): interim results from a prospective cohort study under real-life clinical practice. BMC Womens Health. 2019;19(1):68. Epub 20190516. doi: 10.1186/s12905-019-0758-6. PubMed PMID: 31096979; PubMed Central PMCID: PMC6524261.
17. Schindler AE. Dienogest in long-term treatment of endometriosis. Int J Womens Health. 2011;3:175-84. Epub 20110706. doi: 10.2147/ ijwh.S5633. PubMed PMID: 21792339; PubMed Central PMCID: PMC3140813.
18. Techatraisak K, Hestiantoro A, Soon R, et al. Impact of Long- Term Dienogest Therapy on Quality of Life in Asian Women with Endometriosis: the Prospective Non-Interventional Study ENVISIOeN. Reprod Sci. 2022;29(4):1157-69. Epub 20220202. doi: 10.1007/s43032-021-00787-w. PubMed PMID: 35112299; PubMed Central PMCID: PMC8907083.

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Details

Primary Language	English
Subjects	Obstetrics and Gynaecology
Journal Section	Research Articles
Authors	Tevfik Berk Bıldacı 0000-0002-6432-6777 Yasemin Ozgunayer Atmaca 0009-0009-2633-634X Can Ata 0000-0002-0841-0480 Ufuk Atlıhan 0000-0002-2109-1373 Hüseyin Aytuğ Avşar 0000-0003-0636-3104 Selçuk Erkılınç 0000-0002-6512-9070
Early Pub Date	September 15, 2025
Publication Date	October 1, 2025
Submission Date	April 1, 2025
Acceptance Date	June 24, 2025
Published in Issue	Year 2025 Volume: 16 Issue: 4

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EndNote	Bıldacı TB, Ozgunayer Atmaca Y, Ata C, Atlıhan U, Avşar HA, Erkılınç S (October 1, 2025) Evaluating the Impact of Dienogest on Quality of Life in Turkish Patients with Endometriosis: A Clinical Study. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 16 4 534–539.

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